The link to register doesn't seem to work 🥲

Finally, I don't know why we resist defining scientific research as a creative endeavor. Any scientist who has achieved some degree of professional success recognizes the creativity and the bursts of conceptual understanding that accompany major innovation.

Thanks Allison! Would love to hear your thoughts sometime!

Huge thanks to NIAMS for funding support, the reviewers who were fantastic, and my co-authors for all their help and support!

#teamtendon #teamepitenon

Still a lot of super interesting questions, and a lot more to learn about these cells, but happy to finally have this piece out in the world despite all the hurdles (global pandemic, supply chain issues, drug shortages, the academic job market....)!

Most exciting, targeted ablation of epitenon-derived cells improves functional recovery, suggesting they are a good target to improve tendon healing.

It ALSO turns out that mouse epitenon cells are really similar to the cells found in human peritendinous scar tissue, and express conserved markers that suggest shared function in mice and humans.

Not only did we find a driver, but we used it to explore the origins and fates of epitenon cells. As it turns out, they contribute to both peritendinous adhesions and to the pool of new tenocytes that appear post-injury.

This paper started as a wild hair- could I find a genetic driver that would let us trace epitenon cells during tendon healing? Short answer: yes. Long answer: YES beyond any of my initial hopes for the project. Huge thanks to my postdoc mentor Alayna Loiselle for encouraging me to chase this rabbit.

Huge thanks to NIAMS for funding support, the reviewers who were fantastic, and my co-authors for all their help and support!

#teamtendon #teamepitenon

Still a lot of super interesting questions, and a lot more to learn about these cells, but happy to finally have this piece out in the world despite all the hurdles (global pandemic, supply chain issues, drug shortages, the academic job market....)!

Most exciting, targeted ablation of epitenon-derived cells improves functional recovery, suggesting they are a good target to improve tendon healing.

It ALSO turns out that mouse epitenon cells are really similar to the cells found in human peritendinous scar tissue, and express conserved markers that suggest shared function in mice and humans.

Not only did we find a driver, but we used it to explore the origins and fates of epitenon cells. As it turns out, they contribute to both peritendinous adhesions and to the pool of new tenocytes that appear post-injury.

This paper started as a wild hare- could I find a genetic driver that would let us trace epitenon cells during tendon healing? Short answer: yes. Long answer: YES beyond any of my initial hopes for the project. Huge thanks to my postdoc mentor Alayna Loiselle for encouraging me to chase this rabbit.