Alexander L. Nielsen
@alexanderln.bsky.social
senior scientist @ novo nordisk | tweets about (cyclic) peptides | christian heinis & christian a olsen alumni | views are my own
ex-twitter: alexanderln91
ex-twitter: alexanderln91
Looking for a PhD in peptide chemistry?
Apply for this exciting collaboration between Novo Nordisk and the Grob lab at ETH!
Apply for this exciting collaboration between Novo Nordisk and the Grob lab at ETH!
We are hiring! Check out our open PhD position for an exciting industry collaboration with Novo Nordisk:
jobs.ethz.ch/job/view/JOP...
jobs.ethz.ch/job/view/JOP...
PhD Position in Peptide-Based Drug Discovery (Industry Collaboration, w/m/d)
jobs.ethz.ch
June 10, 2025 at 3:50 PM
Looking for a PhD in peptide chemistry?
Apply for this exciting collaboration between Novo Nordisk and the Grob lab at ETH!
Apply for this exciting collaboration between Novo Nordisk and the Grob lab at ETH!
Very pleased to share the 'last' first-author paper from my postdoc with Prof. Christian Heinis at EPFL.
Now out in its final form in @angewandtechemie.bsky.social as a 'Very Important Paper' 🔥 (1/🧵) #chemsky
onlinelibrary.wiley.com/doi/10.1002/...
Now out in its final form in @angewandtechemie.bsky.social as a 'Very Important Paper' 🔥 (1/🧵) #chemsky
onlinelibrary.wiley.com/doi/10.1002/...
Bulk Measurement of Membrane Permeability for Random Cyclic Peptides in Living Cells to Guide Drug Development
Some cyclic peptides can cross membranes, which is highly attractive for drug development, but it remains difficult to accurately predict membrane permeability or to test it experimentally for large ...
onlinelibrary.wiley.com
June 2, 2025 at 10:01 AM
Very pleased to share the 'last' first-author paper from my postdoc with Prof. Christian Heinis at EPFL.
Now out in its final form in @angewandtechemie.bsky.social as a 'Very Important Paper' 🔥 (1/🧵) #chemsky
onlinelibrary.wiley.com/doi/10.1002/...
Now out in its final form in @angewandtechemie.bsky.social as a 'Very Important Paper' 🔥 (1/🧵) #chemsky
onlinelibrary.wiley.com/doi/10.1002/...
Sharing for better reach:
Join a fun, talented and social lab.
#postdocjob available in the Knowles group
(Univ. of Cambridge).
Experience with mRNA/phage/yeast display is a plus.
www.jobs.cam.ac.uk/job/50546/
Join a fun, talented and social lab.
#postdocjob available in the Knowles group
(Univ. of Cambridge).
Experience with mRNA/phage/yeast display is a plus.
www.jobs.cam.ac.uk/job/50546/
Post-Doctoral Research Associate (Fixed Term) - Job Opportunities - University of Cambridge
Post-Doctoral Research Associate (Fixed Term) in the Yusuf Hamied Department of Chemistry at the University of Cambridge.
www.jobs.cam.ac.uk
March 24, 2025 at 5:08 PM
Sharing for better reach:
Join a fun, talented and social lab.
#postdocjob available in the Knowles group
(Univ. of Cambridge).
Experience with mRNA/phage/yeast display is a plus.
www.jobs.cam.ac.uk/job/50546/
Join a fun, talented and social lab.
#postdocjob available in the Knowles group
(Univ. of Cambridge).
Experience with mRNA/phage/yeast display is a plus.
www.jobs.cam.ac.uk/job/50546/
Reposted by Alexander L. Nielsen
Very happy to see this story out in #JACS_Au!
Discovery of De Novo Macrocycle Inhibitors of Histone Deacetylase 11
pubs.acs.org/doi/10.1021/...
#ChemBio #chemsky #HDAC
Discovery of De Novo Macrocycle Inhibitors of Histone Deacetylase 11
pubs.acs.org/doi/10.1021/...
#ChemBio #chemsky #HDAC
Discovery of De Novo Macrocycle Inhibitors of Histone Deacetylase 11
Histone deacetylase (HDAC) enzymes are epigenetic regulators that affect diverse protein function by removing acyl groups from lysine side chains throughout the proteome. The most recently discovered ...
pubs.acs.org
February 19, 2025 at 11:54 AM
Very happy to see this story out in #JACS_Au!
Discovery of De Novo Macrocycle Inhibitors of Histone Deacetylase 11
pubs.acs.org/doi/10.1021/...
#ChemBio #chemsky #HDAC
Discovery of De Novo Macrocycle Inhibitors of Histone Deacetylase 11
pubs.acs.org/doi/10.1021/...
#ChemBio #chemsky #HDAC
Our work on macrocyclic HDAC11 inhibitors is now out in JACS Au! pubs.acs.org/doi/10.1021/...
#openaccess #chemsky
#openaccess #chemsky
February 16, 2025 at 8:26 PM
Our work on macrocyclic HDAC11 inhibitors is now out in JACS Au! pubs.acs.org/doi/10.1021/...
#openaccess #chemsky
#openaccess #chemsky
Reposted by Alexander L. Nielsen
#SIRT7 is a histone deacetylase with highly specific activity on #chromatin substrates.
We just published mechanism-based #cryoEM structures of #SIRT7 on nucleosomes to understand its activity 👇
www.nature.com/articles/s41...
(1/8) #ChemBio #ChemSky
We just published mechanism-based #cryoEM structures of #SIRT7 on nucleosomes to understand its activity 👇
www.nature.com/articles/s41...
(1/8) #ChemBio #ChemSky
February 4, 2025 at 1:13 PM
#SIRT7 is a histone deacetylase with highly specific activity on #chromatin substrates.
We just published mechanism-based #cryoEM structures of #SIRT7 on nucleosomes to understand its activity 👇
www.nature.com/articles/s41...
(1/8) #ChemBio #ChemSky
We just published mechanism-based #cryoEM structures of #SIRT7 on nucleosomes to understand its activity 👇
www.nature.com/articles/s41...
(1/8) #ChemBio #ChemSky
Come join Craig in his new lab in wonderful Copenhagen! 🇩🇰
𝐏𝐡𝐃 𝐏𝐨𝐬𝐢𝐭𝐢𝐨𝐧𝐬 𝐚𝐯𝐚𝐢𝐥𝐚𝐛𝐥𝐞! 🎉
The Day lab is hiring two PhD candidates to work on developing new transition-metal-catalyzed methods to transform CO2 into polymers or pharmaceuticals!
jobportal.ku.dk/phd?show=163...
Applications are open until February 14th 2025.
Please feel free to share!
The Day lab is hiring two PhD candidates to work on developing new transition-metal-catalyzed methods to transform CO2 into polymers or pharmaceuticals!
jobportal.ku.dk/phd?show=163...
Applications are open until February 14th 2025.
Please feel free to share!
PhD fellowship in synthesizing CO2-derived materials
jobportal.ku.dk
January 13, 2025 at 4:42 PM
Come join Craig in his new lab in wonderful Copenhagen! 🇩🇰
Reposted by Alexander L. Nielsen
We are hiring! Exciting project on the performance enhancement of peptides. Check out and share: jobs.uzh.ch/job-vacancie...
UZH: PhD Student Position in Peptide Chemistry
A PhD Student position is available in the group of Prof. Dr. Karl Gademann, located in the Department of Chemistry at the University of Zurich (Switzerland). Our group combines the synthesis of natur...
jobs.uzh.ch
January 9, 2025 at 7:55 AM
We are hiring! Exciting project on the performance enhancement of peptides. Check out and share: jobs.uzh.ch/job-vacancie...
Reposted by Alexander L. Nielsen
Happy to share the latest preprint from my PhD studies on the discovery of de novo macrocyclic inhibitors of HDAC11. This was a great collaboration between @christianaolsen.bsky.social lab (@carlosmyruela.bsky.social, @tnhansen.bsky.social) and Christian Heinis lab (@alexanderln.bsky.social).
New preprint @chemrxiv.bsky.social on discovery of macrocyclic inhibitors of HDAC11 with the Christian Heinis #EPFL
Main contributors @danieladankova.bsky.social, @alexanderln.bsky.social, @carlosmyruela.bsky.social
🙏 @ERC_Research, @novonordiskfond, @DFF_raad for 💶
chemrxiv.org/engage/chemr...
Main contributors @danieladankova.bsky.social, @alexanderln.bsky.social, @carlosmyruela.bsky.social
🙏 @ERC_Research, @novonordiskfond, @DFF_raad for 💶
chemrxiv.org/engage/chemr...
December 13, 2024 at 7:06 AM
Happy to share the latest preprint from my PhD studies on the discovery of de novo macrocyclic inhibitors of HDAC11. This was a great collaboration between @christianaolsen.bsky.social lab (@carlosmyruela.bsky.social, @tnhansen.bsky.social) and Christian Heinis lab (@alexanderln.bsky.social).
Reposted by Alexander L. Nielsen
New preprint @chemrxiv.bsky.social on discovery of macrocyclic inhibitors of HDAC11 with the Christian Heinis #EPFL
Main contributors @danieladankova.bsky.social, @alexanderln.bsky.social, @carlosmyruela.bsky.social
🙏 @ERC_Research, @novonordiskfond, @DFF_raad for 💶
chemrxiv.org/engage/chemr...
Main contributors @danieladankova.bsky.social, @alexanderln.bsky.social, @carlosmyruela.bsky.social
🙏 @ERC_Research, @novonordiskfond, @DFF_raad for 💶
chemrxiv.org/engage/chemr...
December 10, 2024 at 2:28 PM
New preprint @chemrxiv.bsky.social on discovery of macrocyclic inhibitors of HDAC11 with the Christian Heinis #EPFL
Main contributors @danieladankova.bsky.social, @alexanderln.bsky.social, @carlosmyruela.bsky.social
🙏 @ERC_Research, @novonordiskfond, @DFF_raad for 💶
chemrxiv.org/engage/chemr...
Main contributors @danieladankova.bsky.social, @alexanderln.bsky.social, @carlosmyruela.bsky.social
🙏 @ERC_Research, @novonordiskfond, @DFF_raad for 💶
chemrxiv.org/engage/chemr...
Happy to share a fun collaboration between EPFL and UCPH initiated by @carlosmyruela.bsky.social, Christian Heinis, @christianaolsen.bsky.social and I!
Big shout-out to @danieladankova.bsky.social who spearheaded the project.
Now out on @chemrxiv.bsky.social
chemrxiv.org/engage/chemr...
Big shout-out to @danieladankova.bsky.social who spearheaded the project.
Now out on @chemrxiv.bsky.social
chemrxiv.org/engage/chemr...
Discovery of de novo Macrocycle Inhibitors of Histone Deacetylase 11
Histone deacetylase (HDAC) enzymes are epigenetic regulators that affect diverse protein function by removing acyl groups from lysine side chains throughout the proteome. The most recently discovered ...
chemrxiv.org
December 9, 2024 at 12:44 PM
Happy to share a fun collaboration between EPFL and UCPH initiated by @carlosmyruela.bsky.social, Christian Heinis, @christianaolsen.bsky.social and I!
Big shout-out to @danieladankova.bsky.social who spearheaded the project.
Now out on @chemrxiv.bsky.social
chemrxiv.org/engage/chemr...
Big shout-out to @danieladankova.bsky.social who spearheaded the project.
Now out on @chemrxiv.bsky.social
chemrxiv.org/engage/chemr...
Amazing work by my colleagues! Now out in Nature Comms!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Photochemically-enabled, post-translational production of C-terminal amides - Nature Communications
C-terminal α-amidated peptides are attractive therapeutic targets, but preparative methods to access amidated pharmaceuticals are limited both on lab and manufacturing-scale. Here, the authors report ...
www.nature.com
November 30, 2024 at 2:28 PM
Amazing work by my colleagues! Now out in Nature Comms!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Latest paper from the Heinis lab. Solid-phase peptide synthesis in 4 × 384 well-plates to prepare 1,536 peptides per run! Out now in J. Pept. Sci!
onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com/doi/10.1002/...
January 15, 2024 at 7:07 AM
Latest paper from the Heinis lab. Solid-phase peptide synthesis in 4 × 384 well-plates to prepare 1,536 peptides per run! Out now in J. Pept. Sci!
onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com/doi/10.1002/...
The latest paper from the Heinis on the development of orally available cyclic peptides is finally out in Nature Chemical Biology! Big congrats to Manuel who spearheaded this project!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
De novo development of small cyclic peptides that are orally bioavailable - Nature Chemical Biology
Cyclic peptides show promise for modulating difficult disease targets; however, they often cannot be administered orally. The authors developed a method to synthesize and screen large libraries of sma...
www.nature.com
December 28, 2023 at 10:44 AM
The latest paper from the Heinis on the development of orally available cyclic peptides is finally out in Nature Chemical Biology! Big congrats to Manuel who spearheaded this project!
www.nature.com/articles/s41...
www.nature.com/articles/s41...