Reposted by Alessio Yang
Thrilled to share that my first paper in the lab of @drmichaelway.bsky.social is now published in @narjournal.bsky.social!
We showed that Topoisomerase 2α and 2β have opposing roles in vaccinia virus replication, one promoting and the other restricting it 👇🏼
doi.org/10.1093/nar/...
We showed that Topoisomerase 2α and 2β have opposing roles in vaccinia virus replication, one promoting and the other restricting it 👇🏼
doi.org/10.1093/nar/...
Nonredundant roles of topoisomerase 2α and 2β in the cytosolic replication of vaccinia virus
Abstract. Vaccinia virus is a large enveloped DNA virus, which, like all poxviruses, replicates in the cytoplasm of infected cells. Vaccinia was historical
doi.org
June 26, 2025 at 6:48 PM
Thrilled to share that my first paper in the lab of @drmichaelway.bsky.social is now published in @narjournal.bsky.social!
We showed that Topoisomerase 2α and 2β have opposing roles in vaccinia virus replication, one promoting and the other restricting it 👇🏼
doi.org/10.1093/nar/...
We showed that Topoisomerase 2α and 2β have opposing roles in vaccinia virus replication, one promoting and the other restricting it 👇🏼
doi.org/10.1093/nar/...
Reposted by Alessio Yang
Happy to see @embl.org highlight our work on protein design at Korbel group with @typaslab.bsky.social and @hennig-lab.bsky.social !
Working with everyone was a blast and helping to bring our software to production at DenovAI was quite the exciting experience.
Working with everyone was a blast and helping to bring our software to production at DenovAI was quite the exciting experience.
EMBL researchers have developed a new AI framework – AlphaDesign – which can design new proteins that might have therapeutic benefits.
Using AlphaDesign, the researchers succeeded in creating synthetic inhibitors for a bacterial phage defence system.
www.embopress.org/doi/full/10....
Using AlphaDesign, the researchers succeeded in creating synthetic inhibitors for a bacterial phage defence system.
www.embopress.org/doi/full/10....
June 26, 2025 at 2:24 AM
Happy to see @embl.org highlight our work on protein design at Korbel group with @typaslab.bsky.social and @hennig-lab.bsky.social !
Working with everyone was a blast and helping to bring our software to production at DenovAI was quite the exciting experience.
Working with everyone was a blast and helping to bring our software to production at DenovAI was quite the exciting experience.
Reposted by Alessio Yang
Excited for New Approaches and Concepts in Microbiology 2025 with sessions on Bacterial systems biology, Bacterial cell biology & protein machines, Microbiomes, Environment & evolution, Pathogenesis & phage, Antibiotic discovery, mechanisms, and resistance. #EESMicrobiology
June 23, 2025 at 7:23 PM
Excited for New Approaches and Concepts in Microbiology 2025 with sessions on Bacterial systems biology, Bacterial cell biology & protein machines, Microbiomes, Environment & evolution, Pathogenesis & phage, Antibiotic discovery, mechanisms, and resistance. #EESMicrobiology
Happy to see it out!
Very cool work I was able to contribute in. If you are interested in how we can use AlphaDesign to make de novo inhibitors of phage defence systems check the paper out!
Very cool work I was able to contribute in. If you are interested in how we can use AlphaDesign to make de novo inhibitors of phage defence systems check the paper out!
Happy to announce the first paper from my PhD at Korbel group at @embl.org has finally been published:
embopress.org/doi/full/10.1038…
Collaborating with @typaslab.bsky.social, @hennig-lab.bsky.social and the EMBL PEPCF, we designed de novo inhibitors to a bacterial phage defense system 1/🧵
embopress.org/doi/full/10.1038…
Collaborating with @typaslab.bsky.social, @hennig-lab.bsky.social and the EMBL PEPCF, we designed de novo inhibitors to a bacterial phage defense system 1/🧵
June 19, 2025 at 4:43 PM
Happy to see it out!
Very cool work I was able to contribute in. If you are interested in how we can use AlphaDesign to make de novo inhibitors of phage defence systems check the paper out!
Very cool work I was able to contribute in. If you are interested in how we can use AlphaDesign to make de novo inhibitors of phage defence systems check the paper out!
Reposted by Alessio Yang
Very excited to share our preprint on a new resource: the Encyclopaedia of Viral Anti-Defence Systems (EVADES)! This is the main result of my PhD at EMBL-EBI (@ebi.embl.org)
and the University of Cambridge (@cam.ac.uk)! 🔗 www.biorxiv.org/content/10.1... 🧵1/n"
and the University of Cambridge (@cam.ac.uk)! 🔗 www.biorxiv.org/content/10.1... 🧵1/n"
Elucidating the mechanisms of action and evolutionary history of phage anti-defence proteins
Phages and bacteria are locked in a molecular arms race, with phage anti-defence proteins (ADPs) enabling them to evade bacterial immune systems. To streamline access to information on ADPs, we develo...
www.biorxiv.org
June 8, 2025 at 11:08 AM
Very excited to share our preprint on a new resource: the Encyclopaedia of Viral Anti-Defence Systems (EVADES)! This is the main result of my PhD at EMBL-EBI (@ebi.embl.org)
and the University of Cambridge (@cam.ac.uk)! 🔗 www.biorxiv.org/content/10.1... 🧵1/n"
and the University of Cambridge (@cam.ac.uk)! 🔗 www.biorxiv.org/content/10.1... 🧵1/n"
Reposted by Alessio Yang
🧵 🧪 1/ Hi! I’m excited to share our latest work, now on arXiv:
Repulsive particle interactions at cellular interfaces enable selective information processing (arxiv.org/abs/2506.14739)
Where we explore how the physical properties of living systems can help cells process spatial information.
Repulsive particle interactions at cellular interfaces enable selective information processing (arxiv.org/abs/2506.14739)
Where we explore how the physical properties of living systems can help cells process spatial information.
June 18, 2025 at 5:07 PM
🧵 🧪 1/ Hi! I’m excited to share our latest work, now on arXiv:
Repulsive particle interactions at cellular interfaces enable selective information processing (arxiv.org/abs/2506.14739)
Where we explore how the physical properties of living systems can help cells process spatial information.
Repulsive particle interactions at cellular interfaces enable selective information processing (arxiv.org/abs/2506.14739)
Where we explore how the physical properties of living systems can help cells process spatial information.
Reposted by Alessio Yang
Excited to share our preprint with @savitski_lab led by @tarabartolec.bsky.social, @KMitosch & Clément Potel! We uncovered a mechanism by which the T7 phage broadly counteracts DNA-targeting bacterial defenses by deploying a loose cannon kinase in its genome @embl.org www.biorxiv.org/content/10.1...
Pervasive phosphorylation by phage T7 kinase disarms bacterial defenses
Bacteria and bacteriophages are in a constant arms race to develop bacterial defense and phage counter-defense systems. Currently known phage counter-defense systems are specific to (the activity of) ...
www.biorxiv.org
December 23, 2024 at 7:29 AM
Excited to share our preprint with @savitski_lab led by @tarabartolec.bsky.social, @KMitosch & Clément Potel! We uncovered a mechanism by which the T7 phage broadly counteracts DNA-targeting bacterial defenses by deploying a loose cannon kinase in its genome @embl.org www.biorxiv.org/content/10.1...
Reposted by Alessio Yang
1/11 - With Karin Mitosch and Clément Potel + colleagues in Savitski lab and @typaslab.bsky.social @embl.org, I’m very happy to share our discovery of a hyper-promiscuous phage protein kinase (T7K) which broadly deactivates bacterial defenses! 🦠
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
December 23, 2024 at 7:29 AM
1/11 - With Karin Mitosch and Clément Potel + colleagues in Savitski lab and @typaslab.bsky.social @embl.org, I’m very happy to share our discovery of a hyper-promiscuous phage protein kinase (T7K) which broadly deactivates bacterial defenses! 🦠
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...