Amy Webster
@amywebster.bsky.social
Assistant Professor of Biological Science at Florida State.
epigenomics of complex traits, gene x environment interactions, and phenotyping-by-sequencing with C. elegans
amykwebster.github.io
epigenomics of complex traits, gene x environment interactions, and phenotyping-by-sequencing with C. elegans
amykwebster.github.io
Reposted by Amy Webster
From nematode to Nobel: How community-shared resources fueled the rise of Caenorhabditis elegans as a research organism - a perspective written by 11 scientists, six of whom are Nobel laureates
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
www.pnas.org
November 24, 2025 at 11:08 PM
From nematode to Nobel: How community-shared resources fueled the rise of Caenorhabditis elegans as a research organism - a perspective written by 11 scientists, six of whom are Nobel laureates
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
Reposted by Amy Webster
Make males live more than 400% longer and prevent sexual disfunction late in life?! We're down with it. Our latest preprint: Disruption of the insulin signaling pathway in C. elegans dramatically increases male longevity and enhances reproductive health late in life. www.biorxiv.org/content/10.1...
November 6, 2025 at 11:14 PM
Make males live more than 400% longer and prevent sexual disfunction late in life?! We're down with it. Our latest preprint: Disruption of the insulin signaling pathway in C. elegans dramatically increases male longevity and enhances reproductive health late in life. www.biorxiv.org/content/10.1...
Reposted by Amy Webster
Save the date! #PEQG26 June 9-12 2026 in Asilomar, CA. Happens only every 2yrs, but is my favorite conference. Full website coming soon, and registration and abstract submission opens November 14, but I'm allowed to tease that keynotes will be @jnovembre.bsky.social @jennytung.bsky.social and me!
Homepage - Population, Evolutionary, and Quantitative Genetics Conference
Visit our website to learn more.
genetics-gsa.org
September 3, 2025 at 6:51 PM
Save the date! #PEQG26 June 9-12 2026 in Asilomar, CA. Happens only every 2yrs, but is my favorite conference. Full website coming soon, and registration and abstract submission opens November 14, but I'm allowed to tease that keynotes will be @jnovembre.bsky.social @jennytung.bsky.social and me!
Reposted by Amy Webster
Just out in press in eLife, a cool and brilliant piece of work by @amywebster.bsky.social: Gene expression variation across genetically identical individuals predicts reproductive traits. elifesciences.org/articles/106...
September 2, 2025 at 11:09 PM
Just out in press in eLife, a cool and brilliant piece of work by @amywebster.bsky.social: Gene expression variation across genetically identical individuals predicts reproductive traits. elifesciences.org/articles/106...
Reposted by Amy Webster
Fresh on the heels of #worm25, our new preprint just dropped: Pro-longevity compounds extend Caenorhabditis elegans male lifespan and reproductive healthspan, by @rosealsaadi.bsky.social www.biorxiv.org/content/10.1...
Pro-longevity compounds extend Caenorhabditis elegans male lifespan and reproductive healthspan
Sex differences in aging are robust and ubiquitous. Demographic differences in aging generated by sex have long been recognized, but the underlying biological basis for these differences and the poten...
www.biorxiv.org
July 2, 2025 at 8:18 PM
Fresh on the heels of #worm25, our new preprint just dropped: Pro-longevity compounds extend Caenorhabditis elegans male lifespan and reproductive healthspan, by @rosealsaadi.bsky.social www.biorxiv.org/content/10.1...
It was great to participate in this virtual workshop yesterday (recorded for those who missed it)! Looking forward to the rest of #worm25
C. elegans enthusiasts - join me and @stern-lab.bsky.social for a pre #worm25 meeting online workshop on *Monitoring inter-individual diversity across multiple levels and timescales* - Jun 26, 2025 12:30 PM Eastern Time
us06web.zoom.us/j/8544967372...
please share!
us06web.zoom.us/j/8544967372...
please share!
Join our Cloud HD Video Meeting
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us06web.zoom.us
June 27, 2025 at 5:42 PM
It was great to participate in this virtual workshop yesterday (recorded for those who missed it)! Looking forward to the rest of #worm25
Reposted by Amy Webster
Hey fellow Drosophila researchers - if you haven't heard, the UMGC is offering ultra low-cost genome sequencing! See here to learn more: z.umn.edu/UMGC-MOSS #Dros25
March 22, 2025 at 11:39 PM
Hey fellow Drosophila researchers - if you haven't heard, the UMGC is offering ultra low-cost genome sequencing! See here to learn more: z.umn.edu/UMGC-MOSS #Dros25
Reposted by Amy Webster
A systems-level, semi-quantitative landscape of metabolic flux in C. elegans
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A systems-level, semi-quantitative landscape of metabolic flux in C. elegans - Nature
A strategy is introduced that infers whole-animal metabolic flux wiring from transcriptional phenotypes in the nematode Caenorhabditis elegans and several features in its adult metabolism are discover...
www.nature.com
March 2, 2025 at 3:27 PM
A systems-level, semi-quantitative landscape of metabolic flux in C. elegans
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Amy Webster
NEW: NSF confirmed that they fired 168 employees today, out of their staff of ~1,500 feds.
This includes some people who'd finished their 1-year probationary periods, which were extended to 2-years last month without explanation. More to come.
This includes some people who'd finished their 1-year probationary periods, which were extended to 2-years last month without explanation. More to come.
February 18, 2025 at 4:16 PM
NEW: NSF confirmed that they fired 168 employees today, out of their staff of ~1,500 feds.
This includes some people who'd finished their 1-year probationary periods, which were extended to 2-years last month without explanation. More to come.
This includes some people who'd finished their 1-year probationary periods, which were extended to 2-years last month without explanation. More to come.
Reposted by Amy Webster
One of the coolest and most novel findings I’ve seen in years. This is why I work in worms. To find things no one even really knew to look for. Like a conserved system that splices transposons out of mRNAs to prevent otherwise lethal insertions in essential genes! - www.biorxiv.org/content/10.1...
An RNA Splicing System that Excises Transposons from Animal mRNAs
All genomes harbor mobile genetic parasites called transposable elements (TEs). Here we describe a system, which we term SOS splicing, that protects C. elegans and human genes from DNA transposon-medi...
www.biorxiv.org
February 18, 2025 at 11:10 AM
One of the coolest and most novel findings I’ve seen in years. This is why I work in worms. To find things no one even really knew to look for. Like a conserved system that splices transposons out of mRNAs to prevent otherwise lethal insertions in essential genes! - www.biorxiv.org/content/10.1...
Reposted by Amy Webster
On January 6th, 1995, my (now ex) wife and I boarded a flight from Heathrow to JFK on a one way ticket. We had two suitcases and about $900 in cash - this was everything we owned and we were moving to the US. We thought it was maybe for 2-3 years. I had visited the US once, for a conference, and
February 15, 2025 at 5:48 AM
On January 6th, 1995, my (now ex) wife and I boarded a flight from Heathrow to JFK on a one way ticket. We had two suitcases and about $900 in cash - this was everything we owned and we were moving to the US. We thought it was maybe for 2-3 years. I had visited the US once, for a conference, and
Reposted by Amy Webster
1. Today the NIH director issued a new directive slashing overhead rates to 15%.
I want to provide some context on what that means and why it matters.
grants.nih.gov/grants/guide...
I want to provide some context on what that means and why it matters.
grants.nih.gov/grants/guide...
NOT-OD-25-068: Supplemental Guidance to the 2024 NIH Grants Policy Statement: Indirect Cost Rates
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Supplemental Guidance to the 2024 NIH Grants Policy Statement: Indirect Cost Rates NOT-OD-25-068. OD
grants.nih.gov
February 8, 2025 at 12:18 AM
1. Today the NIH director issued a new directive slashing overhead rates to 15%.
I want to provide some context on what that means and why it matters.
grants.nih.gov/grants/guide...
I want to provide some context on what that means and why it matters.
grants.nih.gov/grants/guide...
Reposted by Amy Webster
In the present discussions about NIH and the need for reform, two recurring points I am seeing are:
(1) NIH doesn't fund truly high impact research
(2) NIH needs to experiment with alternative approaches to peer review, particularly for high risk-high impact research
1/n
(1) NIH doesn't fund truly high impact research
(2) NIH needs to experiment with alternative approaches to peer review, particularly for high risk-high impact research
1/n
January 26, 2025 at 2:51 PM
In the present discussions about NIH and the need for reform, two recurring points I am seeing are:
(1) NIH doesn't fund truly high impact research
(2) NIH needs to experiment with alternative approaches to peer review, particularly for high risk-high impact research
1/n
(1) NIH doesn't fund truly high impact research
(2) NIH needs to experiment with alternative approaches to peer review, particularly for high risk-high impact research
1/n
Very happy to see this out! It was great to think deeply about integrating epigenetic variation into the genotype-phenotype map, from historical perspectives, to current research, to future possibilities. I hope others interested in these topics find the framework and scope of this review helpful.
Just out in @natrevgenet.bsky.social, led by @amywebster.bsky.social: Epigenetics and individuality: from concepts to causality across timescales. Access available via the Sharedit Initiative. rdcu.be/d5LYh
Epigenetics and individuality: from concepts to causality across timescales
Nature Reviews Genetics - Recent genomic approaches are providing unprecedented opportunity to disentangle how genotype and environment affect organismal traits. The authors review the role of...
rdcu.be
January 10, 2025 at 4:41 AM
Very happy to see this out! It was great to think deeply about integrating epigenetic variation into the genotype-phenotype map, from historical perspectives, to current research, to future possibilities. I hope others interested in these topics find the framework and scope of this review helpful.
Reposted by Amy Webster
Following the news that eLife will not receive an Impact Factor in 2025, we’ve shared an update on how our model is doing since we were first placed “on hold” by Web of Science, and what we’re up to now. Find out more.
https://buff.ly/3ATRAFT
https://buff.ly/3ATRAFT
The eLife Model: An update on progress following changes in Web of Science indexing status
Following the decision that eLife will not receive an Impact Factor in 2025, we share an update on how our model is doing since we were first placed “on hold” by Web of Science, and what we’re up to…
buff.ly
November 20, 2024 at 5:44 PM
Following the news that eLife will not receive an Impact Factor in 2025, we’ve shared an update on how our model is doing since we were first placed “on hold” by Web of Science, and what we’re up to now. Find out more.
https://buff.ly/3ATRAFT
https://buff.ly/3ATRAFT
Reposted by Amy Webster
Important new preprint from the lab: Precise Lineage Tracking Using Molecular Barcodes Demonstrates Fitness Trade-offs for Ivermectin Resistance in Nematodes. First use of random barcodes for the analysis of natural selection in a multicellular animal! www.biorxiv.org/content/10.1...
Precise Lineage Tracking Using Molecular Barcodes Demonstrates Fitness Trade-offs for Ivermectin Resistance in Nematodes
A fundamental tenet of evolutionary genetics is that the direction and strength of selection on individual loci varies with the environment. Barcoded evolutionary lineage tracking is a powerful approa...
www.biorxiv.org
November 10, 2024 at 5:11 AM
Important new preprint from the lab: Precise Lineage Tracking Using Molecular Barcodes Demonstrates Fitness Trade-offs for Ivermectin Resistance in Nematodes. First use of random barcodes for the analysis of natural selection in a multicellular animal! www.biorxiv.org/content/10.1...
My C. elegans biology lab is looking to hire a technician. You can find the ad at FSU jobs with job ID 58889 for the next week, or feel free to email me a CV and cover letter anytime. Could be a good fit for people about to graduate or recent grads. Please share!
jobs.omni.fsu.edu/psc/sprdhr_e...
jobs.omni.fsu.edu/psc/sprdhr_e...
Welcome | PS LINKS
jobs.omni.fsu.edu
October 28, 2024 at 6:14 PM
My C. elegans biology lab is looking to hire a technician. You can find the ad at FSU jobs with job ID 58889 for the next week, or feel free to email me a CV and cover letter anytime. Could be a good fit for people about to graduate or recent grads. Please share!
jobs.omni.fsu.edu/psc/sprdhr_e...
jobs.omni.fsu.edu/psc/sprdhr_e...
I am very excited to announce I am starting my lab as an Assistant Professor @FloridaState this week! We will be focused on understanding the basis of individual variation in complex traits using a variety of genomic approaches and primarily using C. elegans as a model.
August 5, 2024 at 11:09 PM
I am very excited to announce I am starting my lab as an Assistant Professor @FloridaState this week! We will be focused on understanding the basis of individual variation in complex traits using a variety of genomic approaches and primarily using C. elegans as a model.
Reposted by Amy Webster
Now officially online at G3: Heritable epigenetic variation facilitates long-term maintenance of epigenetic and genetic variation, by @amywebster.bsky.social academic.oup.com/g3journal/ad...
December 19, 2023 at 7:12 PM
Now officially online at G3: Heritable epigenetic variation facilitates long-term maintenance of epigenetic and genetic variation, by @amywebster.bsky.social academic.oup.com/g3journal/ad...
Check out our preprint on the basis of phenotypic differences across genetically identical individuals!
Truly epic preprint from @amywebster.bsky.social : Epigenetic context predicts gene expression variation and reproductive traits across genetically identical individuals. www.biorxiv.org/content/10.1...
October 14, 2023 at 7:27 PM
Check out our preprint on the basis of phenotypic differences across genetically identical individuals!
Reposted by Amy Webster
'Using an inbred line from a natural population with high diapause plasticity, we demonstrate that diapause is determined epigenetically: only a subset of genetically identical individuals enter diapause and this diapause plasticity is epigenetically transmitted for at least three generations'
Histone methylation regulates reproductive diapause in Drosophila melanogaster
Author summary Fluctuating environments pose significant challenges to developing organisms. To better match the immediate, local environment, many organisms follow distinct developmental trajectories...
journals.plos.org
September 24, 2023 at 9:59 AM
'Using an inbred line from a natural population with high diapause plasticity, we demonstrate that diapause is determined epigenetically: only a subset of genetically identical individuals enter diapause and this diapause plasticity is epigenetically transmitted for at least three generations'