Uriel Urquiza-Garcia
@uurquiza.bsky.social
Interested in programming plants with DNA, currently building a Plant Artificial Chromosome and Plant Synthetic Genomics developer|CEPLAS
https://www.synthetic-biology.hhu.de/research/urquiza-group
https://www.synthetic-biology.hhu.de/research/urquiza-group
Pinned
Abundant clock proteins point to missing molecular regulation in the plant circadian clock | Molecular Systems Biology
imageimage~100,000 copies of plant circadian clock proteins per cell were predicted from RNA
levels and included in detailed models. Protein levels and DNA-binding were validated,
using NanoLUC report...
www.embopress.org
Abundant clock proteins point to missing regulation in the plant circadian clock www.embopress.org/doi/full/10.... first experimental determination of the abundance of transcription factors in Plants and for the circadian clock. It was such a challenge but finally out after peer review !!!
Reposted by Uriel Urquiza-Garcia
Systemic and local regulation of root growth by vascular trehalose 6-phosphate is correlated with re-allocation of primary metabolites between shoots and roots https://www.biorxiv.org/content/10.1101/2025.11.13.688188v1
November 14, 2025 at 5:01 AM
Systemic and local regulation of root growth by vascular trehalose 6-phosphate is correlated with re-allocation of primary metabolites between shoots and roots https://www.biorxiv.org/content/10.1101/2025.11.13.688188v1
Reposted by Uriel Urquiza-Garcia
Our #cryoET of #plasmodesmata preprint is out! Will write more on it later. 🌿❄️
In situ architecture of plasmodesmata suggests mechanisms controlling intercellular exchange https://www.biorxiv.org/content/10.1101/2025.07.24.666190v1
July 26, 2025 at 7:20 AM
Our #cryoET of #plasmodesmata preprint is out! Will write more on it later. 🌿❄️
Bringing back to life some 10 year old constructs I did during my PhD CCA1pro:NanoLUC-PEST
June 25, 2025 at 7:12 AM
Bringing back to life some 10 year old constructs I did during my PhD CCA1pro:NanoLUC-PEST
Reposted by Uriel Urquiza-Garcia
🎊 We made it!! @dfg.de has just announced that we have been successful with our CEPLAS III proposal in the current funding round of the Excellence Strategy! Many thanks to all our supporters! @hhu.de @unicologne.bsky.social @mpipz.bsky.social @fz-juelich.de @leibnizipk.bsky.social
May 22, 2025 at 3:37 PM
🎊 We made it!! @dfg.de has just announced that we have been successful with our CEPLAS III proposal in the current funding round of the Excellence Strategy! Many thanks to all our supporters! @hhu.de @unicologne.bsky.social @mpipz.bsky.social @fz-juelich.de @leibnizipk.bsky.social
@ceplas.bsky.social continues!! Let’s continue delivering excellent plant research now SMARTe plants in dynamic environments!
May 22, 2025 at 3:12 PM
@ceplas.bsky.social continues!! Let’s continue delivering excellent plant research now SMARTe plants in dynamic environments!
Reposted by Uriel Urquiza-Garcia
Moose – Die Gamechanger der Medizin und Forschung!
Mein Interview für #FrischeFische auf YouTube.
#Exzellenzinitiative #Moose #Medizin #Evolution #Forschung #scicomm #wisskomm
@cibss.bsky.social #livMatS @biologyunifreiburg.bsky.social
www.youtube.com/watch?v=JzgL...
Mein Interview für #FrischeFische auf YouTube.
#Exzellenzinitiative #Moose #Medizin #Evolution #Forschung #scicomm #wisskomm
@cibss.bsky.social #livMatS @biologyunifreiburg.bsky.social
www.youtube.com/watch?v=JzgL...
🌱 Moose – Die Gamechanger der Medizin und Forschung! 🌱
YouTube video by Gary Silver
www.youtube.com
March 28, 2025 at 1:05 PM
Moose – Die Gamechanger der Medizin und Forschung!
Mein Interview für #FrischeFische auf YouTube.
#Exzellenzinitiative #Moose #Medizin #Evolution #Forschung #scicomm #wisskomm
@cibss.bsky.social #livMatS @biologyunifreiburg.bsky.social
www.youtube.com/watch?v=JzgL...
Mein Interview für #FrischeFische auf YouTube.
#Exzellenzinitiative #Moose #Medizin #Evolution #Forschung #scicomm #wisskomm
@cibss.bsky.social #livMatS @biologyunifreiburg.bsky.social
www.youtube.com/watch?v=JzgL...
Reposted by Uriel Urquiza-Garcia
Finally!
Im so excited to present to culmination of many years of work from the fantastic Defeng Shen and some great collaborators. For details, I have made a digested thread below, but if you are more interested feel free to reach out (and read the paper of course).
www.science.org/doi/10.1126/...
Im so excited to present to culmination of many years of work from the fantastic Defeng Shen and some great collaborators. For details, I have made a digested thread below, but if you are more interested feel free to reach out (and read the paper of course).
www.science.org/doi/10.1126/...
Apoplastic barriers are essential for nodule formation and nitrogen fixation in Lotus japonicus
Establishment of the apoplastic root barrier known as the Casparian strip occurs early in root development. In legumes, this area overlaps with nitrogen-fixing nodule formation, which raises the possi...
www.science.org
March 21, 2025 at 5:53 AM
Finally!
Im so excited to present to culmination of many years of work from the fantastic Defeng Shen and some great collaborators. For details, I have made a digested thread below, but if you are more interested feel free to reach out (and read the paper of course).
www.science.org/doi/10.1126/...
Im so excited to present to culmination of many years of work from the fantastic Defeng Shen and some great collaborators. For details, I have made a digested thread below, but if you are more interested feel free to reach out (and read the paper of course).
www.science.org/doi/10.1126/...
Reposted by Uriel Urquiza-Garcia
After a lot of work, we are finally able to share this project about the cell cycle in Marchantia from the Haseloff lab. If you want to find out how cell division is controlled, you can’t miss out this one… #PlantScience #Synbio #EvoDevo
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
The minimal cell-cycle control system in Marchantia as a framework for understanding plant cell proliferation
The regulation of cell division is broadly conserved across eukaryotes, governed by cyclins and cyclin-dependent kinases (CDKs) to coordinate progression through the cell cycle. Plants have evolved a ...
www.biorxiv.org
March 14, 2025 at 9:16 AM
After a lot of work, we are finally able to share this project about the cell cycle in Marchantia from the Haseloff lab. If you want to find out how cell division is controlled, you can’t miss out this one… #PlantScience #Synbio #EvoDevo
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Uriel Urquiza-Garcia
If you are looking for published plant genomes www.plabipd.de/pubplant_mai... might be useful where Rainer is tracking species with genomes for almost 10 years now... time flies. As he has added new useful views, we thought it is time to summarize this. www.biorxiv.org/content/10.1...
March 14, 2025 at 9:08 AM
If you are looking for published plant genomes www.plabipd.de/pubplant_mai... might be useful where Rainer is tracking species with genomes for almost 10 years now... time flies. As he has added new useful views, we thought it is time to summarize this. www.biorxiv.org/content/10.1...
Reposted by Uriel Urquiza-Garcia
Our updated preprint now on bioRxiv:
Production of human papillomavirus type 16 virus-like particles in #Physcomitrella photobioreactors
www.biorxiv.org/content/10.1...
Production of human papillomavirus type 16 virus-like particles in #Physcomitrella photobioreactors
www.biorxiv.org/content/10.1...
Production of human papillomavirus type 16 virus-like particles in Physcomitrella photobioreactors
Human papillomavirus (HPV) infections are the main causal agent of cervical and other anogenital cancers. Modern HPV vaccines are based on virus-like particles (VLPs), which are self-assembling nanopa...
www.biorxiv.org
March 13, 2025 at 12:45 PM
Our updated preprint now on bioRxiv:
Production of human papillomavirus type 16 virus-like particles in #Physcomitrella photobioreactors
www.biorxiv.org/content/10.1...
Production of human papillomavirus type 16 virus-like particles in #Physcomitrella photobioreactors
www.biorxiv.org/content/10.1...
Laura Trimborn, [...] and Ute Hoecker
CRY1 inhibits the activity of COP1 by competitively displacing substrates from COP1
pubmed.ncbi.nlm.nih.gov/40052249/
CRY1 inhibits the activity of COP1 by competitively displacing substrates from COP1
pubmed.ncbi.nlm.nih.gov/40052249/
Cryptochrome 1 promotes photomorphogenesis in Arabidopsis by displacing substrates from the COP1 ubiquitin ligase - PubMed
In blue light, cryptochrome photoreceptors inhibit the key repressor of light signaling, the COP1/SPA ubiquitin ligase, to promote photomorphogenic responses. This inhibition relies on the direct inte...
pubmed.ncbi.nlm.nih.gov
March 10, 2025 at 8:11 AM
Laura Trimborn, [...] and Ute Hoecker
CRY1 inhibits the activity of COP1 by competitively displacing substrates from COP1
pubmed.ncbi.nlm.nih.gov/40052249/
CRY1 inhibits the activity of COP1 by competitively displacing substrates from COP1
pubmed.ncbi.nlm.nih.gov/40052249/
Reposted by Uriel Urquiza-Garcia
Our new review in @theplantjournal.bsky.social on synthetic gene circuits is out! I am super proud of this. I hope that it acts as a useful resource for people new to gene circuits.
The switch-liker's guide to plant synthetic gene circuits
onlinelibrary.wiley.com/doi/10.1111/...
The switch-liker's guide to plant synthetic gene circuits
onlinelibrary.wiley.com/doi/10.1111/...
The switch‐liker's guide to plant synthetic gene circuits
Synthetic gene circuits have the potential to revolutionise how plants can be engineered by allowing highly customised gene expression patterns to be designed. Gene circuits can sense and integrate m....
onlinelibrary.wiley.com
March 9, 2025 at 1:15 AM
Our new review in @theplantjournal.bsky.social on synthetic gene circuits is out! I am super proud of this. I hope that it acts as a useful resource for people new to gene circuits.
The switch-liker's guide to plant synthetic gene circuits
onlinelibrary.wiley.com/doi/10.1111/...
The switch-liker's guide to plant synthetic gene circuits
onlinelibrary.wiley.com/doi/10.1111/...
Reposted by Uriel Urquiza-Garcia
I’m happy to share that I will join the LIT in Regensburg (lit.eu) as a Group Leader in Structural Biochemistry in May. We will combine synthetic biology and protein design to develop synthetic receptors and protein therapeutics to improve immunotherapy. Job openings will be available soon!
Leibniz Institute for Immunotherapy
The LIT develops innovative therapies for the treatment of cancer, autoimmunity, and chronic inflammation by reprogramming immune cells.
lit.eu
February 26, 2025 at 5:45 PM
I’m happy to share that I will join the LIT in Regensburg (lit.eu) as a Group Leader in Structural Biochemistry in May. We will combine synthetic biology and protein design to develop synthetic receptors and protein therapeutics to improve immunotherapy. Job openings will be available soon!
My first students in Plant Synthetic Genomics put together a nice tool for biodesign automation of random DNA fragments for synthetic genomics applications. "Gearing up Golden Braid assembly for plant synthetic genomics with RepTiles" @hhu.de @ceplas.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Gearing up Golden Braid assembly for plant synthetic genomics with RepTiles
We have developed RepTiles, a system for generating traces of random DNA for synthetic genomics applications. The system uses synthetic random DNA domesticated using the Phytobricks syntax. RepTiles h...
www.biorxiv.org
March 2, 2025 at 12:00 PM
My first students in Plant Synthetic Genomics put together a nice tool for biodesign automation of random DNA fragments for synthetic genomics applications. "Gearing up Golden Braid assembly for plant synthetic genomics with RepTiles" @hhu.de @ceplas.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Uriel Urquiza-Garcia
Hey can y'all check to see if the NCBI blastn page is working? Genbank page seems down, too. Same on your end? TYIA
www.ncbi.nlm.nih.gov/genbank/
www.ncbi.nlm.nih.gov/genbank/
March 2, 2025 at 1:05 AM
Hey can y'all check to see if the NCBI blastn page is working? Genbank page seems down, too. Same on your end? TYIA
www.ncbi.nlm.nih.gov/genbank/
www.ncbi.nlm.nih.gov/genbank/
Abundant clock proteins point to missing regulation in the plant circadian clock www.embopress.org/doi/full/10.... first experimental determination of the abundance of transcription factors in Plants and for the circadian clock. It was such a challenge but finally out after peer review !!!
Abundant clock proteins point to missing molecular regulation in the plant circadian clock | Molecular Systems Biology
imageimage~100,000 copies of plant circadian clock proteins per cell were predicted from RNA
levels and included in detailed models. Protein levels and DNA-binding were validated,
using NanoLUC report...
www.embopress.org
February 20, 2025 at 5:55 PM
Abundant clock proteins point to missing regulation in the plant circadian clock www.embopress.org/doi/full/10.... first experimental determination of the abundance of transcription factors in Plants and for the circadian clock. It was such a challenge but finally out after peer review !!!
Reposted by Uriel Urquiza-Garcia
After becoming the 2nd FRS to quit over Elon Musk, @andrewmillar.bsky.social explains why
Musk's actions "are not compatible with the conduct required of a fellow...they undermine the purpose of the Royal Society"
The @royalsociety.org has called fellows to a 3rd March meeting as the crisis grows
Musk's actions "are not compatible with the conduct required of a fellow...they undermine the purpose of the Royal Society"
The @royalsociety.org has called fellows to a 3rd March meeting as the crisis grows
‘I do not want a fellowship that can include such actions’ - Research Professional News
Elon Musk’s actions undermine the purpose of the Royal Society, writes resigning fellow Andrew Millar
www.researchprofessionalnews.com
February 14, 2025 at 7:43 AM
After becoming the 2nd FRS to quit over Elon Musk, @andrewmillar.bsky.social explains why
Musk's actions "are not compatible with the conduct required of a fellow...they undermine the purpose of the Royal Society"
The @royalsociety.org has called fellows to a 3rd March meeting as the crisis grows
Musk's actions "are not compatible with the conduct required of a fellow...they undermine the purpose of the Royal Society"
The @royalsociety.org has called fellows to a 3rd March meeting as the crisis grows
@andrewmillar.bsky.social has resigned from the #RoyalSociety I hope others follow
I have resigned my Fellowship of the #RoyalSociety due to their Council's inability to act proportionately on #ElonMusk.
See fediscience.org/@A_J_Millar/...
See fediscience.org/@A_J_Millar/...
Andrew Millar (@A_J_Millar@fediscience.org)
Attached: 1 image · Content warning: #ElonMusk #RoyalSociety
fediscience.org
February 13, 2025 at 11:15 PM
@andrewmillar.bsky.social has resigned from the #RoyalSociety I hope others follow
Reposted by Uriel Urquiza-Garcia
It’s been a tough few weeks. My 10yo daughter was diagnosed with a very rare, aggressive cancer called interdigitating dendritic cell sarcoma (IDCS). I’m reaching out to identify clinicians/patients who have encountered pediatric IDCS or other (non-LCH) dendritic or histiocytic sarcomas cases.
February 8, 2025 at 9:21 PM
It’s been a tough few weeks. My 10yo daughter was diagnosed with a very rare, aggressive cancer called interdigitating dendritic cell sarcoma (IDCS). I’m reaching out to identify clinicians/patients who have encountered pediatric IDCS or other (non-LCH) dendritic or histiocytic sarcomas cases.
Insighful review from André Marques nph.onlinelibrary.wiley.com/share/5UPJFE...
Centromere diversity and its evolutionary impacts on plant karyotypes and plant reproduction
You have to enable JavaScript in your browser's settings in order to use the eReader.
nph.onlinelibrary.wiley.com
February 9, 2025 at 12:41 PM
Insighful review from André Marques nph.onlinelibrary.wiley.com/share/5UPJFE...
Reposted by Uriel Urquiza-Garcia
#Tomorrow @uni-freiburg.de: panel discussion on the pros and cons of #GreenGeneTech. Join us for an exciting discussion!
👉 kurzlinks.de/twhu
@friasunifreiburg.bsky.social@testbiotech.bsky.social@mpi-mp-potsdam.bsky.social@bund.net@ceplas.bsky.social@oekoprog.bsky.social@progagrarwende.bsky.social
👉 kurzlinks.de/twhu
@friasunifreiburg.bsky.social@testbiotech.bsky.social@mpi-mp-potsdam.bsky.social@bund.net@ceplas.bsky.social@oekoprog.bsky.social@progagrarwende.bsky.social
Yesterday's talk was a perfect lead to next week's panel discussion: Join us as @augustinsvenja.bsky.social, Caroline Gutjahr, Martha Mertens, Christoph Then and @rensingstefan.bsky.social discuss the pros and cons of #GreenGeneTech!
22.01.2025, 19:15
HS 1010, KG 1,@uni-freiburg.de
kurzlinks.de/f7vw
22.01.2025, 19:15
HS 1010, KG 1,@uni-freiburg.de
kurzlinks.de/f7vw
January 21, 2025 at 10:55 AM
#Tomorrow @uni-freiburg.de: panel discussion on the pros and cons of #GreenGeneTech. Join us for an exciting discussion!
👉 kurzlinks.de/twhu
@friasunifreiburg.bsky.social@testbiotech.bsky.social@mpi-mp-potsdam.bsky.social@bund.net@ceplas.bsky.social@oekoprog.bsky.social@progagrarwende.bsky.social
👉 kurzlinks.de/twhu
@friasunifreiburg.bsky.social@testbiotech.bsky.social@mpi-mp-potsdam.bsky.social@bund.net@ceplas.bsky.social@oekoprog.bsky.social@progagrarwende.bsky.social
I wonder when will DNA be a commodity like electricity
January 9, 2025 at 8:35 PM
I wonder when will DNA be a commodity like electricity
Reposted by Uriel Urquiza-Garcia
Reposted by Uriel Urquiza-Garcia
Abundant clock proteins point to missing molecular regulation in the plant circadian clock.
Urquiza-García et al 2024; study by @andrewmillar.bsky.social
bioRxiv doi.org/10.1101/2024.09.03.609973
#preprintpeerreview by Review Commons eeb.embo.org/doi/10.1101/2024.09.03.609973.
Urquiza-García et al 2024; study by @andrewmillar.bsky.social
bioRxiv doi.org/10.1101/2024.09.03.609973
#preprintpeerreview by Review Commons eeb.embo.org/doi/10.1101/2024.09.03.609973.
doi.org
December 19, 2024 at 4:18 PM
Abundant clock proteins point to missing molecular regulation in the plant circadian clock.
Urquiza-García et al 2024; study by @andrewmillar.bsky.social
bioRxiv doi.org/10.1101/2024.09.03.609973
#preprintpeerreview by Review Commons eeb.embo.org/doi/10.1101/2024.09.03.609973.
Urquiza-García et al 2024; study by @andrewmillar.bsky.social
bioRxiv doi.org/10.1101/2024.09.03.609973
#preprintpeerreview by Review Commons eeb.embo.org/doi/10.1101/2024.09.03.609973.