Thomas Pulinilkunnil
@tpulinil.bsky.social
Professor in cell biology and signaling. Discovery Scientist, Teacher, Learner, Dad, Husband, enjoy everything on research in Metabolism, Autophagy, Signalling, Organelles, Nutrients. metabolismlab.com
Congrats to Gurpreet Kaur, on a successful MSc. defence. Incredibly proud of Gurpreet for a thesis well done, examining the role of #TFE3 in #cardiomyocyte #metabolism and function. Thanks to the examining and supervisory research committee for their feedback @dalhousieu.bsky.social
August 19, 2025 at 12:25 PM
Congrats to Gurpreet Kaur, on a successful MSc. defence. Incredibly proud of Gurpreet for a thesis well done, examining the role of #TFE3 in #cardiomyocyte #metabolism and function. Thanks to the examining and supervisory research committee for their feedback @dalhousieu.bsky.social
Thrilled to have attended #SHVM2025. Outstanding science showcased by the #metabolism community. Excellent time connecting with family and friends. Grateful for #Bordeaux Hospitality and looking forward to #SHVM2026 in Osaka Japan @Soc_HrtVasMetab @DalMedNB
June 26, 2025 at 2:39 PM
Thrilled to have attended #SHVM2025. Outstanding science showcased by the #metabolism community. Excellent time connecting with family and friends. Grateful for #Bordeaux Hospitality and looking forward to #SHVM2026 in Osaka Japan @Soc_HrtVasMetab @DalMedNB
Lymphatic #endothelial #BCAA catabolic defects inhibit vascular endothelial growth factor receptor 3 (#VEGFR3) to undermine cardiac lymphatic integrity. Cardiac lymphatic disruption driven by impaired #BCAA catabolism drives HFpEF.
@americanheart.bsky.social
ahajournals.org/doi/10.1161/...
@americanheart.bsky.social
ahajournals.org/doi/10.1161/...
April 5, 2025 at 6:15 PM
Lymphatic #endothelial #BCAA catabolic defects inhibit vascular endothelial growth factor receptor 3 (#VEGFR3) to undermine cardiac lymphatic integrity. Cardiac lymphatic disruption driven by impaired #BCAA catabolism drives HFpEF.
@americanheart.bsky.social
ahajournals.org/doi/10.1161/...
@americanheart.bsky.social
ahajournals.org/doi/10.1161/...
#Genome-wide association study meta-analysis provides insights into the etiology of #heartfailure and its subtypes. Nat Genet (2025). doi.org/10.1038/s415...
@natureportfolio.nature.com
www.nature.com/articles/s41...
@natureportfolio.nature.com
www.nature.com/articles/s41...
Genome-wide association study meta-analysis provides insights into the etiology of heart failure and its subtypes - Nature Genetics
Genome-wide association analyses identify new risk loci for heart failure and its subtypes, extending understanding of the underlying biological pathways and disease mechanisms.
www.nature.com
March 20, 2025 at 9:29 PM
#Genome-wide association study meta-analysis provides insights into the etiology of #heartfailure and its subtypes. Nat Genet (2025). doi.org/10.1038/s415...
@natureportfolio.nature.com
www.nature.com/articles/s41...
@natureportfolio.nature.com
www.nature.com/articles/s41...
Excellent meeting of #IHCVS2025 at @UHCancerCenter. Thrilled to network with colleagues in #cardiovascular sciences. A treat to outstanding science, wonderful company, beautiful @gohawaii weather with friends and family @PKienesberger
abp.jabsom.hawaii.edu/ihcvs/
abp.jabsom.hawaii.edu/ihcvs/
February 9, 2025 at 4:10 AM
Excellent meeting of #IHCVS2025 at @UHCancerCenter. Thrilled to network with colleagues in #cardiovascular sciences. A treat to outstanding science, wonderful company, beautiful @gohawaii weather with friends and family @PKienesberger
abp.jabsom.hawaii.edu/ihcvs/
abp.jabsom.hawaii.edu/ihcvs/
Our lab is thrilled to receive @CIHR_IRSC project grant funding to study the #cardiometabolic and #signaling role of #TFEB protein. Excited to see how understanding of TFEB control of cardiac metabolism evolves.Thank you, reviewers, team, and collaborators. We are hiring; please DM if interested.
February 1, 2025 at 2:57 AM
Our lab is thrilled to receive @CIHR_IRSC project grant funding to study the #cardiometabolic and #signaling role of #TFEB protein. Excited to see how understanding of TFEB control of cardiac metabolism evolves.Thank you, reviewers, team, and collaborators. We are hiring; please DM if interested.
Nutrient Signalling and Metabolism Lab wishes you and your family a wonderful Christmas and a healthy, joyful and productive New Year. Season’s Greetings from Pulinilkunnil and Kienesberger labs @tpulinil.bsky.social @pkienesberger.bsky.social .
December 24, 2024 at 3:25 PM
Nutrient Signalling and Metabolism Lab wishes you and your family a wonderful Christmas and a healthy, joyful and productive New Year. Season’s Greetings from Pulinilkunnil and Kienesberger labs @tpulinil.bsky.social @pkienesberger.bsky.social .
A fascinating evolution of the functional role of BCAA in cancer. Interesting study showing human HDAC6 as a valine sensor to regulate DNA integrity. Nuclear-localized HDAC6 binds and deacetylates TET2 to induce DNA demethylation and damage
@natureportfolio.bsky.social
Nature (2024). rdcu.be/d1waX
@natureportfolio.bsky.social
Nature (2024). rdcu.be/d1waX
Human HDAC6 senses valine abundancy to regulate DNA damage
Nature - The histone deacetylase HDAC6 is a sensor of valine levels, and the abundance of valine in cells regulates DNA damage and cell homeostasis functions.
rdcu.be
November 26, 2024 at 2:50 PM
A fascinating evolution of the functional role of BCAA in cancer. Interesting study showing human HDAC6 as a valine sensor to regulate DNA integrity. Nuclear-localized HDAC6 binds and deacetylates TET2 to induce DNA demethylation and damage
@natureportfolio.bsky.social
Nature (2024). rdcu.be/d1waX
@natureportfolio.bsky.social
Nature (2024). rdcu.be/d1waX
Had a great time at the 2024 @DiabetesCanada meeting in #Halifax, networking and learning from colleagues and witnessing stellar posters and talks from trainees @pkienesberger.bsky.social @DalMedNB @DalMedSchool @impartteam
November 24, 2024 at 5:09 AM
Had a great time at the 2024 @DiabetesCanada meeting in #Halifax, networking and learning from colleagues and witnessing stellar posters and talks from trainees @pkienesberger.bsky.social @DalMedNB @DalMedSchool @impartteam
Reposted by Thomas Pulinilkunnil
mTORC1 activity licenses its own release from the lysosomal surface
www.cell.com/molecular-ce...
www.cell.com/molecular-ce...
mTORC1 activity licenses its own release from the lysosomal surface
The activation of mTORC1 is intricately linked to its subcellular localization, with
the Rag GTPases controlling its lysosomal recruitment in response to nutrient cues.
Acharya and Demetriades uncover...
www.cell.com
November 23, 2024 at 11:13 AM
mTORC1 activity licenses its own release from the lysosomal surface
www.cell.com/molecular-ce...
www.cell.com/molecular-ce...
Reposted by Thomas Pulinilkunnil
Hi everyone! New to Bluesky, but happy to share the final chapter of my PhD @uconnhealth.bsky.social out today in Nature Immunology! Here, we uncovered a noncanonical function of the glucose transporter GLUT4 in regulating RLR signaling in muscle and adipocytes
www.nature.com/articles/s41...
www.nature.com/articles/s41...
UBXN9 governs GLUT4-mediated spatial confinement of RIG-I-like receptors and signaling - Nature Immunology
Wang and colleagues show that in skeletal muscle cells and cardiomyocytes, the glucose transporter GLUT4 is a negative regulator of RIG-I-like receptor signaling during viral infection by redistributi...
www.nature.com
November 20, 2024 at 7:28 PM
Hi everyone! New to Bluesky, but happy to share the final chapter of my PhD @uconnhealth.bsky.social out today in Nature Immunology! Here, we uncovered a noncanonical function of the glucose transporter GLUT4 in regulating RLR signaling in muscle and adipocytes
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Thomas Pulinilkunnil
Mitochondrial pyruvate transport regulates presynaptic metabolism and neurotransmission
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Mitochondrial pyruvate transport regulates presynaptic metabolism and neurotransmission
The brain uses pyruvate as an energy source, and mitochondrial pyruvate metabolism in nerve terminals controls neurotransmission.
www.science.org
November 20, 2024 at 1:31 PM
Mitochondrial pyruvate transport regulates presynaptic metabolism and neurotransmission
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Thomas Pulinilkunnil
Published a few weeks ago in Cancer Research, we show benefit of targeting HMCR with pitavastatin in combo with AKT inhibitors in TNBC. Many amazing people contributed, led by the magnificently talented @alissandra-hillis.bsky.social! Looking to initiate new clinical trials based on this combo. 🧪
Targeting Cholesterol Biosynthesis with Statins Synergizes with AKT Inhibitors in Triple-Negative Breast Cancer
Two FDA-approved compounds, AKT inhibitors and pitavastatin, synergize to induce cell death in triple-negative breast cancer, motivating evaluation of the efficacy of this combination in clinical tria...
aacrjournals.org
November 20, 2024 at 12:09 PM
Published a few weeks ago in Cancer Research, we show benefit of targeting HMCR with pitavastatin in combo with AKT inhibitors in TNBC. Many amazing people contributed, led by the magnificently talented @alissandra-hillis.bsky.social! Looking to initiate new clinical trials based on this combo. 🧪
Reposted by Thomas Pulinilkunnil
we are excited to join the community by sharing latest story from the lab where we show that mitochondrial pyruvate uptake is a critical step ATP production in hippocampal terminals and regulated by lysine acetylation of MPC. www.science.org/doi/full/10....
Mitochondrial pyruvate transport regulates presynaptic metabolism and neurotransmission
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science.org
November 20, 2024 at 4:10 PM
we are excited to join the community by sharing latest story from the lab where we show that mitochondrial pyruvate uptake is a critical step ATP production in hippocampal terminals and regulated by lysine acetylation of MPC. www.science.org/doi/full/10....
Reposted by Thomas Pulinilkunnil
Oncogenic fatty acid oxidation senses #circadian disruption in sleep-deficiency-enhanced tumorigenesis
www.cell.com/cell-metabol...
www.cell.com/cell-metabol...
November 21, 2024 at 6:35 AM
Oncogenic fatty acid oxidation senses #circadian disruption in sleep-deficiency-enhanced tumorigenesis
www.cell.com/cell-metabol...
www.cell.com/cell-metabol...
Reposted by Thomas Pulinilkunnil
Reducing the mitochondrial oxidative burden alleviates lipid-induced muscle insulin resistance in humans
In our latest study, we provide mechanistic evidence implicating mitochondrial ROS in the development of muscle insulin resistance in hyperlipidemic states such as obesity.
1/7 🧵👇
In our latest study, we provide mechanistic evidence implicating mitochondrial ROS in the development of muscle insulin resistance in hyperlipidemic states such as obesity.
1/7 🧵👇
Reducing the mitochondrial oxidative burden alleviates lipid-induced muscle insulin resistance in humans
Selective targeting of mitochondrial oxidative stress mitigates lipid-induced insulin resistance in humans.
science.org
November 20, 2024 at 3:42 PM
Reducing the mitochondrial oxidative burden alleviates lipid-induced muscle insulin resistance in humans
In our latest study, we provide mechanistic evidence implicating mitochondrial ROS in the development of muscle insulin resistance in hyperlipidemic states such as obesity.
1/7 🧵👇
In our latest study, we provide mechanistic evidence implicating mitochondrial ROS in the development of muscle insulin resistance in hyperlipidemic states such as obesity.
1/7 🧵👇
Reposted by Thomas Pulinilkunnil
Probing the mechanical properties of microtubules and actin from inside the cell using magnets 🧲 doi.org/10.1083/jcb.... in @jcellbiol.bsky.social
November 19, 2024 at 5:34 PM
Probing the mechanical properties of microtubules and actin from inside the cell using magnets 🧲 doi.org/10.1083/jcb.... in @jcellbiol.bsky.social
Reposted by Thomas Pulinilkunnil
The muscle of a heart photographed through an electron microscope. Pseudo-color shows the myosin II filaments that sit at the core of the #sarcomere (cyan), the borders of the sarcomere (purple), and #Mitochondria (pink)
#science #biology #cellbiology #microscopy #photography #cardiosky #medsky
#science #biology #cellbiology #microscopy #photography #cardiosky #medsky
November 18, 2024 at 4:48 PM
The muscle of a heart photographed through an electron microscope. Pseudo-color shows the myosin II filaments that sit at the core of the #sarcomere (cyan), the borders of the sarcomere (purple), and #Mitochondria (pink)
#science #biology #cellbiology #microscopy #photography #cardiosky #medsky
#science #biology #cellbiology #microscopy #photography #cardiosky #medsky
My first post on @bsky.app to connect with the scientific community. A glutamine metabolic switch supports erythropoiesis. Enhancing Glutamine Synthetese activity alleviates the pathological defects in β-thalassemia.
DOI: 10.1126/science.adh9215
www-science-org.ezproxy.library.dal.ca/doi/10.1126/...
DOI: 10.1126/science.adh9215
www-science-org.ezproxy.library.dal.ca/doi/10.1126/...
November 18, 2024 at 2:36 AM
My first post on @bsky.app to connect with the scientific community. A glutamine metabolic switch supports erythropoiesis. Enhancing Glutamine Synthetese activity alleviates the pathological defects in β-thalassemia.
DOI: 10.1126/science.adh9215
www-science-org.ezproxy.library.dal.ca/doi/10.1126/...
DOI: 10.1126/science.adh9215
www-science-org.ezproxy.library.dal.ca/doi/10.1126/...