Ahmed Alhendi
@aalhendi.bsky.social
Bioinformatician | Senior Research Fellow @UCL | Multicomics | Early lung cancer
Reposted by Ahmed Alhendi
Nature research paper: Clonal driver neoantigen loss under EGFR TKI and immune selection pressures
https://go.nature.com/4k6SCQD
https://go.nature.com/4k6SCQD
Clonal driver neoantigen loss under EGFR TKI and immune selection pressures - Nature
We show the evolution of a case of EGFR mutant lung cancer treated with a combination of erlotinib, osimertinib, radiotherapy and a personalized neopeptide vaccine targeting somatic mutations, including EGFR exon 19 deletion.
go.nature.com
February 20, 2025 at 2:49 PM
Nature research paper: Clonal driver neoantigen loss under EGFR TKI and immune selection pressures
https://go.nature.com/4k6SCQD
https://go.nature.com/4k6SCQD
New paper published in Science: www.science.org/doi/10.1126/...
Proud to have contributed to this amazing work, driving the informatics analysis. A huge team effort from the @lungs4living.bsky.social team 💙 and brilliant collaborators at @sangerinstitute.bsky.social
Proud to have contributed to this amazing work, driving the informatics analysis. A huge team effort from the @lungs4living.bsky.social team 💙 and brilliant collaborators at @sangerinstitute.bsky.social
Aberrant basal cell clonal dynamics shape early lung carcinogenesis
Preinvasive squamous lung lesions are precursors of lung squamous cell carcinoma (LUSC). The cellular events underlying lesion formation are unknown. Using a carcinogen-induced model of LUSC with no a...
www.science.org
May 2, 2025 at 4:19 PM
New paper published in Science: www.science.org/doi/10.1126/...
Proud to have contributed to this amazing work, driving the informatics analysis. A huge team effort from the @lungs4living.bsky.social team 💙 and brilliant collaborators at @sangerinstitute.bsky.social
Proud to have contributed to this amazing work, driving the informatics analysis. A huge team effort from the @lungs4living.bsky.social team 💙 and brilliant collaborators at @sangerinstitute.bsky.social
Reposted by Ahmed Alhendi
Our work describing the biological mechanisms driving the formation of a cancerized field in the airways is now out @science.org!
Huge team effort from @lungs4living.bsky.social and amazing collaborators to delineate the origin of precancerous lung disease 🫁
www.science.org/doi/full/10....
Huge team effort from @lungs4living.bsky.social and amazing collaborators to delineate the origin of precancerous lung disease 🫁
www.science.org/doi/full/10....
www.science.org
May 2, 2025 at 12:14 PM
Our work describing the biological mechanisms driving the formation of a cancerized field in the airways is now out @science.org!
Huge team effort from @lungs4living.bsky.social and amazing collaborators to delineate the origin of precancerous lung disease 🫁
www.science.org/doi/full/10....
Huge team effort from @lungs4living.bsky.social and amazing collaborators to delineate the origin of precancerous lung disease 🫁
www.science.org/doi/full/10....
Reposted by Ahmed Alhendi
Yuki Ishii, @jess0rr.bsky.social Sam Janes, @robhynds.bsky.social @epicentr.bsky.social & team identify Wnt pathway activators as potential pro-regenerative therapies in their compound screen in human airway basal cells.
journals.biologists.com/jcs/article/...
journals.biologists.com/jcs/article/...
journals.biologists.com/jcs/article/...
journals.biologists.com/jcs/article/...
April 17, 2025 at 12:52 PM
Yuki Ishii, @jess0rr.bsky.social Sam Janes, @robhynds.bsky.social @epicentr.bsky.social & team identify Wnt pathway activators as potential pro-regenerative therapies in their compound screen in human airway basal cells.
journals.biologists.com/jcs/article/...
journals.biologists.com/jcs/article/...
journals.biologists.com/jcs/article/...
journals.biologists.com/jcs/article/...
Reposted by Ahmed Alhendi
🚀 Our paper introducing ImmuneLENS, a new tool that measures T and B cell fractions from WGS data. This builds on our previous method, T cell ExTRECT, that used a signal from V(D)J recombination to measure T cells.
Out today in @naturegenet.bsky.social :
doi.org/10.1038/s41588-025-02086-5
🧵👇
Out today in @naturegenet.bsky.social :
doi.org/10.1038/s41588-025-02086-5
🧵👇
ImmuneLENS characterizes systemic immune dysregulation in aging and cancer - Nature Genetics
Immune lymphocyte estimation from nucleotide sequencing (ImmuneLENS) infers B cell and T cell fractions from whole-genome sequencing data. Applied to the 100,000 Genomes Project datasets, circulating ...
www.nature.com
February 18, 2025 at 3:24 PM
🚀 Our paper introducing ImmuneLENS, a new tool that measures T and B cell fractions from WGS data. This builds on our previous method, T cell ExTRECT, that used a signal from V(D)J recombination to measure T cells.
Out today in @naturegenet.bsky.social :
doi.org/10.1038/s41588-025-02086-5
🧵👇
Out today in @naturegenet.bsky.social :
doi.org/10.1038/s41588-025-02086-5
🧵👇