Aidan Quinn
@aidoq.bsky.social
Systems Biologist studying Cancer Epigenomics (biochemistry + genomics) in the Kadoch Lab @ Harvard DFCI Broad • Postdoctoral Fellow • KC1TXH • opinions are my own • Boston + NYC
Big step forward in phenotype-directed drug discovery:
By learning the latent representation of phenotype space, they speed up and directly learn the phenotype transition --> perturbagen mapping.
Super cool!!
www.nature.com/articles/s41...
#AI #drugdiscovery #cancer
By learning the latent representation of phenotype space, they speed up and directly learn the phenotype transition --> perturbagen mapping.
Super cool!!
www.nature.com/articles/s41...
#AI #drugdiscovery #cancer
September 9, 2025 at 3:52 PM
Big step forward in phenotype-directed drug discovery:
By learning the latent representation of phenotype space, they speed up and directly learn the phenotype transition --> perturbagen mapping.
Super cool!!
www.nature.com/articles/s41...
#AI #drugdiscovery #cancer
By learning the latent representation of phenotype space, they speed up and directly learn the phenotype transition --> perturbagen mapping.
Super cool!!
www.nature.com/articles/s41...
#AI #drugdiscovery #cancer
Beautiful foggy morning run on Martha’s Vineyard… a little time away from the lab goes a long way to help keep me focused back in the lab!
May 30, 2025 at 5:31 PM
Beautiful foggy morning run on Martha’s Vineyard… a little time away from the lab goes a long way to help keep me focused back in the lab!
1/ Why does haploinsufficency of cGAS nearly completely rescue Trex1-loss? Chen mentioned that monoalellic loss of STING is also sufficient, so can’t just be cGAMP levels, right?
Source: Gao et al, PNAS 2105 doi.org/10.1073/pnas...
🧪
Source: Gao et al, PNAS 2105 doi.org/10.1073/pnas...
🧪
May 7, 2025 at 12:46 PM
1/ Why does haploinsufficency of cGAS nearly completely rescue Trex1-loss? Chen mentioned that monoalellic loss of STING is also sufficient, so can’t just be cGAMP levels, right?
Source: Gao et al, PNAS 2105 doi.org/10.1073/pnas...
🧪
Source: Gao et al, PNAS 2105 doi.org/10.1073/pnas...
🧪
Great round up of cGAS-STING mediated dsDNA sensing with Zhijian Chen - lots to think about!
#HarvardImmunology 🧪
#HarvardImmunology 🧪
May 7, 2025 at 12:46 PM
Great round up of cGAS-STING mediated dsDNA sensing with Zhijian Chen - lots to think about!
#HarvardImmunology 🧪
#HarvardImmunology 🧪
It turns out I am a stage of lymphocyte differentiation, apparently a CLP gives rise to a fully differentiated @aido!
File under: Things I learn in lab meetings
File under: Things I learn in lab meetings
February 26, 2025 at 8:53 PM
It turns out I am a stage of lymphocyte differentiation, apparently a CLP gives rise to a fully differentiated @aido!
File under: Things I learn in lab meetings
File under: Things I learn in lab meetings
Super paper out of the Voigt group, that answers some longstanding questions about bivalent #histone marks!
They show asymmetric bivalency recruits repressive readers (but not H3K4me3 readers) and have emergent properties that neither of the two alone do (e.g. recruitment of KAT6B complex)!
🧪
They show asymmetric bivalency recruits repressive readers (but not H3K4me3 readers) and have emergent properties that neither of the two alone do (e.g. recruitment of KAT6B complex)!
🧪
February 24, 2025 at 11:22 PM
Super paper out of the Voigt group, that answers some longstanding questions about bivalent #histone marks!
They show asymmetric bivalency recruits repressive readers (but not H3K4me3 readers) and have emergent properties that neither of the two alone do (e.g. recruitment of KAT6B complex)!
🧪
They show asymmetric bivalency recruits repressive readers (but not H3K4me3 readers) and have emergent properties that neither of the two alone do (e.g. recruitment of KAT6B complex)!
🧪
The Boston sunset view from my bench never gets old!
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February 1, 2025 at 10:05 PM
The Boston sunset view from my bench never gets old!
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Did y’all see that Beaver Moon last night?! Awesome show from the lab
November 16, 2024 at 5:41 PM
Did y’all see that Beaver Moon last night?! Awesome show from the lab
Wow!!! IDO1 inhibition rescues LTP in both Tau and AB models of Alzheimers Disease
Not my field but a very surprising and exciting result! Beautiful dissection of the phenotype and the biological mechanisms!
#neurodegenerativeDeisease #science #drugTargets
Not my field but a very surprising and exciting result! Beautiful dissection of the phenotype and the biological mechanisms!
#neurodegenerativeDeisease #science #drugTargets
September 3, 2024 at 6:40 PM
Wow!!! IDO1 inhibition rescues LTP in both Tau and AB models of Alzheimers Disease
Not my field but a very surprising and exciting result! Beautiful dissection of the phenotype and the biological mechanisms!
#neurodegenerativeDeisease #science #drugTargets
Not my field but a very surprising and exciting result! Beautiful dissection of the phenotype and the biological mechanisms!
#neurodegenerativeDeisease #science #drugTargets
Great talk today by Alec Kimmelman today at DFCI - enjoyed learning about the supportive role of tumor innervating neurons in PDAC and the metastatic tumor microenvironment! 🧬
May 14, 2024 at 9:17 PM
Great talk today by Alec Kimmelman today at DFCI - enjoyed learning about the supportive role of tumor innervating neurons in PDAC and the metastatic tumor microenvironment! 🧬
Super interesting!! 🧬
Epigenetic states favored by the organ of residence can influence the function of driver genes in metastatic tumors
www.biorxiv.org/content/10.1...
Epigenetic states favored by the organ of residence can influence the function of driver genes in metastatic tumors
www.biorxiv.org/content/10.1...
March 19, 2024 at 7:23 PM
Super interesting!! 🧬
Epigenetic states favored by the organ of residence can influence the function of driver genes in metastatic tumors
www.biorxiv.org/content/10.1...
Epigenetic states favored by the organ of residence can influence the function of driver genes in metastatic tumors
www.biorxiv.org/content/10.1...
I’m no expert but I’m pretty sure Boston roadway engineers are paid to maximize confusion
Whatever they’re doing, it’s working bc we’re 3rd highest relative likelihood of having a collision, but only 2.6 traffic fatalities per 100k population.
QED: confused drivers crash often and gently
Whatever they’re doing, it’s working bc we’re 3rd highest relative likelihood of having a collision, but only 2.6 traffic fatalities per 100k population.
QED: confused drivers crash often and gently
March 11, 2024 at 9:08 PM
I’m no expert but I’m pretty sure Boston roadway engineers are paid to maximize confusion
Whatever they’re doing, it’s working bc we’re 3rd highest relative likelihood of having a collision, but only 2.6 traffic fatalities per 100k population.
QED: confused drivers crash often and gently
Whatever they’re doing, it’s working bc we’re 3rd highest relative likelihood of having a collision, but only 2.6 traffic fatalities per 100k population.
QED: confused drivers crash often and gently
The @fda.gov CBER updated their CAR T cell product guidance - enhanced focus on acute toxicities and long term follow up
🧬 #genomicMedicines #drugDevelopment #biotech
🧬 #genomicMedicines #drugDevelopment #biotech
March 7, 2024 at 6:51 PM
The @fda.gov CBER updated their CAR T cell product guidance - enhanced focus on acute toxicities and long term follow up
🧬 #genomicMedicines #drugDevelopment #biotech
🧬 #genomicMedicines #drugDevelopment #biotech
No well-dressed penguins allowed!
March 6, 2024 at 4:54 PM
No well-dressed penguins allowed!
Highlighting the importance of use of informative initialization in low-dimensional projection of single cell seq data, Kobak and Linderman explain why Laplacian eigenmaps should be default behavior of both UMAP and t-SNE. Great quick read! 🧬
www.nature.com/articles/s41...
www.nature.com/articles/s41...
February 25, 2024 at 4:40 PM
Highlighting the importance of use of informative initialization in low-dimensional projection of single cell seq data, Kobak and Linderman explain why Laplacian eigenmaps should be default behavior of both UMAP and t-SNE. Great quick read! 🧬
www.nature.com/articles/s41...
www.nature.com/articles/s41...