Thomas Boettcher
@thomasboettcher.bsky.social
Professor of Microbial Biochemistry at University of Vienna at the Faculty of Chemistry and CeMESS. Investigating microbial metabolites and modulating bacterial behavior. #ChemicalBiology #Phages #Antibiotics
https://boettcher-lab.univie.ac.at/
https://boettcher-lab.univie.ac.at/
Reposted by Thomas Boettcher
3/3 🐝CoE Postdoc @davidszamosvari.bsky.social from @thomasboettcher.bsky.social lab @Faculty of Chemistry @univie.ac.at explores specialized enzymes breaking down complex wax esters in human skin, beeswax, and plant cuticles.
More info: www.microplanet.at/index.php/re...
More info: www.microplanet.at/index.php/re...
February 5, 2026 at 11:01 AM
3/3 🐝CoE Postdoc @davidszamosvari.bsky.social from @thomasboettcher.bsky.social lab @Faculty of Chemistry @univie.ac.at explores specialized enzymes breaking down complex wax esters in human skin, beeswax, and plant cuticles.
More info: www.microplanet.at/index.php/re...
More info: www.microplanet.at/index.php/re...
Reposted by Thomas Boettcher
Congrats to CoE Key Researcher @thomasboettcher.bsky.social @univie.ac.at on his ERC Proof of Concept Grant! 👏 His project, PhageTRAP, uses a modular platform to capture and release phages to tackle antibiotic resistance and advance biotech. @fwf-at.bsky.social @erc.europa.eu #MicroSky #AMR #ERCPoC
January 28, 2026 at 10:58 AM
Congrats to CoE Key Researcher @thomasboettcher.bsky.social @univie.ac.at on his ERC Proof of Concept Grant! 👏 His project, PhageTRAP, uses a modular platform to capture and release phages to tackle antibiotic resistance and advance biotech. @fwf-at.bsky.social @erc.europa.eu #MicroSky #AMR #ERCPoC
Reposted by Thomas Boettcher
Der Chemiker @thomasboettcher.bsky.social erhält einen Proof of Concept Grant des @erc.europa.eu. Wir gratulieren herzlichst! 🎉
Im Projekt 'PhageTRAP' entwickelt Thomas Böttcher eine modulare Plattform, die Bakteriophagen mithilfe synthetischer Erkennungsmotive gezielt einfängt und freisetzt. ⤵️ 🧪
Im Projekt 'PhageTRAP' entwickelt Thomas Böttcher eine modulare Plattform, die Bakteriophagen mithilfe synthetischer Erkennungsmotive gezielt einfängt und freisetzt. ⤵️ 🧪
Neuer ERC Proof of Concept für die Universität Wien
Förderung für den Chemiker Thomas Böttcher
www.univie.ac.at
January 27, 2026 at 1:28 PM
Der Chemiker @thomasboettcher.bsky.social erhält einen Proof of Concept Grant des @erc.europa.eu. Wir gratulieren herzlichst! 🎉
Im Projekt 'PhageTRAP' entwickelt Thomas Böttcher eine modulare Plattform, die Bakteriophagen mithilfe synthetischer Erkennungsmotive gezielt einfängt und freisetzt. ⤵️ 🧪
Im Projekt 'PhageTRAP' entwickelt Thomas Böttcher eine modulare Plattform, die Bakteriophagen mithilfe synthetischer Erkennungsmotive gezielt einfängt und freisetzt. ⤵️ 🧪
Proud to see our work on bacteriophage inhibitors featured on one of the covers of the first issue of this year of
@rscchembio.rsc.org
@rscchembio.rsc.org
First issue of 2026 is now online and #openaccess!
In this issue: G-clamp based RNA-binding molecular probes, bacteriophage small molecule inhibitors, translation-enhancing peptide screening platforms, bioluminescent D-luciferin analogues and much more!
📰Read the full issue here: lnkd.in/eYSvHxtp
In this issue: G-clamp based RNA-binding molecular probes, bacteriophage small molecule inhibitors, translation-enhancing peptide screening platforms, bioluminescent D-luciferin analogues and much more!
📰Read the full issue here: lnkd.in/eYSvHxtp
January 17, 2026 at 12:06 PM
Proud to see our work on bacteriophage inhibitors featured on one of the covers of the first issue of this year of
@rscchembio.rsc.org
@rscchembio.rsc.org
Reposted by Thomas Boettcher
Congrats to CoE Key Researcher @thomasboettcher.bsky.social @univie.ac.at on securing @fwf-at.bsky.social funding for Collaborative Research Centre with @dfg.de. Focus on bacterial effector proteins, infection mechanisms, and therapeutic strategies. cemess.univie.ac.at/news-detail/...
January 16, 2026 at 7:27 AM
Congrats to CoE Key Researcher @thomasboettcher.bsky.social @univie.ac.at on securing @fwf-at.bsky.social funding for Collaborative Research Centre with @dfg.de. Focus on bacterial effector proteins, infection mechanisms, and therapeutic strategies. cemess.univie.ac.at/news-detail/...
Reposted by Thomas Boettcher
Congratulations to Thomas Böttcher and his team @univie.ac.at, Faculty of Chemistry | #CeMESS) on @fwf-at.bsky.social “International – Multilateral Initiatives” funding alongside @dfg.de for “CRC 1756”!
Learn more 🔗 cemess.univie.ac.at/news-detail/...
Learn more 🔗 cemess.univie.ac.at/news-detail/...
cemess.univie.ac.at
January 8, 2026 at 2:00 PM
Congratulations to Thomas Böttcher and his team @univie.ac.at, Faculty of Chemistry | #CeMESS) on @fwf-at.bsky.social “International – Multilateral Initiatives” funding alongside @dfg.de for “CRC 1756”!
Learn more 🔗 cemess.univie.ac.at/news-detail/...
Learn more 🔗 cemess.univie.ac.at/news-detail/...
Just hot from the press: nice work by Konstantin Plöchl of our lab on solute binding proteins of P. aeruginosa out now in Scientific Reports.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
The solute-binding proteins DppA1–5 of Pseudomonas aeruginosa have distinct substrate profiles - Scientific Reports
Scientific Reports - The solute-binding proteins DppA1–5 of Pseudomonas aeruginosa have distinct substrate profiles
www.nature.com
December 23, 2025 at 1:58 PM
Just hot from the press: nice work by Konstantin Plöchl of our lab on solute binding proteins of P. aeruginosa out now in Scientific Reports.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Uni Vienna awards 20 postdoctoral positions for 4 years to outstanding female scientists. Our lab boettcher-lab.univie.ac.at participates as host in the field of chemical biology. Eligibility: female, PhD in 2022 or after
The E-STEEM call opens on 07.01.2026:
careers.univie.ac.at/en/postdoc/e...
The E-STEEM call opens on 07.01.2026:
careers.univie.ac.at/en/postdoc/e...
careers.univie.ac.at
December 15, 2025 at 4:27 PM
Uni Vienna awards 20 postdoctoral positions for 4 years to outstanding female scientists. Our lab boettcher-lab.univie.ac.at participates as host in the field of chemical biology. Eligibility: female, PhD in 2022 or after
The E-STEEM call opens on 07.01.2026:
careers.univie.ac.at/en/postdoc/e...
The E-STEEM call opens on 07.01.2026:
careers.univie.ac.at/en/postdoc/e...
Reposted by Thomas Boettcher
New @fwf-at.bsky.social CoE Microplanet study from @thomasboettcher.bsky.social lab @univie.ac.at with colleagues from @tumunich.bsky.social introduces High-Level Oxidative Stress (HiLOS) response that enables strong oxidative agents to activate prophages. pubs.rsc.org/en/content/a...
December 1, 2025 at 10:49 AM
New @fwf-at.bsky.social CoE Microplanet study from @thomasboettcher.bsky.social lab @univie.ac.at with colleagues from @tumunich.bsky.social introduces High-Level Oxidative Stress (HiLOS) response that enables strong oxidative agents to activate prophages. pubs.rsc.org/en/content/a...
Reposted by Thomas Boettcher
New @fwf-at.bsky.social CoE Microplanet study from @thomasboettcher.bsky.social lab with first author Konstantin Plöchl @univie.ac.at identified a new class of phage blockers, enabling detailed study of phage's role in IBD, diabetes, and infections. pubs.rsc.org/en/content/a...
November 10, 2025 at 10:24 AM
New @fwf-at.bsky.social CoE Microplanet study from @thomasboettcher.bsky.social lab with first author Konstantin Plöchl @univie.ac.at identified a new class of phage blockers, enabling detailed study of phage's role in IBD, diabetes, and infections. pubs.rsc.org/en/content/a...
We are excited to be part of the newly approved SFB contributing from @univie.ac.at to this wonderful collaborative research centre!
In der aktuellen Auswahlrunde hat die @dfg.de gleich zwei neue #UniKonstanz Sonderforschungsbereiche bewilligt. Die Forschungsteams werden sich intensiv mit Trigger-Signalen bei biologischen Zellen sowie mit „Stille“ und „Störung“ in der menschlichen Sprache beschäftigen: https://t1p.de/e1ksl
November 22, 2025 at 8:56 PM
We are excited to be part of the newly approved SFB contributing from @univie.ac.at to this wonderful collaborative research centre!
Check out our latest work, which got just published in Chemical Science. The study about SOS-independent prophage induction was led by Dr. Magdalena Jancheva: pubs.rsc.org/en/content/a... @univie.ac.at #phages #chemicalbiology #FWF #ERC
A phage-selective trigger hints at an SOS-independent mechanism of prophage induction by oxidative stress
We identified a prophage-selective induction in poly-lysogenic Staphylococcus aureus induced by certain phenazines, such as pyocyanin, produced by Pseudomonas aeruginosa. Using a focused library of ph...
pubs.rsc.org
November 20, 2025 at 1:11 PM
Check out our latest work, which got just published in Chemical Science. The study about SOS-independent prophage induction was led by Dr. Magdalena Jancheva: pubs.rsc.org/en/content/a... @univie.ac.at #phages #chemicalbiology #FWF #ERC
Our latest research just accepted in RSC Chemical Biology:
pubs.rsc.org/en/content/a...
In this study led by Konstantin Plöchl from our lab, we report a novel class of small-molecule inhibitors targeting bacteriophage infection. #phages #chemicalbiology
@univie.ac.at
pubs.rsc.org/en/content/a...
In this study led by Konstantin Plöchl from our lab, we report a novel class of small-molecule inhibitors targeting bacteriophage infection. #phages #chemicalbiology
@univie.ac.at
November 6, 2025 at 9:58 PM
Our latest research just accepted in RSC Chemical Biology:
pubs.rsc.org/en/content/a...
In this study led by Konstantin Plöchl from our lab, we report a novel class of small-molecule inhibitors targeting bacteriophage infection. #phages #chemicalbiology
@univie.ac.at
pubs.rsc.org/en/content/a...
In this study led by Konstantin Plöchl from our lab, we report a novel class of small-molecule inhibitors targeting bacteriophage infection. #phages #chemicalbiology
@univie.ac.at
Reposted by Thomas Boettcher
New WHO report finds 1 in 6 bacterial infections were resistant to antibiotic treatments.
Data from over 100 countries warns that rising resistance to essential antibiotics poses a growing threat to global health.
Read more 👉bit.ly/438Ta1u
Data from over 100 countries warns that rising resistance to essential antibiotics poses a growing threat to global health.
Read more 👉bit.ly/438Ta1u
October 14, 2025 at 6:19 AM
New WHO report finds 1 in 6 bacterial infections were resistant to antibiotic treatments.
Data from over 100 countries warns that rising resistance to essential antibiotics poses a growing threat to global health.
Read more 👉bit.ly/438Ta1u
Data from over 100 countries warns that rising resistance to essential antibiotics poses a growing threat to global health.
Read more 👉bit.ly/438Ta1u
For our antimicrobial drug development efforts at the University of Vienna we are looking for input from physicians/clinicians who are familiar with treatment, diagnostics, infection control, etc.
Your insights would be highly valuable!
docs.google.com/forms/d/e/1F...
Your insights would be highly valuable!
docs.google.com/forms/d/e/1F...
Survey on the clinical need for an ultra-narrow spectrum N. gonorrhoeae Antibiotic
Welcome and thank you for participating in this survey!
We are the researchers in Boettcher's group at University of Vienna, who are developing the new antibiotic specifically targeting N. gonorrhoeae...
docs.google.com
September 10, 2025 at 3:34 PM
For our antimicrobial drug development efforts at the University of Vienna we are looking for input from physicians/clinicians who are familiar with treatment, diagnostics, infection control, etc.
Your insights would be highly valuable!
docs.google.com/forms/d/e/1F...
Your insights would be highly valuable!
docs.google.com/forms/d/e/1F...
Wonderful work in collaboration with the lab of @davidberry1.bsky.social
www.tandfonline.com/doi/full/10....
www.tandfonline.com/doi/full/10....
Lactulose selectively stimulates members of the gut microbiota, as determined by multi-modal activity-based sorting
There is much interest in the development of dietary supplements that selectively promote the growth of beneficial gut bacteria. The selectivity of many candidate prebiotics has, however, not been ...
www.tandfonline.com
July 4, 2025 at 9:55 PM
Wonderful work in collaboration with the lab of @davidberry1.bsky.social
www.tandfonline.com/doi/full/10....
www.tandfonline.com/doi/full/10....
Good to read an informed scientific opinion on this topic. I couldn't agree more. Safety considerations for additives regardless whether synthetic or natural should be only based on scientific data and not on ideology or personal beliefs.
I couldn’t care less whether companies use synthetic or naturally-derived dyes — I have zero skin in the game.
The issue? The war on “synthetic food dyes” isn’t about food dyes:
It’s about letting uninformed opinions & misinformation undermine science, data, & public health.
A thread 👇🏻
1/
The issue? The war on “synthetic food dyes” isn’t about food dyes:
It’s about letting uninformed opinions & misinformation undermine science, data, & public health.
A thread 👇🏻
1/
April 28, 2025 at 8:36 AM
Good to read an informed scientific opinion on this topic. I couldn't agree more. Safety considerations for additives regardless whether synthetic or natural should be only based on scientific data and not on ideology or personal beliefs.
We are looking for an excellent and highly motivated PhD student in Chemical Biology for a position in our group within the AIDD docfunds program @univie.ac.at to investigate anti-infectives from antagonistic microbial interactions. Apply until 03.05.2025:
vds-phanuspo.univie.ac.at/application/...
vds-phanuspo.univie.ac.at/application/...
April 22, 2025 at 5:22 PM
We are looking for an excellent and highly motivated PhD student in Chemical Biology for a position in our group within the AIDD docfunds program @univie.ac.at to investigate anti-infectives from antagonistic microbial interactions. Apply until 03.05.2025:
vds-phanuspo.univie.ac.at/application/...
vds-phanuspo.univie.ac.at/application/...
A new cover feature from our lab, designed by first author Viktoriia Savchenko, went online in ACS Chemical Biology.
Here is the article link: pubs.acs.org/doi/10.1021/...
@univie.ac.at @cemess.bsky.social
Here is the article link: pubs.acs.org/doi/10.1021/...
@univie.ac.at @cemess.bsky.social
April 20, 2025 at 9:18 PM
A new cover feature from our lab, designed by first author Viktoriia Savchenko, went online in ACS Chemical Biology.
Here is the article link: pubs.acs.org/doi/10.1021/...
@univie.ac.at @cemess.bsky.social
Here is the article link: pubs.acs.org/doi/10.1021/...
@univie.ac.at @cemess.bsky.social
Reposted by Thomas Boettcher
💊🦠OUT NOW - new research showing that 2-nonyl-4-quinolone N-oxide and its 3-methyl derivative kill Neisseria gonorrhoeae in vitro and significantly reduce bacterial numbers in vivo, in mouse infection models
#MicroSky
www.nature.com/articles/s41...
#MicroSky
www.nature.com/articles/s41...
A quinolone N-oxide antibiotic selectively targets Neisseria gonorrhoeae via its toxin–antitoxin system - Nature Microbiology
Pseudomonas aeruginosa-derived 2-nonyl-4-quinolone N-oxide exerts bactericidal effects on Neisseria gonorrhoea via zeta1–epsilon1 toxin–antitoxin activation in vitro and abrogates experimental infecti...
www.nature.com
April 4, 2025 at 2:15 AM
💊🦠OUT NOW - new research showing that 2-nonyl-4-quinolone N-oxide and its 3-methyl derivative kill Neisseria gonorrhoeae in vitro and significantly reduce bacterial numbers in vivo, in mouse infection models
#MicroSky
www.nature.com/articles/s41...
#MicroSky
www.nature.com/articles/s41...
Reposted by Thomas Boettcher
#weekendreading🔬
A chemical radar allows bacteria to detect and kill predators
@cellpress.bsky.social #microsky
www.cell.com/cell/fulltex...
A chemical radar allows bacteria to detect and kill predators
@cellpress.bsky.social #microsky
www.cell.com/cell/fulltex...
A chemical radar allows bacteria to detect and kill predators
Pseudomonas syringae can detect and kill microbial predators via a chemical radar
(Cra), which also allows the bacterium to infect plants despite predation pressure.
www.cell.com
April 4, 2025 at 3:36 PM
#weekendreading🔬
A chemical radar allows bacteria to detect and kill predators
@cellpress.bsky.social #microsky
www.cell.com/cell/fulltex...
A chemical radar allows bacteria to detect and kill predators
@cellpress.bsky.social #microsky
www.cell.com/cell/fulltex...
Work of our lab @univie.ac.at in close collaboration with the Hauck Lab @uni-konstanz.de was published in @naturemicrobiol.bsky.social today. A compound highly selective in targeting Neisseria gonorrhoeae using a novel mode of action. @cemess.bsky.social
medienportal.univie.ac.at/en/media/rec...
medienportal.univie.ac.at/en/media/rec...
New antibiotic for multidrug resistant superbug, that causes gonorrhoea
This novel antibiotic activates an existing "suicide" mechanism in gonococci
medienportal.univie.ac.at
April 2, 2025 at 7:43 PM
Work of our lab @univie.ac.at in close collaboration with the Hauck Lab @uni-konstanz.de was published in @naturemicrobiol.bsky.social today. A compound highly selective in targeting Neisseria gonorrhoeae using a novel mode of action. @cemess.bsky.social
medienportal.univie.ac.at/en/media/rec...
medienportal.univie.ac.at/en/media/rec...
Reposted by Thomas Boettcher
Die Zunahme von antibiotikaresistenten Keimen ist ein wachsendes Problem. Dazu gehört etwa der Problemkeim Neisseria gonorrhoeae, der Tripper (Gonorrhö) auslöst. Forscher*innen der Universitäten Konstanz und Wien entdeckten nun eine neue Klasse von Antibiotika, die selektiv dagegen wirken. 💊
Neues Antibiotikum gegen Problemkeim, der Tripper (Gonorrhö) auslöst
Neuartiges Antibiotikum aktiviert einen in den Gonokokken bereits vorhandenen Selbsttötungsmechanismus
medienportal.univie.ac.at
April 2, 2025 at 9:22 AM
Die Zunahme von antibiotikaresistenten Keimen ist ein wachsendes Problem. Dazu gehört etwa der Problemkeim Neisseria gonorrhoeae, der Tripper (Gonorrhö) auslöst. Forscher*innen der Universitäten Konstanz und Wien entdeckten nun eine neue Klasse von Antibiotika, die selektiv dagegen wirken. 💊
Reposted by Thomas Boettcher
Research-team of #UniKonstanz + @univie.ac.at have identified a new class of antibiotics that selectively target Neisseria gonorrhoeae—the bacteria behind gonorrhea. Full story: https://t1p.de/7svjt @naturebicrobiol.bsky.social. Read scientific publication: https://t1p.de/wtlae
April 2, 2025 at 11:31 AM
Research-team of #UniKonstanz + @univie.ac.at have identified a new class of antibiotics that selectively target Neisseria gonorrhoeae—the bacteria behind gonorrhea. Full story: https://t1p.de/7svjt @naturebicrobiol.bsky.social. Read scientific publication: https://t1p.de/wtlae