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Antibodies.com supplies high-quality research tools at cost-effective prices.
We congratulate this year’s Nobel laureates and the wider community advancing #TCell #biology and #ImmuneRegulation. At Antibodies.com, we’re proud to support such progress by providing tools that enable deeper insights into #ImmuneFunction.
Antibodies.com | Antibodies, Proteins, and ELISA Kits
Antibodies.com supplies high-quality antibodies, proteins, and ELISA kits to life science researchers at cost-effective prices. Discover more, for less.
Antibodies.com
December 10, 2025 at 8:45 AM
We congratulate this year’s Nobel laureates and the wider community advancing #TCell #biology and #ImmuneRegulation. At Antibodies.com, we’re proud to support such progress by providing tools that enable deeper insights into #ImmuneFunction.
The identification of regulatory T cells and #Foxp3 has shaped modern #immunology and contributes to antibody-research approaches worldwide! Along with spurring the advancement in treatments for #cancer and #AutoimmuneDiseases.
Antibodies.com | Antibodies, Proteins, and ELISA Kits
Antibodies.com supplies high-quality antibodies, proteins, and ELISA kits to life science researchers at cost-effective prices. Discover more, for less.
Antibodies.com
December 10, 2025 at 8:45 AM
The identification of regulatory T cells and #Foxp3 has shaped modern #immunology and contributes to antibody-research approaches worldwide! Along with spurring the advancement in treatments for #cancer and #AutoimmuneDiseases.
At antibodies.com we’re continually inspired by the discoveries that shape modern biology and by the global research community advancing them. Supporting that work remains core to what we do!
Antibodies.com | Antibodies, Proteins, and ELISA Kits
Antibodies.com supplies high-quality antibodies, proteins, and ELISA kits to life science researchers at cost-effective prices. Discover more, for less.
antibodies.com
December 9, 2025 at 9:52 AM
At antibodies.com we’re continually inspired by the discoveries that shape modern biology and by the global research community advancing them. Supporting that work remains core to what we do!
The #NobelPrize went to David Julius and Ardem Patapoutian in 2021, for identifying the #IonChannels that let us sense heat, cold and force. This landmark discovery revealed how physical stimuli are converted into neural signals, as well as guide research in pain and touch.
Antibodies.com | Antibodies, Proteins, and ELISA Kits
Antibodies.com supplies high-quality antibodies, proteins, and ELISA kits to life science researchers at cost-effective prices. Discover more, for less.
antibodies.com
December 9, 2025 at 9:52 AM
The #NobelPrize went to David Julius and Ardem Patapoutian in 2021, for identifying the #IonChannels that let us sense heat, cold and force. This landmark discovery revealed how physical stimuli are converted into neural signals, as well as guide research in pain and touch.
In 2022 Svante Pääbo was given the #NobelPrize for establishing the scientific discipline #paleogenomics and sequencing the genome of a #Neanderthal. Providing a unique resource for scientists to better understand human evolution.
Antibodies.com | Antibodies, Proteins, and ELISA Kits
Antibodies.com supplies high-quality antibodies, proteins, and ELISA kits to life science researchers at cost-effective prices. Discover more, for less.
antibodies.com
December 9, 2025 at 9:52 AM
In 2022 Svante Pääbo was given the #NobelPrize for establishing the scientific discipline #paleogenomics and sequencing the genome of a #Neanderthal. Providing a unique resource for scientists to better understand human evolution.
The 2023 #NobelPrize honors Katalin Karikó and Drew Weissman, whose discoveries in nucleoside-modified #mRNA unlocked the path to effective #mRNAVaccines. A milestone that continues to shape how researchers study immunity and innovate future #therapeutics.
Antibodies.com | Antibodies, Proteins, and ELISA Kits
Antibodies.com supplies high-quality antibodies, proteins, and ELISA kits to life science researchers at cost-effective prices. Discover more, for less.
antibodies.com
December 9, 2025 at 9:52 AM
The 2023 #NobelPrize honors Katalin Karikó and Drew Weissman, whose discoveries in nucleoside-modified #mRNA unlocked the path to effective #mRNAVaccines. A milestone that continues to shape how researchers study immunity and innovate future #therapeutics.
In 2024 the #NobelPrize was awarded to Victor Ambros and Gary Ruvkun for their discovery of #microRNA that revealed a new layer of #GeneRegulation, shaping how researchers decode cellular control.
Antibodies.com | Antibodies, Proteins, and ELISA Kits
Antibodies.com supplies high-quality antibodies, proteins, and ELISA kits to life science researchers at cost-effective prices. Discover more, for less.
antibodies.com
December 9, 2025 at 9:52 AM
In 2024 the #NobelPrize was awarded to Victor Ambros and Gary Ruvkun for their discovery of #microRNA that revealed a new layer of #GeneRegulation, shaping how researchers decode cellular control.
Using the phosphor-YAP1 (Ser128) antibody from antibodies.com, the group also revealed increased #YAP1 #phosphorylation in persister cells. We’re proud that our product, helped uncover the potential role of YAP-TEAD activity in supporting cell survival.
Antibodies.com | Antibodies, Proteins, and ELISA Kits
Antibodies.com supplies high-quality antibodies, proteins, and ELISA kits to life science researchers at cost-effective prices. Discover more, for less.
antibodies.com
December 8, 2025 at 7:20 AM
Using the phosphor-YAP1 (Ser128) antibody from antibodies.com, the group also revealed increased #YAP1 #phosphorylation in persister cells. We’re proud that our product, helped uncover the potential role of YAP-TEAD activity in supporting cell survival.
The study highlights CDK1 as an actional vulnerability in drug-tolerant cells. Targeting CDK1-driven survival signaling could help prevent or delay Osimertinib resistance, improving long-term treatment outcomes
Antibodies.com | Antibodies, Proteins, and ELISA Kits
Antibodies.com supplies high-quality antibodies, proteins, and ELISA kits to life science researchers at cost-effective prices. Discover more, for less.
antibodies.com
December 8, 2025 at 7:20 AM
The study highlights CDK1 as an actional vulnerability in drug-tolerant cells. Targeting CDK1-driven survival signaling could help prevent or delay Osimertinib resistance, improving long-term treatment outcomes
Persister cells reactivated multiple signaling survival pathways, including #MAPK, #PI3K/ #AKT and #mTOR. #CDK1 activity increased markedly, and inhibiting CDK1 significantly reduced persister cell survival and regrowth.
Antibodies.com | Antibodies, Proteins, and ELISA Kits
Antibodies.com supplies high-quality antibodies, proteins, and ELISA kits to life science researchers at cost-effective prices. Discover more, for less.
antibodies.com
December 8, 2025 at 7:20 AM
The group conducted #proteomic and #phosphoproteomic analyses to track how EGFR-mutant #LungCancer cells respond to Osimertinib treatment over time, mapping how cells transition into drug-tolerant cells.
Antibodies.com | Antibodies, Proteins, and ELISA Kits
Antibodies.com supplies high-quality antibodies, proteins, and ELISA kits to life science researchers at cost-effective prices. Discover more, for less.
antibodies.com
December 8, 2025 at 7:20 AM
The group conducted #proteomic and #phosphoproteomic analyses to track how EGFR-mutant #LungCancer cells respond to Osimertinib treatment over time, mapping how cells transition into drug-tolerant cells.
#Osimertinib was originally developed to overcome resistance to earlier treatment versions, when resistance to it often begins with a small population of #PersisterCells. The study aimed to uncover signaling changes underlying how these cells survive, and to identify new therapeutic targets.
Antibodies.com | Antibodies, Proteins, and ELISA Kits
Antibodies.com supplies high-quality antibodies, proteins, and ELISA kits to life science researchers at cost-effective prices. Discover more, for less.
antibodies.com
December 8, 2025 at 7:20 AM
#Osimertinib was originally developed to overcome resistance to earlier treatment versions, when resistance to it often begins with a small population of #PersisterCells. The study aimed to uncover signaling changes underlying how these cells survive, and to identify new therapeutic targets.
Demonstrating how drug-tolerant lung cancer cells survive Osimertinib treatment, revealing new therapeutic targets to prevent resistance in EGFR-mutant lung cancer.
Antibodies.com | Antibodies, Proteins, and ELISA Kits
Antibodies.com supplies high-quality antibodies, proteins, and ELISA kits to life science researchers at cost-effective prices. Discover more, for less.
antibodies.com
December 8, 2025 at 7:20 AM
Demonstrating how drug-tolerant lung cancer cells survive Osimertinib treatment, revealing new therapeutic targets to prevent resistance in EGFR-mutant lung cancer.
We at antibodies.com are proud to see our Rat SDF1 (CXCL12) ELISA Kit being used of such innovative research! So pleased to see that our products were used to distinguish between changes in the chemokine vs its receptor.
Antibodies.com | Antibodies, Proteins, and ELISA Kits
Antibodies.com supplies high-quality antibodies, proteins, and ELISA kits to life science researchers at cost-effective prices. Discover more, for less.
antibodies.com
December 5, 2025 at 1:35 PM
We at antibodies.com are proud to see our Rat SDF1 (CXCL12) ELISA Kit being used of such innovative research! So pleased to see that our products were used to distinguish between changes in the chemokine vs its receptor.
Overall, altering immune cell retention and maturation, highlighting a new mechanism linking T2D to immune dysfunction and cognitive decline. The CXCL12/ CXCR4 signalling axis emerging as a promising target for therapeutic strategies treating T2D associated neurodegeneration.
Antibodies.com | Antibodies, Proteins, and ELISA Kits
Antibodies.com supplies high-quality antibodies, proteins, and ELISA kits to life science researchers at cost-effective prices. Discover more, for less.
antibodies.com
December 5, 2025 at 1:35 PM
Overall, altering immune cell retention and maturation, highlighting a new mechanism linking T2D to immune dysfunction and cognitive decline. The CXCL12/ CXCR4 signalling axis emerging as a promising target for therapeutic strategies treating T2D associated neurodegeneration.
Although CXCL12 levels stayed unchanged, chronic amylin secretion dysregulates the CXCL12/ CXCR4 axis by elevating CXCR4 expression. Showing chronic amylin overload reshapes the CXCL12/ CXCR4 axis at the receptor level in these rodent models of T2D.
Antibodies.com | Antibodies, Proteins, and ELISA Kits
Antibodies.com supplies high-quality antibodies, proteins, and ELISA kits to life science researchers at cost-effective prices. Discover more, for less.
antibodies.com
December 5, 2025 at 1:35 PM
Although CXCL12 levels stayed unchanged, chronic amylin secretion dysregulates the CXCL12/ CXCR4 axis by elevating CXCR4 expression. Showing chronic amylin overload reshapes the CXCL12/ CXCR4 axis at the receptor level in these rodent models of T2D.
Using rat and mice models expressing human amylin, the team found that amylin hypersecretion in T2D limits immune cell migration into lymphoid tissues and the CNS. It also causes defects in B-cell lymphopoiesis, linked to abnormal upregulation of CXCR4.
Antibodies.com | Antibodies, Proteins, and ELISA Kits
Antibodies.com supplies high-quality antibodies, proteins, and ELISA kits to life science researchers at cost-effective prices. Discover more, for less.
antibodies.com
December 5, 2025 at 1:35 PM
Using rat and mice models expressing human amylin, the team found that amylin hypersecretion in T2D limits immune cell migration into lymphoid tissues and the CNS. It also causes defects in B-cell lymphopoiesis, linked to abnormal upregulation of CXCR4.
Previous evidence shows CXCL12 is elevated in T2D, while CXCR4+ drops in peripheral circulation. Since CXCL12 recruits CXCR4+ immune cells to inflamed CNS tissue, this axis is thought to play a role in regulating immune cell migration.
Antibodies.com | Antibodies, Proteins, and ELISA Kits
Antibodies.com supplies high-quality antibodies, proteins, and ELISA kits to life science researchers at cost-effective prices. Discover more, for less.
antibodies.com
December 5, 2025 at 1:35 PM
Previous evidence shows CXCL12 is elevated in T2D, while CXCR4+ drops in peripheral circulation. Since CXCL12 recruits CXCR4+ immune cells to inflamed CNS tissue, this axis is thought to play a role in regulating immune cell migration.
The CXCL12/ CXCR4 axis, consisting of the chemokine CXCL12 (also known as SDF-1) and its receptor CXCR4, have been implicated in multiple immune processes and a range of pathologies; including #neurodegeneration.
Antibodies.com | Antibodies, Proteins, and ELISA Kits
Antibodies.com supplies high-quality antibodies, proteins, and ELISA kits to life science researchers at cost-effective prices. Discover more, for less.
antibodies.com
December 5, 2025 at 1:35 PM
The CXCL12/ CXCR4 axis, consisting of the chemokine CXCL12 (also known as SDF-1) and its receptor CXCR4, have been implicated in multiple immune processes and a range of pathologies; including #neurodegeneration.
The group set out to determine how amylin accumulation impacts immune cell populations in the brain and periphery, as well as the relationship between amylin accumulation and the #CXCL12/ #CXCR4 axis.
Antibodies.com | Antibodies, Proteins, and ELISA Kits
Antibodies.com supplies high-quality antibodies, proteins, and ELISA kits to life science researchers at cost-effective prices. Discover more, for less.
antibodies.com
December 5, 2025 at 1:35 PM
#Amylin is a hormone peptide oversecreted alongside insulin, forming #amyloid deposits in pancreatic β-cells and cerebral blood vessels of patients with comorbid T2D and dementia. Suggesting a pathological function of amylin in the brain.
Antibodies.com | Antibodies, Proteins, and ELISA Kits
Antibodies.com supplies high-quality antibodies, proteins, and ELISA kits to life science researchers at cost-effective prices. Discover more, for less.
antibodies.com
December 5, 2025 at 1:35 PM
#T2D is a major risk factor for cognitive decline. While hyperglycaemia and altered #insulin signalling are known contributors, the immune system’s role in accelerating #neurodegeneration related to T2D has been unclear.
Antibodies.com | Antibodies, Proteins, and ELISA Kits
Antibodies.com supplies high-quality antibodies, proteins, and ELISA kits to life science researchers at cost-effective prices. Discover more, for less.
antibodies.com
December 5, 2025 at 1:35 PM
#T2D is a major risk factor for cognitive decline. While hyperglycaemia and altered #insulin signalling are known contributors, the immune system’s role in accelerating #neurodegeneration related to T2D has been unclear.