Sushant Suresh
@sushantsuresh.bsky.social
PhD candidate in the John Burke lab at University of Victoria | Structural Biology | HDX-MS | lipid kinases
Final part of my PhD work is now out! We were able to develop a nanobody that inhibits EFR3 mediated PI4KA membrane recruitment. Potential therapeutic idea?
Amazing collaboration with different labs using a host of different techniques. @alexlouiseshaw.bsky.social
Amazing collaboration with different labs using a host of different techniques. @alexlouiseshaw.bsky.social
Cool new paper (www.jbc.org/article/S002... from my lab spearheaded by graduate students Sushant @sushantsuresh.bsky.social and Alex @alexlouiseshaw.bsky.social . This was a very cool collaboration with the Scott Hansen, Jennifer Cobb, Tamas Balla labs
www.jbc.org
November 6, 2025 at 12:17 AM
Final part of my PhD work is now out! We were able to develop a nanobody that inhibits EFR3 mediated PI4KA membrane recruitment. Potential therapeutic idea?
Amazing collaboration with different labs using a host of different techniques. @alexlouiseshaw.bsky.social
Amazing collaboration with different labs using a host of different techniques. @alexlouiseshaw.bsky.social
Great collaborative work where we developed a nanobody based tool to block EFR3 mediated recruitment of PI4KA. A potential therapeutic window maybe?
Thanks @alexlouiseshaw.bsky.social for the assist!
Thanks @alexlouiseshaw.bsky.social for the assist!
New preprint from the lab headed up by
@sushantsuresh.bsky.social! Late last year, we published the molecular basis of PI4KA plasma membrane recruitment by EFR3 (PMID:39705356). This work builds on these findings and identifies a new potential therapeutic avenue! Check it out!
@sushantsuresh.bsky.social! Late last year, we published the molecular basis of PI4KA plasma membrane recruitment by EFR3 (PMID:39705356). This work builds on these findings and identifies a new potential therapeutic avenue! Check it out!
Development of an inhibitory TTC7B selective nanobody that blocks EFR3 recruitment of PI4KA https://www.biorxiv.org/content/10.1101/2025.07.28.667261v1
August 7, 2025 at 5:13 AM
Great collaborative work where we developed a nanobody based tool to block EFR3 mediated recruitment of PI4KA. A potential therapeutic window maybe?
Thanks @alexlouiseshaw.bsky.social for the assist!
Thanks @alexlouiseshaw.bsky.social for the assist!
Reposted by Sushant Suresh
New preprint from the lab headed up by
@sushantsuresh.bsky.social! Late last year, we published the molecular basis of PI4KA plasma membrane recruitment by EFR3 (PMID:39705356). This work builds on these findings and identifies a new potential therapeutic avenue! Check it out!
@sushantsuresh.bsky.social! Late last year, we published the molecular basis of PI4KA plasma membrane recruitment by EFR3 (PMID:39705356). This work builds on these findings and identifies a new potential therapeutic avenue! Check it out!
Development of an inhibitory TTC7B selective nanobody that blocks EFR3 recruitment of PI4KA https://www.biorxiv.org/content/10.1101/2025.07.28.667261v1
August 6, 2025 at 4:19 AM
New preprint from the lab headed up by
@sushantsuresh.bsky.social! Late last year, we published the molecular basis of PI4KA plasma membrane recruitment by EFR3 (PMID:39705356). This work builds on these findings and identifies a new potential therapeutic avenue! Check it out!
@sushantsuresh.bsky.social! Late last year, we published the molecular basis of PI4KA plasma membrane recruitment by EFR3 (PMID:39705356). This work builds on these findings and identifies a new potential therapeutic avenue! Check it out!
Back from vacation and really glad to share some work from my PhD research. Great collaborative effort @alexlouiseshaw.bsky.social Check out this post from my PI to learn more about Lipid kinase PI4KA and its regulation!
First post up, sharing some cool work from my lab by @alexlouiseshaw.bsky.social and @sushantsuresh.bsky.social out today in Science Advances (www.science.org/doi/10.1126/...)
Molecular basis for plasma membrane recruitment of PI4KA by EFR3
The structure of the EFR3A-PI4KA complex reveals insight into PI4KA membrane localization and its role in human disease.
www.science.org
January 6, 2025 at 5:08 PM
Back from vacation and really glad to share some work from my PhD research. Great collaborative effort @alexlouiseshaw.bsky.social Check out this post from my PI to learn more about Lipid kinase PI4KA and its regulation!