Tom Doherty
@tdoherty.bsky.social
AD Clinical development scientist working in industry. Views are my own. #NUFC
Reposted by Tom Doherty
Promising clinical trials in Alzheimer's prevention www.cbsnews.com/news/promisi...
#Alzheimers #dementia #neuroscience #science
#Alzheimers #dementia #neuroscience #science
Promising clinical trials in Alzheimer's prevention
Washington University Medicine in St. Louis is conducting important research into treating early-onset Alzheimer's before symptoms arise.
www.cbsnews.com
November 11, 2025 at 9:40 PM
Promising clinical trials in Alzheimer's prevention www.cbsnews.com/news/promisi...
#Alzheimers #dementia #neuroscience #science
#Alzheimers #dementia #neuroscience #science
Reposted by Tom Doherty
Assessing the clinical meaningfulness of slowing CDR‐SB progression with disease‐modifying therapies for Alzheimer's disease in A&D:TRCI by Hartz et al.
Changes in the CDR-SB were connected to time of retaining functions like paying bills and driving. #ENDALZ
doi.org/10.1002/trc2...
Changes in the CDR-SB were connected to time of retaining functions like paying bills and driving. #ENDALZ
doi.org/10.1002/trc2...
Assessing the clinical meaningfulness of slowing CDR‐SB progression with disease‐modifying therapies for Alzheimer's disease
INTRODUCTION
For many patients and caregivers, a major goal of disease-modifying treatments (DMTs) for Alzheimer's disease (AD) dementia is to extend independence in instrumental and basic activitie.....
doi.org
February 13, 2025 at 6:30 PM
Assessing the clinical meaningfulness of slowing CDR‐SB progression with disease‐modifying therapies for Alzheimer's disease in A&D:TRCI by Hartz et al.
Changes in the CDR-SB were connected to time of retaining functions like paying bills and driving. #ENDALZ
doi.org/10.1002/trc2...
Changes in the CDR-SB were connected to time of retaining functions like paying bills and driving. #ENDALZ
doi.org/10.1002/trc2...
Reposted by Tom Doherty
In pardoning all of the J6th insurrectionists, with barely a whimper of opposition, Trump has signalled a new age of acquiescence in American politics.
He's trying to control not just the present but the past. In effect, he was pardoning himself.
New from me. open.substack.com/pub/goodalla...
He's trying to control not just the present but the past. In effect, he was pardoning himself.
New from me. open.substack.com/pub/goodalla...
Trump's new age of acquiesence
The first week has been dark stuff. In pardoning the Jan6th insurrectionists, Trump has achieved the ultimate victory: over history itself.
open.substack.com
January 24, 2025 at 7:54 PM
In pardoning all of the J6th insurrectionists, with barely a whimper of opposition, Trump has signalled a new age of acquiescence in American politics.
He's trying to control not just the present but the past. In effect, he was pardoning himself.
New from me. open.substack.com/pub/goodalla...
He's trying to control not just the present but the past. In effect, he was pardoning himself.
New from me. open.substack.com/pub/goodalla...
Reposted by Tom Doherty
This article discusses clinical use of biomarker tests for Alzheimer's disease pathology, including indications for testing, review of biomarker modalities (PET, CSF, blood), selection of modality based on individual factors, and interpretation and return of results. #ENDALZ
doi.org/10.1002/alz....
doi.org/10.1002/alz....
Clinical use of biomarkers in the era of Alzheimer's disease treatments
With the advent of treatments that specifically target Alzheimer's disease brain pathology, biomarker tests will become an increasingly important part of the routine clinical evaluation of cognitive ....
doi.org
January 1, 2025 at 6:13 AM
This article discusses clinical use of biomarker tests for Alzheimer's disease pathology, including indications for testing, review of biomarker modalities (PET, CSF, blood), selection of modality based on individual factors, and interpretation and return of results. #ENDALZ
doi.org/10.1002/alz....
doi.org/10.1002/alz....
Reposted by Tom Doherty
I hope everyone will watch this video from Syria. Extraordinary, terrifying and hopeful moments.
It's a reminder of why we fight.
www.cnn.com/2024/12/11/w...
It's a reminder of why we fight.
www.cnn.com/2024/12/11/w...
‘My God there is light’: CNN witnesses moment Syrian prisoner is freed from Assad’s forced detention | CNN
While searching a secretive prison in the belly of the Assad regime’s legacy of torture for American journalist Austin Tice, CNN’s Clarissa Ward made a startling discovery when a rebel fighter uncover...
www.cnn.com
December 12, 2024 at 1:24 AM
I hope everyone will watch this video from Syria. Extraordinary, terrifying and hopeful moments.
It's a reminder of why we fight.
www.cnn.com/2024/12/11/w...
It's a reminder of why we fight.
www.cnn.com/2024/12/11/w...
Reposted by Tom Doherty
Over 30 prominent scientists call for a ban on the creation of a "mirror cell"--a microbe made of molecules that are mirror images of their natural forms. It could cause a mind-boggling global disaster. Here's my story [gift link] 🧪https://nyti.ms/3OUCXp6
A ‘Second Tree of Life’ Could Wreak Havoc, Scientists Warn (Gift Article)
Research on so-called mirror cells, which defy fundamental properties of living organisms, should be prohibited as too dangerous, biologists said.
nyti.ms
December 12, 2024 at 8:04 PM
Over 30 prominent scientists call for a ban on the creation of a "mirror cell"--a microbe made of molecules that are mirror images of their natural forms. It could cause a mind-boggling global disaster. Here's my story [gift link] 🧪https://nyti.ms/3OUCXp6
Happy to share our latest publication on predicting regional Tau PET loads using blood based biomarkers. We used the Tau PET data from Clarity AD and the ADNI cohort to predict continuous regional tau loads (AUCs 0.71-0.95).
alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
Plasma pTau217 ratio predicts continuous regional brain tau accumulation in amyloid‐positive early Alzheimer's disease
BACKGROUND This study examines whether phosphorylated plasma Tau217 ratio (pTau217R) can predict tau accumulation in different brain regions, as measured by positron emission tomography (PET) standa...
alz-journals.onlinelibrary.wiley.com
November 24, 2024 at 9:31 AM
Happy to share our latest publication on predicting regional Tau PET loads using blood based biomarkers. We used the Tau PET data from Clarity AD and the ADNI cohort to predict continuous regional tau loads (AUCs 0.71-0.95).
alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
alz-journals.onlinelibrary.wiley.com/doi/10.1002/...