tycheleturner.bsky.social
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tycheleturner.bsky.social
@tycheleturner.bsky.social
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New paper in @BiologyOpen: “Generation and characterization of a knockout mouse of an enhancer of EBF3.”
@washugenetics.bsky.social @jacksonlab.bsky.social
journals.biologists.com/bio/article/...
Generation and characterization of a knockout mouse of an enhancer of EBF3
Summary: This study focuses on the generation and initial characterization of a knockout mouse for a region of noncoding, regulatory DNA that was previously implicated in autism.
journals.biologists.com
November 7, 2025 at 2:16 PM
Wow, @github.com contributions look different today. No green. It looks like corn 🌽

Happy Halloween!
October 31, 2025 at 8:35 PM
1/
WashU research news; excited to share our new paper on Chromosome 9p Syndromes 🧬 Hope you take the time to read it. Here is the link:
link.springer.com/article/10.1...

@washugenetics.bsky.social
Whole-genome sequencing reveals individual and cohort level insights into chromosome 9p syndromes - Genome Medicine
Background Previous genomic efforts on chromosome 9p deletion and duplication syndromes have utilized low-resolution strategies (i.e., karyotypes, chromosome microarrays). These studies have provided ...
link.springer.com
October 28, 2025 at 11:27 PM
❤️
link.springer.com/10.1186/s130...
Whole-genome sequencing reveals individual and cohort level insights into chromosome 9p syndromes - Genome Medicine
Background Previous genomic efforts on chromosome 9p deletion and duplication syndromes have utilized low-resolution strategies (i.e., karyotypes, chromosome microarrays). These studies have provided ...
link.springer.com
October 24, 2025 at 11:22 AM
Thank you to Dr. Evan Eichler for visiting #WashU and presenting in our Department of Genetics seminar series. An inspiring talk from one of my academic fathers! @washugenetics.bsky.social #genetics #genomics
October 24, 2025 at 3:28 AM
Big milestone for the @TNTurnerLab as our very first postdoc officially started this week!
Welcome Arvinden to the team!
@WashUGenetics #genomics #genetics #noncoding #mpra #postdoc
September 19, 2025 at 10:23 PM
🐭This week the detail sheet for the enhancer knockout mouse we describe in doi.org/10.1101/2025... became available at the MMRRC www.mmrrc.org/catalog/sds..... Please check it out if you are interested in ordering the mice. #noncoding #enhancer #ebf3 #genomics #genetics @TNTurnerLab @WashUGenetics 🐭
Generation and Characterization of a Knockout Mouse of an Enhancer of EBF3
Genomic studies of autism and other neurodevelopmental disorders have identified several relevant protein-coding and noncoding variants. One gene with an excess of protein-coding de novo variants is E...
doi.org
September 19, 2025 at 10:19 PM
Just an FYI: I am not, nor have I ever been, affiliated with Boston University. The ASHG program listed me there in error. I remain with Washington University in St. Louis @washugenetics.bsky.social. ASHG has been notified, and I appreciate those who reached out about the inaccurate listing.
September 9, 2025 at 7:09 PM
Here’s to all my colleagues rocking bowties! Happy #BowtieDay! Shoutout to Sandy Boynton for the image. #Style #WorkLife
August 28, 2025 at 10:24 PM
Reposted by tycheleturner.bsky.social
mydennis.bsky.social
Check out our latest work co-led by @dcsoto.bsky.social and @jmuribescr.bsky.social identifying hundreds of human duplicated gene families using the new T2T-CHM13 assembly, with a focus on those potentially contributing to brain evolution 🧪: authors.elsevier.com/a/1lTQtL7PXu...
authors.elsevier.com
July 21, 2025 at 4:26 PM
New from TNTurnerLab at WashUGenetics!

Check out our latest paper on efficient genome-wide copy number genotyping in WGS data: sciencedirect.com/science/arti...

Also explore the CNPI toolkit powering this work: github.com/TNTurnerLab/...

#genomics #WGS #copyNumber #cnv
CNPI: Rapid Analyses of Human Copy Number Data
Tools for genotyping copy number in whole-genome sequencing (WGS) data exist. Despite their availability, there are a limited number of tools that eff…
sciencedirect.com
July 16, 2025 at 12:42 PM
Currently, I have a a formal postdoctoral job listing for a position in @TNTurnerLab @WashUGenetics, See also turnerlab.wustl.edu/employment/ and wustl.wd1.myworkdayjobs.com/External/job.... #genomics #genetics #neuroscience #molecularBiology #computationalBiology #oncology #postdoc
Employment
Students Graduate students in the Division of Biology & Biomedical Sciences at Washington University School of Medicine are welcome to contact Dr. Turner to discuss potential rotation projects.…
turnerlab.wustl.edu
May 19, 2025 at 9:03 PM
View my verified achievement from Compass Training and Mentoring Program at Washington University School of Medicine in St. Louis. www.credly.com/badges/7ac68... via @credly
Compass Foundational Training was issued by Compass Training and Mentoring Program at Washington University School of Medicine in St. Louis to Tychele Turner.
The Compass program provides researchers with the training and mentoring they need to successfully launch their careers. Program Scholars receive guidance and tools to be intentional about leading the...
www.credly.com
April 22, 2025 at 11:45 PM
Visium HD Spatial Transcriptomics of E13.5 Wild Type Mouse Head we generated in our preprint medrxiv.org/content/10.1... is now available on Zenodo doi.org/10.5281/zeno.... #genomics #genetics #9p #neuroscience #brain #development
April 15, 2025 at 10:36 PM
Reposted by tycheleturner.bsky.social
github.com
⭐ In 2005, Git made its first commit.
⏩ Fast-forward to 2025, we relive the birth of Git with the creator, Linus Torvalds.
❤️ Head down memory lane with us.
github.blog/open-source/...
April 8, 2025 at 12:25 AM
Happened upon this interesting website 42basepairs.com/browse. Came across it today when looking at some publicly available whole-genome sequencing data. #genetics #genomics
Browse - 42basepairs
42basepairs.com
April 8, 2025 at 12:19 AM
Our new collaborative preprint is online now “Whole-Genome Sequencing Reveals Individual and Cohort Level Insights into Chromosome 9p Syndromes” www.medrxiv.org/content/10.1... and is the result of many colleagues working together towards understanding of 9p-related syndromes #genomics #genetics #9p
Whole-Genome Sequencing Reveals Individual and Cohort Level Insights into Chromosome 9p Syndromes
Previous genomic efforts on chromosome 9p deletion and duplication syndromes have utilized low resolution strategies (i.e., karyotypes, chromosome microarrays). We present the first large-scale whole-...
www.medrxiv.org
March 31, 2025 at 8:06 PM
Reposted by tycheleturner.bsky.social
rachelkarchin.bsky.social
Excited to share new joint publication with the Tychele Turner lab at WashU now published in Cell Genomics! We do a proteome-wide assessment of differential missense variant clustering in neurodevelopmental disorders and cancers and find some interesting differences!

tinyurl.com/2p9j559n
Proteome-wide assessment of differential missense variant clustering in neurodevelopmental disorders and cancer - PubMed
Prior studies examining genomic variants suggest that some proteins contribute to both neurodevelopmental disorders (NDDs) and cancer. While there are several potential etiologies, here, we hypothesiz...
pubmed.ncbi.nlm.nih.gov
March 15, 2025 at 7:42 PM
Just curious, has anyone ever generated a complete T2T human genome assembly using only PacBio HiFi data?

www.pacb.com/vega-genomes...

If yes, that would be awesome. Please post the link.
Vega genomes datasets - PacBio
Explore Vega genomes demo datasets on Vega benchtop system
www.pacb.com
March 13, 2025 at 3:03 PM
Our new paper is online today in Cell Genomics “Proteome-wide assessment of differential missense variant clustering in neurodevelopmental disorders and cancer”
www.cell.com/cell-genomic...
#genetics #protein #cancer #neurodevelopmentalDisorder #TNTurnerLab @washugenetics.bsky.social
Proteome-wide assessment of differential missense variant clustering in neurodevelopmental disorders and cancer
Proteins implicated in neurodevelopmental disorders (NDDs) and cancer have been identified from analyses of genomic variation. Some of these proteins occur in both phenotypes, but the reason for this ...
www.cell.com
March 11, 2025 at 10:41 PM
Today, TNTurnerLab undergraduate researcher Emily Cordova Hurtado presented her project “Generation and Characterization of a Knockout Mouse of an Enhancer of EBF3” @washugenetics.bsky.social department seminar today! #genetics #genomics
March 6, 2025 at 1:15 AM
February 13, 2025 at 2:22 AM
Check out our new collaborative preprint “Generation and Characterization of a Knockout Mouse of an Enhancer of EBF3” on bioRxiv #genetics #ebf3 #mouse #enhancer #noncoding #genomics
www.biorxiv.org/content/10.1...
Generation and Characterization of a Knockout Mouse of an Enhancer of EBF3
Genomic studies of autism and other neurodevelopmental disorders have identified several relevant protein-coding and noncoding variants. One gene with an excess of protein-coding de novo variants is E...
www.biorxiv.org
January 12, 2025 at 10:29 PM
Reposted by tycheleturner.bsky.social
iddrc-washu.bsky.social
www.youtube.com/watch?v=c8Bz...
IDDRC Introduction by Co-directors Joseph Dougherty, PhD and Christina A. Gurnett, MD, PhD
YouTube video by WashU IDDRC
www.youtube.com
December 20, 2024 at 10:23 PM
I am looking for serious applicants who are interested in doing a postdoc in Human #Genetics in my lab. Looking for wet and/or dry lab postdocs. If you are interested, DM me.
November 1, 2024 at 7:33 PM