Al-Sady lab
@al-sadylab.bsky.social
Associate Professor | Dad, Husband |Studying the dynamic epigenome with Chromatin Biochemistry, Biophysics, and Single Cell Biology | fission yeast and murine cells | UCSF Microbiology & Immunology | Parnassus
Congratulations Scotland !! That game to directly qualify for the first time to the World Cup since '98 was one of the most exciting things I have ever seen. Looking forward to seeing that team next year! Maybe you get to play in SF !
November 20, 2025 at 4:38 AM
Congratulations Scotland !! That game to directly qualify for the first time to the World Cup since '98 was one of the most exciting things I have ever seen. Looking forward to seeing that team next year! Maybe you get to play in SF !
First one! Did it.
November 16, 2025 at 7:33 PM
First one! Did it.
TFW for once, just once, you get 3 reasonable reviews that are actually doable in 3 months.
November 13, 2025 at 7:16 PM
TFW for once, just once, you get 3 reasonable reviews that are actually doable in 3 months.
Biggest ever democratic win for VA gov (since 1961!) : tonight. By a lot. With big BIG coattails. Look for Spanberger.
November 5, 2025 at 5:21 AM
Biggest ever democratic win for VA gov (since 1961!) : tonight. By a lot. With big BIG coattails. Look for Spanberger.
Walking to lab not thinking of much, being greeted by this lovely creature that dutifully waited at the traffic light once it reached the end of Kezar triangle… slightly surreal. Big one too.
November 4, 2025 at 10:16 PM
Walking to lab not thinking of much, being greeted by this lovely creature that dutifully waited at the traffic light once it reached the end of Kezar triangle… slightly surreal. Big one too.
Nicely done @oaklandroots.bsky.social great win to end season and what fireworks!
October 26, 2025 at 6:09 AM
Nicely done @oaklandroots.bsky.social great win to end season and what fireworks!
Money does talk, it turns out.
October 24, 2025 at 1:22 PM
Money does talk, it turns out.
Well, I guess it’s time to carry that passport in my work bag. Especially bizarre as a naturalized citizen of German upbringing…..
October 23, 2025 at 2:47 AM
Well, I guess it’s time to carry that passport in my work bag. Especially bizarre as a naturalized citizen of German upbringing…..
Boy, am I sick of mediocre $5 Bay Area croissants.
October 21, 2025 at 3:41 PM
Boy, am I sick of mediocre $5 Bay Area croissants.
Morning after the rain
October 14, 2025 at 2:44 PM
Morning after the rain
Very proud of this story and the amazing Agnisrota Mazumder @agnisrota.bsky.social. An exciting joint journey of exploration with @thebraunlab.bsky.social in subtelomeric heterochromatin. Many surprises but, one that stuck are the unique co-existing epigenetic states in the same domain.
This one feels special: our latest work on subtelomeric heterochromatin is now on www.biorxiv.org/content/10.1....
This story was driven by the virtuoso PhD work of Agnisrota Mazumder @agnisrota.bsky.social, co-mentored with @al-sadylab.bsky.social, and grew out of our #MSCA Cell2Cell network.
This story was driven by the virtuoso PhD work of Agnisrota Mazumder @agnisrota.bsky.social, co-mentored with @al-sadylab.bsky.social, and grew out of our #MSCA Cell2Cell network.
Discrete Subdomains Establish Epigenetic Diversity in Subtelomeric Heterochromatin
Subtelomeres are imperfect repeats adjacent to telomeres that are repressed by heterochromatin. Although essential for genome integrity, their repetitive nature has thwarted dissection of local hetero...
www.biorxiv.org
September 27, 2025 at 5:12 PM
Very proud of this story and the amazing Agnisrota Mazumder @agnisrota.bsky.social. An exciting joint journey of exploration with @thebraunlab.bsky.social in subtelomeric heterochromatin. Many surprises but, one that stuck are the unique co-existing epigenetic states in the same domain.
Best weekend feeling. Co coaching your kids competitive team and they come back to win against a very physical opponent, first time playing on a full regulation field. The best.
September 14, 2025 at 1:08 AM
Best weekend feeling. Co coaching your kids competitive team and they come back to win against a very physical opponent, first time playing on a full regulation field. The best.
why won't Youtube understand I just don't like Chopin. Esp when I work. AI should take care of that no?
September 11, 2025 at 8:25 PM
why won't Youtube understand I just don't like Chopin. Esp when I work. AI should take care of that no?
“Critics call it extortion.”
August 20, 2025 at 2:01 AM
“Critics call it extortion.”
The Bay Area job market for young people (undergrads, PhD grads) is truly dismal. It's very hard to see this.
August 8, 2025 at 3:15 PM
The Bay Area job market for young people (undergrads, PhD grads) is truly dismal. It's very hard to see this.
Reposted by Al-Sady lab
A 37.5% cut being implemented now by NIH. Less because the policy is only effective for part of a fiscal year. But if congress does nothing, a 50% cut next fiscal year. Nefarious accounting trick from the ONB to thwart the intent of Congress.
NIH staff are being required to fully fund ~ 50% of their grants. This means that all 4 years of an award will be paid out of this appropriation. This will help them get the appropriated funds spent, but will mean they can only fund (1/2 + 1/4*1/2) = 5/8 has many grants as they would have otherwise.
July 23, 2025 at 1:42 PM
A 37.5% cut being implemented now by NIH. Less because the policy is only effective for part of a fiscal year. But if congress does nothing, a 50% cut next fiscal year. Nefarious accounting trick from the ONB to thwart the intent of Congress.
Reposted by Al-Sady lab
Scenes from a science crisis: a selection of recent developments 🧵1/6
July 18, 2025 at 1:39 PM
Scenes from a science crisis: a selection of recent developments 🧵1/6
Reposted by Al-Sady lab
The NIH ‘s new forward funding approach is an accounting trick designed to artificially reduce the budget by committing next year’s funds to this year’s budget without making the funds available. It’s an excuse to fund fewer grants. Bureaucratic authoritarianism to nullify congressional intent.
July 18, 2025 at 1:50 AM
The NIH ‘s new forward funding approach is an accounting trick designed to artificially reduce the budget by committing next year’s funds to this year’s budget without making the funds available. It’s an excuse to fund fewer grants. Bureaucratic authoritarianism to nullify congressional intent.
Slack enabled /launched AI today. I disabled it for our workspaces. Right call? Unnecessary?
July 17, 2025 at 3:10 PM
Slack enabled /launched AI today. I disabled it for our workspaces. Right call? Unnecessary?
Last days of Japan- Paris trip. Not ready to go.
July 13, 2025 at 9:18 PM
Last days of Japan- Paris trip. Not ready to go.
Paris is gleaming everywhere
July 10, 2025 at 4:29 PM
Paris is gleaming everywhere
Harajuku (Tokyo) and St Germain (Paris) people watching within coupe of days … one has much more interesting examples of self expression in fashion.
July 3, 2025 at 2:15 PM
Harajuku (Tokyo) and St Germain (Paris) people watching within coupe of days … one has much more interesting examples of self expression in fashion.
Amazing trip to Japan ended with TeamLabs Planet, animal cafe for kids and the KillBill restaurant for a Tokyo flair…. And now Lufthansa has us delayed 11 hrs onto the destination ;-)
July 2, 2025 at 2:44 AM
Amazing trip to Japan ended with TeamLabs Planet, animal cafe for kids and the KillBill restaurant for a Tokyo flair…. And now Lufthansa has us delayed 11 hrs onto the destination ;-)
First trip to Japan- like many in the “low Yen” era. My god, what a civilized place. The family is having a really wonderful time. Just a few more days. Surprisingly outside the big cities very few tourists unlike what you are used to say in Europe.
June 26, 2025 at 11:24 PM
First trip to Japan- like many in the “low Yen” era. My god, what a civilized place. The family is having a really wonderful time. Just a few more days. Surprisingly outside the big cities very few tourists unlike what you are used to say in Europe.