Alfredo Smiriglia
@alfredo95.bsky.social
PostDoc, University of Florence.
Reposted by Alfredo Smiriglia
📣 It’s been a productive few days for our group!
💡Our new paper in 𝘊𝘦𝘭𝘭 𝘋𝘦𝘢𝘵𝘩 & 𝘋𝘪𝘴𝘦𝘢𝘴𝘦 shows that lead nitrate drives NRF2-dependent metabolic reprogramming and proliferation in hepatocytes.
With Università di Cagliari & Università di Torino, funded by MUR#PRIN2022.
🔗 www.nature.com/articles/s41...
💡Our new paper in 𝘊𝘦𝘭𝘭 𝘋𝘦𝘢𝘵𝘩 & 𝘋𝘪𝘴𝘦𝘢𝘴𝘦 shows that lead nitrate drives NRF2-dependent metabolic reprogramming and proliferation in hepatocytes.
With Università di Cagliari & Università di Torino, funded by MUR#PRIN2022.
🔗 www.nature.com/articles/s41...
Lead induces cell-autonomous proliferation and metabolic reprogramming of hepatocytes - Cell Death & Disease
Cell Death & Disease - Lead induces cell-autonomous proliferation and metabolic reprogramming of hepatocytes
www.nature.com
November 11, 2025 at 10:48 AM
📣 It’s been a productive few days for our group!
💡Our new paper in 𝘊𝘦𝘭𝘭 𝘋𝘦𝘢𝘵𝘩 & 𝘋𝘪𝘴𝘦𝘢𝘴𝘦 shows that lead nitrate drives NRF2-dependent metabolic reprogramming and proliferation in hepatocytes.
With Università di Cagliari & Università di Torino, funded by MUR#PRIN2022.
🔗 www.nature.com/articles/s41...
💡Our new paper in 𝘊𝘦𝘭𝘭 𝘋𝘦𝘢𝘵𝘩 & 𝘋𝘪𝘴𝘦𝘢𝘴𝘦 shows that lead nitrate drives NRF2-dependent metabolic reprogramming and proliferation in hepatocytes.
With Università di Cagliari & Università di Torino, funded by MUR#PRIN2022.
🔗 www.nature.com/articles/s41...
Reposted by Alfredo Smiriglia
🚨 Our new paper is now out in 𝘊𝘢𝘯𝘤𝘦𝘳 𝘙𝘦𝘴𝘦𝘢𝘳𝘤𝘩!
ESR1 mutations in ER⁺ breast cancer rewire lipid metabolism, creating a ferroptosis vulnerability 🔬
ACSL4 is a key biomarker & combo with SERDs offers a new strategy.
👏 Congrats to the whole #TBTlab & collaborators!
aacrjournals.org/cancerres/ar...
ESR1 mutations in ER⁺ breast cancer rewire lipid metabolism, creating a ferroptosis vulnerability 🔬
ACSL4 is a key biomarker & combo with SERDs offers a new strategy.
👏 Congrats to the whole #TBTlab & collaborators!
aacrjournals.org/cancerres/ar...
ESR1 Activating Mutations Confer Metabolic Vulnerabilities in ER+ Breast Cancer
Abstract. Endocrine therapy (ET) is the standard of care for estrogen receptor-positive (ER+) breast cancer. Point mutations in the ligand-binding domain of the gene encoding the estrogen receptor (ES...
aacrjournals.org
November 7, 2025 at 8:20 PM
🚨 Our new paper is now out in 𝘊𝘢𝘯𝘤𝘦𝘳 𝘙𝘦𝘴𝘦𝘢𝘳𝘤𝘩!
ESR1 mutations in ER⁺ breast cancer rewire lipid metabolism, creating a ferroptosis vulnerability 🔬
ACSL4 is a key biomarker & combo with SERDs offers a new strategy.
👏 Congrats to the whole #TBTlab & collaborators!
aacrjournals.org/cancerres/ar...
ESR1 mutations in ER⁺ breast cancer rewire lipid metabolism, creating a ferroptosis vulnerability 🔬
ACSL4 is a key biomarker & combo with SERDs offers a new strategy.
👏 Congrats to the whole #TBTlab & collaborators!
aacrjournals.org/cancerres/ar...
Reposted by Alfredo Smiriglia
Ecstatic to share out latest research looking at the role of mitochondrial ABHD11 in controlling T-cell responses. We think this may be a viable target for autoimmunity. Please do give it a read, we would love to hear your thoughts.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Mitochondrial ABHD11 inhibition drives sterol metabolism to modulate T-cell effector function - Nature Communications
α/β-hydrolase domain-containing protein 11 (ABHD11) is a mitochondrial hydrolase, and its expression in CD4 + T-cells has been linked to remission status in rheumatoid arthritis. Here the authors repo...
www.nature.com
November 3, 2025 at 10:20 AM
Ecstatic to share out latest research looking at the role of mitochondrial ABHD11 in controlling T-cell responses. We think this may be a viable target for autoimmunity. Please do give it a read, we would love to hear your thoughts.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Alfredo Smiriglia
Reposted by Alfredo Smiriglia
.🧬We looked for a CD44:SLC1A2 fusion in breast cancer. The data said no. Instead of shelving it, we published.
📢 Now out in @SpringerNature MCB: link.springer.com/article/10.1...
Negative results matter. Transparency matters. Proud of this one 🥳! #OpenScience
📢 Now out in @SpringerNature MCB: link.springer.com/article/10.1...
Negative results matter. Transparency matters. Proud of this one 🥳! #OpenScience
CD44 and SLC1A2 are commonly regulated but do not form a fusion transcript in ER+ breast cancer - Molecular and Cellular Biochemistry
Endocrine therapy (ET) is essential for managing ER+ HER2− breast cancer; however, resistance remains a significant clinical challenge. This study investigated whether CD44-SLC1A2 gene fusions, report...
link.springer.com
May 24, 2025 at 9:21 AM
.🧬We looked for a CD44:SLC1A2 fusion in breast cancer. The data said no. Instead of shelving it, we published.
📢 Now out in @SpringerNature MCB: link.springer.com/article/10.1...
Negative results matter. Transparency matters. Proud of this one 🥳! #OpenScience
📢 Now out in @SpringerNature MCB: link.springer.com/article/10.1...
Negative results matter. Transparency matters. Proud of this one 🥳! #OpenScience
Reposted by Alfredo Smiriglia
Discover exciting new publications in the March 2025 edition of our Highlights in Cancer Research!
From immune evasion through mitochondrial transfer to estrogen-dependent activation of TRX2, discover the highlights now: magazine.eacr.org/highlights-i...
From immune evasion through mitochondrial transfer to estrogen-dependent activation of TRX2, discover the highlights now: magazine.eacr.org/highlights-i...
March 24, 2025 at 6:14 PM
Reposted by Alfredo Smiriglia
🚨 📣 Our latest study out in @springernature.com 𝘊𝘦𝘭𝘭 𝘋𝘦𝘢𝘵𝘩 & 𝘋𝘪𝘴𝘦𝘢𝘴𝘦, takes us beyond our usual cancer research comfort zone to explore how #estrogen influences the progression of #MASLD. Well done to @alfredo95.bsky.social and the rest of the team! 🙏
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Estrogen-dependent activation of TRX2 reverses oxidative stress and metabolic dysfunction associated with steatotic disease - Cell Death & Disease
Cell Death & Disease - Estrogen-dependent activation of TRX2 reverses oxidative stress and metabolic dysfunction associated with steatotic disease
www.nature.com
January 31, 2025 at 4:33 PM
🚨 📣 Our latest study out in @springernature.com 𝘊𝘦𝘭𝘭 𝘋𝘦𝘢𝘵𝘩 & 𝘋𝘪𝘴𝘦𝘢𝘴𝘦, takes us beyond our usual cancer research comfort zone to explore how #estrogen influences the progression of #MASLD. Well done to @alfredo95.bsky.social and the rest of the team! 🙏
www.nature.com/articles/s41...
www.nature.com/articles/s41...