Author | Lightnews

Andreas Aufschnaiter

@whateveroptosis.bsky.social

180 followers 670 following 2 posts

Cell death enthusiast. MSc molecular medicine, atm persuing PhD on oncolytic viruses in Innsbruck AUT🇦🇹. Ferroptosis believer. Not too bad at sports climbing.

Posts Replies Media Videos

Reposted by Andreas Aufschnaiter

TRAstonDrs

@castltrastondrs.bsky.social

#Medsky🧪#microsky #immunosky Finding the “dark proteins” .There are thousands of unconventional open reading frames (ORF) - stretches of code with specific three-letter-sequences - in the human genome that aren't expected to produce a protein, but seem to do so anyway.

WHERE ARE ALL THE DARK PROTEINS? There are thousands of unconventional open reading frames (ORF) - stretches of code with specific three-letter-sequences - in the human genome that aren't expected to produce a protein, but seem to do so anyway. They can be upstream or downstream of a conventional gene, or they can overlap with it to varying degrees. Many are found within long non-coding RNAs, which weren't thought to encode proteins. Some of these peptides seem to regulate the activity of nearby
genes, but for most, their purpose is unclear.

February 7, 2025 at 3:41 AM

Reposted by Andreas Aufschnaiter

Stephan Amstler

@stephanamstler.bsky.social

Med Uni Innsbruck @i-med.ac.at · Jan 20

Die neue Methode UMI-Nanopore-Sequencing erlaubt es, einen komplexen Abschnitt des Lipoprotein(a)-Gens (Atherosklerose-Risikofaktor) präzise zu entschlüsseln und unbekannte Mutationsmuster und deren Wiederholungen zu zählen. Team um Stephan Amstler und Stefan Coassin: www.i-med.ac.at/mypoint/news...