Jonas Möcking
@cryonas.bsky.social
Marie Curie Postdoc Fellow at Utrecht University 🇳🇱 Protein-Biochemist diving into cryo-ET ❄️
Reposted by Jonas Möcking
Very happy that NWO supports this major upgrade of our national EM infrastructure. It is great that this initiative got broad support all over NL, and it will EMPower fantastic science - looking forward to that!
www.uu.nl/en/news/33-m...
www.uu.nl/en/news/33-m...
33 million euro investment for national electron microscope facility EMPower
A major new national facility for electron microscopy, called EMPower, has been awarded to a consortium of Dutch universities and medical centers. EMPower aims to pave the way for major discoveries im...
www.uu.nl
November 4, 2025 at 7:14 AM
Very happy that NWO supports this major upgrade of our national EM infrastructure. It is great that this initiative got broad support all over NL, and it will EMPower fantastic science - looking forward to that!
www.uu.nl/en/news/33-m...
www.uu.nl/en/news/33-m...
Reposted by Jonas Möcking
my friend and wonderful colleague Stan is hiring at Genentech in South San Francisco! 🧬 🌉
Biochemist/structural biologist looking for your first position in industry? I can’t recommend working with Stan enough ☺️ please repost for visibility
www.linkedin.com/posts/stanis...
Biochemist/structural biologist looking for your first position in industry? I can’t recommend working with Stan enough ☺️ please repost for visibility
www.linkedin.com/posts/stanis...
#hiring #researchassociate #structuralbiology #proteinsciences #cryoem #biochemistry #biophysics #dnarepair #drugdiscovery | Stanislau Yatskevich
We’re hiring a 𝐑𝐞𝐬𝐞𝐚𝐫𝐜𝐡 𝐀𝐬𝐬𝐨𝐜𝐢𝐚𝐭𝐞 (Contractor) to join our 𝐒𝐭𝐫𝐮𝐜𝐭𝐮𝐫𝐚𝐥 𝐁𝐢𝐨𝐥𝐨𝐠𝐲 team in 𝐏𝐫𝐨𝐭𝐞𝐢𝐧 𝐒𝐜𝐢𝐞𝐧𝐜𝐞𝐬 focused on the molecular mechanisms of DNA repair.
𝐖𝐡𝐲 𝐭𝐡𝐢𝐬 𝐫𝐨𝐥𝐞 𝐦𝐚𝐭𝐭𝐞𝐫𝐬
You’ll help purify and ...
www.linkedin.com
October 31, 2025 at 9:05 PM
my friend and wonderful colleague Stan is hiring at Genentech in South San Francisco! 🧬 🌉
Biochemist/structural biologist looking for your first position in industry? I can’t recommend working with Stan enough ☺️ please repost for visibility
www.linkedin.com/posts/stanis...
Biochemist/structural biologist looking for your first position in industry? I can’t recommend working with Stan enough ☺️ please repost for visibility
www.linkedin.com/posts/stanis...
Reposted by Jonas Möcking
Jonas Moecking et al.: Cryo-EM single-particle analysis expanding towards increasingly native samples ##SingleParticleAnalysis##InSitu##CryoEM@uniutrecht@uniutrecht...##IUCrhttps://journals.iucr.org/paper?S2059798325008332
Cryo-EM single-particle analysis expanding towards increasingly native samples
Cryo-EM single-particle analysis has revolutionized structural biology by allowing high-resolution analysis of large molecular assemblies that are not amenable to crystallography or NMR. Combination of this technology with innovative sample-preparation protocols further expands the range of potential targets.
journals.iucr.org
October 24, 2025 at 12:00 AM
Jonas Moecking et al.: Cryo-EM single-particle analysis expanding towards increasingly native samples ##SingleParticleAnalysis##InSitu##CryoEM@uniutrecht@uniutrecht...##IUCrhttps://journals.iucr.org/paper?S2059798325008332
Happy to see this out :)
How close does single-particle cryo-EM get to in situ structure determination? In this review, @tzviyazbm.bsky.social and I explore recent examples of studies that we believe push the boundaries of what's possible. #cryo-EM
How close does single-particle cryo-EM get to in situ structure determination? In this review, @tzviyazbm.bsky.social and I explore recent examples of studies that we believe push the boundaries of what's possible. #cryo-EM
Cryo-EM single-particle analysis expanding towards increasingly native samples pubmed.ncbi.nlm.nih.gov/41129371/ #cryoem
October 29, 2025 at 11:44 AM
Happy to see this out :)
How close does single-particle cryo-EM get to in situ structure determination? In this review, @tzviyazbm.bsky.social and I explore recent examples of studies that we believe push the boundaries of what's possible. #cryo-EM
How close does single-particle cryo-EM get to in situ structure determination? In this review, @tzviyazbm.bsky.social and I explore recent examples of studies that we believe push the boundaries of what's possible. #cryo-EM
Reposted by Jonas Möcking
Repost appreciated:
Open #PhDposition in structural virology in my group! Join us in Umeå, Sweden to uncover how arboviruses remodel infected cells. In situ #cryoET and #cryoEM combined with #virology, #cellbiology, and #biophysics.
Deadline 7 September. More info: www.carlsonlab.se/join/
Open #PhDposition in structural virology in my group! Join us in Umeå, Sweden to uncover how arboviruses remodel infected cells. In situ #cryoET and #cryoEM combined with #virology, #cellbiology, and #biophysics.
Deadline 7 September. More info: www.carlsonlab.se/join/
August 13, 2025 at 10:10 PM
Repost appreciated:
Open #PhDposition in structural virology in my group! Join us in Umeå, Sweden to uncover how arboviruses remodel infected cells. In situ #cryoET and #cryoEM combined with #virology, #cellbiology, and #biophysics.
Deadline 7 September. More info: www.carlsonlab.se/join/
Open #PhDposition in structural virology in my group! Join us in Umeå, Sweden to uncover how arboviruses remodel infected cells. In situ #cryoET and #cryoEM combined with #virology, #cellbiology, and #biophysics.
Deadline 7 September. More info: www.carlsonlab.se/join/
Reposted by Jonas Möcking
I am happy our recent study on the human sperm head-tail junction is now online. We find that SUN5 form an hexagonal lattice at the nuclear membrane, rationalising how mutations in SUN5 lead to infertility. Great work of @cryonas.bsky.social !
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
SUN5 forms a regular protein lattice reinforcing the sperm head-tail junction
Linker of nucleo- and cytoskeleton (LINC) complexes reside in the nuclear envelope, the double-membrane surrounding the nucleus, where they establish a physical bridge between nucleus and cytoplasm. L...
www.biorxiv.org
July 31, 2025 at 3:07 PM
I am happy our recent study on the human sperm head-tail junction is now online. We find that SUN5 form an hexagonal lattice at the nuclear membrane, rationalising how mutations in SUN5 lead to infertility. Great work of @cryonas.bsky.social !
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
ASS is short for acephalic spermatozoa syndrome in which head and tail of sperm are detached⛓️💥, commonly caused by mutations in the gene encoding for SUN5. Using in situ cryo-ET❄️🔬 we find that SUN5 forms a protein lattice in the nuclear envelope (NE) at the head-tail junction of mammalian sperm.1/4
July 31, 2025 at 3:40 PM
ASS is short for acephalic spermatozoa syndrome in which head and tail of sperm are detached⛓️💥, commonly caused by mutations in the gene encoding for SUN5. Using in situ cryo-ET❄️🔬 we find that SUN5 forms a protein lattice in the nuclear envelope (NE) at the head-tail junction of mammalian sperm.1/4
Reposted by Jonas Möcking
Asgard archaea have actin - but what about microtubules? Where do they come from? 🧐 Our new paper www.cell.com/cell/fulltex... by @xujwet.bsky.social & @florianwollweber.bsky.social, in collaboration with the Schleper & Wieczorek labs, describes tiny Asgard microtubules! #TeamTomo #ArchaeaSky 1/6
March 21, 2025 at 3:16 PM
Asgard archaea have actin - but what about microtubules? Where do they come from? 🧐 Our new paper www.cell.com/cell/fulltex... by @xujwet.bsky.social & @florianwollweber.bsky.social, in collaboration with the Schleper & Wieczorek labs, describes tiny Asgard microtubules! #TeamTomo #ArchaeaSky 1/6
Reposted by Jonas Möcking
Mature #HIV-1 contains >2000 copies of “spacer peptide 2”, but we didn’t know why. We now see that SP2 binds the matrix protein and triggers the change into its mature arrangement. Summary video from @margotriggi.bsky.social
February 28, 2025 at 2:04 PM
Mature #HIV-1 contains >2000 copies of “spacer peptide 2”, but we didn’t know why. We now see that SP2 binds the matrix protein and triggers the change into its mature arrangement. Summary video from @margotriggi.bsky.social