We analyzed development of activity over time across the different cell lines. The dissociated organoids had unsynchronized activity to begin with, but firing became synchronized across electrodes over time, and this happened across different cell lines. [Warning - video has flashing imagery.] 3/5

We grew unguided human neural organoids from four different ESC and iPSC lines and then dissociated them to 2D cultures that we plated onto micro electrode plates. We then recorded activity over time to characterize these networks and how that vary between lines and batches. 2/5

Excited to share our newest preprint, Electrophysiological development and functional plasticity in dissociated human cerebral #organoids across multiple cell lines 🧠🔬🧪: doi.org/10.1101/2025... This is based on some of the work I did in my PhD with the great @ncndgroup.bsky.social 1/5

Excited to have passed my PhD viva yesterday with no corrections! Thank you to my examiners Prof. John Mason and Prof. Marisa Karow, as well as everyone that has supported me on this journey, especially my amazing supervisors Prof. Deepak Srivastava and Prof. Anthony Vernon and the Srivastava lab!