Stepped Wedgehog
@steppedwedgehog.bsky.social
Stepped Wedgehog (you won't be surprised to hear) posts on stepped wedge trials and related topics. Visit the website at https://steppedwedgehog.org.
Reposted by Stepped Wedgehog
A scoping review identified additional considerations for defining estimands in cluster randomised trials - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...
A scoping review identified additional considerations for defining estimands in cluster randomised trials
An estimand is a clear description of the treatment effect a study aims to quantify.
The ICH E9(R1) addendum lists five attributes that should be described when defining
an estimand. However, the adde...
www.jclinepi.com
October 19, 2025 at 2:33 PM
A scoping review identified additional considerations for defining estimands in cluster randomised trials - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...
Reposted by Stepped Wedgehog
Lots of feedback and engagement after this session. Some gentle push-back still: "But what if there's even just a *perception* from sites that a stepped wedge is preferable?" 🧵
The recording of this webinar is now available on the @nihr-rss.bsky.social YouTube channel: www.youtube.com/watch?v=4cNz...
October 21, 2025 at 3:39 PM
Lots of feedback and engagement after this session. Some gentle push-back still: "But what if there's even just a *perception* from sites that a stepped wedge is preferable?" 🧵
📢 Registration now open for the 11th annual meeting on Current Developments in Cluster Randomised Trials & Stepped Wedge Designs on 18th & 19th November 2025 in Birmingham UK.
shop.bham.ac.uk/conferences-...
shop.bham.ac.uk/conferences-...
September 25, 2025 at 3:59 PM
📢 Registration now open for the 11th annual meeting on Current Developments in Cluster Randomised Trials & Stepped Wedge Designs on 18th & 19th November 2025 in Birmingham UK.
shop.bham.ac.uk/conferences-...
shop.bham.ac.uk/conferences-...
Assessing mediation in cross-sectional stepped wedge cluster randomized trials onlinelibrary.wiley.com/doi/10.1002/...
Assessing Mediation in Cross‐Sectional Stepped Wedge Cluster Randomized Trials
Mediation analysis has been studied for independent data, but relatively little work has been done for correlated data observed under stepped wedge cluster randomized trials (SW-CRTs). Motivated by t...
onlinelibrary.wiley.com
September 16, 2025 at 8:49 AM
Assessing mediation in cross-sectional stepped wedge cluster randomized trials onlinelibrary.wiley.com/doi/10.1002/...
Save the date: Fifth International Conference on Stepped Wedge Design 2026 12th-14th May (online)
www.york.ac.uk/healthscienc...
www.york.ac.uk/healthscienc...
September 12, 2025 at 9:19 AM
Save the date: Fifth International Conference on Stepped Wedge Design 2026 12th-14th May (online)
www.york.ac.uk/healthscienc...
www.york.ac.uk/healthscienc...
Information-theoretic criteria for optimizing designs of individually randomized stepped-wedge clinical trials link.springer.com/article/10.1...
Information-Theoretic Criteria for Optimizing Designs of Individually Randomized Stepped-Wedge Clinical Trials - Statistics and Computing
Clinical trials are essential for advancing medical knowledge and improving health care, with Randomized Clinical Trials (RCTs) considered the gold standard for minimizing bias and generating reliable...
link.springer.com
August 22, 2025 at 1:05 PM
Information-theoretic criteria for optimizing designs of individually randomized stepped-wedge clinical trials link.springer.com/article/10.1...
A useful reminder of the original meaning of a "stepped wedge".
Stepped aluminium wedge that would be placed on the x-ray film to determine density of exposure and a fluoroscope that would let doctors view x-ray images 'in real time' without the use of film, I don't want to imagine the damage that could cause.
August 5, 2025 at 12:21 PM
A useful reminder of the original meaning of a "stepped wedge".
Improving the design of staggered implementation cluster randomised trials qualitysafety.bmj.com/content/earl...
Grand rounds in methodology: improving the design of staggered implementation cluster randomised trials
The stepped-wedge cluster randomised trial is a popular design in implementation and health services research. All clusters, such as clinics or hospitals, start in the control state, and gradually swi...
qualitysafety.bmj.com
August 5, 2025 at 12:20 PM
Improving the design of staggered implementation cluster randomised trials qualitysafety.bmj.com/content/earl...
Reposted by Stepped Wedgehog
Super happy to say that my first Biometrics article was published this week!😃 Along with Fan Li, Monica Taljaard, & Denise Esserman, we derive sample size & power formula for cross-sectional stepped-wedge trials with time-to-event outcomes, & explored the impact of finite sample variance corrections
Power calculation for cross-sectional stepped wedge cluster randomized trials with a time-to-event endpoint
ABSTRACT. Stepped wedge cluster randomized trials (SW-CRTs) are a form of randomized trial whereby clusters are progressively transitioned from control to
doi.org
June 26, 2025 at 2:05 PM
Super happy to say that my first Biometrics article was published this week!😃 Along with Fan Li, Monica Taljaard, & Denise Esserman, we derive sample size & power formula for cross-sectional stepped-wedge trials with time-to-event outcomes, & explored the impact of finite sample variance corrections
📢 The 11th annual meeting on Current Developments in Cluster Randomised Trials & Stepped Wedge Designs will take place 18/19 November 2025 in Birmingham UK.
Abstract submission is open, deadline for submission 11 July 2025 forms.gle/jS83TAKhs4U8.... Info on registration etc to follow!
Abstract submission is open, deadline for submission 11 July 2025 forms.gle/jS83TAKhs4U8.... Info on registration etc to follow!
June 13, 2025 at 9:28 AM
📢 The 11th annual meeting on Current Developments in Cluster Randomised Trials & Stepped Wedge Designs will take place 18/19 November 2025 in Birmingham UK.
Abstract submission is open, deadline for submission 11 July 2025 forms.gle/jS83TAKhs4U8.... Info on registration etc to follow!
Abstract submission is open, deadline for submission 11 July 2025 forms.gle/jS83TAKhs4U8.... Info on registration etc to follow!
Identifying less burdensome and more cost-efficient incomplete stepped wedge designs for continuous outcomes collected via repeated cross-sections onlinelibrary.wiley.com/doi/10.1002/...
Identifying Less Burdensome and More Cost‐Efficient Incomplete Stepped Wedge Designs for Continuous Outcomes Collected via Repeated Cross‐Sections
Stepped wedge trials can be costly and burdensome. Recent work has investigated the iterative removal of cluster-period cells from stepped wedge designs, producing a series of candidate incomplete de...
onlinelibrary.wiley.com
May 8, 2025 at 11:55 AM
Identifying less burdensome and more cost-efficient incomplete stepped wedge designs for continuous outcomes collected via repeated cross-sections onlinelibrary.wiley.com/doi/10.1002/...
How should parallel cluster randomized trials with a baseline period be analyzed?—a survey of estimands and common estimators onlinelibrary.wiley.com/doi/10.1002/...
How Should Parallel Cluster Randomized Trials With a Baseline Period be Analyzed?—A Survey of Estimands and Common Estimators
The parallel cluster randomized trial with baseline (PB-CRT) is a common variant of the standard parallel cluster randomized trial (P-CRT). We define two natural estimands in the context of PB-CRTs w....
onlinelibrary.wiley.com
April 30, 2025 at 3:38 PM
How should parallel cluster randomized trials with a baseline period be analyzed?—a survey of estimands and common estimators onlinelibrary.wiley.com/doi/10.1002/...
What is a stepped wedge cluster randomized trial? jamanetwork.com/journals/jam...
What Is a Stepped-Wedge Cluster Randomized Trial?
This Guide to Statistics and Methods describes design, interpretation, and examples of a stepped-wedge cluster randomized trial.
jamanetwork.com
March 11, 2025 at 1:19 PM
What is a stepped wedge cluster randomized trial? jamanetwork.com/journals/jam...
Bayesian hierarchical penalized spline models for immediate and time-varying intervention effects in stepped wedge cluster randomized trials pmc.ncbi.nlm.nih.gov/articles/PMC...
Bayesian Hierarchical Penalized Spline Models for Immediate and Time‐Varying Intervention Effects in Stepped Wedge Cluster Randomized Trials
Stepped wedge cluster randomized trials (SWCRTs) often face challenges related to potential confounding by time. Traditional frequentist methods may not provide adequate coverage of an intervention's ...
pmc.ncbi.nlm.nih.gov
February 28, 2025 at 9:22 AM
Bayesian hierarchical penalized spline models for immediate and time-varying intervention effects in stepped wedge cluster randomized trials pmc.ncbi.nlm.nih.gov/articles/PMC...
Analysis of cohort stepped wedge cluster-randomized trials with nonignorable dropout via joint modeling pubmed.ncbi.nlm.nih.gov/39963907/
Analysis of Cohort Stepped Wedge Cluster-Randomized Trials With Nonignorable Dropout via Joint Modeling - PubMed
Stepped wedge cluster-randomized trial (CRTs) designs randomize clusters of individuals to intervention sequences, ensuring that every cluster eventually transitions from a control period to receive t...
pubmed.ncbi.nlm.nih.gov
February 28, 2025 at 9:19 AM
Analysis of cohort stepped wedge cluster-randomized trials with nonignorable dropout via joint modeling pubmed.ncbi.nlm.nih.gov/39963907/
The relative efficiency of staircase and stepped wedge cluster randomised trial designs journals.sagepub.com/doi/full/10....
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journals.sagepub.com
February 28, 2025 at 9:17 AM
The relative efficiency of staircase and stepped wedge cluster randomised trial designs journals.sagepub.com/doi/full/10....
A systematic review of stepped wedge cluster randomized trials in high impact journals: assessing the design, rationale, and analysis www.jclinepi.com/article/S089...
A systematic review of stepped wedge cluster randomized trials in high impact journals: assessing the design, rationale, and analysis
Stepped wedge cluster randomized trials (SW-CRTs) are an appealing study design because
they enable sequential roll out of an intervention across clusters, bringing logistical
advantages. This review ...
www.jclinepi.com
January 24, 2025 at 10:31 AM
A systematic review of stepped wedge cluster randomized trials in high impact journals: assessing the design, rationale, and analysis www.jclinepi.com/article/S089...
How nurse researchers can use stepped-wedge design and analysis journals.rcni.com/nurse-resear...
How nurse researchers can use stepped-wedge design and analysis
How nurse researchers can use stepped-wedge design and analysis
journals.rcni.com
January 16, 2025 at 9:45 AM
How nurse researchers can use stepped-wedge design and analysis journals.rcni.com/nurse-resear...
Multilevel intervention stepped wedge designs link.springer.com/article/10.1...
Multilevel Intervention Stepped Wedge Designs (MLI-SWDs) - Prevention Science
Multilevel interventions (MLIs) hold promise for reducing health inequities by intervening at multiple types of social determinants of health consistent with the socioecological model of health. In sp...
link.springer.com
January 16, 2025 at 9:42 AM
Multilevel intervention stepped wedge designs link.springer.com/article/10.1...
Reporting of cluster randomised crossover trials: extension of the CONSORT 2010 statement with explanation and elaboration www.bmj.com/content/388/...
Reporting of cluster randomised crossover trials: extension of the CONSORT 2010 statement with explanation and elaboration
This article presents the CONSORT (consolidated standards of reporting trials) extension for cluster randomised crossover trials. A cluster randomised crossover trial involves randomisation of groups ...
www.bmj.com
January 7, 2025 at 12:26 PM
Reporting of cluster randomised crossover trials: extension of the CONSORT 2010 statement with explanation and elaboration www.bmj.com/content/388/...
Reposted by Stepped Wedgehog
Hey, can someone please get Fan Li and Michael Harhay over here already!?
cc @timpmorris.bsky.social @suziecro.bsky.social @brennankahan.bsky.social
cc @timpmorris.bsky.social @suziecro.bsky.social @brennankahan.bsky.social
December 4, 2024 at 5:43 AM
Hey, can someone please get Fan Li and Michael Harhay over here already!?
cc @timpmorris.bsky.social @suziecro.bsky.social @brennankahan.bsky.social
cc @timpmorris.bsky.social @suziecro.bsky.social @brennankahan.bsky.social
Reposted by Stepped Wedgehog
A Systematic Review of Stepped Wedge Cluster Randomized Trials in High Impact Journals: Assessing the Design, Rationale, and Analysis - @jclinepi.bsky.social www.jclinepi.com/article/S089...
A Systematic Review of Stepped Wedge Cluster Randomized Trials in High Impact Journals: Assessing the Design, Rationale, and Analysis
Stepped wedge cluster randomized trials (SW-CRTs) are an appealing study design because
they enable sequential roll out of an intervention across clusters, bringing logistical
advantages. This review ...
www.jclinepi.com
December 2, 2024 at 11:50 AM
A Systematic Review of Stepped Wedge Cluster Randomized Trials in High Impact Journals: Assessing the Design, Rationale, and Analysis - @jclinepi.bsky.social www.jclinepi.com/article/S089...
The application of stepped-wedge cluster-randomized controlled trial study designs in oncology settings: A systematic review www.sciencedirect.com/science/arti...
The application of stepped-wedge cluster-randomized controlled trial study designs in oncology settings: A systematic review
Stepped-wedge cluster-randomized trials (SW-CRTs) offer advantages for implementation research in healthcare and have been increasingly utilised in th…
www.sciencedirect.com
November 29, 2024 at 5:34 PM
The application of stepped-wedge cluster-randomized controlled trial study designs in oncology settings: A systematic review www.sciencedirect.com/science/arti...