Ali Ezzati, MD
@ae-md.bsky.social
Dad. Scientist. Neurologist.
Epidemiology & data science, Alzheimer's, Migraine & a few more neurological dis. @UC-Irvine
Epidemiology & data science, Alzheimer's, Migraine & a few more neurological dis. @UC-Irvine
Pinned
Ali Ezzati, MD
@ae-md.bsky.social
· Aug 2
Postdoctoral Scholar – Clinical Neuroscience Research
University of California, Irvine is hiring. Apply now!
recruit.ap.uci.edu
Please share! 🙏 Outreach is difficult given current social media algorithms.
🥼🔬🧪🧑🔬 I am recruiting 2 or 3 postdocs in Alzheimer’s and Dementia, Epidemiology, and Translational Neuroscience!
recruit.ap.uci.edu/JPF09486
🥼🔬🧪🧑🔬 I am recruiting 2 or 3 postdocs in Alzheimer’s and Dementia, Epidemiology, and Translational Neuroscience!
recruit.ap.uci.edu/JPF09486
Reposted by Ali Ezzati, MD
Please share! 🙏 Outreach is difficult given current social media algorithms.
🥼🔬🧪🧑🔬 I am recruiting 2 or 3 postdocs in Alzheimer’s and Dementia, Epidemiology, and Translational Neuroscience!
recruit.ap.uci.edu/JPF09486
🥼🔬🧪🧑🔬 I am recruiting 2 or 3 postdocs in Alzheimer’s and Dementia, Epidemiology, and Translational Neuroscience!
recruit.ap.uci.edu/JPF09486
Postdoctoral Scholar – Clinical Neuroscience Research
University of California, Irvine is hiring. Apply now!
recruit.ap.uci.edu
August 2, 2025 at 5:36 PM
Please share! 🙏 Outreach is difficult given current social media algorithms.
🥼🔬🧪🧑🔬 I am recruiting 2 or 3 postdocs in Alzheimer’s and Dementia, Epidemiology, and Translational Neuroscience!
recruit.ap.uci.edu/JPF09486
🥼🔬🧪🧑🔬 I am recruiting 2 or 3 postdocs in Alzheimer’s and Dementia, Epidemiology, and Translational Neuroscience!
recruit.ap.uci.edu/JPF09486
Please share! 🙏 Outreach is difficult given current social media algorithms.
🥼🔬🧪🧑🔬 I am recruiting 2 or 3 postdocs in Alzheimer’s and Dementia, Epidemiology, and Translational Neuroscience!
recruit.ap.uci.edu/JPF09486
🥼🔬🧪🧑🔬 I am recruiting 2 or 3 postdocs in Alzheimer’s and Dementia, Epidemiology, and Translational Neuroscience!
recruit.ap.uci.edu/JPF09486
Postdoctoral Scholar – Clinical Neuroscience Research
University of California, Irvine is hiring. Apply now!
recruit.ap.uci.edu
August 2, 2025 at 5:36 PM
Please share! 🙏 Outreach is difficult given current social media algorithms.
🥼🔬🧪🧑🔬 I am recruiting 2 or 3 postdocs in Alzheimer’s and Dementia, Epidemiology, and Translational Neuroscience!
recruit.ap.uci.edu/JPF09486
🥼🔬🧪🧑🔬 I am recruiting 2 or 3 postdocs in Alzheimer’s and Dementia, Epidemiology, and Translational Neuroscience!
recruit.ap.uci.edu/JPF09486
Can we predict who’s unlikely to decline in Alzheimer’s clinical trials ⁉️
In our new Neurology paper, we used machine learning to identify cognitively stable individuals in the placebo arm of EXPEDITION3—aiming to optimize trial design and boost power. 🔭
www.neurology.org/doi/10.1212/...
In our new Neurology paper, we used machine learning to identify cognitively stable individuals in the placebo arm of EXPEDITION3—aiming to optimize trial design and boost power. 🔭
www.neurology.org/doi/10.1212/...
A Machine Learning Approach to Predict Cognitive Decline in Alzheimer Disease Clinical Trials | Neurology
Background and ObjectivesAmong the participants of Alzheimer disease (AD) treatment trials, 40% do not show
cognitive decline over 80 weeks of follow-up. Identifying and excluding these individuals
ca...
www.neurology.org
March 28, 2025 at 11:12 PM
Can we predict who’s unlikely to decline in Alzheimer’s clinical trials ⁉️
In our new Neurology paper, we used machine learning to identify cognitively stable individuals in the placebo arm of EXPEDITION3—aiming to optimize trial design and boost power. 🔭
www.neurology.org/doi/10.1212/...
In our new Neurology paper, we used machine learning to identify cognitively stable individuals in the placebo arm of EXPEDITION3—aiming to optimize trial design and boost power. 🔭
www.neurology.org/doi/10.1212/...
1) what?
The Trump administration has terminated $800 million in grants to Johns Hopkins University, spurring the nation’s top spender on research and development to plan layoffs and cancel health projects
Johns Hopkins Plans Staff Layoffs After $800 Million Grant Cuts
Local and international health research efforts are already winding down as the university braces for even more potential cuts.
www.wsj.com
March 12, 2025 at 6:23 PM
1) what?
Very insightful.
I agree and add that imho:
Data sharing is the achilles heel of academia.
I agree and add that imho:
Data sharing is the achilles heel of academia.
I'm frustrated with the messaging that indiscriminate firings at NIH and proposed decimation of research via changes to indirect rates are about increasing efficiency. Here are some thoughts on how to actually increase returns to NIH investments. shorturl.at/KnWU9
#EpiSky #ScienceSky
#EpiSky #ScienceSky
Maria Glymour on LinkedIn: Building on 90 Years of Progress: Approaches to Increase Efficiency of…
#NIH #HealthResearch #Efficiency #Government
www.linkedin.com
February 17, 2025 at 4:04 AM
Very insightful.
I agree and add that imho:
Data sharing is the achilles heel of academia.
I agree and add that imho:
Data sharing is the achilles heel of academia.
Reposted by Ali Ezzati, MD
Live footage of the average NIH-funding academic as we cycle between maybe no longer having a job and court rulings allow NIH to resume evaluating and funding grants.
I do not recommend this life style, it sucks
Most of us just want to do important science unpeturbed.
I do not recommend this life style, it sucks
Most of us just want to do important science unpeturbed.
an elderly woman is riding a roller coaster with her mouth open .
ALT: an elderly woman is riding a roller coaster with her mouth open .
media.tenor.com
February 12, 2025 at 9:22 PM
Live footage of the average NIH-funding academic as we cycle between maybe no longer having a job and court rulings allow NIH to resume evaluating and funding grants.
I do not recommend this life style, it sucks
Most of us just want to do important science unpeturbed.
I do not recommend this life style, it sucks
Most of us just want to do important science unpeturbed.
Reposted by Ali Ezzati, MD
Trump & Musk are making massive cuts to the National Institutes of Health.
I know there is a lot going on right now, but this is one of worst things they have done so far, will affect cancer research and trials, the search for cures, innovation and competitiveness, our universities. Your lives.
I know there is a lot going on right now, but this is one of worst things they have done so far, will affect cancer research and trials, the search for cures, innovation and competitiveness, our universities. Your lives.
February 8, 2025 at 11:16 PM
Trump & Musk are making massive cuts to the National Institutes of Health.
I know there is a lot going on right now, but this is one of worst things they have done so far, will affect cancer research and trials, the search for cures, innovation and competitiveness, our universities. Your lives.
I know there is a lot going on right now, but this is one of worst things they have done so far, will affect cancer research and trials, the search for cures, innovation and competitiveness, our universities. Your lives.
Except in academia, nowhere in the U.S. economy can you hire PhDs or MDs for a meager salary of less than $70,000 (as postdocs or scientists) and still call it an over-expenditure & then trying to kill this business model with the excuse of "efficiency". It's absolutely ridiculous.
February 9, 2025 at 4:48 PM
Except in academia, nowhere in the U.S. economy can you hire PhDs or MDs for a meager salary of less than $70,000 (as postdocs or scientists) and still call it an over-expenditure & then trying to kill this business model with the excuse of "efficiency". It's absolutely ridiculous.
Reposted by Ali Ezzati, MD
I have not seen a crisis of this magnitude since yesterday
February 8, 2025 at 12:53 AM
I have not seen a crisis of this magnitude since yesterday
Reposted by Ali Ezzati, MD
The NIH overhead cut doesn't just hurt universities.
It's deadly to the US economy.
The US is a world leader in tech due to the ecosystem that NIH and NSF propel. It drives innovation for tech transfer, creates a highly-skilled sci/tech workforce, and fosters academic/industry crossfertilization.
It's deadly to the US economy.
The US is a world leader in tech due to the ecosystem that NIH and NSF propel. It drives innovation for tech transfer, creates a highly-skilled sci/tech workforce, and fosters academic/industry crossfertilization.
2. While NSF and NIH indeed have a mission to fund specific research innovations via grantmaking, they do a lot more than that.
Their principal role is support a scientific ecosystem in the United States, that includes everything from education and training to infrastructure and communication.
Their principal role is support a scientific ecosystem in the United States, that includes everything from education and training to infrastructure and communication.
February 8, 2025 at 2:03 AM
The NIH overhead cut doesn't just hurt universities.
It's deadly to the US economy.
The US is a world leader in tech due to the ecosystem that NIH and NSF propel. It drives innovation for tech transfer, creates a highly-skilled sci/tech workforce, and fosters academic/industry crossfertilization.
It's deadly to the US economy.
The US is a world leader in tech due to the ecosystem that NIH and NSF propel. It drives innovation for tech transfer, creates a highly-skilled sci/tech workforce, and fosters academic/industry crossfertilization.
Can someone tell us (Scientists) if we all need to search for a new job or what? Acadmec work is already impossible for physician scientists (& others). We don't need more hurdles. Universities are going to stop functioning with a shock of this magnitude.
grants.nih.gov/grants/guide...
grants.nih.gov/grants/guide...
NOT-OD-25-068: Supplemental Guidance to the 2024 NIH Grants Policy Statement: Indirect Cost Rates
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Supplemental Guidance to the 2024 NIH Grants Policy Statement: Indirect Cost Rates NOT-OD-25-068. OD
grants.nih.gov
February 8, 2025 at 2:23 AM
Can someone tell us (Scientists) if we all need to search for a new job or what? Acadmec work is already impossible for physician scientists (& others). We don't need more hurdles. Universities are going to stop functioning with a shock of this magnitude.
grants.nih.gov/grants/guide...
grants.nih.gov/grants/guide...
I’m not sure which academics need to hear this, but kindness costs nothing—and it makes all the difference. The people I remember and want to collaborate with are the ones who lead with respect and empathy.
February 1, 2025 at 2:31 AM
I’m not sure which academics need to hear this, but kindness costs nothing—and it makes all the difference. The people I remember and want to collaborate with are the ones who lead with respect and empathy.
Kudos to all my fellow researchers working hard this week to finalize their abstracts for AAIC! Drop a comment below, and I'll make sure to attend your presentation in Toronto. Let's support each other!
January 25, 2025 at 5:31 AM
Kudos to all my fellow researchers working hard this week to finalize their abstracts for AAIC! Drop a comment below, and I'll make sure to attend your presentation in Toronto. Let's support each other!
Reposted by Ali Ezzati, MD
Most folks do not understand how far in advance the planning and logistics of NIH grants take.
We prepare for months or years for these submissions for one of 3 cycles per year.
This study section cancellation delays grants by at least 6 months when study sections are cancelled.
We prepare for months or years for these submissions for one of 3 cycles per year.
This study section cancellation delays grants by at least 6 months when study sections are cancelled.
January 22, 2025 at 11:44 PM
Most folks do not understand how far in advance the planning and logistics of NIH grants take.
We prepare for months or years for these submissions for one of 3 cycles per year.
This study section cancellation delays grants by at least 6 months when study sections are cancelled.
We prepare for months or years for these submissions for one of 3 cycles per year.
This study section cancellation delays grants by at least 6 months when study sections are cancelled.
Reposted by Ali Ezzati, MD
If you’ve been directly impacted by a pause or cancellation of an NIH study session, we @forbes.com would like to talk to you
All NIH study sections canceled indefinitely. This will halt science and devastate research budgets in universities.
January 22, 2025 at 10:59 PM
If you’ve been directly impacted by a pause or cancellation of an NIH study session, we @forbes.com would like to talk to you
This is an excellent read. I agree that we're perhaps jumping the gun by labeling amyloid as the ultimate root cause of everything Alzheimer's.
An Open Letter to Dennis J. Selkoe, M.D. | ALZFORUM
www.alzforum.org
December 24, 2024 at 12:13 AM
This is an excellent read. I agree that we're perhaps jumping the gun by labeling amyloid as the ultimate root cause of everything Alzheimer's.
Literally everyone in Academia after Thanksgiving.
December 20, 2024 at 4:00 AM
Literally everyone in Academia after Thanksgiving.
A good read on probability
Why probability probably doesn’t exist (but it is useful to act like it does)
All of statistics and much of science depends on probability — an astonishing achievement, considering no one’s really sure what it is.
www.nature.com
December 20, 2024 at 2:22 AM
A good read on probability
Help needed!
Colleagues in Alzheimer's (or other clinical research), what are some of the resources that you use for teachings basics of biology and clinical aspects to new lab members who come from non-biological and non-medical fields? e.g. Someone from statistics or informatics background.
Colleagues in Alzheimer's (or other clinical research), what are some of the resources that you use for teachings basics of biology and clinical aspects to new lab members who come from non-biological and non-medical fields? e.g. Someone from statistics or informatics background.
December 10, 2024 at 12:25 AM
Help needed!
Colleagues in Alzheimer's (or other clinical research), what are some of the resources that you use for teachings basics of biology and clinical aspects to new lab members who come from non-biological and non-medical fields? e.g. Someone from statistics or informatics background.
Colleagues in Alzheimer's (or other clinical research), what are some of the resources that you use for teachings basics of biology and clinical aspects to new lab members who come from non-biological and non-medical fields? e.g. Someone from statistics or informatics background.
Ok, so how should we interpret impact scores for R01s? Isn't it a simple average of scores?
So an impact score of 40 could be much better than a percentile score of 20 in theory?
So an impact score of 40 could be much better than a percentile score of 20 in theory?
December 7, 2024 at 6:33 PM
Ok, so how should we interpret impact scores for R01s? Isn't it a simple average of scores?
So an impact score of 40 could be much better than a percentile score of 20 in theory?
So an impact score of 40 could be much better than a percentile score of 20 in theory?
It only took 14 months for us to publish this. Isn't it amazing? 😬
I am happy see this paper get published this week. It was a fun project to work on with @ae-md.bsky.social and others.
"MRI-guided clustering of patients with mild dementia due to Alzheimer's disease using self-organizing maps"
www.sciencedirect.com/science/arti...
"MRI-guided clustering of patients with mild dementia due to Alzheimer's disease using self-organizing maps"
www.sciencedirect.com/science/arti...
November 22, 2024 at 3:27 PM
It only took 14 months for us to publish this. Isn't it amazing? 😬
Yes. 100%
November 21, 2024 at 4:04 AM
Yes. 100%
Reposted by Ali Ezzati, MD
I am happy see this paper get published this week. It was a fun project to work on with @ae-md.bsky.social and others.
"MRI-guided clustering of patients with mild dementia due to Alzheimer's disease using self-organizing maps"
www.sciencedirect.com/science/arti...
"MRI-guided clustering of patients with mild dementia due to Alzheimer's disease using self-organizing maps"
www.sciencedirect.com/science/arti...
November 20, 2024 at 5:34 PM
I am happy see this paper get published this week. It was a fun project to work on with @ae-md.bsky.social and others.
"MRI-guided clustering of patients with mild dementia due to Alzheimer's disease using self-organizing maps"
www.sciencedirect.com/science/arti...
"MRI-guided clustering of patients with mild dementia due to Alzheimer's disease using self-organizing maps"
www.sciencedirect.com/science/arti...
One of the stranger things that I've seen in the "grant writing business" is that some people put a lot of time into one grant then after first failure they just give up or don't follow with another submission or resubmition. Basically valuing that 2-3 months effort they put in as none.
November 19, 2024 at 6:53 PM
One of the stranger things that I've seen in the "grant writing business" is that some people put a lot of time into one grant then after first failure they just give up or don't follow with another submission or resubmition. Basically valuing that 2-3 months effort they put in as none.