I wonder if this has something to do with Jon Lorsch moving up from NIGMS to Acting deputy director of all extramural research

This work shines because of @zjmaggiexu.bsky.social passion for these cells. She built it all—the cultures, transcriptomes, analyses, modeling and collaborations—from scratch. I can’t begin to express how brilliant and hard-working a scientist she is (and she's 👀 for postdocs!). So proud of her 🥲

Very fair point that it was not clear in the original question why the other data wasn’t included, but that is actually critical information for deciding what to do!

What if the excluded drugs have a massive off-target effect that makes your quantification uninterpretable?

Eg aggregates that mess up your counting of objects in the cell.

I don’t think that variation is meaningful for ANOVA. Tho you probably want to discuss that result qualitatively!

My guess having never been on the other side is that folks think“let’s add this question to make my life easier as a reviewer” and don’t think about the implication on their own work as letter writers for other schools. But I am just speculating!

Yes. I guess I am surprised that if academics make the LoR form they don’t think about their own experience filling them out for 5-20 ppl and 5-20 schools per person per year. I was wondering what stakeholders influence the LoR form questions. I’m probably just stating the obvious! 🫠

What a pain! I imagine you have served on admissions committees. Do you know where the pressure is to add these kind of hurdles? Is it above the dept level?

Fantastic! I’ve been waiting for someone to get these structures. Intrigued to hear about conformational changes in bound tubulin. Looking forward to digging in!