🍊Amir Dehsarvi
@amirdehsarvi.bsky.social
Principal Scientist Neuroimaging @boehringerglobal.bsky.social
Bridging the gap between Machine Learning 🤖 + 🧠 Neuroimaging
Bridging the gap between Machine Learning 🤖 + 🧠 Neuroimaging
Reposted by 🍊Amir Dehsarvi
New paper out!
We systematically compared how ATN biomarker changes track cognitive decline in AD:
Tau-PET, plasma ptau217 & cortical thickness changes track cognition, amyloid-PET does not.
Ptau217 = cost-effective proxy for monitoring cognitive changes in AD
doi.org/10.1002/alz....
We systematically compared how ATN biomarker changes track cognitive decline in AD:
Tau-PET, plasma ptau217 & cortical thickness changes track cognition, amyloid-PET does not.
Ptau217 = cost-effective proxy for monitoring cognitive changes in AD
doi.org/10.1002/alz....
A systematic comparison of ATN biomarkers for monitoring longitudinal cognitive changes in Alzheimer's disease
INTRODUCTION
With anti-amyloid beta (Aβ) therapies approved for Alzheimer's disease (AD), surrogate biomarkers are needed to monitor clinical treatment efficacy. Therefore, we systematically compare.....
doi.org
October 25, 2025 at 5:26 AM
New paper out!
We systematically compared how ATN biomarker changes track cognitive decline in AD:
Tau-PET, plasma ptau217 & cortical thickness changes track cognition, amyloid-PET does not.
Ptau217 = cost-effective proxy for monitoring cognitive changes in AD
doi.org/10.1002/alz....
We systematically compared how ATN biomarker changes track cognitive decline in AD:
Tau-PET, plasma ptau217 & cortical thickness changes track cognition, amyloid-PET does not.
Ptau217 = cost-effective proxy for monitoring cognitive changes in AD
doi.org/10.1002/alz....
Reposted by 🍊Amir Dehsarvi
UCL Hawkes Institute seeks postdoc to develop joint text-vision AI models for MRI analysis in dementia and longevity, led by Prof James Cole at MANIFOLD lab. Closing date: 17th October
www.dementiaresearcher.nihr.ac.uk/job/research...
www.dementiaresearcher.nihr.ac.uk/job/research...
Research Fellow: Medical imaging analysis
UCL Hawkes Institute seeks postdoc to develop joint text-vision AI models for MRI analysis in dementia and longevity, led by Prof James Cole at MANIFOLD lab.
www.dementiaresearcher.nihr.ac.uk
October 4, 2025 at 8:39 PM
UCL Hawkes Institute seeks postdoc to develop joint text-vision AI models for MRI analysis in dementia and longevity, led by Prof James Cole at MANIFOLD lab. Closing date: 17th October
www.dementiaresearcher.nihr.ac.uk/job/research...
www.dementiaresearcher.nihr.ac.uk/job/research...
Reposted by 🍊Amir Dehsarvi
Out now in Brain: Our new study shows that tau deposits in Alzheimer’s disease not affect gray matter but also drive degeneration of connected white matter tracts, offering mechanistic insight into how tau disrupts brain networks
academic.oup.com/brain/articl...
academic.oup.com/brain/articl...
September 15, 2025 at 7:55 AM
Out now in Brain: Our new study shows that tau deposits in Alzheimer’s disease not affect gray matter but also drive degeneration of connected white matter tracts, offering mechanistic insight into how tau disrupts brain networks
academic.oup.com/brain/articl...
academic.oup.com/brain/articl...
Reposted by 🍊Amir Dehsarvi
Very happy to share our 2nd paper today, led by Lukas Frontzkowski: We developed a novel data driven reference region for PI-2620 PET tailored to assess 4R tauopathies, improving i) PSP vs. control separation and ii) PET associations with clinical scores
doi.org/10.1007/s002...
doi.org/10.1007/s002...
June 10, 2025 at 1:39 PM
Very happy to share our 2nd paper today, led by Lukas Frontzkowski: We developed a novel data driven reference region for PI-2620 PET tailored to assess 4R tauopathies, improving i) PSP vs. control separation and ii) PET associations with clinical scores
doi.org/10.1007/s002...
doi.org/10.1007/s002...
Reposted by 🍊Amir Dehsarvi
Happy to share our new work by Carla Palleis in Movement Disorders showing that brain networks shape neurodegeneration patterns in PSP
=> This suggests that grey matter atrophy expands across connected brain regions, potentially following tau accumulation in PSP
doi.org/10.1002/mds....
=> This suggests that grey matter atrophy expands across connected brain regions, potentially following tau accumulation in PSP
doi.org/10.1002/mds....
June 10, 2025 at 1:24 PM
Happy to share our new work by Carla Palleis in Movement Disorders showing that brain networks shape neurodegeneration patterns in PSP
=> This suggests that grey matter atrophy expands across connected brain regions, potentially following tau accumulation in PSP
doi.org/10.1002/mds....
=> This suggests that grey matter atrophy expands across connected brain regions, potentially following tau accumulation in PSP
doi.org/10.1002/mds....
Reposted by 🍊Amir Dehsarvi
How does the brain reorganize in the context of age and AD?
Are functional changes in age and AD similar?
Are these changes dynamic across the age/AD spectrum?
We unpack these questions in a sample of N=973 with AD biomarkers
Preprint: tinyurl.com/ymv8s7h8
⬇️🧵
1/
Are functional changes in age and AD similar?
Are these changes dynamic across the age/AD spectrum?
We unpack these questions in a sample of N=973 with AD biomarkers
Preprint: tinyurl.com/ymv8s7h8
⬇️🧵
1/
May 27, 2025 at 1:53 PM
How does the brain reorganize in the context of age and AD?
Are functional changes in age and AD similar?
Are these changes dynamic across the age/AD spectrum?
We unpack these questions in a sample of N=973 with AD biomarkers
Preprint: tinyurl.com/ymv8s7h8
⬇️🧵
1/
Are functional changes in age and AD similar?
Are these changes dynamic across the age/AD spectrum?
We unpack these questions in a sample of N=973 with AD biomarkers
Preprint: tinyurl.com/ymv8s7h8
⬇️🧵
1/
Reposted by 🍊Amir Dehsarvi
The European Medicines Agency’s Committee for Medicinal Products for Human Use (CHMP) has recommended against granting the marketing authorisation of #donanemab ( #Kisunla ) in the treatment of the mild dementia stage of Alzheimer’s disease across the EU and EEA.
www.ema.europa.eu/en/medicines...
www.ema.europa.eu/en/medicines...
March 28, 2025 at 12:03 PM
The European Medicines Agency’s Committee for Medicinal Products for Human Use (CHMP) has recommended against granting the marketing authorisation of #donanemab ( #Kisunla ) in the treatment of the mild dementia stage of Alzheimer’s disease across the EU and EEA.
www.ema.europa.eu/en/medicines...
www.ema.europa.eu/en/medicines...
نوروز مبارک
با آرزوی سالی سرشار از آزادی، شادی،و سلامتی برای همه
با آرزوی سالی سرشار از آزادی، شادی،و سلامتی برای همه
March 20, 2025 at 10:47 AM
نوروز مبارک
با آرزوی سالی سرشار از آزادی، شادی،و سلامتی برای همه
با آرزوی سالی سرشار از آزادی، شادی،و سلامتی برای همه
Reposted by 🍊Amir Dehsarvi
Excited to share our new work in Molecular Neurodegeneration, showing that α-synuclein co-pathology is common in Alzheimer’s and accelerates amyloid-related tau accumulation, supporting its role as a tau co-aggregation factor.
doi.org/10.1186/s130...
doi.org/10.1186/s130...
Alpha synuclein co-pathology is associated with accelerated amyloid-driven tau accumulation in Alzheimer’s disease - Molecular Neurodegeneration
Background Aggregated alpha-Synuclein (αSyn) is a hallmark pathology in Parkinson’s disease but also one of the most common co-pathologies in Alzheimer’s disease (AD). Preclinical studies suggest that...
doi.org
March 18, 2025 at 9:15 AM
Excited to share our new work in Molecular Neurodegeneration, showing that α-synuclein co-pathology is common in Alzheimer’s and accelerates amyloid-related tau accumulation, supporting its role as a tau co-aggregation factor.
doi.org/10.1186/s130...
doi.org/10.1186/s130...
Reposted by 🍊Amir Dehsarvi
We did it and now it is published: A highly Lewy-fold selective and quantitative Synuclein Aggregate Amplification Assay (SAA). Huge thanks to the amazing teams at MODAG GmbH, LMU Munich, and Bologna University!
rdcu.be/eaISM
rdcu.be/eaISM
A quantitative Lewy-fold-specific alpha-synuclein seed amplification assay as a progression marker for Parkinson’s disease
rdcu.be
February 21, 2025 at 5:23 PM
We did it and now it is published: A highly Lewy-fold selective and quantitative Synuclein Aggregate Amplification Assay (SAA). Huge thanks to the amazing teams at MODAG GmbH, LMU Munich, and Bologna University!
rdcu.be/eaISM
rdcu.be/eaISM
Reposted by 🍊Amir Dehsarvi
We're now hiring for a Director of our Center for Data-Driven Discovery. The ideal candidate will spearhead efforts to create new methods for representing, analyzing, and interpreting large-scale biological data.
Learn more and apply: alleninstitute.org/careers/jobs...
#compneuro
Learn more and apply: alleninstitute.org/careers/jobs...
#compneuro
Jobs
We are working to solve the biggest mysteries in bioscience.
alleninstitute.org
February 18, 2025 at 12:42 AM
We're now hiring for a Director of our Center for Data-Driven Discovery. The ideal candidate will spearhead efforts to create new methods for representing, analyzing, and interpreting large-scale biological data.
Learn more and apply: alleninstitute.org/careers/jobs...
#compneuro
Learn more and apply: alleninstitute.org/careers/jobs...
#compneuro
Reposted by 🍊Amir Dehsarvi
This is incredibly stressful to our Alzheimer's community (families and researchers). There are Alzheimer Disease Research Centers that are in limbo now - no council meetings means no notice of awards, means all the research we are doing to slow or prevent this disease is paused indefinitely.
This. 👇👇👇👇
No study sections, no council meetings = nothing funded. If it's not in the federal register, not happening. Nothing in there after 2/20/25 re: NIH.
Era commons is not being updated. Still says my Advisory Council Meeting was held on 1/28/25 at 3pm. It was not.
Clearly.
1/2
No study sections, no council meetings = nothing funded. If it's not in the federal register, not happening. Nothing in there after 2/20/25 re: NIH.
Era commons is not being updated. Still says my Advisory Council Meeting was held on 1/28/25 at 3pm. It was not.
Clearly.
1/2
I still don't think it's sunk in to many that after February 20th, there ain't no study sections.
February 18, 2025 at 12:55 AM
This is incredibly stressful to our Alzheimer's community (families and researchers). There are Alzheimer Disease Research Centers that are in limbo now - no council meetings means no notice of awards, means all the research we are doing to slow or prevent this disease is paused indefinitely.
Reposted by 🍊Amir Dehsarvi
EDoN Research Assistant Research Assistant responsible for harmonizing data, linking with traditional phenotypes from clinical assessments, biomarkers, and imaging, and beginning analysis. Closing date: 13th March
www.dementiaresearcher.nihr.ac.uk/job/research...
www.dementiaresearcher.nihr.ac.uk/job/research...
Research Assistant: EDoN Initiative (Early Detection of Neurodegeneration)
EDoN Research Assistant Research Assistant responsible for harmonizing data, linking with traditional phenotypes from clinical assessments, biomarkers, and imaging, and beginning analysis.
www.dementiaresearcher.nihr.ac.uk
February 15, 2025 at 9:17 PM
EDoN Research Assistant Research Assistant responsible for harmonizing data, linking with traditional phenotypes from clinical assessments, biomarkers, and imaging, and beginning analysis. Closing date: 13th March
www.dementiaresearcher.nihr.ac.uk/job/research...
www.dementiaresearcher.nihr.ac.uk/job/research...
Reposted by 🍊Amir Dehsarvi
Fascinating postdoc opportunity with @JingQiuCDBS (UK DRI at Edinburgh) looking at endothelial cell dysfunction in small vessel disease 🧠
🗓️ Deadline: 20 Feb
More about the new project & how to apply 👉 www.ukdri.ac.uk/news-and-eve...
🗓️ Deadline: 20 Feb
More about the new project & how to apply 👉 www.ukdri.ac.uk/news-and-eve...
Project launched to identify new drug target for vascular dementia
Vascular dementia is one of the most common types of dementia and is growing in prevalence. There are currently no effective treatments for the condition. A new UK DRI project, funded by the British H...
www.ukdri.ac.uk
February 14, 2025 at 12:54 PM
Fascinating postdoc opportunity with @JingQiuCDBS (UK DRI at Edinburgh) looking at endothelial cell dysfunction in small vessel disease 🧠
🗓️ Deadline: 20 Feb
More about the new project & how to apply 👉 www.ukdri.ac.uk/news-and-eve...
🗓️ Deadline: 20 Feb
More about the new project & how to apply 👉 www.ukdri.ac.uk/news-and-eve...
NOT male/men
BUT female/women
BUT female/women
🚨BREAKING. From a program officer at the National Science Foundation, a list of keywords that can cause a grant to be pulled. I will be sharing screenshots of these keywords along with a decision tree. Please share widely. This is a crisis for academic freedom & science.
February 4, 2025 at 10:50 AM
NOT male/men
BUT female/women
BUT female/women
Reposted by 🍊Amir Dehsarvi
A one-year post doc opportunity on an ESRC-funded project at the University of Leeds. Details ->
jobs.leeds.ac.uk/vacancy.aspx...
Get in touch if you'd like to know more!
jobs.leeds.ac.uk/vacancy.aspx...
Get in touch if you'd like to know more!
Job Opportunity at University of Leeds: Research Fellow in Cognitive Ageing and Brain Imaging
Are you looking for an exciting PostDoc position working in brain imaging and cognition? Do you have a PhD or near to completion using imaging methods? Are you interested in how strategies can improve...
jobs.leeds.ac.uk
February 3, 2025 at 4:48 PM
A one-year post doc opportunity on an ESRC-funded project at the University of Leeds. Details ->
jobs.leeds.ac.uk/vacancy.aspx...
Get in touch if you'd like to know more!
jobs.leeds.ac.uk/vacancy.aspx...
Get in touch if you'd like to know more!
Reposted by 🍊Amir Dehsarvi
Vacancy for a Senior Research Technician to join Professor Sarah Tabrizi’s research group at UCL to provide maternity cover at the Huntington’s Disease Centre. Closing date: 12th February
www.dementiaresearcher.nihr.ac.uk/job/senior-r...
www.dementiaresearcher.nihr.ac.uk/job/senior-r...
Senior Research Technician - DEMENTIA RESEARCHER
Vacancy for a Senior Research Technician to join Professor Sarah Tabrizi’s research group at UCL to provide maternity cover at the Huntington’s Disease Centre.
www.dementiaresearcher.nihr.ac.uk
February 2, 2025 at 9:10 PM
Vacancy for a Senior Research Technician to join Professor Sarah Tabrizi’s research group at UCL to provide maternity cover at the Huntington’s Disease Centre. Closing date: 12th February
www.dementiaresearcher.nihr.ac.uk/job/senior-r...
www.dementiaresearcher.nihr.ac.uk/job/senior-r...
Reposted by 🍊Amir Dehsarvi
Excited to be chairing a new Stanford faculty search in Neurology. We are looking for MD and MD/PhD physician-scientists who have a strong research program (wet lab or dry lab) and who are also excellent clinicians. Please spread the word. Here's the link to the job posting:
lnkd.in/d6REUGfM
lnkd.in/d6REUGfM
January 31, 2025 at 6:25 PM
Excited to be chairing a new Stanford faculty search in Neurology. We are looking for MD and MD/PhD physician-scientists who have a strong research program (wet lab or dry lab) and who are also excellent clinicians. Please spread the word. Here's the link to the job posting:
lnkd.in/d6REUGfM
lnkd.in/d6REUGfM
Reposted by 🍊Amir Dehsarvi
Huge thanks to alzforum for covering our most recent work!
Great summary!
www.alzforum.org/news/researc...
Great summary!
www.alzforum.org/news/researc...
Plaques Spur Spread of Tangles by Sending Synapses into Overdrive | ALZFORUM
www.alzforum.org
January 23, 2025 at 10:44 PM
Huge thanks to alzforum for covering our most recent work!
Great summary!
www.alzforum.org/news/researc...
Great summary!
www.alzforum.org/news/researc...
Reposted by 🍊Amir Dehsarvi
Nice to see Alzforum covering our most recent article in Science Transl Med and highlighting its importance for future lines of research and therapy! Special thanks David Jones and Tarick Pascoal for the great comments on our work!
alzforum.org/news/research-…
alzforum.org/news/research-…
January 24, 2025 at 1:41 AM
Nice to see Alzforum covering our most recent article in Science Transl Med and highlighting its importance for future lines of research and therapy! Special thanks David Jones and Tarick Pascoal for the great comments on our work!
alzforum.org/news/research-…
alzforum.org/news/research-…
Reposted by 🍊Amir Dehsarvi
Incredibly happy and proud to share our newest work in
Science Transl Med showing that Aβ promotes neuronal hyperconnectivity, thereby driving tau spread across connected brain regions. Many thanks to first authors @sebroemer.bsky.social and Fabian Wagner!
science.org/doi/10.1126/...
Thread below
Science Transl Med showing that Aβ promotes neuronal hyperconnectivity, thereby driving tau spread across connected brain regions. Many thanks to first authors @sebroemer.bsky.social and Fabian Wagner!
science.org/doi/10.1126/...
Thread below
Amyloid-associated hyperconnectivity drives tau spread across connected brain regions in Alzheimer’s disease
Aβ induces neuronal hyperconnectivity, which promotes tau spreading from temporal lobe epicenters to connected brain regions in Alzheimer’s disease.
science.org
January 22, 2025 at 7:37 PM
Incredibly happy and proud to share our newest work in
Science Transl Med showing that Aβ promotes neuronal hyperconnectivity, thereby driving tau spread across connected brain regions. Many thanks to first authors @sebroemer.bsky.social and Fabian Wagner!
science.org/doi/10.1126/...
Thread below
Science Transl Med showing that Aβ promotes neuronal hyperconnectivity, thereby driving tau spread across connected brain regions. Many thanks to first authors @sebroemer.bsky.social and Fabian Wagner!
science.org/doi/10.1126/...
Thread below
Reposted by 🍊Amir Dehsarvi
Happy to share our new preprint led by Johannes Gnörich and @matthiasbrendel.bsky.social, showcasing a full ATN staging approach using a single dynamic PI-2620 scan, leveraging advanced kinetic modelling techniques
www.medrxiv.org/content/10.1...
www.medrxiv.org/content/10.1...
January 16, 2025 at 6:18 PM
Happy to share our new preprint led by Johannes Gnörich and @matthiasbrendel.bsky.social, showcasing a full ATN staging approach using a single dynamic PI-2620 scan, leveraging advanced kinetic modelling techniques
www.medrxiv.org/content/10.1...
www.medrxiv.org/content/10.1...
Reposted by 🍊Amir Dehsarvi
Happy to share Davina Biels newest work in @embomolmed.bsky.social, showing stronger Aβ-dependent p-tau increases in women, potentially driven by elevated sTREM2-related microglial activation and stronger effects of ApoE4 carriership in women
Many thanks also to co-senior Matthias Brendel!
Many thanks also to co-senior Matthias Brendel!
Female sex is linked to a stronger association between sTREM2 and CSF p-tau in Alzheimer’s disease | EMBO Molecular Medicine
imageimageThis study examined whether sex, age, microglial activation or ApoE4 modulates the Aβ to p-tau axis, a critical event in the amyloid cascade that triggers the progression of Alzheimer’s disease (AD) from amyloidosis towards tauopathy. ...
doi.org
January 13, 2025 at 4:15 PM
Happy to share Davina Biels newest work in @embomolmed.bsky.social, showing stronger Aβ-dependent p-tau increases in women, potentially driven by elevated sTREM2-related microglial activation and stronger effects of ApoE4 carriership in women
Many thanks also to co-senior Matthias Brendel!
Many thanks also to co-senior Matthias Brendel!
Reposted by 🍊Amir Dehsarvi
Happy to share our new work led by Johannes Gnörich and Matthias Brendel, suggesting a visual read algorithm for PI-2620 in 4R taupathies. Early imaging windows, kinetic modelling and basal ganglia are key!
doi.org/10.1016/j.ne...
doi.org/10.1016/j.ne...
January 12, 2025 at 8:40 AM
Happy to share our new work led by Johannes Gnörich and Matthias Brendel, suggesting a visual read algorithm for PI-2620 in 4R taupathies. Early imaging windows, kinetic modelling and basal ganglia are key!
doi.org/10.1016/j.ne...
doi.org/10.1016/j.ne...