Alex Lercher
@alercher.bsky.social
Immunologist | HFSP Postdoctoral Fellow @RiceLaboratory | PhD @bergthalerlab | opinions are my own.
Pinned
Alex Lercher
@alercher.bsky.social
· Nov 17
How do past viral infections influence future viral diseases? We found that SARS-CoV-2 recovery protected from severe influenza A virus disease. But how come? There seemed to be some antigen-independent immunological memory going on..
Paper at Immunity: www.sciencedirect.com/science/arti...
Paper at Immunity: www.sciencedirect.com/science/arti...
Thank you very much #ASciNA and @fwf-at.bsky.social for the ASciNA Young Investigator Award!
Link to publication @cp-immunity.bsky.social : www.cell.com/immunity/abs...
Link to publication @cp-immunity.bsky.social : www.cell.com/immunity/abs...
October 14, 2025 at 6:15 PM
Thank you very much #ASciNA and @fwf-at.bsky.social for the ASciNA Young Investigator Award!
Link to publication @cp-immunity.bsky.social : www.cell.com/immunity/abs...
Link to publication @cp-immunity.bsky.social : www.cell.com/immunity/abs...
Reposted by Alex Lercher
Innate immune memory is wild 🧠
Alexander Lercher from Rockefeller dives into how cells remember past infections and prep for future ones. Type I interferon doing way more than just fighting viruses!
Full interview: buff.ly/5TKEJ9o
#CytokineSociety #ImmuneMemory #TypeIInterferon #CellsHaveMemoriesToo
Alexander Lercher from Rockefeller dives into how cells remember past infections and prep for future ones. Type I interferon doing way more than just fighting viruses!
Full interview: buff.ly/5TKEJ9o
#CytokineSociety #ImmuneMemory #TypeIInterferon #CellsHaveMemoriesToo
Member Highlight: Alexander Lercher on Innate Immune Memory and Real-World Microbe Responses - Biweekly newsletter of the International Cytokine & Interferon Society
My name is Alexander Lercher, and I am currently a Postdoc in the lab of Charlie Rice at Rockefeller University in New York, and I am particularly excited about studying immune responses in the context...
signals.cytokinesociety.org
October 10, 2025 at 7:04 PM
Innate immune memory is wild 🧠
Alexander Lercher from Rockefeller dives into how cells remember past infections and prep for future ones. Type I interferon doing way more than just fighting viruses!
Full interview: buff.ly/5TKEJ9o
#CytokineSociety #ImmuneMemory #TypeIInterferon #CellsHaveMemoriesToo
Alexander Lercher from Rockefeller dives into how cells remember past infections and prep for future ones. Type I interferon doing way more than just fighting viruses!
Full interview: buff.ly/5TKEJ9o
#CytokineSociety #ImmuneMemory #TypeIInterferon #CellsHaveMemoriesToo
Thank you for the member highlight @cytokinesociety.bsky.social and see you all in Seattle for Cytokines 2025!
signals.cytokinesociety.org/2025/09/28/m...
signals.cytokinesociety.org/2025/09/28/m...
Member Highlight: Alexander Lercher on Innate Immune Memory and Real-World Microbe Responses - Biweekly newsletter of the International Cytokine & Interferon Society
My name is Alexander Lercher, and I am currently a Postdoc in the lab of Charlie Rice at Rockefeller University in New York, and I am particularly excited about studying immune responses in the context of real-world microbe exposure. Out from the lab, my biggest hobby for the past years has been to explore the
signals.cytokinesociety.org
October 3, 2025 at 12:56 PM
Thank you for the member highlight @cytokinesociety.bsky.social and see you all in Seattle for Cytokines 2025!
signals.cytokinesociety.org/2025/09/28/m...
signals.cytokinesociety.org/2025/09/28/m...
Extremely happy to be awarded the Sidney & Joan Pestka Post-graduate award!
Thank you @cytokinesociety.bsky.social and all my mentors, colleagues and collaborators throughout my career so far!
Thank you @cytokinesociety.bsky.social and all my mentors, colleagues and collaborators throughout my career so far!
The International Cytokine & Interferon Society congratulates the winners of the 2025 Sidney & Joan Pestka Graduate and Post-Graduate Awards, the ICIS-Christina Fleischmann Award and the ICIS-Amanda Proudfoot Award. Read more at signals.cytokinesociety.org/2025/07/14/2...
July 17, 2025 at 2:47 AM
Extremely happy to be awarded the Sidney & Joan Pestka Post-graduate award!
Thank you @cytokinesociety.bsky.social and all my mentors, colleagues and collaborators throughout my career so far!
Thank you @cytokinesociety.bsky.social and all my mentors, colleagues and collaborators throughout my career so far!
Location, infection history, antigen persistence shape the phenotype of tissue-resident T cells (Trm), challenging the idea of a universal framework for Trm identity across organs and diseases.
High/low antigen immunogenicity may add another layer...
@cp-immunity.bsky.social
tinyurl.com/49dkc3j7
High/low antigen immunogenicity may add another layer...
@cp-immunity.bsky.social
tinyurl.com/49dkc3j7
December 27, 2024 at 7:42 PM
Location, infection history, antigen persistence shape the phenotype of tissue-resident T cells (Trm), challenging the idea of a universal framework for Trm identity across organs and diseases.
High/low antigen immunogenicity may add another layer...
@cp-immunity.bsky.social
tinyurl.com/49dkc3j7
High/low antigen immunogenicity may add another layer...
@cp-immunity.bsky.social
tinyurl.com/49dkc3j7
A commensal bacterium triggers systemic antibody responses via skin lymphoid structures and can be engineered as a topical vaccine – great therapeutic potential!
Two studies in @nature.com.web.brid.gy by the Fischbach and Belkaid labs
tinyurl.com/5yahn47t
tinyurl.com/4n4btxap
Two studies in @nature.com.web.brid.gy by the Fischbach and Belkaid labs
tinyurl.com/5yahn47t
tinyurl.com/4n4btxap
December 15, 2024 at 5:07 PM
A commensal bacterium triggers systemic antibody responses via skin lymphoid structures and can be engineered as a topical vaccine – great therapeutic potential!
Two studies in @nature.com.web.brid.gy by the Fischbach and Belkaid labs
tinyurl.com/5yahn47t
tinyurl.com/4n4btxap
Two studies in @nature.com.web.brid.gy by the Fischbach and Belkaid labs
tinyurl.com/5yahn47t
tinyurl.com/4n4btxap
Great Spotlight by @virusesimmunity.bsky.social and #SashaTabachnikova on our recent publication in #Immunity, where we studied antiviral innate immune memory in alveolar macrophages in the context of respiratory viral infections!
www.cell.com/trends/immun...
www.cell.com/trends/immun...
SARS-CoV-2 reprograms murine alveolar macrophages to dampen flu
Innate immune cells that are epigenetically reprogrammed by infection can modify host
responses to subsequent infections. Lercher et al. have identified epigenetic reprogramming
of murine airway-resid...
www.cell.com
November 25, 2024 at 11:10 PM
Great Spotlight by @virusesimmunity.bsky.social and #SashaTabachnikova on our recent publication in #Immunity, where we studied antiviral innate immune memory in alveolar macrophages in the context of respiratory viral infections!
www.cell.com/trends/immun...
www.cell.com/trends/immun...
If you are rather an auditory person than a reading person – TWIV discussed our recent paper on antiviral innate immune memory in sequential respiratory viral infections.
Paper review starts at 37:00, more general discussion and broader implications at 1:10:00.
open.spotify.com/episode/777w...
Paper review starts at 37:00, more general discussion and broader implications at 1:10:00.
open.spotify.com/episode/777w...
TWiV 1165: What doesn't kill us primes our macrophages
This Week in Virology · Episode
open.spotify.com
November 18, 2024 at 8:41 PM
If you are rather an auditory person than a reading person – TWIV discussed our recent paper on antiviral innate immune memory in sequential respiratory viral infections.
Paper review starts at 37:00, more general discussion and broader implications at 1:10:00.
open.spotify.com/episode/777w...
Paper review starts at 37:00, more general discussion and broader implications at 1:10:00.
open.spotify.com/episode/777w...
How do past viral infections influence future viral diseases? We found that SARS-CoV-2 recovery protected from severe influenza A virus disease. But how come? There seemed to be some antigen-independent immunological memory going on..
Paper at Immunity: www.sciencedirect.com/science/arti...
Paper at Immunity: www.sciencedirect.com/science/arti...
November 17, 2024 at 2:44 PM
How do past viral infections influence future viral diseases? We found that SARS-CoV-2 recovery protected from severe influenza A virus disease. But how come? There seemed to be some antigen-independent immunological memory going on..
Paper at Immunity: www.sciencedirect.com/science/arti...
Paper at Immunity: www.sciencedirect.com/science/arti...
Chronic autoimmunity rewires metabolism in progenitors, correlating with innate immune memory formation in macrophages that increases antibacterial activity but might also aggravate autoimmune diseases?
shorturl.at/SZ1Ww
#CellStemCell
shorturl.at/SZ1Ww
#CellStemCell
November 15, 2024 at 10:46 PM
Chronic autoimmunity rewires metabolism in progenitors, correlating with innate immune memory formation in macrophages that increases antibacterial activity but might also aggravate autoimmune diseases?
shorturl.at/SZ1Ww
#CellStemCell
shorturl.at/SZ1Ww
#CellStemCell
Curious how commonly circulating respiratory viruses affect respective disease?
Past SARS2 infection ameliorates disease caused by secondary influenza virus via innate immune memory in airway-resident macrophages. @biorxivpreprint.bsky.social link below.
www.biorxiv.org/content/10.1...
Past SARS2 infection ameliorates disease caused by secondary influenza virus via innate immune memory in airway-resident macrophages. @biorxivpreprint.bsky.social link below.
www.biorxiv.org/content/10.1...
February 8, 2024 at 4:48 AM
Curious how commonly circulating respiratory viruses affect respective disease?
Past SARS2 infection ameliorates disease caused by secondary influenza virus via innate immune memory in airway-resident macrophages. @biorxivpreprint.bsky.social link below.
www.biorxiv.org/content/10.1...
Past SARS2 infection ameliorates disease caused by secondary influenza virus via innate immune memory in airway-resident macrophages. @biorxivpreprint.bsky.social link below.
www.biorxiv.org/content/10.1...