Lauren Bird
@laurenbird.bsky.social
Postdoc, Lamason lab @ MIT Biology (formerly Newton lab @ Unimelb). Interested in intracellular pathogens 🧫👩🏻🔬 (she/her)
Reposted by Lauren Bird
Thrilled to share our latest story from postdoc @sitbrandon.bsky.social! Using a functional genetic screen, he discovered an unexpected way that Rickettsia relies on the host to stabilize the Sca2 surface protein that drives pathogen motility and virulence.
Host cyclophilin-mediated maturation of an obligate intracellular bacterial surface virulence factor https://www.biorxiv.org/content/10.1101/2025.10.28.684717v1
October 29, 2025 at 10:59 AM
Thrilled to share our latest story from postdoc @sitbrandon.bsky.social! Using a functional genetic screen, he discovered an unexpected way that Rickettsia relies on the host to stabilize the Sca2 surface protein that drives pathogen motility and virulence.
Reposted by Lauren Bird
#Legionella pumps 100s of effector proteins into host cells, including to #mitochondria. @drdstojanovski.bsky.social &co show that effector LpPIP is a tail-anchored protein of the MOM that recruits protein phosphatase 1 to modulate the host mitochondrial P-proteome @plosbiology.org 🧪 plos.io/4f2T5kE
July 25, 2025 at 1:57 PM
#Legionella pumps 100s of effector proteins into host cells, including to #mitochondria. @drdstojanovski.bsky.social &co show that effector LpPIP is a tail-anchored protein of the MOM that recruits protein phosphatase 1 to modulate the host mitochondrial P-proteome @plosbiology.org 🧪 plos.io/4f2T5kE
Excited to share this story from my PhD, out today in Nature Communications! We show that Coxiella removes cathepsin B to reduce lysosomal hostility and promote bacterial success. This depends on a vacuole established by effector CvpB.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Coxiella burnetii manipulates the lysosomal protease cathepsin B to facilitate intracellular success - Nature Communications
The zoonotic pathogen Coxiella burnetiiestablishes a unique intracellular niche within a lysosome-derived vacuole. Here Bird et al. undertook proteomic, cell biology and microbiology approaches to cha...
www.nature.com
April 25, 2025 at 12:14 AM
Excited to share this story from my PhD, out today in Nature Communications! We show that Coxiella removes cathepsin B to reduce lysosomal hostility and promote bacterial success. This depends on a vacuole established by effector CvpB.
www.nature.com/articles/s41...
www.nature.com/articles/s41...