When a larval zebrafish twitches its tail, the vascular endothelium lights up with a calcium signal, mediated by Piezo1. We used to think mechanosensing in endothelial cells was about sensing blood flow, but at least in this case it's about sensing body motion.

History of modern art: abstracts expressionism and cerealism.

Jurassic parking.

Using light to sculpt vertebrate development! OptoNodal2 converts patterns of illumination into patterns of morphogen signaling.
journals.biologists.com/dev/article/...

It's such a trip to see former lab members flourish (fluoresce?) in their independent careers. Four generations present at the Dendrites GRC!

At the Dendrites GRC. Now where, oh where, did I park?

Did you know that when zebrafish swim, this motion evokes calcium signals in their *blood vessels*? Bill Jia and Xin Tang showed that this effect is mediated by Piezo1, and only requires physical motion, not neural activity or blood flow.

We use this code in almost all our projects, from optical electrophysiology to magnetochemistry to developmental biology.

Katherine worked out the photocycle, measured the rates, and built a quantitative model which reproduces her data in purified protein and in live E. coli.

Weak magnetic fields can induce >20% changes in the fluorescence of mScarlet3 in E. coli! It's not a subtle effect.

Our digital overlords are drunk. From my inbox: