Aidan Quinn
@aidoq.bsky.social
Systems Biologist studying Cancer Epigenomics (biochemistry + genomics) in the Kadoch Lab @ Harvard DFCI Broad • Postdoctoral Fellow • KC1TXH • opinions are my own • Boston + NYC
The cool thing about this transformer model based approach (over diffusion, eg) is that they were able to abstract away the issues diffusion models face with intrinsically disordered regions, engineering IDRs without knowing structure. Very elegant & results-focused solution
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September 26, 2025 at 7:32 PM
The cool thing about this transformer model based approach (over diffusion, eg) is that they were able to abstract away the issues diffusion models face with intrinsically disordered regions, engineering IDRs without knowing structure. Very elegant & results-focused solution
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Congrats, JP! It's a really intriguing model for regulation over early ATP-dependent remodeling events! I wonder if there are PTMs that regulate transition or even more distal events like TF binding that could promote it... Very nice story!
May 30, 2025 at 5:49 PM
Congrats, JP! It's a really intriguing model for regulation over early ATP-dependent remodeling events! I wonder if there are PTMs that regulate transition or even more distal events like TF binding that could promote it... Very nice story!
3b/ This underscores the double-edged sword of #aging intervention: cGAS-activation of senescence helps prevent oncogenic transformation, but too much cellular senescence means runaway inflammation. Maybe we should treat the underlying genomic instability and distal inflammation separately?
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May 7, 2025 at 12:46 PM
3b/ This underscores the double-edged sword of #aging intervention: cGAS-activation of senescence helps prevent oncogenic transformation, but too much cellular senescence means runaway inflammation. Maybe we should treat the underlying genomic instability and distal inflammation separately?
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3a/ Chen highlighted the age-related increase in cGAMP and mused about the use of cGAS inhibitors in inflammation associated with #aging. But should we really be thinking about inhibiting the proximal sensor of age-related genomic instability?
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May 7, 2025 at 12:46 PM
3a/ Chen highlighted the age-related increase in cGAMP and mused about the use of cGAS inhibitors in inflammation associated with #aging. But should we really be thinking about inhibiting the proximal sensor of age-related genomic instability?
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2/ Nuclear cGAS seems to be very strongly associated with nucleosomal DNA - does it have a role on #chromatin or is it just sequestration?
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May 7, 2025 at 12:46 PM
2/ Nuclear cGAS seems to be very strongly associated with nucleosomal DNA - does it have a role on #chromatin or is it just sequestration?
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1/ Why does haploinsufficency of cGAS nearly completely rescue Trex1-loss? Chen mentioned that monoalellic loss of STING is also sufficient, so can’t just be cGAMP levels, right?
Source: Gao et al, PNAS 2105 doi.org/10.1073/pnas...
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Source: Gao et al, PNAS 2105 doi.org/10.1073/pnas...
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May 7, 2025 at 12:46 PM
1/ Why does haploinsufficency of cGAS nearly completely rescue Trex1-loss? Chen mentioned that monoalellic loss of STING is also sufficient, so can’t just be cGAMP levels, right?
Source: Gao et al, PNAS 2105 doi.org/10.1073/pnas...
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Source: Gao et al, PNAS 2105 doi.org/10.1073/pnas...
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Hahahaha, I was looking for the same!They use AlphaFold for structure prediction of their hit, I think that’s it… such silly clickbait for an actually quote interesting paper that has almost nothing to do with AI
April 3, 2025 at 9:55 PM
Hahahaha, I was looking for the same!They use AlphaFold for structure prediction of their hit, I think that’s it… such silly clickbait for an actually quote interesting paper that has almost nothing to do with AI
This is a report of correlational findings in an observational study. If you make many measurements (as they did) you will find some correlate. Nothing about this is 'critical'. It might constitute preliminary data in support of doing an actual experiment to validate any possible role, likely none
March 25, 2025 at 6:30 PM
This is a report of correlational findings in an observational study. If you make many measurements (as they did) you will find some correlate. Nothing about this is 'critical'. It might constitute preliminary data in support of doing an actual experiment to validate any possible role, likely none
www.sciencedirect.com/science/arti... and its open! Enjoy!! 🧪
Nucleosomal asymmetry shapes histone mark binding and promotes poising at bivalent domains
Promoters of developmental genes in embryonic stem cells (ESCs) are marked by histone H3 lysine 4 trimethylation (H3K4me3) and H3K27me3 in an asymmetr…
www.sciencedirect.com
February 24, 2025 at 11:22 PM
www.sciencedirect.com/science/arti... and its open! Enjoy!! 🧪
Dickson was enormously optimistic and always sought to better the world around him. More than a microbiologist, he was an epidemiologist, environmentalist and a humanitarian working on some of the biggest challenges facing the world. Even writing a super interesting book about vertical farming:
Vertical Farms: From Vision to Reality
Dr. Dickson Despommier believes vertical farming—the growing of crops indoors in multi-story urban buildings—can help feed the growing global population and undo the environmental damage caused by con...
news.climate.columbia.edu
February 16, 2025 at 4:06 AM
Dickson was enormously optimistic and always sought to better the world around him. More than a microbiologist, he was an epidemiologist, environmentalist and a humanitarian working on some of the biggest challenges facing the world. Even writing a super interesting book about vertical farming: