Andrei Thomas-Tikhonenko
@andrei-thomas-t.bsky.social
“There is a crack, a crack in everything | That’s how the light gets in” | @PennMedicine @PennCancer @CHOP_Research @RNASociety
The hallmark of pediatric high-grade glioma is pervasive mis-splicing of microexons•Transcripts encoding NRCAM skip exons 5 and 19•Δex5Δex19, but not full-length NRCAM drives tumor growth in orthotopic glioma models•Δex5Δex19 NRCAM-selective mAb enables killing by T cells armed with the Fc receptor.
August 8, 2025 at 3:33 PM
The hallmark of pediatric high-grade glioma is pervasive mis-splicing of microexons•Transcripts encoding NRCAM skip exons 5 and 19•Δex5Δex19, but not full-length NRCAM drives tumor growth in orthotopic glioma models•Δex5Δex19 NRCAM-selective mAb enables killing by T cells armed with the Fc receptor.
Thank you!
November 22, 2024 at 7:51 PM
Thank you!