Wolfram Zückert
@wolfzueckert.bsky.social
🇨🇭🇺🇸 in 🌻• Professor • Spirochetal envelope biogenesis, lipoprotein secretion mechanisms, protein structure-function • he/him/his • AOMO • US Immigrant and X Emirant
Reposted by Wolfram Zückert
Human exposure to spirochete-infected Ornithodoros turicata collected from the home of an individual in the Austin, Texas Metropolitan Area https://www.biorxiv.org/content/10.1101/2025.11.12.688062v1
November 13, 2025 at 3:17 AM
Human exposure to spirochete-infected Ornithodoros turicata collected from the home of an individual in the Austin, Texas Metropolitan Area https://www.biorxiv.org/content/10.1101/2025.11.12.688062v1
Reposted by Wolfram Zückert
The University of Minnesota just announced the "Meal-A-Day Program" which will provide one meal a day for SNAP benefit recipients while the SNAP program is limited or unavailable. This makes me very happy. A lot of students, faculty, and staff at the U need this, unfortunately.
November 3, 2025 at 8:53 PM
The University of Minnesota just announced the "Meal-A-Day Program" which will provide one meal a day for SNAP benefit recipients while the SNAP program is limited or unavailable. This makes me very happy. A lot of students, faculty, and staff at the U need this, unfortunately.
Roseola – HHV-6/7 before it was cool...
November 3, 2025 at 2:21 AM
Roseola – HHV-6/7 before it was cool...
Reposted by Wolfram Zückert
Mark your calendars! #mmpc2026 The 2026 Midwest Microbial Pathogenesis Conference will be take place September 25-27, 2026 at the University of Minnesota! We are excited to welcome keynote speaker Dr. Andy Camilli. Give us a follow and watch for important information here ➡️ mmpc2026.umn.edu
Midwest Microbial Pathogenesis Conference | Midwest Microbial Pathogenesis Conference 2026
mmpc2026.umn.edu
October 23, 2025 at 10:59 PM
Mark your calendars! #mmpc2026 The 2026 Midwest Microbial Pathogenesis Conference will be take place September 25-27, 2026 at the University of Minnesota! We are excited to welcome keynote speaker Dr. Andy Camilli. Give us a follow and watch for important information here ➡️ mmpc2026.umn.edu
When you manage to sneak “6 7” into a conversation about Toll-like receptors 😎
My work here is done. #AcademicLife #ScienceHumor
My work here is done. #AcademicLife #ScienceHumor
October 22, 2025 at 7:42 PM
When you manage to sneak “6 7” into a conversation about Toll-like receptors 😎
My work here is done. #AcademicLife #ScienceHumor
My work here is done. #AcademicLife #ScienceHumor
We’re hiring! KUMC's Dept. of Microbiol., Mol. Genet. & Immunol. seeks a new Asst. Professor in Immunology. Be part of a vibrant department and benefit from association with the NCI-designated KU Cancer Center. Come join us in Kansas City! Apply here: kumc.wd5.myworkdayjobs.com/en-US/kumc-j...
October 20, 2025 at 8:57 PM
We’re hiring! KUMC's Dept. of Microbiol., Mol. Genet. & Immunol. seeks a new Asst. Professor in Immunology. Be part of a vibrant department and benefit from association with the NCI-designated KU Cancer Center. Come join us in Kansas City! Apply here: kumc.wd5.myworkdayjobs.com/en-US/kumc-j...
Reposted by Wolfram Zückert
after millions of views and shares of my Portland Frog art. (thank you all🙏🏾) I got requests to highlight priests, and chickens, and Chicagoans, and T-Rexes, and more… all of us who refuse to bend the knee. so this is for US.
𝚂𝚝𝚊𝚗𝚍 𝚃𝚊𝚕𝚕.
𝚆𝚎 𝚆𝚒𝚕𝚕 𝚆𝚒𝚗.
𝚂𝚝𝚊𝚗𝚍 𝚃𝚊𝚕𝚕.
𝚆𝚎 𝚆𝚒𝚕𝚕 𝚆𝚒𝚗.
October 10, 2025 at 9:11 PM
after millions of views and shares of my Portland Frog art. (thank you all🙏🏾) I got requests to highlight priests, and chickens, and Chicagoans, and T-Rexes, and more… all of us who refuse to bend the knee. so this is for US.
𝚂𝚝𝚊𝚗𝚍 𝚃𝚊𝚕𝚕.
𝚆𝚎 𝚆𝚒𝚕𝚕 𝚆𝚒𝚗.
𝚂𝚝𝚊𝚗𝚍 𝚃𝚊𝚕𝚕.
𝚆𝚎 𝚆𝚒𝚕𝚕 𝚆𝚒𝚗.
Known to me as the «Barf and Polish» approach…
It’s been described to me as ‘write something, so you have something to change’
It’s true. If I had learned this… I dunno, 35 years ago?… I’d have had a very different writing career.
August 17, 2025 at 1:42 PM
Known to me as the «Barf and Polish» approach…
Reposted by Wolfram Zückert
Yesterday, I noted that the missing funding for non-competitive renewals and new awards had decreased from June to July by approximately $1.99 B.
It appears that ~$0.28 B is due to the use of multi-year funding.
This still represents 651 grants and investigators that could have been funded.
8/9
It appears that ~$0.28 B is due to the use of multi-year funding.
This still represents 651 grants and investigators that could have been funded.
8/9
August 14, 2025 at 8:54 PM
Yesterday, I noted that the missing funding for non-competitive renewals and new awards had decreased from June to July by approximately $1.99 B.
It appears that ~$0.28 B is due to the use of multi-year funding.
This still represents 651 grants and investigators that could have been funded.
8/9
It appears that ~$0.28 B is due to the use of multi-year funding.
This still represents 651 grants and investigators that could have been funded.
8/9
Reposted by Wolfram Zückert
My quote of the day
This is no time for ease and comfort. It is time to dare and endure.
Winston Churchill
This is no time for ease and comfort. It is time to dare and endure.
Winston Churchill
August 12, 2025 at 11:52 AM
My quote of the day
This is no time for ease and comfort. It is time to dare and endure.
Winston Churchill
This is no time for ease and comfort. It is time to dare and endure.
Winston Churchill
Reposted by Wolfram Zückert
Fantastic preprint of Bert van den Berg, @sykhalid.bsky.social Syma Khalid, and colleagues on the molecular mechanism of how phages target LptD as host receptor👇🏼🧬🔐
Small siphophage binding to an open state of the LptDE outer membrane lipopolysaccharide translocon https://www.biorxiv.org/content/10.1101/2025.07.07.663478v1
July 8, 2025 at 7:44 PM
Fantastic preprint of Bert van den Berg, @sykhalid.bsky.social Syma Khalid, and colleagues on the molecular mechanism of how phages target LptD as host receptor👇🏼🧬🔐
Reposted by Wolfram Zückert
Predicted structures from the AFDB are poor substitutes for experimental structures when training inverse folding NNs. Here, authors show that this is because they are "too perfect", and passing them through a custom-trained AFDB-to-PDB NN helps fix this
threadreaderapp.com/thread/19384...
threadreaderapp.com/thread/19384...
June 27, 2025 at 11:33 AM
Predicted structures from the AFDB are poor substitutes for experimental structures when training inverse folding NNs. Here, authors show that this is because they are "too perfect", and passing them through a custom-trained AFDB-to-PDB NN helps fix this
threadreaderapp.com/thread/19384...
threadreaderapp.com/thread/19384...
Reposted by Wolfram Zückert
Science is an economic driver in Hamilton, Mont., thanks to Rocky Mountain Laboratories, a federal research lab. Now, layoffs and funding cuts are having an impact in this town far from Washington.
A small Montana town grapples with the fallouts from federal worker cuts
Science is an economic driver in Hamilton, Mont., thanks to Rocky Mountain Laboratories, a federal research lab. Now, layoffs and funding cuts are having an impact in this town far from Washington.
www.npr.org
May 26, 2025 at 3:12 PM
Science is an economic driver in Hamilton, Mont., thanks to Rocky Mountain Laboratories, a federal research lab. Now, layoffs and funding cuts are having an impact in this town far from Washington.
Seriously cool paper that helps explain how the agent of Q fever is idiosyncratically able to thrive in an acidified phagolysosome by pumping out a host protease! 🧪🧫🦠 #MicroSky
Excited to share this story from my PhD, out today in Nature Communications! We show that Coxiella removes cathepsin B to reduce lysosomal hostility and promote bacterial success. This depends on a vacuole established by effector CvpB.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Coxiella burnetii manipulates the lysosomal protease cathepsin B to facilitate intracellular success - Nature Communications
The zoonotic pathogen Coxiella burnetiiestablishes a unique intracellular niche within a lysosome-derived vacuole. Here Bird et al. undertook proteomic, cell biology and microbiology approaches to cha...
www.nature.com
April 25, 2025 at 12:43 PM
Seriously cool paper that helps explain how the agent of Q fever is idiosyncratically able to thrive in an acidified phagolysosome by pumping out a host protease! 🧪🧫🦠 #MicroSky
Reposted by Wolfram Zückert
"The peptidoglycan of Borrelia burgdorferi can persist in discrete tissues and cause systemic responses consistent with chronic illness"
Yet another important publication from @jutraslab.bsky.social, @lochhead.bsky.social, and colleagues.
www.science.org/doi/10.1126/...
#MicroSky 🦠🧫🔬
Yet another important publication from @jutraslab.bsky.social, @lochhead.bsky.social, and colleagues.
www.science.org/doi/10.1126/...
#MicroSky 🦠🧫🔬
The peptidoglycan of Borrelia burgdorferi can persist in discrete tissues and cause systemic responses consistent with chronic illness
Polymeric Borrelia burgdorferi peptidoglycan cell wall can persist in murine livers for weeks to months after direct injection or infection.
www.science.org
April 24, 2025 at 12:25 PM
"The peptidoglycan of Borrelia burgdorferi can persist in discrete tissues and cause systemic responses consistent with chronic illness"
Yet another important publication from @jutraslab.bsky.social, @lochhead.bsky.social, and colleagues.
www.science.org/doi/10.1126/...
#MicroSky 🦠🧫🔬
Yet another important publication from @jutraslab.bsky.social, @lochhead.bsky.social, and colleagues.
www.science.org/doi/10.1126/...
#MicroSky 🦠🧫🔬
The new Klarna approach to conservation...
in case you're wondering, "what's the harm in claiming an extinct species has been brought back from the dead" when it most certainly has not, our interior secretary is already using it to justify taking animals off the endangered species list
April 10, 2025 at 3:38 PM
The new Klarna approach to conservation...
Reposted by Wolfram Zückert
Shout out to the home of my monthly column, @newscientist.com, which nailed their headline about the genetically modified GREY wolves
www.newscientist.com/article/2475...
www.newscientist.com/article/2475...
No, the dire wolf has not been brought back from extinction
Colossal Biosciences claims three pups born recently are dire wolves, but they are actually grey wolves with genetic edits intended to make them resemble the lost species
www.newscientist.com
April 8, 2025 at 6:53 PM
Shout out to the home of my monthly column, @newscientist.com, which nailed their headline about the genetically modified GREY wolves
www.newscientist.com/article/2475...
www.newscientist.com/article/2475...
An email that is predatory, yet so fitting the times we live in...
April 1, 2025 at 9:28 PM
An email that is predatory, yet so fitting the times we live in...
"DC’s hottest Signal chat is Houthis PC Small Group. This place has everything: war plans, flame emojis, the editor-in-chief of the Atlantic…" 😆
March 29, 2025 at 1:32 AM
"DC’s hottest Signal chat is Houthis PC Small Group. This place has everything: war plans, flame emojis, the editor-in-chief of the Atlantic…" 😆
CONGRATULATIONS 🎉 to the newly minted Ph.D. Candidate Nick Freitas (not on 🦋), shown below as a #K-INBRE undergraduate summer student in 2019. Yes, we let him wear his K-State T-shirt.
ONWARD through the inner membrane, the periplasm to the surface! #KUMedicalCenter #IGPBS 🦠🧫🧪
ONWARD through the inner membrane, the periplasm to the surface! #KUMedicalCenter #IGPBS 🦠🧫🧪
March 26, 2025 at 5:46 PM
CONGRATULATIONS 🎉 to the newly minted Ph.D. Candidate Nick Freitas (not on 🦋), shown below as a #K-INBRE undergraduate summer student in 2019. Yes, we let him wear his K-State T-shirt.
ONWARD through the inner membrane, the periplasm to the surface! #KUMedicalCenter #IGPBS 🦠🧫🧪
ONWARD through the inner membrane, the periplasm to the surface! #KUMedicalCenter #IGPBS 🦠🧫🧪
Just x'd x yesterday. Mieux vaut tard...
March 9, 2025 at 10:58 PM
Just x'd x yesterday. Mieux vaut tard...
Reposted by Wolfram Zückert
There are no illegal protests in a democracy. Fuck that guy.
If you're wondering what happens when a democracy slides into authoritarianism, here it is!
truthsocial.com/@realDonaldT...
truthsocial.com/@realDonaldT...
March 4, 2025 at 3:41 PM
There are no illegal protests in a democracy. Fuck that guy.
phys.org/news/2025-02...
Model organisms are just pioneer lab bench organisms.
Model organisms are just pioneer lab bench organisms.
What is a model organism? Moving beyond E. coli
You wouldn't know by looking at Escherichia coli that it's kind of a big deal.
phys.org
February 28, 2025 at 3:55 PM
phys.org/news/2025-02...
Model organisms are just pioneer lab bench organisms.
Model organisms are just pioneer lab bench organisms.
Reposted by Wolfram Zückert
Everyone who ever got funding through NIAID should be aware of this bill and start sending messages to their US legislators. The bill intends to dissolve NIAID. This is Project 2025
www.congress.gov/bill/119th-c...
www.congress.gov/bill/119th-c...
www.congress.gov
February 22, 2025 at 9:38 PM
Everyone who ever got funding through NIAID should be aware of this bill and start sending messages to their US legislators. The bill intends to dissolve NIAID. This is Project 2025
www.congress.gov/bill/119th-c...
www.congress.gov/bill/119th-c...
In case you were "adhocking" in one of the postponed NIH study sections and were hoping to benefit from the 2-week late submission policy for reviewers for your own grant submission (grants.nih.gov/grants/guide...), here's the info received from DRR (Division of Receipt and Referral) by my SRO:
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1/2
NOT-OD-15-039: Simplifying the NIH Policy for Late Application Submission
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Simplifying the NIH Policy for Late Application Submission NOT-OD-15-039. OD
grants.nih.gov
February 20, 2025 at 8:26 PM
In case you were "adhocking" in one of the postponed NIH study sections and were hoping to benefit from the 2-week late submission policy for reviewers for your own grant submission (grants.nih.gov/grants/guide...), here's the info received from DRR (Division of Receipt and Referral) by my SRO:
1/2
1/2