@ameens.bsky.social
Reposted
This is a big advance, folks. We've never had a disease-modifying drug for this devastating inherited disease
www.science.org/content/arti...
www.washingtonpost.com/health/2025/...
www.economist.com/science-and-...
www.science.org/content/arti...
www.washingtonpost.com/health/2025/...
www.economist.com/science-and-...
September 25, 2025 at 8:13 PM
This is a big advance, folks. We've never had a disease-modifying drug for this devastating inherited disease
www.science.org/content/arti...
www.washingtonpost.com/health/2025/...
www.economist.com/science-and-...
www.science.org/content/arti...
www.washingtonpost.com/health/2025/...
www.economist.com/science-and-...
Huntington's disease successfully treated for first time | BBC News
YouTube video by BBC News
youtu.be
September 26, 2025 at 4:02 AM
Reposted
It turns out the immune system is playing 4D chess while we thought it was just playing checkers. Using #spatialtranscriptomics from @10xgenomics.bsky.social and @vizgen.bsky.social we were able to peek into the secret lives of tissue resident T cells in the gut as they form after infection 1/n
Tissue-resident memory CD8 T cell diversity is spatiotemporally imprinted - Nature
Profiling of the location and transcriptome of tissue-resident memory CD8 T cell formation at single-transcript resolution finds regionalized signalling as the basis of immune diversity in t...
www.nature.com
January 22, 2025 at 5:37 PM
It turns out the immune system is playing 4D chess while we thought it was just playing checkers. Using #spatialtranscriptomics from @10xgenomics.bsky.social and @vizgen.bsky.social we were able to peek into the secret lives of tissue resident T cells in the gut as they form after infection 1/n
Reposted
FastReseg: using transcript locations to refine image-based cell segmentation results in spatial transcriptomics, from Broker Spatial Biology, former NanoString
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
FastReseg: using transcript locations to refine image-based cell segmentation results in spatial transcriptomics
Spatial transcriptomics (ST) is a rapidly advancing field, yet it is challenged by persistent issues with cell segmentation accuracy, which can bias biological interpretations by making cells appear m...
www.biorxiv.org
December 14, 2024 at 5:49 AM
FastReseg: using transcript locations to refine image-based cell segmentation results in spatial transcriptomics, from Broker Spatial Biology, former NanoString
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
For us epithelial and progenitor cell biologists:
www.nature.com/articles/d41...
www.nature.com/articles/d41...
Notching up a win: fresh tools for activating Notch
Synthetic protein agonists could boost T-cell biomanufacturing and therapeutic strategies.
www.nature.com
December 10, 2024 at 6:08 PM
For us epithelial and progenitor cell biologists:
www.nature.com/articles/d41...
www.nature.com/articles/d41...
Opinion | My Last Column: Finding Hope in an Age of Resentment
Where have all the good vibes gone?
www.nytimes.com
December 10, 2024 at 6:01 PM
Reposted
Colleagues:
We have one unfilled position for July 2025 in our ID fellowship program at Medical College of Wisconsin in Milwaukee. Interested candidates please DM me or email at id_info@mcw.edu.
#IDSky
#MedSky
Please amplify 🙏🙏
www.mcw.edu/departments/...
We have one unfilled position for July 2025 in our ID fellowship program at Medical College of Wisconsin in Milwaukee. Interested candidates please DM me or email at id_info@mcw.edu.
#IDSky
#MedSky
Please amplify 🙏🙏
www.mcw.edu/departments/...
Fellowship Program | Infectious Diseases | Medical College of Wisconsin
Information on the Medical College of Wisconsin Infectious Disease Fellowship program.
www.mcw.edu
December 4, 2024 at 5:40 PM
Colleagues:
We have one unfilled position for July 2025 in our ID fellowship program at Medical College of Wisconsin in Milwaukee. Interested candidates please DM me or email at id_info@mcw.edu.
#IDSky
#MedSky
Please amplify 🙏🙏
www.mcw.edu/departments/...
We have one unfilled position for July 2025 in our ID fellowship program at Medical College of Wisconsin in Milwaukee. Interested candidates please DM me or email at id_info@mcw.edu.
#IDSky
#MedSky
Please amplify 🙏🙏
www.mcw.edu/departments/...
For all of those in the lung organoid field, add 100ug/mL holotransferrin to your growth media to boost your human adult AT2 cultures. Great example of how serendipity in a mouse model yields insight into human biology.
New in @natureportfolio.bsky.social from the Tuomas Tammela Lab: how aging suppresses tumorigenesis and stemness in the lung by promoting functional iron insufficiency in the alveolar epithelium. Interestingly, this renders aged cells resistant to ferroptosis. #OncSky www.nature.com/articles/s41...
Ageing limits stemness and tumorigenesis by reprogramming iron homeostasis - Nature
Studies using mouse models of lung adenocarcinoma identify an association between age, iron homeostasis and tumour initiation potential that involves NUPR1 and lipocalin-2.
www.nature.com
December 5, 2024 at 1:56 PM
For all of those in the lung organoid field, add 100ug/mL holotransferrin to your growth media to boost your human adult AT2 cultures. Great example of how serendipity in a mouse model yields insight into human biology.
Reposted
New in @natureportfolio.bsky.social from the Tuomas Tammela Lab: how aging suppresses tumorigenesis and stemness in the lung by promoting functional iron insufficiency in the alveolar epithelium. Interestingly, this renders aged cells resistant to ferroptosis. #OncSky www.nature.com/articles/s41...
Ageing limits stemness and tumorigenesis by reprogramming iron homeostasis - Nature
Studies using mouse models of lung adenocarcinoma identify an association between age, iron homeostasis and tumour initiation potential that involves NUPR1 and lipocalin-2.
www.nature.com
December 4, 2024 at 6:23 PM
New in @natureportfolio.bsky.social from the Tuomas Tammela Lab: how aging suppresses tumorigenesis and stemness in the lung by promoting functional iron insufficiency in the alveolar epithelium. Interestingly, this renders aged cells resistant to ferroptosis. #OncSky www.nature.com/articles/s41...
Reposted
Durvalumab now FDA approved for limited stage #SCLC based on the phase III ADRIATIC trial showing a PFS and an OS benefit (HR 0.73) with 2y of durvalumab after completion of definitive chemoradiation (avoid concurrent use). #LCSM #OncSky
www.targetedonc.com/view/durvalu....
www.targetedonc.com/view/durvalu....
Durvalumab Wins FDA Approval in Limited-Stage Small Cell Lung Cancer
The approval of durvalumab, based on data from the phase 3 ADRIATIC study, offers a new standard of care for patients with limited-stage small cell lung cancer.
www.targetedonc.com
December 4, 2024 at 11:51 PM
Durvalumab now FDA approved for limited stage #SCLC based on the phase III ADRIATIC trial showing a PFS and an OS benefit (HR 0.73) with 2y of durvalumab after completion of definitive chemoradiation (avoid concurrent use). #LCSM #OncSky
www.targetedonc.com/view/durvalu....
www.targetedonc.com/view/durvalu....
Hi everyone, for giving Tuesday I have set up a patient fund for assistance with the basics to complete curative intent cancer treatments. My patients often have incomplete treatments due to transportation or food issues, despite being fully insured. DM me if you can help! Repost to spread the word!
December 4, 2024 at 2:10 AM
Hi everyone, for giving Tuesday I have set up a patient fund for assistance with the basics to complete curative intent cancer treatments. My patients often have incomplete treatments due to transportation or food issues, despite being fully insured. DM me if you can help! Repost to spread the word!
Bskypt | Bluesky Social Receipts
Generate social receipts for you BlueSky activity.
bskypt.vercel.app
December 3, 2024 at 8:18 AM
Reposted
When Susan was diagnosed with lung cancer we quickly learned we had many unanswered questions. We launched the @23andme Lung Cancer Community with the intention of getting answers.
23andme.com/lung-cancer/
23andme.com/lung-cancer/
November 26, 2024 at 3:21 PM
When Susan was diagnosed with lung cancer we quickly learned we had many unanswered questions. We launched the @23andme Lung Cancer Community with the intention of getting answers.
23andme.com/lung-cancer/
23andme.com/lung-cancer/
Reposted
As we embark on Thanksgiving week I want to take a moment to reflect on this year and my family. Unfortunately I lost my sister to lung cancer in August.
blog.youtube/inside-youtu...
blog.youtube/inside-youtu...
From Susan
blog.youtube
November 26, 2024 at 3:15 PM
As we embark on Thanksgiving week I want to take a moment to reflect on this year and my family. Unfortunately I lost my sister to lung cancer in August.
blog.youtube/inside-youtu...
blog.youtube/inside-youtu...
Reposted
www.nature.com/articles/s41...
Sharing our latest review article to highlight the importance of appropriately developing combination strategies for immune checkpoint therapy. Grateful for working with 3 brilliant scientists: Sangeeta Goswami, Kristen Pauken & Linghua Wang
Sharing our latest review article to highlight the importance of appropriately developing combination strategies for immune checkpoint therapy. Grateful for working with 3 brilliant scientists: Sangeeta Goswami, Kristen Pauken & Linghua Wang
Next-generation combination approaches for immune checkpoint therapy - Nature Immunology
In this Review, Sharma and colleagues describe the current landscape of combination therapies and discuss requirements for the development of effective combination strategies.
www.nature.com
November 25, 2024 at 8:43 PM
www.nature.com/articles/s41...
Sharing our latest review article to highlight the importance of appropriately developing combination strategies for immune checkpoint therapy. Grateful for working with 3 brilliant scientists: Sangeeta Goswami, Kristen Pauken & Linghua Wang
Sharing our latest review article to highlight the importance of appropriately developing combination strategies for immune checkpoint therapy. Grateful for working with 3 brilliant scientists: Sangeeta Goswami, Kristen Pauken & Linghua Wang
Ironically I recall a major motivation for Musk's acquisition of Twitter was to reduce censorship and promote free speech.
Twitter “confirmed that posts containing links in their main text are deprioritized on X in a revelation that renews criticism that the platform is restricting the visibility of & access to external sources of info.”
#MedSky, reread that. Keep informing the public.
www.mediaite.com/news/elon-mu...
#MedSky, reread that. Keep informing the public.
www.mediaite.com/news/elon-mu...
Elon Musk Admits X is Throttling Links — Effectively Limiting People From Reading News
Musk confirmed that posts containing links are deprioritized, renewing criticism that the platform is restricting access to external sources of information.
www.mediaite.com
November 26, 2024 at 4:52 AM
Ironically I recall a major motivation for Musk's acquisition of Twitter was to reduce censorship and promote free speech.
Reposted
The unknown factor you didn't account for going to ruin your experiment
November 24, 2024 at 4:45 PM
The unknown factor you didn't account for going to ruin your experiment
Reposted
If interested in this list mark it 📌
Let's create a starter pack for #lungcancer patient advocates. Once you complete your profile, please add your bsky handle in a comment. @dhendrickson.bsky.social @findlungcancer.bsky.social #LCSM
go.bsky.app/LtNfehd
go.bsky.app/LtNfehd
November 24, 2024 at 11:53 PM
If interested in this list mark it 📌
Reposted
Nailing down risk in early stage breast cancer —with @coffeemommy.bsky.social and Dr. Kevin Kalinsky #OncSky #MedSky
doi.org/10.1093/jnci...
doi.org/10.1093/jnci...
“Nailing down” risk and improving outcomes in early-stage breast cancer
Whether via the strain of academic advancement or hyper-competitive industry-funded drug-development landscape,1 there has been increasing focus to shift c
doi.org
November 24, 2024 at 12:52 PM
Nailing down risk in early stage breast cancer —with @coffeemommy.bsky.social and Dr. Kevin Kalinsky #OncSky #MedSky
doi.org/10.1093/jnci...
doi.org/10.1093/jnci...
Reposted
🎨 In case anyone need…
The NIH BioArt Source is an awesome library of *free* professionally drawn illustrations for scientific presentations or figures. Downloadable in HD. Thank you NIH for this invaluable tool 🙏!
Check it out 👇
bioart.niaid.nih.gov
The NIH BioArt Source is an awesome library of *free* professionally drawn illustrations for scientific presentations or figures. Downloadable in HD. Thank you NIH for this invaluable tool 🙏!
Check it out 👇
bioart.niaid.nih.gov
November 23, 2024 at 3:50 PM
🎨 In case anyone need…
The NIH BioArt Source is an awesome library of *free* professionally drawn illustrations for scientific presentations or figures. Downloadable in HD. Thank you NIH for this invaluable tool 🙏!
Check it out 👇
bioart.niaid.nih.gov
The NIH BioArt Source is an awesome library of *free* professionally drawn illustrations for scientific presentations or figures. Downloadable in HD. Thank you NIH for this invaluable tool 🙏!
Check it out 👇
bioart.niaid.nih.gov
Reposted
Here's a few I liked alot:
www.cell.com/news-do/50-i...
www.cell.com/news-do/50-i...
www.cell.com/news-do/50-i...
www.cell.com/news-do/50-i...
www.cell.com/news-do/50-i...
www.cell.com/news-do/50-i...
Cancer genomicist Melissa B. Davis on surrounding yourself with supportive mentors and allies
Why studying diverse groups of patients in medical research and believing in one’s own potential is critical according to Dr. Davis.
www.cell.com
November 22, 2024 at 6:09 PM
Here's a few I liked alot:
www.cell.com/news-do/50-i...
www.cell.com/news-do/50-i...
www.cell.com/news-do/50-i...
www.cell.com/news-do/50-i...
www.cell.com/news-do/50-i...
www.cell.com/news-do/50-i...
Reposted
Truly brilliant work. Calling it a foundation model is a stretch (a mistake many people in the field make). But, the only single-cell AI model in its class that I think is worth the GPU energy expended and one that I excited to utilize. My stamp of approval. www.nature.com/articles/s41...
A cell atlas foundation model for scalable search of similar human cells - Nature
Nature - A cell atlas foundation model for scalable search of similar human cells
www.nature.com
November 22, 2024 at 10:34 PM
Truly brilliant work. Calling it a foundation model is a stretch (a mistake many people in the field make). But, the only single-cell AI model in its class that I think is worth the GPU energy expended and one that I excited to utilize. My stamp of approval. www.nature.com/articles/s41...
Reposted
Typical single-cell preprocessing can be unfair to certain cell types. For example, fewer genes are typically detected in neutrophils and they are often mistakenly removed.
I’ve made a short video covering this simple but important concept:
youtu.be/r4A_QgseUfw?...
I’ve made a short video covering this simple but important concept:
youtu.be/r4A_QgseUfw?...
Single-cell iterative preprocessing. Don't throw away real cells!
YouTube video by Sanbomics
youtu.be
November 21, 2024 at 1:41 AM
Typical single-cell preprocessing can be unfair to certain cell types. For example, fewer genes are typically detected in neutrophils and they are often mistakenly removed.
I’ve made a short video covering this simple but important concept:
youtu.be/r4A_QgseUfw?...
I’ve made a short video covering this simple but important concept:
youtu.be/r4A_QgseUfw?...
Reposted
Earlier this year, we published an article in Cancer Discovery discussing six hallmarks of precancer and highlighting the need for a multi-omics approach to research in this area. aacrjournals.org/cancerdiscov...
Would love to connect with others working in this area!
Would love to connect with others working in this area!
The Hallmarks of Precancer
Summary:. Research on precancers, as defined as at-risk tissues and early lesions, is of high significance given the effectiveness of early intervention. We discuss the need for risk stratification to...
aacrjournals.org
November 15, 2024 at 4:37 PM
Earlier this year, we published an article in Cancer Discovery discussing six hallmarks of precancer and highlighting the need for a multi-omics approach to research in this area. aacrjournals.org/cancerdiscov...
Would love to connect with others working in this area!
Would love to connect with others working in this area!