Aging Science News
@agingbiology.bsky.social
Latest news in the biology and genetics of aging, covering longevity science, rejuvenation technologies and life-extension research.
Sirt6 prevents the age-related decline of H2S through the control of one-carbon metabolism
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
Sirt6 prevents the age-related decline of H2S through the control of one-carbon metabolism | PNAS
Mice overexpressing Sirt6 or fed a caloric restriction (CR) diet live longer with
improved health. CR increases Sirt6 levels, and its beneficial ef...
www.pnas.org
December 3, 2025 at 10:36 PM
Sirt6 prevents the age-related decline of H2S through the control of one-carbon metabolism
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
Deciphering the timing and impact of life-extending interventions: temporal efficacy profiler distinguishes early, midlife, and senescence phase efficacies
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Deciphering the timing and impact of life-extending interventions: temporal efficacy profiler distinguishes early, midlife, and senescence phase efficacies - Nature Communications
A growing number of compounds are reported to extend lifespan, but it remains unclear whether they reduce mortality across the entire life course or only at specific ages. Here the authors introduce a...
www.nature.com
December 3, 2025 at 4:35 PM
Deciphering the timing and impact of life-extending interventions: temporal efficacy profiler distinguishes early, midlife, and senescence phase efficacies
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Mitochondrial Respiratory Supercomplex Assembly Factor COX7RP Contributes to Lifespan Extension in Mice
onlinelibrary.wiley.com/doi/10.1111/...
onlinelibrary.wiley.com/doi/10.1111/...
Mitochondrial Respiratory Supercomplex Assembly Factor COX7RP Contributes to Lifespan Extension in Mice
Mitochondrial respiratory supercomplex assembly factor COX7RP improves metabolic homeostasis and contributes to lifespan extension in mice. The overexpression of COX7RP reduces white adipose tissue m...
onlinelibrary.wiley.com
December 3, 2025 at 1:18 PM
Mitochondrial Respiratory Supercomplex Assembly Factor COX7RP Contributes to Lifespan Extension in Mice
onlinelibrary.wiley.com/doi/10.1111/...
onlinelibrary.wiley.com/doi/10.1111/...
Psychedelics and immortality: Nature went to a health summit starring RFK and JD Vance
www.nature.com/articles/d41...
www.nature.com/articles/d41...
Psychedelics and immortality: Nature went to a health summit starring RFK and JD Vance
The Make America Healthy Again summit, attended by health secretary Robert F. Kennedy Jr and vice-president JD Vance, gave a sense of what’s driving US health policy.
www.nature.com
December 2, 2025 at 8:22 PM
Psychedelics and immortality: Nature went to a health summit starring RFK and JD Vance
www.nature.com/articles/d41...
www.nature.com/articles/d41...
Genetics of Aging and Life Span: Molecular Mechanisms and Intervention Prospects
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Genetics of Aging and Life Span: Molecular Mechanisms and Intervention Prospects - Russian Journal of Genetics
Abstract The review examines modern advances in the genetics of aging and life span. The key molecular mechanisms regulating aging processes at the genetic level are analyzed, including signaling path...
link.springer.com
December 2, 2025 at 4:49 PM
Genetics of Aging and Life Span: Molecular Mechanisms and Intervention Prospects
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Natural bioactive peptides in photoaging: Multi-target mechanisms, clinical progress, and future anti-aging applications
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Natural bioactive peptides in photoaging: Multi-target mechanisms, clinical progress, and future anti-aging applications
Photoaging is a process of accelerated skin aging induced by ultraviolet radiation (UVR) and other exogenous factors, characterized by deepened wrinkl…
www.sciencedirect.com
December 2, 2025 at 1:21 PM
Natural bioactive peptides in photoaging: Multi-target mechanisms, clinical progress, and future anti-aging applications
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Predicting healthspan and disease risks through biological age
www.cell.com/trends/molec...
www.cell.com/trends/molec...
Predicting healthspan and disease risks through biological age
Aging is the gradual decline in physiological function essential for survival and
reproduction. Unlike age-associated diseases, aging affects all individuals within
a species, causing progressive impa...
www.cell.com
December 1, 2025 at 10:45 PM
Predicting healthspan and disease risks through biological age
www.cell.com/trends/molec...
www.cell.com/trends/molec...
Human Umbilical Cord Plasma Metabolomics Uncover Potential Metabolites for Combating Aging
onlinelibrary.wiley.com/doi/full/10....
onlinelibrary.wiley.com/doi/full/10....
Human Umbilical Cord Plasma Metabolomics Uncover Potential Metabolites for Combating Aging
Untargeted metabolomics reveals a unique cord plasma metabolic landscape versus adult. Age-declining cord-specific enriched metabolites are identified as antiaging candidates, with a 5-compound formu....
onlinelibrary.wiley.com
November 30, 2025 at 10:47 PM
Human Umbilical Cord Plasma Metabolomics Uncover Potential Metabolites for Combating Aging
onlinelibrary.wiley.com/doi/full/10....
onlinelibrary.wiley.com/doi/full/10....
Regulation of stem cell aging and cellular proliferation by Klotho-Sirt1 pathways in heart, kidney and small intestine
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Regulation of stem cell aging and cellular proliferation by Klotho-Sirt1 pathways in heart, kidney and small intestine - npj Aging
npj Aging - Regulation of stem cell aging and cellular proliferation by Klotho-Sirt1 pathways in heart, kidney and small intestine
www.nature.com
November 30, 2025 at 8:54 PM
Regulation of stem cell aging and cellular proliferation by Klotho-Sirt1 pathways in heart, kidney and small intestine
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Association of blood-based DNA methylation of lncRNAs with Alzheimer’s disease diagnosis
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Association of blood-based DNA methylation of lncRNAs with Alzheimer’s disease diagnosis - Clinical Epigenetics
Background DNA methylation has shown great potential in Alzheimer’s disease (AD) blood diagnosis. However, the ability of long non-coding RNAs (lncRNAs), which can be modified by DNA methylation, to s...
link.springer.com
November 30, 2025 at 12:14 AM
Association of blood-based DNA methylation of lncRNAs with Alzheimer’s disease diagnosis
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Reposted by Aging Science News
New methodological appraisal of the DrugAge database of longevity drugs 💊
Our analysis of 667 anti-ageing studies shows poor reporting, big species differences, and limited translation to mammals.
Work led by Austin Parish with many great collaborators.
www.nature.com/articles/s41...
Our analysis of 667 anti-ageing studies shows poor reporting, big species differences, and limited translation to mammals.
Work led by Austin Parish with many great collaborators.
www.nature.com/articles/s41...
Reporting quality, effect sizes, and biases for aging interventions: a methodological appraisal of the DrugAge database - npj Aging
npj Aging - Reporting quality, effect sizes, and biases for aging interventions: a methodological appraisal of the DrugAge database
www.nature.com
November 29, 2025 at 6:45 PM
New methodological appraisal of the DrugAge database of longevity drugs 💊
Our analysis of 667 anti-ageing studies shows poor reporting, big species differences, and limited translation to mammals.
Work led by Austin Parish with many great collaborators.
www.nature.com/articles/s41...
Our analysis of 667 anti-ageing studies shows poor reporting, big species differences, and limited translation to mammals.
Work led by Austin Parish with many great collaborators.
www.nature.com/articles/s41...
Somatic mutations impose an entropic upper bound on human lifespan
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Somatic mutations impose an entropic upper bound on human lifespan
Somatic mutations accumulate with age and can cause cell death, but their quantitative contribution to limiting human lifespan remains unclear. We developed an incremental modeling framework that prog...
www.biorxiv.org
November 29, 2025 at 2:00 PM
Somatic mutations impose an entropic upper bound on human lifespan
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Single-cell analysis of human thymus and peripheral blood unveils the dynamics of T cell development and aging
www.nature.com/articles/s43...
www.nature.com/articles/s43...
Single-cell analysis of human thymus and peripheral blood unveils the dynamics of T cell development and aging - Nature Aging
Profiling the human thymus and peripheral blood, Deng and colleagues demonstrate impaired T cell development and compromised thymic microenvironment during aging, reveal inflammatory characteristics o...
www.nature.com
November 29, 2025 at 12:56 AM
Single-cell analysis of human thymus and peripheral blood unveils the dynamics of T cell development and aging
www.nature.com/articles/s43...
www.nature.com/articles/s43...
Iron homeostasis and cell clonality drive cancer-associated intestinal DNA methylation drift in aging
www.nature.com/articles/s43...
www.nature.com/articles/s43...
Iron homeostasis and cell clonality drive cancer-associated intestinal DNA methylation drift in aging - Nature Aging
Krepelova and colleagues identify an aging- and colon cancer-associated DNA methylation drift in healthy and cancerous human colon samples, echoed in the mouse intestinal epithelium. They show it expa...
www.nature.com
November 28, 2025 at 10:03 PM
Iron homeostasis and cell clonality drive cancer-associated intestinal DNA methylation drift in aging
www.nature.com/articles/s43...
www.nature.com/articles/s43...
Spatial and single-cell transcriptomics reveal the reorganization of cerebellar microglia with aging
www.cell.com/cell-reports...
www.cell.com/cell-reports...
Spatial and single-cell transcriptomics reveal the reorganization of cerebellar microglia with aging
Tsai et al. show that cerebellar microglia undergo distinct molecular and spatial
changes during aging. Integrated single-nucleus and spatial transcriptomics identify
a neuron-associated microglial st...
www.cell.com
November 28, 2025 at 4:38 PM
Spatial and single-cell transcriptomics reveal the reorganization of cerebellar microglia with aging
www.cell.com/cell-reports...
www.cell.com/cell-reports...
Aging as the wound that fails to heal: a bioenergetic continuum of resolution failure
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Aging as the wound that fails to heal: a bioenergetic continuum of resolution failure - Biogerontology
Aging may be conceptualized as a wound that fails to heal, characterized by persistent, unresolved inflammation. Building on Ogrodnik’s “unhealed wound” model, this Perspective extends the Exposure-Re...
link.springer.com
November 28, 2025 at 12:58 AM
Aging as the wound that fails to heal: a bioenergetic continuum of resolution failure
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Topological turning points across the human lifespan
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Topological turning points across the human lifespan - Nature Communications
Researchers discovered five phases of brain rewiring across the lifespan. The eras of childhood, adolescence, adulthood, early aging, and late aging each have characteristic rewiring of structural con...
www.nature.com
November 27, 2025 at 11:46 PM
Topological turning points across the human lifespan
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Defying death: The origins of ageing
www.ft.com/content/a33d...
www.ft.com/content/a33d...
Defying death: The origins of ageing
Why do we age? Can it be stopped?
www.ft.com
November 27, 2025 at 10:15 PM
Defying death: The origins of ageing
www.ft.com/content/a33d...
www.ft.com/content/a33d...
Why we age is still longevity’s biggest question
longevity.technology/news/why-we-...
longevity.technology/news/why-we-...
Why we age is still longevity’s biggest question
Aging researcher expands on how addressing 100 key problems can provide the field with a roadmap for future investigation.
longevity.technology
November 27, 2025 at 6:49 PM
Why we age is still longevity’s biggest question
longevity.technology/news/why-we-...
longevity.technology/news/why-we-...
Potential dietary geroprotectors and their impact on key mechanisms of aging
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Potential dietary geroprotectors and their impact on key mechanisms of aging - Biogerontology
Aging involves progressive accumulation of molecular and cellular damage, leading to functional decline and increased susceptibility to age-related diseases. Natural low-molecular-weight geroprotector...
link.springer.com
November 27, 2025 at 4:41 PM
Potential dietary geroprotectors and their impact on key mechanisms of aging
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Solitary eating is linked to reduced brain volume in cognitively unimpaired individuals and possible future cognitive decline
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Solitary eating is linked to reduced brain volume in cognitively unimpaired individuals and possible future cognitive decline - npj Aging
npj Aging - Solitary eating is linked to reduced brain volume in cognitively unimpaired individuals and possible future cognitive decline
www.nature.com
November 27, 2025 at 12:39 PM
Solitary eating is linked to reduced brain volume in cognitively unimpaired individuals and possible future cognitive decline
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A collagen amino acid composition supplementation reduces biological age in humans and increases health and lifespan in vivo
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A collagen amino acid composition supplementation reduces biological age in humans and increases health and lifespan in vivo - npj Aging
npj Aging - A collagen amino acid composition supplementation reduces biological age in humans and increases health and lifespan in vivo
www.nature.com
November 27, 2025 at 1:16 AM
A collagen amino acid composition supplementation reduces biological age in humans and increases health and lifespan in vivo
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Organ-specific proteomic aging clocks predict disease and longevity across diverse populations
www.nature.com/articles/s43...
www.nature.com/articles/s43...
Organ-specific proteomic aging clocks predict disease and longevity across diverse populations - Nature Aging
Wang, Xiao and colleagues develop and validate organ-specific proteomic aging clocks across large population cohorts in the UK, the USA and China, which show strong performance in tracking organ aging...
www.nature.com
November 26, 2025 at 11:58 PM
Organ-specific proteomic aging clocks predict disease and longevity across diverse populations
www.nature.com/articles/s43...
www.nature.com/articles/s43...
Cellular senescence related gene signature predicts prognosis and immune features in skin cutaneous melanoma
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Cellular senescence related gene signature predicts prognosis and immune features in skin cutaneous melanoma - Discover Oncology
Background Skin cutaneous melanoma (SKCM) is the deadliest skin cancer, with rising global incidence. Cellular senescence plays an essential role in tumorigenesis, progression, and immune modulation i...
link.springer.com
November 26, 2025 at 2:48 PM
Cellular senescence related gene signature predicts prognosis and immune features in skin cutaneous melanoma
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Boy with rare condition amazes doctors after world-first gene therapy
www.bbc.com/news/article...
www.bbc.com/news/article...
Hunter syndrome: Boy with rare condition amazes doctors after world-first gene therapy
Oliver has an inherited condition called Hunter syndrome, which causes progressive damage to the body and brain.
www.bbc.com
November 26, 2025 at 1:26 AM
Boy with rare condition amazes doctors after world-first gene therapy
www.bbc.com/news/article...
www.bbc.com/news/article...