Andrei Thomas-Tikhonenko
@andrei-thomas-t.bsky.social
“There is a crack, a crack in everything | That’s how the light gets in” | @PennMedicine @PennCancer @CHOP_Research @RNASociety
3.5 years ago, we knew very little about #pediatric high-grade #glioma... our strengths were the working knowledge of #mRNA #splicing & #microexons and the ability to put together amazing teams of collaborators. Somehow, CureSearch for Children's Cancer had faith in us! www.cell.com/cell-reports...
NRCAM variant defined by microexon skipping is a targetable cell surface proteoform in high-grade gliomas
Aberrant splicing of microexons yields non-canonical surface receptors, such as the
neuronal cell adhesion molecule (NRCAM) lacking amino acids encoded by exons 5 and
19. Sehgal et al. show that Δex5Δ...
www.cell.com
August 8, 2025 at 3:30 PM
3.5 years ago, we knew very little about #pediatric high-grade #glioma... our strengths were the working knowledge of #mRNA #splicing & #microexons and the ability to put together amazing teams of collaborators. Somehow, CureSearch for Children's Cancer had faith in us! www.cell.com/cell-reports...
This just in…
FY’26 Bill Highlights:
National Institutes of Health: $48.7 billion for biomedical investments in research.
Cancer: $7.4 billion for the National Cancer Institute, including $28 million for the Childhood Cancer STAR Act.
www.statnews.com/2025/07/31/n...
FY’26 Bill Highlights:
National Institutes of Health: $48.7 billion for biomedical investments in research.
Cancer: $7.4 billion for the National Cancer Institute, including $28 million for the Childhood Cancer STAR Act.
www.statnews.com/2025/07/31/n...
Senate committee endorses NIH budget increase, rebuking Trump administration’s proposed 40% cut
Senators from both parties endorsed a $400 million increase to the budget of the National Institutes of Health on Thursday
www.statnews.com
July 31, 2025 at 10:36 PM
This just in…
FY’26 Bill Highlights:
National Institutes of Health: $48.7 billion for biomedical investments in research.
Cancer: $7.4 billion for the National Cancer Institute, including $28 million for the Childhood Cancer STAR Act.
www.statnews.com/2025/07/31/n...
FY’26 Bill Highlights:
National Institutes of Health: $48.7 billion for biomedical investments in research.
Cancer: $7.4 billion for the National Cancer Institute, including $28 million for the Childhood Cancer STAR Act.
www.statnews.com/2025/07/31/n...
I wonder if anyone else was just spending his/her Super Bowl weekend reviewing grants and at ~7 pm of Saturday saw eRA Commons go dark. Not to be paranoid or anything…
February 9, 2025 at 1:37 AM
I wonder if anyone else was just spending his/her Super Bowl weekend reviewing grants and at ~7 pm of Saturday saw eRA Commons go dark. Not to be paranoid or anything…
A project three years in the making finally sees the light of day. Microexons meet macroglia… cancerous macroglia meet engineered T cells (at your peril). Joint venture with @hagentilgner.bsky.social @yosephbarash.bsky.social et al @childrensphila.bsky.social www.biorxiv.org/content/10.1...
Neuronal cell adhesion molecule (NRCAM) variant defined by microexon skipping is an essential, antigenically distinct, and targetable surface proteoform in high-grade glioma
To overcome the paucity of known tumor-specific surface antigens in pediatric high-grade glioma (pHGG), we contrasted splicing patterns in pHGGs and normal brain samples. Among alternative splicing ev...
www.biorxiv.org
January 17, 2025 at 1:56 AM
A project three years in the making finally sees the light of day. Microexons meet macroglia… cancerous macroglia meet engineered T cells (at your peril). Joint venture with @hagentilgner.bsky.social @yosephbarash.bsky.social et al @childrensphila.bsky.social www.biorxiv.org/content/10.1...
This is both public and personal... our latest NIH grant was funded through Gabriella Miller Kids First Research Act... every dollar is re-invested into pediatric cancer research - and real jobs for real people! www.nytimes.com/2024/12/21/u...
Dropped From Spending Bill, Cancer Research and D.C. Stadium Measures Revived by Senate (Gift Article)
Two bills on pediatric cancer research and a football stadium site had been left out of the main spending package, but passed early Saturday as separate legislation.
www.nytimes.com
December 22, 2024 at 2:04 AM
This is both public and personal... our latest NIH grant was funded through Gabriella Miller Kids First Research Act... every dollar is re-invested into pediatric cancer research - and real jobs for real people! www.nytimes.com/2024/12/21/u...
Not every week starts on a bad note… TGIM!
December 18, 2024 at 1:10 AM
Not every week starts on a bad note… TGIM!
One oral and one poster presentations from the ATT lab at #ASH24 in always-sunny San Diego. Cancer immunotherapy through the lenses of RNA metabolism, population genetics, and racial disparities @ash-hematology.bsky.social @pennmedicine.bsky.social
December 6, 2024 at 6:18 PM
One oral and one poster presentations from the ATT lab at #ASH24 in always-sunny San Diego. Cancer immunotherapy through the lenses of RNA metabolism, population genetics, and racial disparities @ash-hematology.bsky.social @pennmedicine.bsky.social
For my first post here, I unveil the just-published definitive version of our NRC Roadmap article, where we argue that “widespread splicing alterations [is a] readily actionable feature of human cancers”. Grateful to Forbeck Foundation for bringing this group together! www.nature.com/articles/s41...
Steering research on mRNA splicing in cancer towards clinical translation - Nature Reviews Cancer
Although splicing factors are altered in cancer through mutations and copy number variations, their exact role remains challenging to define. In this Roadmap, Anczukow, Thomas-Tikhonenko and colleague...
www.nature.com
November 22, 2024 at 7:31 PM
For my first post here, I unveil the just-published definitive version of our NRC Roadmap article, where we argue that “widespread splicing alterations [is a] readily actionable feature of human cancers”. Grateful to Forbeck Foundation for bringing this group together! www.nature.com/articles/s41...