Christian Steinmetzger
@stonebutcher.bsky.social
Senior research engineer in the group of Katja Petzold at Uppsala University: https://petzoldlab.com/
Interested in RNA chemical biology and structure, even better if some NMR is involved
Interested in RNA chemical biology and structure, even better if some NMR is involved
Reposted by Christian Steinmetzger
Check out our latest #NMR study together with @stonebutcher.bsky.social at @katjapetzold.bsky.social lab on an intermediate state of #DNA existing between the well-known Watson–Crick-Franklin and Hoogsteen base pairs stabilised by an anticancer drug Actinomycin D www.biorxiv.org/content/10.1...
1H R1ρ Relaxation Identifies a Hidden Intermediate in DNA Base-Pairing
1H R1ρ Relaxation dispersion (RD) NMR experiments provide valuable atomic-level insights into transient, high-energy conformational states of biomolecules. However, cross-relaxation artifacts can hamp...
www.biorxiv.org
October 6, 2025 at 7:46 PM
Check out our latest #NMR study together with @stonebutcher.bsky.social at @katjapetzold.bsky.social lab on an intermediate state of #DNA existing between the well-known Watson–Crick-Franklin and Hoogsteen base pairs stabilised by an anticancer drug Actinomycin D www.biorxiv.org/content/10.1...
Check out our new method for targeted DNP-enhanced NMR of RNA using site-directed spin labeling, now live as a preprint on ChemRxiv:
doi.org/10.26434/che...
A fruitful collaboration with my colleague @rubindg.bsky.social and the group of Prof. Snorri Th. Sigurdsson from the University of Iceland.
doi.org/10.26434/che...
A fruitful collaboration with my colleague @rubindg.bsky.social and the group of Prof. Snorri Th. Sigurdsson from the University of Iceland.
September 8, 2025 at 2:49 PM
Check out our new method for targeted DNP-enhanced NMR of RNA using site-directed spin labeling, now live as a preprint on ChemRxiv:
doi.org/10.26434/che...
A fruitful collaboration with my colleague @rubindg.bsky.social and the group of Prof. Snorri Th. Sigurdsson from the University of Iceland.
doi.org/10.26434/che...
A fruitful collaboration with my colleague @rubindg.bsky.social and the group of Prof. Snorri Th. Sigurdsson from the University of Iceland.
Checked in at Asilomar and looking forward to a week of exciting science at the #ENCISMAR2025 conference in sunny Pacific Grove
April 6, 2025 at 6:25 PM
Checked in at Asilomar and looking forward to a week of exciting science at the #ENCISMAR2025 conference in sunny Pacific Grove
Reposted by Christian Steinmetzger
A new paper from the Hoebartner Lab @UniWue @chlab.bsky.social reports the crystal structures of the ribozyme SAMURI, revealing the mechanism of its methyltransferase activity and site-selectivity
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Structure and catalytic activity of the SAM-utilizing ribozyme SAMURI - Nature Chemical Biology
Crystal structures of the ribozyme SAMURI reveal the alkyltransferase mechanism and show N3-modified adenosine and dealkylated cofactor in the active site, allowing for a comparison with riboswitches ...
www.nature.com
January 14, 2025 at 5:26 PM
A new paper from the Hoebartner Lab @UniWue @chlab.bsky.social reports the crystal structures of the ribozyme SAMURI, revealing the mechanism of its methyltransferase activity and site-selectivity
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Christian Steinmetzger
Perspective by Higman et al: deposition of data for titrations, relaxation rates, PREs, etc in a standardized way, e.g. the NEF format could help develop AI models to accurately predict the dynamic behaviour of a protein from the primary sequence alone. #NMRchat
doi.org/10.1007/s108...
doi.org/10.1007/s108...
Perspective: on the importance of extensive, high-quality and reliable deposition of biomolecular NMR data in the age of artificial intelligence - Journal of Biomolecular NMR
Artificial intelligence (AI) models are revolutionising scientific data analysis but are reliant on large training data sets. While artificial training data can be used in the context of NMR processin...
doi.org
December 4, 2024 at 10:17 AM
Perspective by Higman et al: deposition of data for titrations, relaxation rates, PREs, etc in a standardized way, e.g. the NEF format could help develop AI models to accurately predict the dynamic behaviour of a protein from the primary sequence alone. #NMRchat
doi.org/10.1007/s108...
doi.org/10.1007/s108...
Reposted by Christian Steinmetzger
Hi Team #NMRchat #NMR. Happy to see you out here!
Let's start spreading the word about the ENC-ISMAR Joint Conference, April 6-10, 2025.
Oral Abstract Deadline: January 10
www.enc-conference.org/enc-ismar-2025
Let's start spreading the word about the ENC-ISMAR Joint Conference, April 6-10, 2025.
Oral Abstract Deadline: January 10
www.enc-conference.org/enc-ismar-2025
December 4, 2024 at 9:35 PM
Hi Team #NMRchat #NMR. Happy to see you out here!
Let's start spreading the word about the ENC-ISMAR Joint Conference, April 6-10, 2025.
Oral Abstract Deadline: January 10
www.enc-conference.org/enc-ismar-2025
Let's start spreading the word about the ENC-ISMAR Joint Conference, April 6-10, 2025.
Oral Abstract Deadline: January 10
www.enc-conference.org/enc-ismar-2025
Reposted by Christian Steinmetzger
For the season that’s in it an NMR advent calendar for us Chemistry Nerds #Chemistry
www.nmr.chemistry.manchester.ac.uk/advent24/
www.nmr.chemistry.manchester.ac.uk/advent24/
Advent Calendar
www.nmr.chemistry.manchester.ac.uk
December 1, 2024 at 12:42 PM
For the season that’s in it an NMR advent calendar for us Chemistry Nerds #Chemistry
www.nmr.chemistry.manchester.ac.uk/advent24/
www.nmr.chemistry.manchester.ac.uk/advent24/
Reposted by Christian Steinmetzger
📣📣 XIVth international conference on #NMR a tool for biology. May 26-28, 2025 @pasteur.fr Paris, France. The registration is open 👉 www.nmr2025.conferences-pasteur.org
Coorganized with
@brukercorporation.bsky.social
Coorganized with
@brukercorporation.bsky.social
November 25, 2024 at 3:35 PM
📣📣 XIVth international conference on #NMR a tool for biology. May 26-28, 2025 @pasteur.fr Paris, France. The registration is open 👉 www.nmr2025.conferences-pasteur.org
Coorganized with
@brukercorporation.bsky.social
Coorganized with
@brukercorporation.bsky.social