Steven Banik
@stevenbanik.bsky.social
Assistant Professor, Stanford University Dept. of Chemistry and Sarafan ChEM-H | Chemical biology, synthetic biology | Small molecules, large molecules, biological mechanisms
Really cool approach to an impactful problem from @greenahn.bsky.social @uwproteindesign.bsky.social!
pH gradients are central to physiology, from vesicle acidification to the acidic tumor microenvironment. But how do we program proteins to respond to pH? In our new preprint biorxiv.org/content/10.110…, we developed computational methods to rationally design pH-sensitive binders. 🧵
https://biorxiv.org/content/10.110…
October 1, 2025 at 5:20 PM
Really cool approach to an impactful problem from @greenahn.bsky.social @uwproteindesign.bsky.social!
Reposted by Steven Banik
Attend the 2025 Bringing Chemistry to Medicine Symposium to learn from leading experts in transcription, chromatin regulation, computational biology and chemical biology. Registration is free and available both in-person and virtually.
July 14, 2025 at 4:00 PM
Attend the 2025 Bringing Chemistry to Medicine Symposium to learn from leading experts in transcription, chromatin regulation, computational biology and chemical biology. Registration is free and available both in-person and virtually.
Incredibly proud of @christineisadora.bsky.social for defending her PhD work today! The first PhD from the Banik lab, and an amazing story on targeted protein relocalization and TRAMs! Her PhD work spans small molecules, neurobiology, cell engineering, and computational method development.
May 29, 2025 at 9:52 PM
Incredibly proud of @christineisadora.bsky.social for defending her PhD work today! The first PhD from the Banik lab, and an amazing story on targeted protein relocalization and TRAMs! Her PhD work spans small molecules, neurobiology, cell engineering, and computational method development.
Reposted by Steven Banik
If you want to understand how cells function, you have to work out what proteins interact with — and where
https://go.nature.com/4hYLaol
https://go.nature.com/4hYLaol
Where do proteins go in cells? Next-generation methods map the molecules’ hidden lives
Spatial proteomics is helping biologists to uncover how cells work by mapping where proteins operate.
go.nature.com
April 7, 2025 at 6:32 PM
If you want to understand how cells function, you have to work out what proteins interact with — and where
https://go.nature.com/4hYLaol
https://go.nature.com/4hYLaol
Reposted by Steven Banik
Check it out, powerful new method for optical imaging of the live ECM, from @hhmijanelia.bsky.social Group Leader Kayvon Pedram #proudofalumni #glycotime
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Live imaging of the extracellular matrix with a glycan-binding fluorophore - Nature Methods
Rhobo6 is a cell-impermeable small-molecule fluorophore that displays reversible fluorogenic binding to glycans, making it a general, wash-free, and non-perturbative label for the extracellular matrix...
www.nature.com
February 6, 2025 at 10:59 PM
Check it out, powerful new method for optical imaging of the live ECM, from @hhmijanelia.bsky.social Group Leader Kayvon Pedram #proudofalumni #glycotime
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Steven Banik
Congratulations to @alesalerno.bsky.social from University of Dundee CeTPD and Christine Ng from @stanford-chemh.bsky.social who have been selected as recipients of our conference travel scholarships to attend the Proximity-based Therapeutics Keystone conference @keystonesymposia.bsky.social!
January 24, 2025 at 6:59 PM
Congratulations to @alesalerno.bsky.social from University of Dundee CeTPD and Christine Ng from @stanford-chemh.bsky.social who have been selected as recipients of our conference travel scholarships to attend the Proximity-based Therapeutics Keystone conference @keystonesymposia.bsky.social!
Amazing to see the LYTAC technology get to this point, catalytic extracellular degraders could open many new therapeutic opportunities or perhaps even become standard of care compared to antagonistic antibodies alone. Congrats to Lycia Tx!
The unique pharmacology of targeted degraders (eg PROTACs) leverages their sub-stoichiometric “catalytic” activity. Now Lycia Tx reports catalytic (cata)LYTACs for potent, durable extracellular #TPD, cleared IgE in NHPs, superior to omalizumab 👏
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Catalytic degradation of circulating targets with FcRn-mediated cycling LYTACs
Circulating proteins are common targets for the discovery of occupancy-based inhibitors including monoclonal antibodies. Effective inhibition of target pathogenicity with blocking approaches, however,...
www.biorxiv.org
January 13, 2025 at 5:04 PM
Amazing to see the LYTAC technology get to this point, catalytic extracellular degraders could open many new therapeutic opportunities or perhaps even become standard of care compared to antagonistic antibodies alone. Congrats to Lycia Tx!