Tzviya Zeev-Ben-Mordehai
@tzviyazbm.bsky.social
The cellular structural biology of fertilization group
Pinned
SUN5 forms a regular protein lattice reinforcing the sperm head-tail junction
Linker of nucleo- and cytoskeleton (LINC) complexes reside in the nuclear envelope, the double-membrane surrounding the nucleus, where they establish a physical bridge between nucleus and cytoplasm. L...
www.biorxiv.org
I am happy our recent study on the human sperm head-tail junction is now online. We find that SUN5 form an hexagonal lattice at the nuclear membrane, rationalising how mutations in SUN5 lead to infertility. Great work of @cryonas.bsky.social !
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Tzviya Zeev-Ben-Mordehai
Very happy that NWO supports this major upgrade of our national EM infrastructure. It is great that this initiative got broad support all over NL, and it will EMPower fantastic science - looking forward to that!
www.uu.nl/en/news/33-m...
www.uu.nl/en/news/33-m...
33 million euro investment for national electron microscope facility EMPower
A major new national facility for electron microscopy, called EMPower, has been awarded to a consortium of Dutch universities and medical centers. EMPower aims to pave the way for major discoveries im...
www.uu.nl
November 4, 2025 at 7:14 AM
Very happy that NWO supports this major upgrade of our national EM infrastructure. It is great that this initiative got broad support all over NL, and it will EMPower fantastic science - looking forward to that!
www.uu.nl/en/news/33-m...
www.uu.nl/en/news/33-m...
Reposted by Tzviya Zeev-Ben-Mordehai
Happy to see this out :)
How close does single-particle cryo-EM get to in situ structure determination? In this review, @tzviyazbm.bsky.social and I explore recent examples of studies that we believe push the boundaries of what's possible. #cryo-EM
How close does single-particle cryo-EM get to in situ structure determination? In this review, @tzviyazbm.bsky.social and I explore recent examples of studies that we believe push the boundaries of what's possible. #cryo-EM
Cryo-EM single-particle analysis expanding towards increasingly native samples pubmed.ncbi.nlm.nih.gov/41129371/ #cryoem
October 29, 2025 at 11:44 AM
Happy to see this out :)
How close does single-particle cryo-EM get to in situ structure determination? In this review, @tzviyazbm.bsky.social and I explore recent examples of studies that we believe push the boundaries of what's possible. #cryo-EM
How close does single-particle cryo-EM get to in situ structure determination? In this review, @tzviyazbm.bsky.social and I explore recent examples of studies that we believe push the boundaries of what's possible. #cryo-EM
I am happy our recent study on the human sperm head-tail junction is now online. We find that SUN5 form an hexagonal lattice at the nuclear membrane, rationalising how mutations in SUN5 lead to infertility. Great work of @cryonas.bsky.social !
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
SUN5 forms a regular protein lattice reinforcing the sperm head-tail junction
Linker of nucleo- and cytoskeleton (LINC) complexes reside in the nuclear envelope, the double-membrane surrounding the nucleus, where they establish a physical bridge between nucleus and cytoplasm. L...
www.biorxiv.org
July 31, 2025 at 3:07 PM
I am happy our recent study on the human sperm head-tail junction is now online. We find that SUN5 form an hexagonal lattice at the nuclear membrane, rationalising how mutations in SUN5 lead to infertility. Great work of @cryonas.bsky.social !
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Tzviya Zeev-Ben-Mordehai
Latest preprint from the lab, many years in the making!
By combining #cryoEM with #AlphaFold3 modelling, we propose that norovirus NS3 forms a transmembrane RNA translocase.
This could have big implications for our understanding of viral replication & assembly (🧵)
www.biorxiv.org/content/10.1...
By combining #cryoEM with #AlphaFold3 modelling, we propose that norovirus NS3 forms a transmembrane RNA translocase.
This could have big implications for our understanding of viral replication & assembly (🧵)
www.biorxiv.org/content/10.1...
June 18, 2025 at 6:32 AM
Latest preprint from the lab, many years in the making!
By combining #cryoEM with #AlphaFold3 modelling, we propose that norovirus NS3 forms a transmembrane RNA translocase.
This could have big implications for our understanding of viral replication & assembly (🧵)
www.biorxiv.org/content/10.1...
By combining #cryoEM with #AlphaFold3 modelling, we propose that norovirus NS3 forms a transmembrane RNA translocase.
This could have big implications for our understanding of viral replication & assembly (🧵)
www.biorxiv.org/content/10.1...
Reposted by Tzviya Zeev-Ben-Mordehai
Amazing meeting amongst great colleagues and friends 🫶🏻. Looking forward to ETW 2027 in Germany 🇩🇪
April 17, 2025 at 12:42 PM
Amazing meeting amongst great colleagues and friends 🫶🏻. Looking forward to ETW 2027 in Germany 🇩🇪
I am honoured to receive a Vici grant from the Dutch Research Council to study sperm functional maturition at the female reproductive tract and to study how sperm establish interaction with an egg
www.uu.nl/en/news/nine...
www.uu.nl/en/news/nine...
Nine Utrecht-based researchers receive Vici-grant
The Dutch Research Council (NWO) has awarded Vici grants to nine Utrecht researchers.
www.uu.nl
February 28, 2025 at 12:59 PM
I am honoured to receive a Vici grant from the Dutch Research Council to study sperm functional maturition at the female reproductive tract and to study how sperm establish interaction with an egg
www.uu.nl/en/news/nine...
www.uu.nl/en/news/nine...
New year, new publication, new social media platform www.nature.com/articles/s41...
Structural diversity of axonemes across mammalian motile cilia - Nature
Cryoelectron microscopy, cryoelectron tomography and proteomics are used to resolve the 96-nm modular repeat of axonemal doublet microtubules from both sperm flagella and epithelial cilia of the ovidu...
www.nature.com
January 15, 2025 at 8:51 AM
New year, new publication, new social media platform www.nature.com/articles/s41...