Contrary to our hypothesis, this effect did not seem caused by the heterosynaptic long-term potentiation like mechanisms underlying pinprick secondary hyperalgesia (central sensitization), as evidenced by the lack of temporal correlation between the decays of both phenomena.

Our results show that the arm raising effect is very robust and that it is driven by the position of the arm relative to the ground (gravity) rather than to the body (i.e., the effect is the same when the arm is vertical, whether a person is sitting or lying down).

Is our sensitivity to pain influenced by signals coming from our blood vessels? This could explain why when we raise the arm on which a capsaicin patch is applied, the pain becomes much worse, a phenomenon we describe and probe in our latest paper doi.org/10.1002/ejp....
A 🧵

The Body Pain and Perception Lab will be well represented at the EFIC congress next week!
Here is a little summary of what we will be presenting.
Looking forward to discuss pain science with old and new friends in Budapest 😊 #EFIC2023

The effect is less visually striking that way but still present