Victor Jimenez Zepeda
@amyloidenthusiast.bsky.social
Hematologist interested in plasma cell disorders and precursor conditions! 🇨🇦🇲🇽 @Arthur Child Comprehensive Cancer Center, Calgary, AB, Canada
For all the amazing things yet to come in 2025. Here's to making memories, achieving goals, and becoming the best version of yourself this year! May your heart be full, your mind be clear, and your journey be filled with joy this new year!
December 31, 2024 at 3:07 PM
For all the amazing things yet to come in 2025. Here's to making memories, achieving goals, and becoming the best version of yourself this year! May your heart be full, your mind be clear, and your journey be filled with joy this new year!
Reposted by Victor Jimenez Zepeda
Using protein large language models to optimize antibodies to SARS-CoV-2 with >20-fold increase in binding affinity
www.pnas.org/doi/10.1073/... @pnas.org
www.pnas.org/doi/10.1073/... @pnas.org
December 31, 2024 at 2:13 AM
Using protein large language models to optimize antibodies to SARS-CoV-2 with >20-fold increase in binding affinity
www.pnas.org/doi/10.1073/... @pnas.org
www.pnas.org/doi/10.1073/... @pnas.org
Reposted by Victor Jimenez Zepeda
In a first of its kind, the @fda.gov has approved the first mesenchymal stem cell therapy, Mesoblast’s Ryoncil for the treatment of graft versus host disease.
In landmark, FDA approves first MSC therapy, Mesoblast's Ryoncil for GvHD - The Niche
Professor discusses FDA approval of first MSC therapy, Mesoblast's Ryoncil for GvHD, a milestone for the field.
ipscell.com
December 25, 2024 at 3:59 PM
In a first of its kind, the @fda.gov has approved the first mesenchymal stem cell therapy, Mesoblast’s Ryoncil for the treatment of graft versus host disease.
Reposted by Victor Jimenez Zepeda
We found that almost 40% of 12-21 year old females are iron deficient.
jamanetwork.com/journals/jam...
I’ve been asked how this is possible evolutionarily.
I have a few thoughts. 🧵
jamanetwork.com/journals/jam...
I’ve been asked how this is possible evolutionarily.
I have a few thoughts. 🧵
Prevalence of Iron Deficiency and Iron-Deficiency Anemia in US Females Aged 12-21 Years, 2003-2020
This study examines prevalence of iron deficiency among females aged 12 to 21 years to inform future screening strategies for iron deficiency and iron-deficiency anemia.
jamanetwork.com
December 18, 2024 at 3:07 PM
We found that almost 40% of 12-21 year old females are iron deficient.
jamanetwork.com/journals/jam...
I’ve been asked how this is possible evolutionarily.
I have a few thoughts. 🧵
jamanetwork.com/journals/jam...
I’ve been asked how this is possible evolutionarily.
I have a few thoughts. 🧵
Reposted by Victor Jimenez Zepeda
Reposted by Victor Jimenez Zepeda
#ASH24 News: ASH Newborn SCD Screening Program in Sub-Saharan Africa Found Feasible: bit.ly/4faSNXk 🩸🌍
#ConquerSCD #Sicklecell #HemeSky #Hematology
#ConquerSCD #Sicklecell #HemeSky #Hematology
December 8, 2024 at 8:12 PM
#ASH24 News: ASH Newborn SCD Screening Program in Sub-Saharan Africa Found Feasible: bit.ly/4faSNXk 🩸🌍
#ConquerSCD #Sicklecell #HemeSky #Hematology
#ConquerSCD #Sicklecell #HemeSky #Hematology
Reposted by Victor Jimenez Zepeda
#ASH24 myeloma, Adolfo Alena from Mount Sinai, MDSC with S100A8/9 expression associated with poor Car-t outcome, incubation of CAr-t with S100A8/9 has linear effect on inhibiting cytotoxic effect, can be salvaged with a blocking antibody. Great talk
December 8, 2024 at 8:12 PM
#ASH24 myeloma, Adolfo Alena from Mount Sinai, MDSC with S100A8/9 expression associated with poor Car-t outcome, incubation of CAr-t with S100A8/9 has linear effect on inhibiting cytotoxic effect, can be salvaged with a blocking antibody. Great talk
Reposted by Victor Jimenez Zepeda
The horse is out of the barn - financial toxicity is the unrecognized adverse event, and I am so proud of Dr. Greg Knight for his resilience in pioneering work to try to help manage it. @shematologist.bsky.social led an extraordinary Symposium on Quality at #ASH24 @ash-hematology.bsky.social
December 8, 2024 at 4:59 PM
The horse is out of the barn - financial toxicity is the unrecognized adverse event, and I am so proud of Dr. Greg Knight for his resilience in pioneering work to try to help manage it. @shematologist.bsky.social led an extraordinary Symposium on Quality at #ASH24 @ash-hematology.bsky.social
Reposted by Victor Jimenez Zepeda
Staggering statistics at #ASH24 #TreatingFairly
Patients with cancer who go bankrupt are nearly 80% more likely to die regardless of disease status.
Our system quite literally kills people.
Patients with cancer who go bankrupt are nearly 80% more likely to die regardless of disease status.
Our system quite literally kills people.
December 8, 2024 at 12:17 AM
Staggering statistics at #ASH24 #TreatingFairly
Patients with cancer who go bankrupt are nearly 80% more likely to die regardless of disease status.
Our system quite literally kills people.
Patients with cancer who go bankrupt are nearly 80% more likely to die regardless of disease status.
Our system quite literally kills people.
Reposted by Victor Jimenez Zepeda
Induced B-Cell Receptor Diversity Predicts PD-1 Blockade Immunotherapy Response. https://www.biorxiv.org/content/10.1101/2024.12.03.626669v1
Induced B-Cell Receptor Diversity Predicts PD-1 Blockade Immunotherapy Response. https://www.biorxiv.org/content/10.1101/2024.12.03.626669v1
Immune checkpoint inhibitors such as anti-PD-1 antibodies (aPD1) can be effective in treating advanc
www.biorxiv.org
December 4, 2024 at 10:47 PM
Induced B-Cell Receptor Diversity Predicts PD-1 Blockade Immunotherapy Response. https://www.biorxiv.org/content/10.1101/2024.12.03.626669v1
Reposted by Victor Jimenez Zepeda
Here they are — the 10 Best Books of 2024.
The 10 Best Books of 2024
The staff of The New York Times Book Review choose the year’s top fiction and nonfiction.
www.nytimes.com
December 4, 2024 at 2:55 AM
Here they are — the 10 Best Books of 2024.
Reposted by Victor Jimenez Zepeda
Guinness, once synonymous with Irish pubs and older men, is winning over younger, beer-bent Americans eager to “split the ‘G.’”
Why Everyone Is Drinking Guinness
Guinness, the beer of Irish pubs and Irish men, has endeared itself to chug-happy Americans eager to “split the ‘G.’”
www.nytimes.com
December 4, 2024 at 5:01 AM
Guinness, once synonymous with Irish pubs and older men, is winning over younger, beer-bent Americans eager to “split the ‘G.’”
Reposted by Victor Jimenez Zepeda
As we progress from unimodal to multimodal w/foundation models of A.I., we're moving from the "scan era" to the "everything era" in medicine (with radiology the leading force)
brief summary of my @rsnasky.bsky.social talk #RSNA2024 today
www.auntminnie.com/resources/co...
@auntminnie.bsky.social
brief summary of my @rsnasky.bsky.social talk #RSNA2024 today
www.auntminnie.com/resources/co...
@auntminnie.bsky.social
Topol: AI gearing for 'everything era'
Eric Topol, MD, founder and director of the Scripps Research Translational Institute discussed AI’s progress toward the future at RSNA 2024.
www.auntminnie.com
December 2, 2024 at 10:34 PM
As we progress from unimodal to multimodal w/foundation models of A.I., we're moving from the "scan era" to the "everything era" in medicine (with radiology the leading force)
brief summary of my @rsnasky.bsky.social talk #RSNA2024 today
www.auntminnie.com/resources/co...
@auntminnie.bsky.social
brief summary of my @rsnasky.bsky.social talk #RSNA2024 today
www.auntminnie.com/resources/co...
@auntminnie.bsky.social
Reposted by Victor Jimenez Zepeda
The @rsnasky.bsky.social meeting is the largest medical meeting in the world. The radiology community is the pacesetter for medical #AI, that we can all learn from. I'm excited to give a presentation during tomorrow morning's plenary session
reg.meeting.rsna.org/flow/rsna/rs... #RSNA2024
reg.meeting.rsna.org/flow/rsna/rs... #RSNA2024
December 1, 2024 at 7:49 PM
The @rsnasky.bsky.social meeting is the largest medical meeting in the world. The radiology community is the pacesetter for medical #AI, that we can all learn from. I'm excited to give a presentation during tomorrow morning's plenary session
reg.meeting.rsna.org/flow/rsna/rs... #RSNA2024
reg.meeting.rsna.org/flow/rsna/rs... #RSNA2024
Reposted by Victor Jimenez Zepeda
Excited to share our latest work in #MultipleMyeloma! 🧬 We uncovered a six-gene signature predicting response to venetoclax, but also revealed that 1q gain can drive resistance—and how CDK7 inhibitors might reverse it. #MyelomaResearch
Mount Sinai Researchers Identify Six-Gene Pattern to Predict Drug Success in Multiple Myeloma Patients
www.mountsinai.org
November 30, 2024 at 7:17 PM
Excited to share our latest work in #MultipleMyeloma! 🧬 We uncovered a six-gene signature predicting response to venetoclax, but also revealed that 1q gain can drive resistance—and how CDK7 inhibitors might reverse it. #MyelomaResearch
Reposted by Victor Jimenez Zepeda
🚨🎉 BREAKING NEWS: The @fda.gov has approved BridgeBio's Attruby™ (acoramidis) for the treatment of patients with transthyretin amyloid cardiomyopathy (#ATTR-CM).
Learn more: arci.org/attruby-attr...
Learn more: arci.org/attruby-attr...
FDA Approves Attruby™ (acoramidis) for the Treatment of ATTR-CM: A New Option for Patients
The FDA’s approval of Attruby is significant for patients with ATTR-CM, providing them with another effective treatment option.
arci.org
November 23, 2024 at 7:11 PM
🚨🎉 BREAKING NEWS: The @fda.gov has approved BridgeBio's Attruby™ (acoramidis) for the treatment of patients with transthyretin amyloid cardiomyopathy (#ATTR-CM).
Learn more: arci.org/attruby-attr...
Learn more: arci.org/attruby-attr...
Reposted by Victor Jimenez Zepeda
The addition of H pylori stool antigen testing to fecal immunochemical testing (FIT) screening did not significantly reduce gastric cancer incidence or mortality.
https://ja.ma/3ZjdjjS
https://ja.ma/3ZjdjjS
November 23, 2024 at 8:00 PM
The addition of H pylori stool antigen testing to fecal immunochemical testing (FIT) screening did not significantly reduce gastric cancer incidence or mortality.
https://ja.ma/3ZjdjjS
https://ja.ma/3ZjdjjS
Reposted by Victor Jimenez Zepeda
A 2-year-old gorilla died of traumatic injuries last week at the Calgary Zoo in Alberta, Canada, after being struck by a hydraulic door that a staff member mistakenly activated, according to the zoo.
2-Year-Old Gorilla Dies After Being Struck by Hydraulic Door at Zoo
A Calgary Zoo staff member mistakenly activated a door that struck the western lowland gorilla named Eyare, a report found.
www.nytimes.com
November 23, 2024 at 8:40 PM
A 2-year-old gorilla died of traumatic injuries last week at the Calgary Zoo in Alberta, Canada, after being struck by a hydraulic door that a staff member mistakenly activated, according to the zoo.
Reposted by Victor Jimenez Zepeda
Based on registry data in 3.9M age 65+ who had 4+ prior doses of #COVID19 vaccine, receiving fall 2023 (XBB 1.5) #COVID #booster:
👉Decreased hospitalization by 58%
👉Decreased death by 75%
due to #Covid at 24 wks follow-up.
🔑 Get boosted!
#MedSky #VaccinesWork
bmjmedicine.bmj.com/content/bmjm...
👉Decreased hospitalization by 58%
👉Decreased death by 75%
due to #Covid at 24 wks follow-up.
🔑 Get boosted!
#MedSky #VaccinesWork
bmjmedicine.bmj.com/content/bmjm...
November 22, 2024 at 2:36 PM
Based on registry data in 3.9M age 65+ who had 4+ prior doses of #COVID19 vaccine, receiving fall 2023 (XBB 1.5) #COVID #booster:
👉Decreased hospitalization by 58%
👉Decreased death by 75%
due to #Covid at 24 wks follow-up.
🔑 Get boosted!
#MedSky #VaccinesWork
bmjmedicine.bmj.com/content/bmjm...
👉Decreased hospitalization by 58%
👉Decreased death by 75%
due to #Covid at 24 wks follow-up.
🔑 Get boosted!
#MedSky #VaccinesWork
bmjmedicine.bmj.com/content/bmjm...
Food for thought! @jamacurrent.bsky.social
Among the government-funded academic inventors on US drug patents, the majority were senior researchers at prestigious institutions.
https://ja.ma/48YWpKB
https://ja.ma/48YWpKB
November 21, 2024 at 5:35 PM
Food for thought! @jamacurrent.bsky.social
Reposted by Victor Jimenez Zepeda
The expansion of GLP-1 drug efficacy evidence in 2024, a concise review by Daniel Drucker, a pioneer of the field nature.com/articles/s41...
Expanding applications of therapies based on GLP1 - Nature Reviews Endocrinology
The evidence base in support of the use of medicines based on glucagon-like peptide 1 beyond glucose control and weight loss was substantially bolstered in 2024, as clinical trial data report benefits...
nature.com
November 21, 2024 at 5:02 PM
The expansion of GLP-1 drug efficacy evidence in 2024, a concise review by Daniel Drucker, a pioneer of the field nature.com/articles/s41...
Reposted by Victor Jimenez Zepeda
A big day of output for the Human Cell Atlas, a global collaborative project with 100 countries to understand our ~37 trillion cells
A Wikipedia of our cells, a "remarkable achievement"
nature.com/articles/d41...
nature.com/immersive/d4...
A Wikipedia of our cells, a "remarkable achievement"
nature.com/articles/d41...
nature.com/immersive/d4...
November 20, 2024 at 5:04 PM
A big day of output for the Human Cell Atlas, a global collaborative project with 100 countries to understand our ~37 trillion cells
A Wikipedia of our cells, a "remarkable achievement"
nature.com/articles/d41...
nature.com/immersive/d4...
A Wikipedia of our cells, a "remarkable achievement"
nature.com/articles/d41...
nature.com/immersive/d4...
Reposted by Victor Jimenez Zepeda
Halving premature deaths (death between birth and age 70) around the world by 2050 is feasible. The US isn't doing well vs peer countries.
www.thelancet.com/journals/lan...
www.thelancet.com/journals/lan...
November 21, 2024 at 1:30 AM
Halving premature deaths (death between birth and age 70) around the world by 2050 is feasible. The US isn't doing well vs peer countries.
www.thelancet.com/journals/lan...
www.thelancet.com/journals/lan...
Reposted by Victor Jimenez Zepeda
Some women across the U.S. are stocking up on emergency contraceptives, abortion pills or both. Interviews with numerous providers of the pills point to a surge in demand in the immediate aftermath of the election.
Orders for Morning-After Pills and Abortion Pills Rise After Trump’s Election
Some women are stocking up on the medications, saying they are concerned that the new administration could take steps to restrict access.
www.nytimes.com
November 19, 2024 at 10:04 PM
Some women across the U.S. are stocking up on emergency contraceptives, abortion pills or both. Interviews with numerous providers of the pills point to a surge in demand in the immediate aftermath of the election.