Adrià Sogues
@adriasogues.bsky.social
Spores, Bacterial S-layers, Cell Envelope & Cell Division. Structural Microbiologist 💎❄️🔬 at Institut Pasteur (Paris). Formerly at VIB-VUB in Brussels (EMBO & MSCA fellow) 🇫🇷🇧🇪🇪🇸
Thanks Yoann! I always hoped to come back, even though I had an amazing time in Brussels! I’ll definitely miss it!
September 18, 2025 at 9:28 AM
Thanks Yoann! I always hoped to come back, even though I had an amazing time in Brussels! I’ll definitely miss it!
Don’t forget to check out the fantastic complementary work by @tbharat-lab.bsky.social and @bupbuse.bsky.social
journals.plos.org/plosbiology/...
journals.plos.org/plosbiology/...
Mapping the ultrastructural topology of the corynebacterial cell surface
The unique cell envelope of corynebacteria remains poorly understood at the ultrastructural level. This study maps the C. glutamicum cell surface, revealing a patchy S-layer organization and the speci...
journals.plos.org
July 30, 2025 at 5:06 AM
Don’t forget to check out the fantastic complementary work by @tbharat-lab.bsky.social and @bupbuse.bsky.social
journals.plos.org/plosbiology/...
journals.plos.org/plosbiology/...
Huge thanks to all the co-authors: @mikesleutel.bsky.social and @remaut-lab.bsky.social (from VIB-VUB), Julienne Petit and Anne Marie Wehenkel (from @pasteur.fr @ipdbsc.bsky.social), Nicolas Bayan(from @i2bcparissaclay.bsky.social ) and Daniela Megrian (from @ipmontevideo.bsky.social)
July 30, 2025 at 5:04 AM
Huge thanks to all the co-authors: @mikesleutel.bsky.social and @remaut-lab.bsky.social (from VIB-VUB), Julienne Petit and Anne Marie Wehenkel (from @pasteur.fr @ipdbsc.bsky.social), Nicolas Bayan(from @i2bcparissaclay.bsky.social ) and Daniela Megrian (from @ipmontevideo.bsky.social)
4/4🧵Finally, we believe that our engineered PS2 S-layer can be exploited in the biomaterials and cell display fields, as S-layers are regular self-assembling platforms in which we can now bind other proteins covalently. We've also added our plasmids to @addgene.bsky.social
July 30, 2025 at 4:57 AM
4/4🧵Finally, we believe that our engineered PS2 S-layer can be exploited in the biomaterials and cell display fields, as S-layers are regular self-assembling platforms in which we can now bind other proteins covalently. We've also added our plasmids to @addgene.bsky.social
3/4🧵How does the S-layer grow during cell division? Using pulse-chase labeling with the SpyTag-SpyCatcher system, we discovered that new S-layer is inserted exclusively at the cell poles, exactly where peptidoglycan synthesis occurs. S-layer assembly and growth are tightly coordinated!
July 30, 2025 at 4:56 AM
3/4🧵How does the S-layer grow during cell division? Using pulse-chase labeling with the SpyTag-SpyCatcher system, we discovered that new S-layer is inserted exclusively at the cell poles, exactly where peptidoglycan synthesis occurs. S-layer assembly and growth are tightly coordinated!
2/4🧵We show across different strains that the S-layer provides mechanical support to the cell wall, especially when it's compromised (such as after lysozyme treatment). The S-layer acts as a protective scaffold, reinforcing the envelope under stress.
July 30, 2025 at 4:55 AM
2/4🧵We show across different strains that the S-layer provides mechanical support to the cell wall, especially when it's compromised (such as after lysozyme treatment). The S-layer acts as a protective scaffold, reinforcing the envelope under stress.
1/4🧵 We show across different strains that the S-layer provides mechanical support to the cell wall, especially when it's compromised (such as after lysozyme treatment). The S-layer acts as a protective scaffold, reinforcing the envelope under stress.
July 30, 2025 at 4:54 AM
1/4🧵 We show across different strains that the S-layer provides mechanical support to the cell wall, especially when it's compromised (such as after lysozyme treatment). The S-layer acts as a protective scaffold, reinforcing the envelope under stress.