Abe et al. unveil phenotypically and spatially distinct T cell subsets that expand in follicular lymphoma using multi-omics single-cell and spatial analyses. These subsets exhibit unique localization patterns within or around neoplastic follicles, likely forming anti-lymphoma immune ecosystems, and predict patient outcomes, offering insights beyond current mechanistic understanding and prognostication.

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Follicular lymphoma is a neoplastic disease of B cell-rich follicular structures of lymphoid origin. In this issue of Cancer Cell, Abe et al. use multi-omics analyses to identify and characterize distinct follicular T cell subsets that can be used to stratify follicular lymphoma prognoses.

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T follicular helper (TFH) cells provide essential help to B cells in germinal centers (GCs). TFH and GC B cell responses are long-lasting in draining mediastinal lymph nodes of Litomosoides sigmodont....

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