AgingResearch
@agingresearch.bsky.social
Creating an Innovative Cool Aging Project
Ph.D 🧬| In Vivo 🐭 | Body Temperature 🌡️
🥶Cold vs Heat 🥵
Ph.D 🧬| In Vivo 🐭 | Body Temperature 🌡️
🥶Cold vs Heat 🥵
Pinned
AgingResearch
@agingresearch.bsky.social
· Dec 13
We agree that cold extends lifespan, but does heat lead to death?
Chili for Longevity? 🌶️ Capsaicin & The Anti-Aging Potential!
Spice up your diet to stay young? Its anti-inflammatory and antioxidant properties may help slow the stiffening and dysfunction of blood vessels associated with age.
www.aginganddisease.org/EN/10.14336/...
Spice up your diet to stay young? Its anti-inflammatory and antioxidant properties may help slow the stiffening and dysfunction of blood vessels associated with age.
www.aginganddisease.org/EN/10.14336/...
Capsaicin and TRPV1: A Novel Therapeutic Approach to Mitigate Vascular Aging
<p>Vascular aging and its associated diseases represent a principal cause of mortality among the global elderly population, making the mitigation of vascular aging a significant aspiration for humanit...
www.aginganddisease.org
October 15, 2025 at 9:17 AM
Chili for Longevity? 🌶️ Capsaicin & The Anti-Aging Potential!
Spice up your diet to stay young? Its anti-inflammatory and antioxidant properties may help slow the stiffening and dysfunction of blood vessels associated with age.
www.aginganddisease.org/EN/10.14336/...
Spice up your diet to stay young? Its anti-inflammatory and antioxidant properties may help slow the stiffening and dysfunction of blood vessels associated with age.
www.aginganddisease.org/EN/10.14336/...
The IARC says your >65 ºC tea or coffee is "probably carcinogenic." Studies show up to a 5.6x greater risk of esophageal cancer due to chronic thermal damage, not the caffeine or the drink itself.
☕ As winter nears, be patient: let it stand and cool.
🔗 pmc.ncbi.nlm.nih.gov/articles/PMC...
☕ As winter nears, be patient: let it stand and cool.
🔗 pmc.ncbi.nlm.nih.gov/articles/PMC...
October 6, 2025 at 6:01 PM
The IARC says your >65 ºC tea or coffee is "probably carcinogenic." Studies show up to a 5.6x greater risk of esophageal cancer due to chronic thermal damage, not the caffeine or the drink itself.
☕ As winter nears, be patient: let it stand and cool.
🔗 pmc.ncbi.nlm.nih.gov/articles/PMC...
☕ As winter nears, be patient: let it stand and cool.
🔗 pmc.ncbi.nlm.nih.gov/articles/PMC...
This new article confirms it: heat makes us age faster — just as we suspected. Its impact is comparable to other risk factors like smoking, poor diet, lack of exercise, or alcohol.
#Heat #AgingResearch #ClimateChange
www.nature.com/articles/s41...
#Heat #AgingResearch #ClimateChange
www.nature.com/articles/s41...
Long-term impacts of heatwaves on accelerated ageing - Nature Climate Change
Ageing is linked to environmental factors. This study shows that although participants gradually adapted to heat over time, cumulative exposure to heatwaves had stable and adverse impacts on ageing, e...
www.nature.com
August 29, 2025 at 6:37 PM
This new article confirms it: heat makes us age faster — just as we suspected. Its impact is comparable to other risk factors like smoking, poor diet, lack of exercise, or alcohol.
#Heat #AgingResearch #ClimateChange
www.nature.com/articles/s41...
#Heat #AgingResearch #ClimateChange
www.nature.com/articles/s41...
Glucose spikes have been linked to aging, along with many other diseases. One of the effects of glucose is an increase in body temperature — could this be one of the mechanisms behind its harmful impact?
#Heat #BodyTemperature #Glucose #AgingResearch
link.springer.com/article/10.1...
#Heat #BodyTemperature #Glucose #AgingResearch
link.springer.com/article/10.1...
Glucose, glycation and aging - Biogerontology
Glycation, a deleterious form of post-translational modification of macromolecules has been linked to diseases such as diabetes, cataract, Alzheimer’s, dialysis related amyloidosis (DRA), atherosclero...
link.springer.com
August 14, 2025 at 8:51 AM
Glucose spikes have been linked to aging, along with many other diseases. One of the effects of glucose is an increase in body temperature — could this be one of the mechanisms behind its harmful impact?
#Heat #BodyTemperature #Glucose #AgingResearch
link.springer.com/article/10.1...
#Heat #BodyTemperature #Glucose #AgingResearch
link.springer.com/article/10.1...
Taking cold showers is an established anti-aging intervention. There are lots of mechanisms behind this effect, but in the end, it leads to a reduction in body temperature. What about you — have you made this part of your routine?
#ColdExposure #AgingResearch #Intervention #Longevity
#ColdExposure #AgingResearch #Intervention #Longevity
August 1, 2025 at 1:06 PM
Taking cold showers is an established anti-aging intervention. There are lots of mechanisms behind this effect, but in the end, it leads to a reduction in body temperature. What about you — have you made this part of your routine?
#ColdExposure #AgingResearch #Intervention #Longevity
#ColdExposure #AgingResearch #Intervention #Longevity
One of the most accepted theories of aging involves increasing disorder. Since entropy rises over time — and temperature can accelerate it — could anti-aging interventions work by reducing entropy through lowering temperature?
#Heat #Aging #AgingResearch
#Heat #Aging #AgingResearch
July 25, 2025 at 7:39 PM
One of the most accepted theories of aging involves increasing disorder. Since entropy rises over time — and temperature can accelerate it — could anti-aging interventions work by reducing entropy through lowering temperature?
#Heat #Aging #AgingResearch
#Heat #Aging #AgingResearch
In vertebrates such as rodents, it’s been shown that they live shorter in hot environments or longer in cold ones. This suggests a clear inverse correlation between lifespan and environmental temperature across different animal models.
#Heat #Cold #AgingResearch
#Heat #Cold #AgingResearch
July 11, 2025 at 10:07 AM
In vertebrates such as rodents, it’s been shown that they live shorter in hot environments or longer in cold ones. This suggests a clear inverse correlation between lifespan and environmental temperature across different animal models.
#Heat #Cold #AgingResearch
#Heat #Cold #AgingResearch
It's known that low temperatures extend lifespan in different animal models — for example, in invertebrates like worms (see image) and flies. Will this be consistent in vertebrate animal models too?
#Heat #Cold #AgingResearch
#Heat #Cold #AgingResearch
July 4, 2025 at 12:23 PM
It's known that low temperatures extend lifespan in different animal models — for example, in invertebrates like worms (see image) and flies. Will this be consistent in vertebrate animal models too?
#Heat #Cold #AgingResearch
#Heat #Cold #AgingResearch
There is a clear decrease in body temperature with age. Do you think it is a cause or a consequence?
June 27, 2025 at 4:19 PM
There is a clear decrease in body temperature with age. Do you think it is a cause or a consequence?
This impressive article analyzes caloric restriction effects on epigenetic aging separating them from lower body temperature. Authors show that caloric restriction alone is not enough to slow down aging — a drop in body temperature is necessary to see these effects.
www.nature.com/articles/s43...
www.nature.com/articles/s43...
A torpor-like state in mice slows blood epigenetic aging and prolongs healthspan - Nature Aging
Dissecting the effects of hypothermic and hypometabolic states on aging processes, the authors show that activation of neurons in the preoptic area induces a torpor-like state in mice that slows epige...
www.nature.com
June 20, 2025 at 11:48 AM
This impressive article analyzes caloric restriction effects on epigenetic aging separating them from lower body temperature. Authors show that caloric restriction alone is not enough to slow down aging — a drop in body temperature is necessary to see these effects.
www.nature.com/articles/s43...
www.nature.com/articles/s43...
Caloric restriction decreases body temperature, and both factors have been linked to slower epigenetic aging. What would happen if their effects on aging were analyzed separately?
#Heat #BodyTemperature #AgingResearch
#Heat #BodyTemperature #AgingResearch
June 13, 2025 at 1:11 PM
Caloric restriction decreases body temperature, and both factors have been linked to slower epigenetic aging. What would happen if their effects on aging were analyzed separately?
#Heat #BodyTemperature #AgingResearch
#Heat #BodyTemperature #AgingResearch
Amazing study!The IC clock—based on DNA methylation changes and linked to lifestyle, and immune and clinical markers—accurately predicts mortality.Was body temperature considered?Its strong inverse correlation with age could make it a valuable readout in future studies
www.nature.com/articles/s43...
www.nature.com/articles/s43...
A blood-based epigenetic clock for intrinsic capacity predicts mortality and is associated with clinical, immunological and lifestyle factors - Nature Aging
Fuentealba and colleagues build and validate a DNA methylation clock of intrinsic capacity (IC) to bridge resource-intensive clinical assessments of IC with molecular readouts of aging, highlighting s...
www.nature.com
June 6, 2025 at 8:51 AM
Amazing study!The IC clock—based on DNA methylation changes and linked to lifestyle, and immune and clinical markers—accurately predicts mortality.Was body temperature considered?Its strong inverse correlation with age could make it a valuable readout in future studies
www.nature.com/articles/s43...
www.nature.com/articles/s43...
We are not surprised. Studies from around the world report the same pattern: more heat, more miscarriages during the first trimester of pregnancy. Fewer babies are being born in the Q1 of the year. We need new solutions to protect ourselves from rising temperatures. #GlobalWarming #Miscarriage #Heat
May 30, 2025 at 9:50 AM
We are not surprised. Studies from around the world report the same pattern: more heat, more miscarriages during the first trimester of pregnancy. Fewer babies are being born in the Q1 of the year. We need new solutions to protect ourselves from rising temperatures. #GlobalWarming #Miscarriage #Heat
As shown in this week The Lancet article, climate change is increasing health problems.It mostly focused on indirect effects of heat—like poverty, isolation,distress over planet harm.But is anyone asking if heat itself directly causes diseases?We are—check our posts
www.thelancet.com/journals/lan...
www.thelancet.com/journals/lan...
A call to action: the second Lancet Commission on adolescent health and wellbeing
Adolescents are the future leaders of our world. Ensuring their health and wellbeing—now
and in the future—is one of the strongest mechanisms available to safeguard the collective
future of humanity a...
www.thelancet.com
May 23, 2025 at 10:31 AM
As shown in this week The Lancet article, climate change is increasing health problems.It mostly focused on indirect effects of heat—like poverty, isolation,distress over planet harm.But is anyone asking if heat itself directly causes diseases?We are—check our posts
www.thelancet.com/journals/lan...
www.thelancet.com/journals/lan...
In camels, the testicles are located close to the body, in the perineal area, protecting sperm from the high desert temperatures. During heat waves, are human testicles too exposed? Are we not as well adapted to heat as camels?
#HeatAdaptation #ReproductiveBiology #AgingResearch
#HeatAdaptation #ReproductiveBiology #AgingResearch
May 16, 2025 at 1:37 PM
In camels, the testicles are located close to the body, in the perineal area, protecting sperm from the high desert temperatures. During heat waves, are human testicles too exposed? Are we not as well adapted to heat as camels?
#HeatAdaptation #ReproductiveBiology #AgingResearch
#HeatAdaptation #ReproductiveBiology #AgingResearch
Humans have their testicles outside the body to keep them at a cooler temperature than the core body temperature. But what happens when it’s hotter outside than inside? Are they unprotected? How do other mammals like camels deal with this?
May 9, 2025 at 3:34 PM
Humans have their testicles outside the body to keep them at a cooler temperature than the core body temperature. But what happens when it’s hotter outside than inside? Are they unprotected? How do other mammals like camels deal with this?
Sperm quality has dropped fast since 2000, and we know that heatwaves make things worse. So how will we protect male fertility from heat?
#Heat #Fertility #AgingResearch
pubmed.ncbi.nlm.nih.gov/38848914/#:~...
#Heat #Fertility #AgingResearch
pubmed.ncbi.nlm.nih.gov/38848914/#:~...
Impact of heat waves on semen quality: A retrospective study in Argentina between 2005 and 2023 - PubMed
Heat waves, defined as periods with daily temperatures surpassing the historical average for a specific region, have become more frequent worldwide in recent years. Previous studies have reported a ne...
pubmed.ncbi.nlm.nih.gov
May 1, 2025 at 11:27 AM
Sperm quality has dropped fast since 2000, and we know that heatwaves make things worse. So how will we protect male fertility from heat?
#Heat #Fertility #AgingResearch
pubmed.ncbi.nlm.nih.gov/38848914/#:~...
#Heat #Fertility #AgingResearch
pubmed.ncbi.nlm.nih.gov/38848914/#:~...
Rats and naked mole rats, two similar small mammals, however one lives less than 3-years, the other one more than 30... What could be the key differences that explain such a dramatic gap in lifespan?
#Lifespan #Longevity #AgingResearch
#Lifespan #Longevity #AgingResearch
December 21, 2024 at 7:09 AM
Rats and naked mole rats, two similar small mammals, however one lives less than 3-years, the other one more than 30... What could be the key differences that explain such a dramatic gap in lifespan?
#Lifespan #Longevity #AgingResearch
#Lifespan #Longevity #AgingResearch
We as humans work with probability. Many interventions, lifestyles are proven to correlate with cancer & shorter lifespans, but we ignore them. Is it because we don’t care, don’t believe, or is it just unawareness? I want to ensure this is known and I will be sharing.
www.nature.com/articles/d41...
www.nature.com/articles/d41...
Why probability probably doesn’t exist (but it is useful to act like it does)
All of statistics and much of science depends on probability — an astonishing achievement, considering no one’s really sure what it is.
www.nature.com
December 20, 2024 at 6:44 AM
We as humans work with probability. Many interventions, lifestyles are proven to correlate with cancer & shorter lifespans, but we ignore them. Is it because we don’t care, don’t believe, or is it just unawareness? I want to ensure this is known and I will be sharing.
www.nature.com/articles/d41...
www.nature.com/articles/d41...
Very nice initiative from @brunetlab.bsky.social
Growing BlueSky together!
Growing BlueSky together!
Updated Aging Starter Packs to find people and labs who work on aging!!
Aging Starter Pack 1 (already reached the maximum number!): go.bsky.app/5UXXaDA
Aging Starter Pack 2 (can still add!): go.bsky.app/RfFYndJ
Let me know if you'd like to be added! 😀
Aging Starter Pack 1 (already reached the maximum number!): go.bsky.app/5UXXaDA
Aging Starter Pack 2 (can still add!): go.bsky.app/RfFYndJ
Let me know if you'd like to be added! 😀
December 18, 2024 at 6:24 AM
Very nice initiative from @brunetlab.bsky.social
Growing BlueSky together!
Growing BlueSky together!
Caloric restriction lowers body temperature. For who practice it, Im curious, do you also cold? its annoying?
www.sciencedirect.com/science/arti....
www.sciencedirect.com/science/arti....
Caloric restriction and longevity: Effects of reduced body temperature
Caloric restriction (CR) causes a reduction in body temperature (Tb) which is suggested to contribute to changes that increase lifespan. Moreover, low…
www.sciencedirect.com
December 17, 2024 at 6:54 AM
Caloric restriction lowers body temperature. For who practice it, Im curious, do you also cold? its annoying?
www.sciencedirect.com/science/arti....
www.sciencedirect.com/science/arti....
I agree, we must avoid overheating our bodies without a justified reason. Stress always increases body temperature , It was selected by nature to fight imminent threats but we pay back ... aging
It's probably not a good idea to be outside when the weather is hot. Human body’s ageing ‘clock’ ticks faster after heat stress Preliminary study suggests possible link between long-term heat exposure and molecular markers of ageing.
Human body’s ageing ‘clock’ ticks faster after heat stress
Preliminary study suggests possible link between long-term heat exposure and molecular markers of ageing.
buff.ly
December 16, 2024 at 5:46 AM
I agree, we must avoid overheating our bodies without a justified reason. Stress always increases body temperature , It was selected by nature to fight imminent threats but we pay back ... aging
After reviewing nearly 2,000 interventions that affect lifespan in rodents, Im still intrigued by this report:
Do mice live longer at 21°C or shorter at 32.5°C?
Do mice live longer at 21°C or shorter at 32.5°C?
December 15, 2024 at 7:39 AM
After reviewing nearly 2,000 interventions that affect lifespan in rodents, Im still intrigued by this report:
Do mice live longer at 21°C or shorter at 32.5°C?
Do mice live longer at 21°C or shorter at 32.5°C?
I would have guessed that the longest-living vertebrate should be aquatic and live in cold water
The longest-living vertebrate could offer clues to extending the human lifespan, scientists say
Scientists mapped the genome of a shark that can live 400 years. It could unlock new secrets to longevity | CNN
Mysteries surround the elusive Greenland shark, the longest-living vertebrate in the world. Researchers have new insight into the unique fish’s genetic makeup.
www.cnn.com
December 14, 2024 at 6:18 AM
I would have guessed that the longest-living vertebrate should be aquatic and live in cold water
We agree that cold extends lifespan, but does heat lead to death?
December 13, 2024 at 5:45 PM
We agree that cold extends lifespan, but does heat lead to death?