Ryan West
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westwingslab.bsky.social
Ryan West
@westwingslab.bsky.social
970 followers 460 following 26 posts
Drosophilist, DIY enthusiast, group leader, senior fellow & Dementia Research Leader Fellow based in SITraN, Sheffield, UK. Working on #FTD, #ALS and #MND

Find us here: sites.google.com/view/the-west-lab-sheffield
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westwingslab.bsky.social
I'm looking forward to discussing our work at Tambourine’s ALS Breakthrough Research Fund investigators meeting this week. A pretty good view from my room
October 20, 2025 at 1:26 PM
westwingslab.bsky.social
taking a break from all the hills and letting the 5 yo loose down the monsal trail
October 12, 2025 at 6:58 PM
westwingslab.bsky.social
Scott Allen and myself have an opportunity for a postdoc working on pyruvate metabolism in normoxia and hypoxia using a combination of C9orf72 patient-derived iNPC and Drosophila models. Based at SITraN (sheffield.ac.uk/sitran)

jobsite.sheffield.ac.uk/job/Research...
Research Associate in C9orf72 ALS metabolic dysfunction
Research Associate in C9orf72 ALS metabolic dysfunction
jobsite.sheffield.ac.uk
September 9, 2025 at 11:42 AM
Reposted by Ryan West
exdrososcientia.bsky.social
Check out our new #neuroscience @BiologyatYork banner to showcase our diverse, multidisciplinary, multi model, and so much fun research environment that you could be in by joining us as an under or postgrad
york.ac.uk/study/undergra… or/and postgrad too!
March 19, 2025 at 11:24 AM
Reposted by Ryan West
natsansor.bsky.social
🚀 Hot off the press! Our team findings @livuni-ismib.bsky.social on brain ageing unveil a novel connection between oxidative stress, neuronal microtubules, and the cytoskeletal protein EB1 driving neuronal atrophy. 🎉 A huge thank you to the fantastic team!
www.aginganddisease.org/EN/10.14336/...
Oxidative Stress Promotes Axonal Atrophy through Alterations in Microtubules and EB1 Function
<p>Axons are crucial for transmitting neurochemical signals. As organisms age, the ability of neurons to maintain their axons declines; hence, aged axons are more susceptible to damage or dysfunction....
www.aginganddisease.org
January 17, 2025 at 9:47 AM
westwingslab.bsky.social
oh ChatGPT what monstrosity is this?
January 15, 2025 at 8:05 AM
westwingslab.bsky.social
There are some hills over there somewhere!
January 7, 2025 at 10:36 AM
westwingslab.bsky.social
Clear skies over SITraN this morning
This image shows the Sheffield Instiute for Translational Neuroscience (SiTraN) building at sunrise, with the sky transitioning from vibrant orange and pink near the horizon to darker blue at the top. The "SiTraN" sign is an integral part of the building's architecture, made of large metallic letters that appear to support the roof. Behind the sign is a wooden facade. The surrounding area includes bare trees silhouetted against the colorful sky and softly lit pathways leading to the building
January 3, 2025 at 8:26 AM
westwingslab.bsky.social
I think santa will enjoy the whisky the 4 year old left for him 👀
This image depicts a wooden table with a bottle of Lagavulin 8 Year Old Scotch Whisky, a glass, a white plate holding a single mince pie, and a small carrot placed beside the plate
December 24, 2024 at 6:45 PM
westwingslab.bsky.social
a slightly chilly lab walk in the peaks
A group of hikers walking uphill on a muddy and rocky path in an open countryside setting. The foreground shows patches of grass, stones, and puddles, while the background features a scenic view of rolling green fields, winding trails, and distant hills under a cloudy sky with hints of blue. The hikers are dressed warmly in winter jackets, hats, and scarves, A group of nine people dressed in winter clothing, including hats, scarves, and jackets, posing outdoors on lose hill (peak district) with a cloudy sky in the background. The landscape features rolling hills and valleys.
December 10, 2024 at 5:02 PM
westwingslab.bsky.social
A birthday card from the lab. A @comeflywithjo.bsky.social special. I wonder what they are trying to imply?
A handmade birthday card. The design features colorful balloons at the top with the letters of "HAPPY BIRTHDAY" written inside them. Below the balloons, the name "RYAN" is prominently displayed in bold, patterned letters. In the center, there’s a humorous drawing of a fruit fly wearing a green hat and leaning on a walking stick
December 9, 2024 at 8:51 AM
westwingslab.bsky.social
Poster session B, 5.30-7 7th December
westwingslab.bsky.social Ryan West @westwingslab.bsky.social · Dec 4
For anyone heading to #alsmndsymp in montreal look out for @mndassoc.bsky.social funded student Charlotte Gale-Rogers work on C9orf72 DPR disruption to locomotor rhythmicity using some of our fly models. Poster IVV-26.
December 7, 2024 at 6:31 PM
westwingslab.bsky.social
I am pleased we were able to help with this nice paper showing RuvBL1/2 can reduce DPR abundance and reduce phenotypes observed in our fly models
www.life-science-alliance.org/content/8/2/...
RuvBL1/2 reduce toxic dipeptide repeat protein burden in multiple models of C9orf72-ALS/FTD
A G4C2 hexanucleotide repeat expansion in C9orf72 is the most common cause of amyotrophic lateral sclerosis and frontotemporal dementia (C9ALS/FTD). Bidirectional transcription and subsequent repeat-a...
www.life-science-alliance.org
December 6, 2024 at 3:45 PM
westwingslab.bsky.social
For anyone heading to #alsmndsymp in montreal look out for @mndassoc.bsky.social funded student Charlotte Gale-Rogers work on C9orf72 DPR disruption to locomotor rhythmicity using some of our fly models. Poster IVV-26.
December 4, 2024 at 8:28 PM
westwingslab.bsky.social
striking views from my office this morning
sunrise showing a sky filled with dramatic clouds illuminated in shades of orange, pink, and red, contrasting against a pale blue sky. In the foreground, silhouettes of tree branches, a utility pole, and buildings are visible. The cityscape of Sheffield is visible below the horizon
November 29, 2024 at 8:12 AM
westwingslab.bsky.social
twitter account deactivated. It's bluesky only now
November 24, 2024 at 2:22 PM
westwingslab.bsky.social
Google scholar vs pubmed wordclouds
Cloud of words in various colors and sizes based on a Google Scholar profile. Some of the largest words include drosophila dementia frontotemporal models disease regulate toxicity activity-dependent chmp2b growth identification model neuronal oxygen parkinson’s plasticity rab8 reactive species using amyotrophic animal c9orf72 conserved dysfunction genetic ik2tbk1 jnk lateral mediates Cloud of words in various colors and sizes. Some of the largest words include drosophila models function repeat ftd synaptic mutation disease genetic mutant neurons kinase als c9orf72 dementia toxicity chmp2b flies length mutants
November 22, 2024 at 8:27 AM
Reposted by Ryan West
scotsfriction.bsky.social
🧠Sharing this Starter Pack again as the list has now reached 80 people! A great mix of Profs/PIs/Post-docs/PhDs/Technicians.

Please re-post so it can reach a wider audience as I'm sure there are more of us out there ☺️🦋

go.bsky.app/S6FfsTp
November 19, 2024 at 2:15 PM
Reposted by Ryan West
westwingslab.bsky.social

a quick trip down to London for a grant panel and to say hello to some old friends
November 18, 2024 at 6:34 PM
westwingslab.bsky.social
back from a very enjoyable @nc3rs.bsky.social Partnership and Impact panel meeting. Lots of great science. Looking forward to seeing some of those projects going forward.
November 19, 2024 at 7:40 PM
Reposted by Ryan West
poppi62.bsky.social
Green, M. M. (2010) 2010: A century of #Drosophila genetics through the prism of the 'white' gene. Genetics 184, 3-7 — www.ncbi.nlm.nih.gov/pubmed/20061...
November 18, 2024 at 5:02 PM
westwingslab.bsky.social

a quick trip down to London for a grant panel and to say hello to some old friends
November 18, 2024 at 6:34 PM
Reposted by Ryan West
dozenoaks.bsky.social
Trying for a molecular and cellular neurobiology starter pack - happy to add folks and connect :) #neuroskyance #cellbiology

go.bsky.app/PgEk7aF
November 11, 2024 at 8:55 PM
Reposted by Ryan West
mangieserrano.bsky.social
As PIs we can mentor our team to select colorblind friendly pseudo colors at acquisition time 🔬and share free (and super cool) resources like colororacle.org and medialab.github.io/iwanthue/ that helps you select or design color friendly palettes for projects that have many categories 💻 #dataViz
November 16, 2024 at 12:46 PM
Reposted by Ryan West
estherverheyen.bsky.social
If you're not sure which Starter Packs you've been added to, you can check them on clearsky.app
That's where I found the ones that I'm part of. Wish we could get notified when added to a pack @bsky.app ?
November 16, 2024 at 12:06 AM