The 33 bacterial pathogens that we investigated in this study are a substantial source of health loss globally, with considerable variation in their distribution across infectious syndromes and locati...

The Indian Council of Medical Research (ICMR) will scale up wastewater surveillance to 50 cities over the next year to track pathogens, strengthening India’s early warning system for outbreaks.

A new major version of ggplot2 has been released on CRAN. Find out what is new here.

This study conducted a 20-year analysis in Stockholm showing that RSV epidemic patterns shifted due to viral interference from influenza, particularly, pandemic H1N1, highlighting the complex interact...

Chikungunya virus (CHIKV) infects both humans and mosquitoes during its transmission cycle. How the virus’s envelope proteins mediate entry in cells from such different species is unclear. MXRA8 is a ...

Zika virus (ZIKV), a member of the Flavivirus genus, can cause severe neurodevelopmental disorders when infection occurs during pregnancy. Phylogenetic analyses classify ZIKV into two major lineages: ...

Viruses exploit extracellular vesicles (EVs) to transfer infection-enhancing viral RNAs. However, mechanisms underlying viral RNA loading remain elusive. We leveraged our previous discovery that dengu...

Key actors of mammalian immunity originated from bacterial antiphage systems. The full extent of immune system conservation between bacteria and eukaryotes is unknown. Here, we show that the silent in...

The World Health Organization issued an urgent call for action on Tuesday to prevent a repeat of an epidemic of the mosquito-borne chikungunya virus that swept the globe two decades ago, as new outbreaks linked to the Indian Ocean region spread to Europe and other continents.

Practicing the theory: Applying genomic epidemiology to guide public health action

Our study demonstrates potent protective immunity induced by homologous vaccination and homologous or heterologous previous SARS-CoV-2 infection. The community breakthrough infections seen with the om...

Publicaciones de la Organización Mundial de la Salud

Sepsis, a clinically defined life-threatening condition, is a global contributor to high morbidity and mortality rates in humans. It is caused by systemic bloodstream bacterial infections, primarily involving aerobic pathogens such as Escherichia coli, Staphylococcus aureus, and Klebsiella pneumoniae. Rapid and accurate identification of these pathogens is a high demand task, as prolonged diagnosis may increase the mortality rate among sepsis patients. Worldwide, commercial blood culture systems, such as BD BACTEC PLUS Aerobic/F culture bottles (used in this study), are routinely used to monitor bloodstream infections. However, due to high costs ($10.00 to $15.00/bottle), limited availability of culture media (especially in low and middle income countries, and war zones), and a lack of customization for antibiotic susceptibility assay and epidemiology research, there is a need for secondary alternatives to facilitate the growth and identification of bloodborne pathogens. Therefore, we developed a low-cost ($4 to $5/bottle) in house culture medium with a newly improved formulation of Brain Heart Infusion media that enhances bacterial growth from spiked human blood tested on a panel of bacteria (Escherichia coli, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterococcus faecalis). The growth dynamics of these microbes in in house formulated BHI Blood+ culture media coincide with those in BACTEC Plus Aerobic/F culture vials, which primarily suggests the compatibility of bloodborne pathogens with this media and can be flagged positive <8h based on cellular growth rate. Additionally, conventional qPCR-based early detection (< 24h) and validation with the Oxford Nanopore MinION NGS platform highlight the value of this in-house culture media as an alternative to commercial culture media in terms of low cost availability. ### Competing Interest Statement The authors have declared no competing interest. The Research Council of Norway, https://ror.org/00epmv149, 336420

RSV can cause severe infections in the elderly. Nirsevimab is a novel prophylactic monoclonal antibody, widely used in infants in France during the 2023/2024 season. It may select for resistant RSV variants that, if transmitted in the community, could compromise vaccine efficacy in the elderly.

Clinical testing and public health surveillance can be significantly improved by incorporating sequencing-based molecular detection and subtyping for real-time monitoring of virus evolution. With phyl...

Bats are important reservoirs of zoonotic pathogens, but suitable model systems for comprehensively exploring host-pathogen interactions and assessing spillover risks remain limited. To address this g...

This study examines the immunogenicity and safety of an investigational mRNA-based vaccine against seasonal influenza and SARS-CoV-2 in adults 50 years and older.