Atefeh Pourkhalili Langeroudi
@atefehpourkhalili.bsky.social
PhD Candidate at Heidelberg University | Cancer Neuroscience at Venkataramani lab
Reposted by Atefeh Pourkhalili Langeroudi
Fantastic work by the amazing @svenjaktetzlaff.bsky.social , @ekinreyhan.bsky.social and the @venkataramanilab.bsky.social !!
Important and beautiful study 🤩 and I am happy and honored to have played a small part in it!
Important and beautiful study 🤩 and I am happy and honored to have played a small part in it!
🧵Just in time for
: New research from the Venkataramani lab @CellCellPress
maps how brain tumor cells create extensive neural networks in glioblastoma. Check out our paper here: authors.elsevier.com/sd/article/S...
@ekinreyhan.bsky.social
@svenjaktetzlaff.bsky.social
1/15
: New research from the Venkataramani lab @CellCellPress
maps how brain tumor cells create extensive neural networks in glioblastoma. Check out our paper here: authors.elsevier.com/sd/article/S...
@ekinreyhan.bsky.social
@svenjaktetzlaff.bsky.social
1/15
December 7, 2024 at 8:31 AM
Fantastic work by the amazing @svenjaktetzlaff.bsky.social , @ekinreyhan.bsky.social and the @venkataramanilab.bsky.social !!
Important and beautiful study 🤩 and I am happy and honored to have played a small part in it!
Important and beautiful study 🤩 and I am happy and honored to have played a small part in it!
Reposted by Atefeh Pourkhalili Langeroudi
Important #cancerneuroscience work from the amazing @venkataramanilab.bsky.social and as shared first @svenjaktetzlaff.bsky.social and @ekinreyhan.bsky.social !
Check it out 👇
Check it out 👇
🧵Just in time for
: New research from the Venkataramani lab @CellCellPress
maps how brain tumor cells create extensive neural networks in glioblastoma. Check out our paper here: authors.elsevier.com/sd/article/S...
@ekinreyhan.bsky.social
@svenjaktetzlaff.bsky.social
1/15
: New research from the Venkataramani lab @CellCellPress
maps how brain tumor cells create extensive neural networks in glioblastoma. Check out our paper here: authors.elsevier.com/sd/article/S...
@ekinreyhan.bsky.social
@svenjaktetzlaff.bsky.social
1/15
December 7, 2024 at 8:32 AM
Important #cancerneuroscience work from the amazing @venkataramanilab.bsky.social and as shared first @svenjaktetzlaff.bsky.social and @ekinreyhan.bsky.social !
Check it out 👇
Check it out 👇
Reposted by Atefeh Pourkhalili Langeroudi
🧵Just in time for
: New research from the Venkataramani lab @CellCellPress
maps how brain tumor cells create extensive neural networks in glioblastoma. Check out our paper here: authors.elsevier.com/sd/article/S...
@ekinreyhan.bsky.social
@svenjaktetzlaff.bsky.social
1/15
: New research from the Venkataramani lab @CellCellPress
maps how brain tumor cells create extensive neural networks in glioblastoma. Check out our paper here: authors.elsevier.com/sd/article/S...
@ekinreyhan.bsky.social
@svenjaktetzlaff.bsky.social
1/15
December 6, 2024 at 11:18 PM
🧵Just in time for
: New research from the Venkataramani lab @CellCellPress
maps how brain tumor cells create extensive neural networks in glioblastoma. Check out our paper here: authors.elsevier.com/sd/article/S...
@ekinreyhan.bsky.social
@svenjaktetzlaff.bsky.social
1/15
: New research from the Venkataramani lab @CellCellPress
maps how brain tumor cells create extensive neural networks in glioblastoma. Check out our paper here: authors.elsevier.com/sd/article/S...
@ekinreyhan.bsky.social
@svenjaktetzlaff.bsky.social
1/15
Reposted by Atefeh Pourkhalili Langeroudi
🌟 Interested in joining our team? We're hiring at all levels - from research technicians, MD and PhD students to postdocs. Contact: varun.venkataramani@med.uni-heidelberg.de 15/15
December 6, 2024 at 11:18 PM
🌟 Interested in joining our team? We're hiring at all levels - from research technicians, MD and PhD students to postdocs. Contact: varun.venkataramani@med.uni-heidelberg.de 15/15
Reposted by Atefeh Pourkhalili Langeroudi
We are incredibly grateful for the patients, their families and the funding agencies for enabling this research!
December 6, 2024 at 11:18 PM
We are incredibly grateful for the patients, their families and the funding agencies for enabling this research!
Reposted by Atefeh Pourkhalili Langeroudi
Sonja Hänzelmann,
@matthiakarreman.bsky.social, Felix Kurz, Manuel Schröter, Marc Thieeir, Abigail Suwala, Karin Forsberg-Nilsson, Claudio Acuna,
@saezlab.bsky.social , Amir Abdollahi, Felix Sahm, Michael Breckwoldt, Bogdana Suchorska, Franz Ricklefs, Dieter Henrik Heiland
@matthiakarreman.bsky.social, Felix Kurz, Manuel Schröter, Marc Thieeir, Abigail Suwala, Karin Forsberg-Nilsson, Claudio Acuna,
@saezlab.bsky.social , Amir Abdollahi, Felix Sahm, Michael Breckwoldt, Bogdana Suchorska, Franz Ricklefs, Dieter Henrik Heiland
Bluesky
arreman.bsky.social
December 6, 2024 at 11:18 PM
Sonja Hänzelmann,
@matthiakarreman.bsky.social, Felix Kurz, Manuel Schröter, Marc Thieeir, Abigail Suwala, Karin Forsberg-Nilsson, Claudio Acuna,
@saezlab.bsky.social , Amir Abdollahi, Felix Sahm, Michael Breckwoldt, Bogdana Suchorska, Franz Ricklefs, Dieter Henrik Heiland
@matthiakarreman.bsky.social, Felix Kurz, Manuel Schröter, Marc Thieeir, Abigail Suwala, Karin Forsberg-Nilsson, Claudio Acuna,
@saezlab.bsky.social , Amir Abdollahi, Felix Sahm, Michael Breckwoldt, Bogdana Suchorska, Franz Ricklefs, Dieter Henrik Heiland
Reposted by Atefeh Pourkhalili Langeroudi
@atefehpourkhalili.bsky.social
@ninadrewa.bsky.social
@afaymonville.bsky.social
ville.bsky.social
@ekeifert.bsky.social
eifert.bsky.social, Julia Wagner,
@stellasoyka.bsky.social @marccschubert.bsky.social
@nirosansivapalan.bsky.social
@ninadrewa.bsky.social
@afaymonville.bsky.social
ville.bsky.social
@ekeifert.bsky.social
eifert.bsky.social, Julia Wagner,
@stellasoyka.bsky.social @marccschubert.bsky.social
@nirosansivapalan.bsky.social
Andres Villegas (@ville.bsky.social)
Systems are life
ville.bsky.social
December 6, 2024 at 11:18 PM
Reposted by Atefeh Pourkhalili Langeroudi
So proud of the shared first authors
@ekinreyhan.bsky.social sky.social @svenjaktetzlaff.bsky.social etzlaff.bsky.social
and the entire team of amazing collaborators
@layern.bsky.social Peter Bengtson, Alina Heuer,
@julianschroers.bsky.social
@afaymonville.bsky.social
@ekinreyhan.bsky.social sky.social @svenjaktetzlaff.bsky.social etzlaff.bsky.social
and the entire team of amazing collaborators
@layern.bsky.social Peter Bengtson, Alina Heuer,
@julianschroers.bsky.social
@afaymonville.bsky.social
Bluesky
Social media as it should be. Find your community among millions of users, unleash your creativity, and have some fun again.
bsky.social
December 6, 2024 at 11:18 PM
So proud of the shared first authors
@ekinreyhan.bsky.social sky.social @svenjaktetzlaff.bsky.social etzlaff.bsky.social
and the entire team of amazing collaborators
@layern.bsky.social Peter Bengtson, Alina Heuer,
@julianschroers.bsky.social
@afaymonville.bsky.social
@ekinreyhan.bsky.social sky.social @svenjaktetzlaff.bsky.social etzlaff.bsky.social
and the entire team of amazing collaborators
@layern.bsky.social Peter Bengtson, Alina Heuer,
@julianschroers.bsky.social
@afaymonville.bsky.social
Reposted by Atefeh Pourkhalili Langeroudi
🔗 This research showcases the importance of bespoke methods development for Cancer Neuroscience, how it will advance our understanding of (brain) cancer circuits and the development of novel therapeutics for yet incurable tumors. 14/15
December 6, 2024 at 11:18 PM
🔗 This research showcases the importance of bespoke methods development for Cancer Neuroscience, how it will advance our understanding of (brain) cancer circuits and the development of novel therapeutics for yet incurable tumors. 14/15
Reposted by Atefeh Pourkhalili Langeroudi
📊 Beyond just mapping, this work provides new therapeutic targets and a platform for testing treatments against these aggressive brain tumors. 13/15
December 6, 2024 at 11:18 PM
📊 Beyond just mapping, this work provides new therapeutic targets and a platform for testing treatments against these aggressive brain tumors. 13/15
Reposted by Atefeh Pourkhalili Langeroudi
🦠 Lastly, modified rabies viruses to disconnect tumor-connected neurons from brain tumor cells offer a potential novel therapeutic approach. 12/15
December 6, 2024 at 11:18 PM
🦠 Lastly, modified rabies viruses to disconnect tumor-connected neurons from brain tumor cells offer a potential novel therapeutic approach. 12/15
Reposted by Atefeh Pourkhalili Langeroudi
💊 This led us to combine radiation with drugs that reduce neuronal activity. The combination proved more effective at treating tumors than either approach alone. 10/15
December 6, 2024 at 11:18 PM
💊 This led us to combine radiation with drugs that reduce neuronal activity. The combination proved more effective at treating tumors than either approach alone. 10/15
Reposted by Atefeh Pourkhalili Langeroudi
📡 Radiation therapy revealed something unexpected: It increased neuronal activity and subsequently connections between neurons and tumor cells. 9/15
December 6, 2024 at 11:18 PM
📡 Radiation therapy revealed something unexpected: It increased neuronal activity and subsequently connections between neurons and tumor cells. 9/15
Reposted by Atefeh Pourkhalili Langeroudi
🔍 A key discovery was the role of cholinergic neurons connected to glioblastoma cells: blocking their communication pathway slowed cortical tumor growth. 8/15
December 6, 2024 at 11:18 PM
🔍 A key discovery was the role of cholinergic neurons connected to glioblastoma cells: blocking their communication pathway slowed cortical tumor growth. 8/15
Reposted by Atefeh Pourkhalili Langeroudi
🧬 Using single-cell RNA sequencing and a functional neurotransmitter receptor screening, we found tumor cells express receptors for multiple neurotransmitters. This allows them to receive signals from many different types of neurons. 7/15
December 6, 2024 at 11:18 PM
🧬 Using single-cell RNA sequencing and a functional neurotransmitter receptor screening, we found tumor cells express receptors for multiple neurotransmitters. This allows them to receive signals from many different types of neurons. 7/15
Reposted by Atefeh Pourkhalili Langeroudi
🌐 These weren't just local connections. The tumor cells established networks with neurons across different brain regions and even between hemispheres across large distances, showing remarkable integration. 5/15
December 6, 2024 at 11:18 PM
🌐 These weren't just local connections. The tumor cells established networks with neurons across different brain regions and even between hemispheres across large distances, showing remarkable integration. 5/15
Reposted by Atefeh Pourkhalili Langeroudi
⚡️ The timeline surprised us: Tumor cells formed functional connections with neurons very quickly with neurons within hours in culture and just days in the brain- much earlier than previously known and expected. 4/15
December 6, 2024 at 11:18 PM
⚡️ The timeline surprised us: Tumor cells formed functional connections with neurons very quickly with neurons within hours in culture and just days in the brain- much earlier than previously known and expected. 4/15
Reposted by Atefeh Pourkhalili Langeroudi
🔬 Our approach used the infection of tumor cells with a modified rabies virus that can only jump once to a directly connected neuron. When a neuron connects to a tumor cell, it lights up, creating a precise map of their connectome. 3/15
December 6, 2024 at 11:18 PM
🔬 Our approach used the infection of tumor cells with a modified rabies virus that can only jump once to a directly connected neuron. When a neuron connects to a tumor cell, it lights up, creating a precise map of their connectome. 3/15
Reposted by Atefeh Pourkhalili Langeroudi
🧪 How do brain tumors communicate with neurons? We developed a tracing system using modified rabies viruses to map these connections across the entire brain, revealing unexpected complexity. 2/15
December 6, 2024 at 11:18 PM
🧪 How do brain tumors communicate with neurons? We developed a tracing system using modified rabies viruses to map these connections across the entire brain, revealing unexpected complexity. 2/15
Reposted by Atefeh Pourkhalili Langeroudi
Thrilled to share our latest work on how glioblastoma integrates into brain-wide networks using rabies-mediated retrograde tracing!🧠 So grateful to have been part of such a big team effort! @svenjaktetzlaff.bsky.social @venkataramanilab.bsky.social
🧵Just in time for
: New research from the Venkataramani lab @CellCellPress
maps how brain tumor cells create extensive neural networks in glioblastoma. Check out our paper here: authors.elsevier.com/sd/article/S...
@ekinreyhan.bsky.social
@svenjaktetzlaff.bsky.social
1/15
: New research from the Venkataramani lab @CellCellPress
maps how brain tumor cells create extensive neural networks in glioblastoma. Check out our paper here: authors.elsevier.com/sd/article/S...
@ekinreyhan.bsky.social
@svenjaktetzlaff.bsky.social
1/15
December 6, 2024 at 11:25 PM
Thrilled to share our latest work on how glioblastoma integrates into brain-wide networks using rabies-mediated retrograde tracing!🧠 So grateful to have been part of such a big team effort! @svenjaktetzlaff.bsky.social @venkataramanilab.bsky.social
Reposted by Atefeh Pourkhalili Langeroudi
So happy this is finally out😊 thank you for the amazing supervision @venkataramanilab.bsky.social, to the best partner-in-crime @ekinreyhan.bsky.social and everyone who contributed, such a team effort!🧠🔬
🧵Just in time for
: New research from the Venkataramani lab @CellCellPress
maps how brain tumor cells create extensive neural networks in glioblastoma. Check out our paper here: authors.elsevier.com/sd/article/S...
@ekinreyhan.bsky.social
@svenjaktetzlaff.bsky.social
1/15
: New research from the Venkataramani lab @CellCellPress
maps how brain tumor cells create extensive neural networks in glioblastoma. Check out our paper here: authors.elsevier.com/sd/article/S...
@ekinreyhan.bsky.social
@svenjaktetzlaff.bsky.social
1/15
December 6, 2024 at 11:25 PM
So happy this is finally out😊 thank you for the amazing supervision @venkataramanilab.bsky.social, to the best partner-in-crime @ekinreyhan.bsky.social and everyone who contributed, such a team effort!🧠🔬
Reposted by Atefeh Pourkhalili Langeroudi
www.cell.com/cell/fulltex... from the immensely talented Venkataramani group, essential work for cancer neuroscience.
Characterizing and targeting glioblastoma neuron-tumor networks with retrograde tracing
Rapid integration of glioblastoma into neuronal circuits promotes glioblastoma invasion and growth, as shown by rabies-based retrograde tracing. Targeting of neuron-tumor networks with pharmacological or rabies-mediated disconnection offers therapeutic potential.
www.cell.com
December 6, 2024 at 7:49 PM
www.cell.com/cell/fulltex... from the immensely talented Venkataramani group, essential work for cancer neuroscience.