Andy P. Tsai
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andyptsai.bsky.social
Andy P. Tsai
@andyptsai.bsky.social
650 followers 350 following 7 posts
Postdoctoral Fellow in Wyss-Coray lab at Stanford
Ph.D trained in Landreth/Lamb lab at IUMedSchool
Posts Replies Media Videos
Reposted by Andy P. Tsai
the-ccad.bsky.social
Join us in congratulating the CCAD Cohort of 2026! We look forward to their innovative contributions to the field of Alzheimer’s disease and the CCAD community.

#CCAD2026 #AlzheimersDisease #NewVisionResearch
October 17, 2025 at 4:06 PM
Reposted by Andy P. Tsai
biorxivpreprint.bsky.social
Spatial and molecular insights into microglial roles in cerebellar aging https://www.biorxiv.org/content/10.1101/2025.03.01.640978v1
March 2, 2025 at 11:15 AM
Reposted by Andy P. Tsai
biorxiv-neursci.bsky.social
Spatial and molecular insights into microglial roles in cerebellar aging https://www.biorxiv.org/content/10.1101/2025.03.01.640978v1
March 2, 2025 at 11:15 AM
Reposted by Andy P. Tsai
biorxiv-neursci.bsky.social
Simultaneous analysis of single-cell gene expression and morphology provides new insight into how microglia change with age https://www.biorxiv.org/content/10.1101/2025.02.28.640888v1
March 1, 2025 at 11:16 AM
Reposted by Andy P. Tsai
biorxivpreprint.bsky.social
Simultaneous analysis of single-cell gene expression and morphology provides new insight into how microglia change with age https://www.biorxiv.org/content/10.1101/2025.02.28.640888v1
March 1, 2025 at 11:16 AM
Reposted by Andy P. Tsai
carolynbertozzi.bskyverified.social
Excited to share this collaborative work led by Guosong Hong’s group @stanfordneuro.bsky.social. A new method to render animals optically transparent for deep tissue imaging across the visible spectrum 🌈

www.biorxiv.org/content/10.1...
Color-neutral and reversible tissue transparency enables longitudinal deep-tissue imaging in live mice
Light scattering in biological tissue presents a significant challenge for deep in vivo imaging. Our previous work demonstrated the ability to achieve optical transparency in live mice using intensely...
www.biorxiv.org
February 28, 2025 at 6:39 AM
Reposted by Andy P. Tsai
labwaggoner.bsky.social
Slippery proteins in the brain’s blood vessels (vascular glycocalyx) form a protective barrier that breaks break down with age @carolynbertozzi.bskyverified.social #wysscoray @sophiamshi.bsky.social @nature.com
www.nature.com/articles/d41...
www.nature.com/articles/s41...
‘Slime’ keeps the brain safe ― and could guard against ageing
Slippery proteins in the brain’s blood vessels form a protective barrier that breaks break down with age, studies in mice show.
www.nature.com
February 26, 2025 at 5:56 PM
Reposted by Andy P. Tsai
lukensjohnr.bsky.social
Glycocalyx dysregulation impairs blood–brain barrier in ageing and disease

www.nature.com/articles/s41...
Glycocalyx dysregulation impairs blood–brain barrier in ageing and disease - Nature
Disruption of mucin-domain glycoprotein expression and function in the endothelial glycocalyx are associated with ageing and Alzheimer’s disease, leading to dysregulated blood–brain barrier function.
www.nature.com
February 26, 2025 at 5:10 PM
andyptsai.bsky.social
Excited to be part of the work-"A high-throughput assay platform to discover small molecule activators of the phospholipase PLCG2 to treat Alzheimer’s disease"- now out in JBC !
Huge thanks to Qisheng and the team for this amazing collaborators! www.jbc.org/article/S002...
A high-throughput assay platform to discover small molecule activators of the phospholipase PLC-γ2 to treat Alzheimer’s disease
A naturally occurring missense variant of the phospholipase C isozyme, PLC-γ2, harboring a single substitution (P522R) protects against several neurodegenerative diseases, including Alzheimer’s diseas...
www.jbc.org
February 26, 2025 at 1:32 AM
andyptsai.bsky.social
Microglia stuffed with fat struggle. Knocking out a lipid-droplet regulator in them boosted their appetite for Aβ and tempered plaque load.

www.alzforum.org/news/researc...
Expunging Microglial Lipid Droplets Boosts Phagocytosis | ALZFORUM
www.alzforum.org
February 8, 2025 at 4:00 PM
Reposted by Andy P. Tsai
brunetlab.bsky.social
Interested in brain aging? We are super excited to share our new review!!

"Brain aging and rejuvenation at single-cell resolution" 🧪🧠

Massive CONGRATS to Eric Sun, Rahul Nagvekar, and Angie Pogson, three phenomenal graduate students in the lab!!

authors.elsevier.com/sd/article/S...
January 9, 2025 at 12:16 AM
Reposted by Andy P. Tsai
brunetlab.bsky.social
Updated Aging Starter Packs to find people and labs who work on aging!!

Aging Starter Pack 1 (already reached the maximum number!): go.bsky.app/5UXXaDA

Aging Starter Pack 2 (can still add!): go.bsky.app/RfFYndJ

Let me know if you'd like to be added! 😀
December 14, 2024 at 6:43 PM
andyptsai.bsky.social

💘 Celebrate Valentine’s Day with cutting-edge science on APOE and lipid droplets!
Join the ImmunityPIA webinar on 2/14/2025!

🎤 Speakers:
@cohenlaboratory.bsky.social
Dr. Xu Chen

🌟 Panelists:
Dr. Kimberley Bruce
Dr. Lance Johnson
👉 Register now:
alz-org.zoom.us/webinar/regi...

Don’t miss it!
Welcome! You are invited to join a webinar: Immunity and Neurodegeneration PIA: APOE and Lipid Droplets. After registering, you will receive a confirmation email about joining the webinar.
Experts reveal how APOE influences astrocyte lipid droplets and how microglial lipid droplet accumulation is linked to brain tauopathies. Discover cutting-edge research on the role of lipid metabolism...
alz-org.zoom.us
December 14, 2024 at 8:26 AM