Interpreting the viral mechanism of SARS-CoV-2 based on the human body level is critical for developing more efficient interventions. Due to the limit…

West Nile virus (WNV) persists in an enzootic cycle between birds and mosquitoes. Human infections are incidental and usually sub-clinical with some cases of neuroinvasive disease. Mitigation relies on surveillance to guide decision making, including RT-qPCR testing pools of mosquitoes. Cycle threshold (Ct) values from these pools\---|semi-quantitative proxies for viral load\---|are binarised to estimate WNV prevalence in mosquitoes as a proxy for human risk. We showed that Ct value variation in Colorado and Nebraska (2022-2024) cannot be explained by laboratory factors, suggesting a role for biological and epidemiological mechanisms. We developed a multiscale model linking pooled Ct values to mosquito viral kinetics, bird-to-mosquito transmission, and seasonal force of infection. A novel method estimating WNV prevalence using pooled Ct values outperformed existing approaches at high prevalence. We demonstrate the importance of treating environmental viral load samples as quantitative, as binarising masks key information for arbovirus surveillance and risk mitigation. ### Competing Interest Statement The authors have declared no competing interest. Wellcome Trust Early Career Award, grant 225001/Z/22/Z UNMC VCR

Avian Influenza A(H5N1) Isolated from Dairy Farm Worker, Michigan

Job description We are recruiting postdocs to contribute to research projects in the Mathematical Modelling of Infectious Diseases Unit, at Institut Pasteur in Paris. The candidates will be expected t...

Please note that job descriptions are not exhaustive, and you may be asked to take on additional duties that align with the key responsibilities ment...

This talk brings together experts in pathogen genomics, virology, ecology, climate science, and data science to explore how AI, genomic surveillance, and…

Introduction: Scabies is a contagious skin disease caused by the infestation of the skin by the Sarcopes scabiei mite, causing an itchy rash. Scabies affects ov

There has been interest in the interactions between infectious disease dynamics and behaviour for most of the history of mathematical epidemiology. This has included consideration of which mathematica...

Grant terminations halt research on improving vaccinations and preventing future pandemics

Influenza of avian origin (H5N1) has been confirmed in a single sheep in Yorkshire.

Effective control of viral infection requires rapid induction of the innate immune response, especially the type I and type III interferon (IFN) systems. Despite the critical role of IFN induction in ...

Published in Journal of Mathematics and the Arts (Ahead of Print, 2025)

PhD Project - Deepening our understanding of cross-species antibody responses to H5Nx influenza viruses at The Pirbright Institute, listed on FindAPhD.com

Careers at The University of Melbourne

Mathematical models have provided a general framework for understanding the dynamics and control of infectious disease. Many compartmental models are limited in that they do not account for the range ...

The Bloomsbury Colleges group was set up in 2004 and consists of five institutions: Birkbeck, London School of Hygiene & Tropical Medicine (LSHTM), the Royal Veterinary College (RVC), the School of Or...