Sonali J. Bracken, MD, PhD
@sjbracken.bsky.social
Rheumatologist, immunologist, and physician-scientist @DukeUniv. B cell and scleroderma enthusiast. Posts reflect my own views.
Reposted by Sonali J. Bracken, MD, PhD
One cool thing about the United States is that there are more people whose job is to deny healthcare coverage without having any medical background than there are people to provide healthcare coverage and they’ve somehow convinced people that the doctors are where the monetary waste is happening
#medsky if an insurer is making a “determination if something is medically necessary”, how is it not a medical decision and therefore practicing medicine?
March 15, 2025 at 11:57 PM
One cool thing about the United States is that there are more people whose job is to deny healthcare coverage without having any medical background than there are people to provide healthcare coverage and they’ve somehow convinced people that the doctors are where the monetary waste is happening
It was an honor to present alongside these two esteemed physician-scientists who have pushed the frontiers of transplantation and cell therapy for patients with autoimmune disorders. #Tandem25
www.tandemmeetingsnews.com/experts-trac...
www.tandemmeetingsnews.com/experts-trac...
Experts trace work to treat autoimmune disorders - Tandem Meetings News
Keith Sullivan, MD, and others discussed progress with transplantation and cell therapy for autoimmune diseases.
www.tandemmeetingsnews.com
February 14, 2025 at 7:22 PM
It was an honor to present alongside these two esteemed physician-scientists who have pushed the frontiers of transplantation and cell therapy for patients with autoimmune disorders. #Tandem25
www.tandemmeetingsnews.com/experts-trac...
www.tandemmeetingsnews.com/experts-trac...
Reposted by Sonali J. Bracken, MD, PhD
Something you don't see every day!
Digitizing the human proteome in >53,000 individuals with 15-year follow-up and, with machine learning, unraveling nearly 500 disease-causing proteins
www.cell.com/cell/fulltex...
open-access
Digitizing the human proteome in >53,000 individuals with 15-year follow-up and, with machine learning, unraveling nearly 500 disease-causing proteins
www.cell.com/cell/fulltex...
open-access
January 10, 2025 at 6:56 PM
Something you don't see every day!
Digitizing the human proteome in >53,000 individuals with 15-year follow-up and, with machine learning, unraveling nearly 500 disease-causing proteins
www.cell.com/cell/fulltex...
open-access
Digitizing the human proteome in >53,000 individuals with 15-year follow-up and, with machine learning, unraveling nearly 500 disease-causing proteins
www.cell.com/cell/fulltex...
open-access
Reposted by Sonali J. Bracken, MD, PhD
Happy Holidays！💐
Credit to: Dario Brunetti
Credit to: Dario Brunetti
December 23, 2024 at 5:41 PM
Happy Holidays！💐
Credit to: Dario Brunetti
Credit to: Dario Brunetti
Reposted by Sonali J. Bracken, MD, PhD
If you want to understand why healthcare pricing is horrific, the first thing to know is that our system puts 100% of the credit risk for deductibles, copays and co-insurance on hospitals and doctors. That's insane.
We have turned them into Sub Prime Lenders 🧵
We have turned them into Sub Prime Lenders 🧵
December 10, 2024 at 6:46 PM
If you want to understand why healthcare pricing is horrific, the first thing to know is that our system puts 100% of the credit risk for deductibles, copays and co-insurance on hospitals and doctors. That's insane.
We have turned them into Sub Prime Lenders 🧵
We have turned them into Sub Prime Lenders 🧵
Happy holidays from the Duke Rheum crew ❄️ ⛄️ 🎄 @mithurheum.bsky.social
December 8, 2024 at 3:16 PM
Happy holidays from the Duke Rheum crew ❄️ ⛄️ 🎄 @mithurheum.bsky.social
Reposted by Sonali J. Bracken, MD, PhD
There is a human tissue that builds itself up and breaks itself down every 28 days (on average) using non-scarring wound healing and instead of studying that and learning everything we can about it we think it's gross and look for other less relevant models to understand wound healing.
December 3, 2023 at 12:06 AM
There is a human tissue that builds itself up and breaks itself down every 28 days (on average) using non-scarring wound healing and instead of studying that and learning everything we can about it we think it's gross and look for other less relevant models to understand wound healing.
The MITIGATE trial of inebilizumab (aCD19 mAb) for IgG4-RD should get us thinking about which rheumatologic diseases do/don’t warrant deep B cell depletion (i.e. CAR Ts)
⬇️ flares
⬆️ GC-free remission (note rapid steroid taper in placebo group)
⬆️ infections & cytopenias
www.nejm.org/doi/full/10....
⬇️ flares
⬆️ GC-free remission (note rapid steroid taper in placebo group)
⬆️ infections & cytopenias
www.nejm.org/doi/full/10....
Inebilizumab for Treatment of IgG4-Related Disease | NEJM
IgG4-related disease is a multiorgan, relapsing, fibroinflammatory, immune-mediated
disorder with no approved therapy. Inebilizumab targets and depletes CD19+ B cells
and may be effective for treat...
www.nejm.org
November 20, 2024 at 11:20 PM
The MITIGATE trial of inebilizumab (aCD19 mAb) for IgG4-RD should get us thinking about which rheumatologic diseases do/don’t warrant deep B cell depletion (i.e. CAR Ts)
⬇️ flares
⬆️ GC-free remission (note rapid steroid taper in placebo group)
⬆️ infections & cytopenias
www.nejm.org/doi/full/10....
⬇️ flares
⬆️ GC-free remission (note rapid steroid taper in placebo group)
⬆️ infections & cytopenias
www.nejm.org/doi/full/10....
Reposted by Sonali J. Bracken, MD, PhD
🆕 #ACR24 | Updated Guidelines for Lupus Nephritis Treatment & Management 🫘
Highlights 🔶
• Critical role of renal biopsy
• Differences for treatment by LN Class
• Adjunctive Rx w/ HCQ & RAASi
• GC pulse ⇢ *moderate/low* dose PDN
#Lupus #NephSky #RheumSky #Rheumatology #MedSky
Highlights 🔶
• Critical role of renal biopsy
• Differences for treatment by LN Class
• Adjunctive Rx w/ HCQ & RAASi
• GC pulse ⇢ *moderate/low* dose PDN
#Lupus #NephSky #RheumSky #Rheumatology #MedSky
November 18, 2024 at 11:37 PM
It was a wonderful #ACR24 and I am truly honored to have received the Distinguished Fellow Award from the American College of Rheumatology this year
Congratulations to @sjbracken.bsky.social & all the ACR Distinguished Fellow award recipients at #ACR24 🥇
Anyone who knows Sonali knows how dedicated and hardworking she is — from her research to patient care — working to improve the lives of patients with #scleroderma! #DukeRheum
Anyone who knows Sonali knows how dedicated and hardworking she is — from her research to patient care — working to improve the lives of patients with #scleroderma! #DukeRheum
November 19, 2024 at 3:21 PM
It was a wonderful #ACR24 and I am truly honored to have received the Distinguished Fellow Award from the American College of Rheumatology this year
First-of-its kind evidence in severe dSSc demonstrates that CD19 CAR T may both stabilize/improve:
🔶 Fibrotic organ dysfunction
🔶 Vascular dysfunction (as marked by ⬇️ in RP severity and digital ulcerations)
🔶 Grip strength, contractures, and hand function
www.thelancet.com/journals/lan...
🔶 Fibrotic organ dysfunction
🔶 Vascular dysfunction (as marked by ⬇️ in RP severity and digital ulcerations)
🔶 Grip strength, contractures, and hand function
www.thelancet.com/journals/lan...
November 19, 2024 at 3:09 PM
First-of-its kind evidence in severe dSSc demonstrates that CD19 CAR T may both stabilize/improve:
🔶 Fibrotic organ dysfunction
🔶 Vascular dysfunction (as marked by ⬇️ in RP severity and digital ulcerations)
🔶 Grip strength, contractures, and hand function
www.thelancet.com/journals/lan...
🔶 Fibrotic organ dysfunction
🔶 Vascular dysfunction (as marked by ⬇️ in RP severity and digital ulcerations)
🔶 Grip strength, contractures, and hand function
www.thelancet.com/journals/lan...