Danica Milovanović
@1995dana.bsky.social
scientist | pacifist | transposable elements | evo-devo
PhD @trono-lab.bsky.social @ EPFL
PhD @trono-lab.bsky.social @ EPFL
Restricted enhancers are active in variety of other tissues 🧠🫁...
May 19, 2025 at 3:05 PM
Restricted enhancers are active in variety of other tissues 🧠🫁...
What happens on a molecular level? 🧬
ZNF436 associates preferentially with PBAF subunits of SWI/SNF and limits the accessibility at L2/MIR-derived enhancers
ZNF436 associates preferentially with PBAF subunits of SWI/SNF and limits the accessibility at L2/MIR-derived enhancers
May 19, 2025 at 2:54 PM
What happens on a molecular level? 🧬
ZNF436 associates preferentially with PBAF subunits of SWI/SNF and limits the accessibility at L2/MIR-derived enhancers
ZNF436 associates preferentially with PBAF subunits of SWI/SNF and limits the accessibility at L2/MIR-derived enhancers
🧬 Loss of ZNF436 leads to impaired cardiomyocyte contractility 🫀
May 19, 2025 at 2:51 PM
🧬 Loss of ZNF436 leads to impaired cardiomyocyte contractility 🫀
🧬 Loss of ZNF436 leads to:
⬇️ downregulation of cardiac genes
⬆️ upregulation of non-cardiac, alternative lineage programs
⬇️ downregulation of cardiac genes
⬆️ upregulation of non-cardiac, alternative lineage programs
May 19, 2025 at 2:10 PM
🧬 Loss of ZNF436 leads to:
⬇️ downregulation of cardiac genes
⬆️ upregulation of non-cardiac, alternative lineage programs
⬇️ downregulation of cardiac genes
⬆️ upregulation of non-cardiac, alternative lineage programs
We first mapped the chromatin state of KZFP-bound TEs in the human genome and found a new twist:
Even ancient TEs (like L2/MIR elements) are preferential KZFP targets — however, without much of the usual H3K9me3 silencing.
Even ancient TEs (like L2/MIR elements) are preferential KZFP targets — however, without much of the usual H3K9me3 silencing.
May 19, 2025 at 2:02 PM
We first mapped the chromatin state of KZFP-bound TEs in the human genome and found a new twist:
Even ancient TEs (like L2/MIR elements) are preferential KZFP targets — however, without much of the usual H3K9me3 silencing.
Even ancient TEs (like L2/MIR elements) are preferential KZFP targets — however, without much of the usual H3K9me3 silencing.
New preprint of @trono-lab.bsky.social and my PhD work!
By modulating SWI/SNF remodeling at ancient transposable elements - LINE/L2s and SINE/MIRs, a "noncanonical" KZFP called ZNF436 protects cardiomyocytes from losing their identity.
🫀heartbeat on 🔁 repeat
www.biorxiv.org/content/10.1... #TEsky
By modulating SWI/SNF remodeling at ancient transposable elements - LINE/L2s and SINE/MIRs, a "noncanonical" KZFP called ZNF436 protects cardiomyocytes from losing their identity.
🫀heartbeat on 🔁 repeat
www.biorxiv.org/content/10.1... #TEsky
May 19, 2025 at 2:01 PM
New preprint of @trono-lab.bsky.social and my PhD work!
By modulating SWI/SNF remodeling at ancient transposable elements - LINE/L2s and SINE/MIRs, a "noncanonical" KZFP called ZNF436 protects cardiomyocytes from losing their identity.
🫀heartbeat on 🔁 repeat
www.biorxiv.org/content/10.1... #TEsky
By modulating SWI/SNF remodeling at ancient transposable elements - LINE/L2s and SINE/MIRs, a "noncanonical" KZFP called ZNF436 protects cardiomyocytes from losing their identity.
🫀heartbeat on 🔁 repeat
www.biorxiv.org/content/10.1... #TEsky