Audrey Ryback
@aryback.bsky.social
ME researcher at the University of Edinburgh. Clare Francis Research Fellow, funded by Action for ME.
Want to join our amazing team for a PhD in ME/CFS research as part of a funded Future Medicine PhD Fellowship?
See: www.findaphd.com/phds/project...
We offer: Exciting and rigorous science, PPI, truly interdisciplinary and fantastic research culture!
Please contact us to discuss before applying!
See: www.findaphd.com/phds/project...
We offer: Exciting and rigorous science, PPI, truly interdisciplinary and fantastic research culture!
Please contact us to discuss before applying!
Personalised blood-based biomarkers for Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME/CFS) symptom severity at University of Edinburgh on FindAPhD.com
PhD Project - Personalised blood-based biomarkers for Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME/CFS) symptom severity at University of Edinburgh, listed on FindAPhD.com
www.findaphd.com
October 28, 2025 at 11:23 PM
Want to join our amazing team for a PhD in ME/CFS research as part of a funded Future Medicine PhD Fellowship?
See: www.findaphd.com/phds/project...
We offer: Exciting and rigorous science, PPI, truly interdisciplinary and fantastic research culture!
Please contact us to discuss before applying!
See: www.findaphd.com/phds/project...
We offer: Exciting and rigorous science, PPI, truly interdisciplinary and fantastic research culture!
Please contact us to discuss before applying!
Reposted by Audrey Ryback
Interested in ME/CFS research?
Want to do a PhD with @aryback.bsky.social, @avakhamseh.bsky.social, @sjoerdvbeentjes.bsky.social & @cgatist.bsky.social?
Then apply for a *funded* Future Medicine PhD Fellowship.
See: www.findaphd.com/phds/project...
Please contact us to discuss before applying.
Want to do a PhD with @aryback.bsky.social, @avakhamseh.bsky.social, @sjoerdvbeentjes.bsky.social & @cgatist.bsky.social?
Then apply for a *funded* Future Medicine PhD Fellowship.
See: www.findaphd.com/phds/project...
Please contact us to discuss before applying.
Personalised blood-based biomarkers for Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME/CFS) symptom severity at University of Edinburgh on FindAPhD.com
PhD Project - Personalised blood-based biomarkers for Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME/CFS) symptom severity at University of Edinburgh, listed on FindAPhD.com
www.findaphd.com
October 28, 2025 at 8:27 PM
Interested in ME/CFS research?
Want to do a PhD with @aryback.bsky.social, @avakhamseh.bsky.social, @sjoerdvbeentjes.bsky.social & @cgatist.bsky.social?
Then apply for a *funded* Future Medicine PhD Fellowship.
See: www.findaphd.com/phds/project...
Please contact us to discuss before applying.
Want to do a PhD with @aryback.bsky.social, @avakhamseh.bsky.social, @sjoerdvbeentjes.bsky.social & @cgatist.bsky.social?
Then apply for a *funded* Future Medicine PhD Fellowship.
See: www.findaphd.com/phds/project...
Please contact us to discuss before applying.
Reposted by Audrey Ryback
The Big Survey is now live!
It has been such a privilege to get to work on this with such a wonderful, inspiring team at @actionforme.bsky.social, including our brilliant Patient and Public Involvement Group, made up of people with lived experience of ME and Long Covid.
It has been such a privilege to get to work on this with such a wonderful, inspiring team at @actionforme.bsky.social, including our brilliant Patient and Public Involvement Group, made up of people with lived experience of ME and Long Covid.
Our 2025 Big Survey is now open! 🎉
For more information, our FAQs, and to take part, head to our web page: www.actionforme.org.uk/research-campaigns/our-research-work/big-survey/
Thank you for supporting our research💙
🤝in collaboration with
@durhamimh.bsky.social @kacheston.bsky.social
For more information, our FAQs, and to take part, head to our web page: www.actionforme.org.uk/research-campaigns/our-research-work/big-survey/
Thank you for supporting our research💙
🤝in collaboration with
@durhamimh.bsky.social @kacheston.bsky.social
October 13, 2025 at 10:30 AM
The Big Survey is now live!
It has been such a privilege to get to work on this with such a wonderful, inspiring team at @actionforme.bsky.social, including our brilliant Patient and Public Involvement Group, made up of people with lived experience of ME and Long Covid.
It has been such a privilege to get to work on this with such a wonderful, inspiring team at @actionforme.bsky.social, including our brilliant Patient and Public Involvement Group, made up of people with lived experience of ME and Long Covid.
Reposted by Audrey Ryback
UK Action for ME Big Survey 2025
The 5 yearly survey of people in the UK with ME/CFS will open on Monday 13th October. It has been developed by AfME in collaboration with @kacheston.bsky.social Dr Katherine Cheston at Durham University.
www.actionforme.org.uk/research-cam...
#MEcfs #PwME #CFS
The 5 yearly survey of people in the UK with ME/CFS will open on Monday 13th October. It has been developed by AfME in collaboration with @kacheston.bsky.social Dr Katherine Cheston at Durham University.
www.actionforme.org.uk/research-cam...
#MEcfs #PwME #CFS
2025 Big Survey
Find out how you can contribute to our 2025 Big Survey - a vital research project aiming to illustrate the impact of ME and long Covid.
www.actionforme.org.uk
October 12, 2025 at 12:31 PM
UK Action for ME Big Survey 2025
The 5 yearly survey of people in the UK with ME/CFS will open on Monday 13th October. It has been developed by AfME in collaboration with @kacheston.bsky.social Dr Katherine Cheston at Durham University.
www.actionforme.org.uk/research-cam...
#MEcfs #PwME #CFS
The 5 yearly survey of people in the UK with ME/CFS will open on Monday 13th October. It has been developed by AfME in collaboration with @kacheston.bsky.social Dr Katherine Cheston at Durham University.
www.actionforme.org.uk/research-cam...
#MEcfs #PwME #CFS
Reposted by Audrey Ryback
🎉 We are delighted to launch this year’s Big Survey in collaboration with @actionforme.bsky.social! If you are in the UK living with ME or Long Covid with ME symptoms, we want to hear from you! tinyurl.com/2s4dbrkx
🧵
🧵
2025 Big Survey
Find out how you can contribute to our 2025 Big Survey - a vital research project aiming to illustrate the impact of ME and long Covid.
tinyurl.com
October 13, 2025 at 1:53 PM
🎉 We are delighted to launch this year’s Big Survey in collaboration with @actionforme.bsky.social! If you are in the UK living with ME or Long Covid with ME symptoms, we want to hear from you! tinyurl.com/2s4dbrkx
🧵
🧵
Reposted by Audrey Ryback
The research used to claim reliability of a ME/CFS blood test has important limitations, shown here.
www.theguardian.com/society/2025...
www.theguardian.com/society/2025...
October 8, 2025 at 6:39 AM
The research used to claim reliability of a ME/CFS blood test has important limitations, shown here.
www.theguardian.com/society/2025...
www.theguardian.com/society/2025...
Reposted by Audrey Ryback
Seeking a Project Manager for the PRIME project:
"Building Infrastructure for Patients, Researchers and Industry for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)". Closing date for applications is 15 September 2025. #pwME #MEcfs
elxw.fa.em3.oraclecloud.com/hcmUI/Candid...
"Building Infrastructure for Patients, Researchers and Industry for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)". Closing date for applications is 15 September 2025. #pwME #MEcfs
elxw.fa.em3.oraclecloud.com/hcmUI/Candid...
PRIME Project Manager
The PRIME project is looking for an experienced and dedicated project manager. This role will be crucial to the successful delivery of PRIME, with the post holder responsible for the strategic executi...
elxw.fa.em3.oraclecloud.com
September 1, 2025 at 8:57 AM
Seeking a Project Manager for the PRIME project:
"Building Infrastructure for Patients, Researchers and Industry for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)". Closing date for applications is 15 September 2025. #pwME #MEcfs
elxw.fa.em3.oraclecloud.com/hcmUI/Candid...
"Building Infrastructure for Patients, Researchers and Industry for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)". Closing date for applications is 15 September 2025. #pwME #MEcfs
elxw.fa.em3.oraclecloud.com/hcmUI/Candid...
Reposted by Audrey Ryback
The ME Association are pleased to announce that we have awarded Decode ME the Howes-Goudsmit Award 2025 for their extensive work and commitment to their genome-wide association study.
Find out more: https://meassociation.org.uk/ir3e
#MECFS #pwME #SevereME #MyalgicE #DecodeME #HowesGoudsmitAward
Find out more: https://meassociation.org.uk/ir3e
#MECFS #pwME #SevereME #MyalgicE #DecodeME #HowesGoudsmitAward
The ME Association awards Decode ME the Howes Goudsmit Award 2025 - The ME Association
The ME Association are pleased to announce that we have […]
meassociation.org.uk
August 29, 2025 at 10:11 AM
The ME Association are pleased to announce that we have awarded Decode ME the Howes-Goudsmit Award 2025 for their extensive work and commitment to their genome-wide association study.
Find out more: https://meassociation.org.uk/ir3e
#MECFS #pwME #SevereME #MyalgicE #DecodeME #HowesGoudsmitAward
Find out more: https://meassociation.org.uk/ir3e
#MECFS #pwME #SevereME #MyalgicE #DecodeME #HowesGoudsmitAward
Reposted by Audrey Ryback
New course “EMBO Causality in Biomedicine”: We have organised the first EMBO course in *causal* stats/ML methods for quantitative biomedicine. @sjoerdvbeentjes.bsky.social @nimahejazi.org @pablormier.bsky.social @DariaSokolova @CarolineUhler
Very much looking forward to teaching and discussing!
Very much looking forward to teaching and discussing!
New course announced!
We're thrilled to be hosting the @embo.org Practical Course 'Causality in biomedicine: going beyond associations' from 4 – 9 October 2026.
Register your interest and be the first to hear when the course opens for applications: www.ebi.ac.uk/training/eve...
We're thrilled to be hosting the @embo.org Practical Course 'Causality in biomedicine: going beyond associations' from 4 – 9 October 2026.
Register your interest and be the first to hear when the course opens for applications: www.ebi.ac.uk/training/eve...
August 12, 2025 at 2:03 PM
New course “EMBO Causality in Biomedicine”: We have organised the first EMBO course in *causal* stats/ML methods for quantitative biomedicine. @sjoerdvbeentjes.bsky.social @nimahejazi.org @pablormier.bsky.social @DariaSokolova @CarolineUhler
Very much looking forward to teaching and discussing!
Very much looking forward to teaching and discussing!
Reposted by Audrey Ryback
"DecodeME is now calling on researchers worldwide to join us in accelerating ME/CFS research.” - Prof Chris Ponting (DecodeME Investigator).
We encourage researchers to explore and build on our findings. Apply for access to our rich dataset now shorturl.at/F8aOM
We encourage researchers to explore and build on our findings. Apply for access to our rich dataset now shorturl.at/F8aOM
August 12, 2025 at 10:11 AM
"DecodeME is now calling on researchers worldwide to join us in accelerating ME/CFS research.” - Prof Chris Ponting (DecodeME Investigator).
We encourage researchers to explore and build on our findings. Apply for access to our rich dataset now shorturl.at/F8aOM
We encourage researchers to explore and build on our findings. Apply for access to our rich dataset now shorturl.at/F8aOM
Reposted by Audrey Ryback
New blog post from DecodeME team explaining new findings and discussing them in a bit more detail:
"X marks the spot where ME/CFS biology can be discovered"
www.decodeme.org.uk/x-marks-the-...
#MyalgicEncephalomyelitis #ChronicFatigueSyndrome #MEcfs #CFS #PwME
"X marks the spot where ME/CFS biology can be discovered"
www.decodeme.org.uk/x-marks-the-...
#MyalgicEncephalomyelitis #ChronicFatigueSyndrome #MEcfs #CFS #PwME
August 7, 2025 at 12:44 AM
New blog post from DecodeME team explaining new findings and discussing them in a bit more detail:
"X marks the spot where ME/CFS biology can be discovered"
www.decodeme.org.uk/x-marks-the-...
#MyalgicEncephalomyelitis #ChronicFatigueSyndrome #MEcfs #CFS #PwME
"X marks the spot where ME/CFS biology can be discovered"
www.decodeme.org.uk/x-marks-the-...
#MyalgicEncephalomyelitis #ChronicFatigueSyndrome #MEcfs #CFS #PwME
Reposted by Audrey Ryback
1) Saw some skepticism about DecodeME, asking if it is overhyped.
As an account that focuses on critically analyzing research (our name was 'ME/CFS Skeptic' for a reason!), we think it’s the real deal.
Here are a couple of reasons why it stands out. 🧵
As an account that focuses on critically analyzing research (our name was 'ME/CFS Skeptic' for a reason!), we think it’s the real deal.
Here are a couple of reasons why it stands out. 🧵
August 10, 2025 at 11:26 AM
1) Saw some skepticism about DecodeME, asking if it is overhyped.
As an account that focuses on critically analyzing research (our name was 'ME/CFS Skeptic' for a reason!), we think it’s the real deal.
Here are a couple of reasons why it stands out. 🧵
As an account that focuses on critically analyzing research (our name was 'ME/CFS Skeptic' for a reason!), we think it’s the real deal.
Here are a couple of reasons why it stands out. 🧵
DecodeME results are out! So inspired by my incredible colleagues at UoE who have carried out this research to the highest standard. I hope these results will bring about a paradigm shift in ME/CFS research and attract more interest and investment to the field. shorturl.at/VwN3s #DecodeME
Initial findings from the DecodeME genome-wide association study of myalgic encephalomyelitis/chronic fatigue syndrome
shorturl.at
August 6, 2025 at 11:01 PM
DecodeME results are out! So inspired by my incredible colleagues at UoE who have carried out this research to the highest standard. I hope these results will bring about a paradigm shift in ME/CFS research and attract more interest and investment to the field. shorturl.at/VwN3s #DecodeME
Reposted by Audrey Ryback
Our initial DNA results! DecodeME have discovered that people with an ME/CFS diagnosis have significant genetic differences compared to the general population.
-
Summary of our results: shorturl.at/pgsjk
Check out our full preprint paper: shorturl.at/VwN3s
-
Summary of our results: shorturl.at/pgsjk
Check out our full preprint paper: shorturl.at/VwN3s
August 6, 2025 at 6:24 PM
Our initial DNA results! DecodeME have discovered that people with an ME/CFS diagnosis have significant genetic differences compared to the general population.
-
Summary of our results: shorturl.at/pgsjk
Check out our full preprint paper: shorturl.at/VwN3s
-
Summary of our results: shorturl.at/pgsjk
Check out our full preprint paper: shorturl.at/VwN3s
Reposted by Audrey Ryback
The initial DNA results from DecodeME are coming this week! We will release them on our website on Wednesday 6th August at 7pm (approx).
We're letting you know the timing in advance so you can pace beforehand.
Thank you to our participants & supporters.
We're letting you know the timing in advance so you can pace beforehand.
Thank you to our participants & supporters.
August 4, 2025 at 5:23 PM
The initial DNA results from DecodeME are coming this week! We will release them on our website on Wednesday 6th August at 7pm (approx).
We're letting you know the timing in advance so you can pace beforehand.
Thank you to our participants & supporters.
We're letting you know the timing in advance so you can pace beforehand.
Thank you to our participants & supporters.
Reposted by Audrey Ryback
@aryback.bsky.social is a Research Fellow at the Uni of Edinburgh, holds the first Clare Francis Postdoctoral Fellowship awarded by Action for ME.
Audrey’s research will play an important part in understanding ME/CFS.
Read the pre-print here 👇
www.actionforme.org.uk/research-upd...
#MECFS #pwME
Audrey’s research will play an important part in understanding ME/CFS.
Read the pre-print here 👇
www.actionforme.org.uk/research-upd...
#MECFS #pwME
Research Update from Dr Audrey Ryback - Findings and Pre-Print Available - Action for ME
An update from Dr Audrey Ryback's research, testing the effect of serum from people with ME on muscle cell mitochondria, and findings.
www.actionforme.org.uk
June 16, 2025 at 1:34 PM
@aryback.bsky.social is a Research Fellow at the Uni of Edinburgh, holds the first Clare Francis Postdoctoral Fellowship awarded by Action for ME.
Audrey’s research will play an important part in understanding ME/CFS.
Read the pre-print here 👇
www.actionforme.org.uk/research-upd...
#MECFS #pwME
Audrey’s research will play an important part in understanding ME/CFS.
Read the pre-print here 👇
www.actionforme.org.uk/research-upd...
#MECFS #pwME
Reposted by Audrey Ryback
📢 Now published:
www.embopress.org/doi/full/10.....
Since the preprint, we replicated 9 of 14 traits in All of Us & showed that #pwME with PEM-like symptoms have stronger biomarker differences.
bsky.app/profile/cgat...
www.embopress.org/doi/full/10.....
Since the preprint, we replicated 9 of 14 traits in All of Us & showed that #pwME with PEM-like symptoms have stronger biomarker differences.
bsky.app/profile/cgat...
June 20, 2025 at 5:44 AM
📢 Now published:
www.embopress.org/doi/full/10.....
Since the preprint, we replicated 9 of 14 traits in All of Us & showed that #pwME with PEM-like symptoms have stronger biomarker differences.
bsky.app/profile/cgat...
www.embopress.org/doi/full/10.....
Since the preprint, we replicated 9 of 14 traits in All of Us & showed that #pwME with PEM-like symptoms have stronger biomarker differences.
bsky.app/profile/cgat...
1/2 New pre-print: We performed a large-scale replication testing the effect of serum from 67 pwME and 53 healthy donors on muscle cell mitochondria, revealing no significant differences. This suggests earlier results may not be true for people with ME in general. doi.org/10.1101/2025...
Indistinguishable mitochondrial phenotypes after exposure of healthy myoblasts to myalgic encephalomyelitis or control serum
Myalgic Encephalomyelitis (ME)/Chronic Fatigue Syndrome is a disease of uncertain aetiology that affects up to 400,000 individuals in the UK. Exposure of cultured cells to the sera of people with ME has been proposed to cause phenotypic changes in these cells in vitro when compared to sera from healthy controls. ME serum factors causing these changes could inform the development of diagnostic tests. In this study, we performed a large-scale, pre-registered replication of an experiment from Fluge et al (2016) that reported an increase in maximal respiratory capacity in healthy myoblasts after treatment with serum from people with ME compared to serum from healthy controls. We replicated the original experiment with a larger sample size, using sera from 67 people with ME and 53 controls to treat healthy cultured myoblasts, and generated results from over 1,700 mitochondrial stress tests performed with a Seahorse Bioanalyser. We observed no significant differences between treatment with ME or healthy control sera for our primary outcome of interest, oxygen consumption rate at maximal respiratory capacity. Results from our study provide strong evidence against the hypothesis that ME blood factors differentially affect healthy myoblast mitochondrial phenotypes in vitro. ### Competing Interest Statement The authors have declared no competing interest. Action for ME, https://ror.org/0569v7v35, Clare Francis Research Fellowship
doi.org
June 9, 2025 at 12:13 PM
1/2 New pre-print: We performed a large-scale replication testing the effect of serum from 67 pwME and 53 healthy donors on muscle cell mitochondria, revealing no significant differences. This suggests earlier results may not be true for people with ME in general. doi.org/10.1101/2025...
Reposted by Audrey Ryback
NEW: There are 400,000 people diagnosed with ME/CFS in the UK, at least there would be if access to diagnosis was equal.
ME/CFS diagnosis however is a postcode lottery. It's much rarer in non-White communities and socioeconomically deprived areas, much worse than for other diseases
rdcu.be/eiEeu
ME/CFS diagnosis however is a postcode lottery. It's much rarer in non-White communities and socioeconomically deprived areas, much worse than for other diseases
rdcu.be/eiEeu
Unequal access to diagnosis of myalgic encephalomyelitis in England
rdcu.be
April 22, 2025 at 7:01 AM
NEW: There are 400,000 people diagnosed with ME/CFS in the UK, at least there would be if access to diagnosis was equal.
ME/CFS diagnosis however is a postcode lottery. It's much rarer in non-White communities and socioeconomically deprived areas, much worse than for other diseases
rdcu.be/eiEeu
ME/CFS diagnosis however is a postcode lottery. It's much rarer in non-White communities and socioeconomically deprived areas, much worse than for other diseases
rdcu.be/eiEeu
Pleased to share this research from my PhD in @graemecowan.bsky.social's lab! We replicated existing evidence of moderately increased IGHV3-30 usage in B cells of patients with mild/moderate, but not severe ME. www.frontiersin.org/journals/imm...
Frontiers | Deep sequencing of BCR heavy chain repertoires in myalgic encephalomyelitis/chronic fatigue syndrome
www.frontiersin.org
February 17, 2025 at 11:01 AM
Pleased to share this research from my PhD in @graemecowan.bsky.social's lab! We replicated existing evidence of moderately increased IGHV3-30 usage in B cells of patients with mild/moderate, but not severe ME. www.frontiersin.org/journals/imm...
Reposted by Audrey Ryback
Significant replication of combinatorial genetic signatures for Long Covid risk www.medrxiv.org/content/10.1...
Reproducibility of Genetic Risk Factors Identified for Long COVID using Combinatorial Analysis Across US and UK Patient Cohorts with Diverse Ancestries
Background Long COVID is a major public health burden causing a diverse array of debilitating symptoms in tens of millions of patients globally. In spite of this overwhelming disease prevalence and st...
www.medrxiv.org
February 7, 2025 at 9:51 AM
Significant replication of combinatorial genetic signatures for Long Covid risk www.medrxiv.org/content/10.1...