You were right! It should be fixed now

And @laurenatlas.bsky.social is also on this site

I think @francescafardo.bsky.social should also be added ☺️

Hi! Could you add me to it? I am a pain neuroscientist interested in how we perceive temperature stimuli and how these perceptions are influenced by expectations

Thank you to all the people involved in this project and the funders who made it possible to pursue it!
And thank you @micahgallen.com for the thread writing advice!

In the paper, we speculate about possible mechanisms, which include crosstalk between the vascular and the nociceptive systems. Overall, we are left with more questions than answers but we think we have laid the groundwork for future investigations of this intriguing phenomenon!

Contrary to our hypothesis, this effect did not seem caused by the heterosynaptic long-term potentiation like mechanisms underlying pinprick secondary hyperalgesia (central sensitization), as evidenced by the lack of temporal correlation between the decays of both phenomena.

Our results show that the arm raising effect is very robust and that it is driven by the position of the arm relative to the ground (gravity) rather than to the body (i.e., the effect is the same when the arm is vertical, whether a person is sitting or lying down).

Intrigued, we set out to replicate this phenomenon and investigate its mechanism. To do so, we repeatedly probed sensations evoked by a capsaicin and a vehicle patch, in resting position and during arm raising, as well as pinprick secondary hyperalgesia (central sensitization).

We stumbled upon this phenomenon while piloting a different experiment. Sabien van Neerven was at her desk, wearing a capsaicin patch on her forearm. When she casually placed her hands behind her head, the pain -which had faded- suddenly flared up, becoming excruciating.