Simon Rössler
@simonrossler.bsky.social
organic chemist attempting peptide drug discovery at Novo Nordisk | postdoc at MIT | PhD at ETH
Reposted by Simon Rössler
Very pleased to share the 'last' first-author paper from my postdoc with Prof. Christian Heinis at EPFL.
Now out in its final form in @angewandtechemie.bsky.social as a 'Very Important Paper' 🔥 (1/🧵) #chemsky
onlinelibrary.wiley.com/doi/10.1002/...
Now out in its final form in @angewandtechemie.bsky.social as a 'Very Important Paper' 🔥 (1/🧵) #chemsky
onlinelibrary.wiley.com/doi/10.1002/...
Bulk Measurement of Membrane Permeability for Random Cyclic Peptides in Living Cells to Guide Drug Development
Some cyclic peptides can cross membranes, which is highly attractive for drug development, but it remains difficult to accurately predict membrane permeability or to test it experimentally for large ...
onlinelibrary.wiley.com
June 2, 2025 at 10:01 AM
Very pleased to share the 'last' first-author paper from my postdoc with Prof. Christian Heinis at EPFL.
Now out in its final form in @angewandtechemie.bsky.social as a 'Very Important Paper' 🔥 (1/🧵) #chemsky
onlinelibrary.wiley.com/doi/10.1002/...
Now out in its final form in @angewandtechemie.bsky.social as a 'Very Important Paper' 🔥 (1/🧵) #chemsky
onlinelibrary.wiley.com/doi/10.1002/...
My colleagues at Novo Nordisk have developed long-acting variants of PYY which, when combined with semaglutide, show promise in improving obesity and blood glucose regulation in preclinical models without muscle loss. Read more here: www.science.org/doi/10.1126/...
Variant screening of PYY3–36 leads to potent long-acting PYY analogs with superior Y2 receptor selectivity
A Y2 receptor–selective and long-acting PYY derivative improves weight loss and glucose metabolism in rodents in combination with a GLP-1 agonist.
www.science.org
March 27, 2025 at 7:12 AM
My colleagues at Novo Nordisk have developed long-acting variants of PYY which, when combined with semaglutide, show promise in improving obesity and blood glucose regulation in preclinical models without muscle loss. Read more here: www.science.org/doi/10.1126/...
Exciting paper by colleagues at Novo Nordisk: a scalable method for C-terminal α-amidation of peptides & proteins. The protocol is highly relevant for the production of amidated peptide drugs such as amylins! #PeptideScience
Read more here: www.nature.com/articles/s41...
Read more here: www.nature.com/articles/s41...
Photochemically-enabled, post-translational production of C-terminal amides - Nature Communications
C-terminal α-amidated peptides are attractive therapeutic targets, but preparative methods to access amidated pharmaceuticals are limited both on lab and manufacturing-scale. Here, the authors report ...
www.nature.com
January 20, 2025 at 6:58 AM
Exciting paper by colleagues at Novo Nordisk: a scalable method for C-terminal α-amidation of peptides & proteins. The protocol is highly relevant for the production of amidated peptide drugs such as amylins! #PeptideScience
Read more here: www.nature.com/articles/s41...
Read more here: www.nature.com/articles/s41...
Reposted by Simon Rössler
Liver metabolizes high fructose corn syrup to fructose, which leads to increase production of LPC lipids that promote tumor growth.
#Glycotime
www.nature.com/articles/s41...
#Glycotime
www.nature.com/articles/s41...
Dietary fructose enhances tumour growth indirectly via interorgan lipid transfer - Nature
Dietary fructose enhances tumour growth in animal models of melanoma, breast cancer and cervical cancer indirectly via metabolite transfer.
www.nature.com
December 11, 2024 at 8:42 AM
Liver metabolizes high fructose corn syrup to fructose, which leads to increase production of LPC lipids that promote tumor growth.
#Glycotime
www.nature.com/articles/s41...
#Glycotime
www.nature.com/articles/s41...
Reposted by Simon Rössler
Happy to share a fun collaboration between EPFL and UCPH initiated by @carlosmyruela.bsky.social, Christian Heinis, @christianaolsen.bsky.social and I!
Big shout-out to @danieladankova.bsky.social who spearheaded the project.
Now out on @chemrxiv.bsky.social
chemrxiv.org/engage/chemr...
Big shout-out to @danieladankova.bsky.social who spearheaded the project.
Now out on @chemrxiv.bsky.social
chemrxiv.org/engage/chemr...
Discovery of de novo Macrocycle Inhibitors of Histone Deacetylase 11
Histone deacetylase (HDAC) enzymes are epigenetic regulators that affect diverse protein function by removing acyl groups from lysine side chains throughout the proteome. The most recently discovered ...
chemrxiv.org
December 9, 2024 at 12:44 PM
Happy to share a fun collaboration between EPFL and UCPH initiated by @carlosmyruela.bsky.social, Christian Heinis, @christianaolsen.bsky.social and I!
Big shout-out to @danieladankova.bsky.social who spearheaded the project.
Now out on @chemrxiv.bsky.social
chemrxiv.org/engage/chemr...
Big shout-out to @danieladankova.bsky.social who spearheaded the project.
Now out on @chemrxiv.bsky.social
chemrxiv.org/engage/chemr...
Another great paper from #NovoNordisk on how housing mice near vs below thermoneutrality affects drug-induced weight loss because thermal stress greatly increases energy expenditure. Key to better evaluating data in the quickly growing field of obesity research! www.sciencedirect.com/science/arti...
Housing mice near vs. below thermoneutrality affects drug-induced weight loss but does not improve prediction of efficacy in humans
Evaluation of weight loss drugs is usually performed in diet-induced obese mice housed at ∼22°C. This is a cold stress that increases energy expenditu…
www.sciencedirect.com
December 9, 2024 at 12:15 PM
Another great paper from #NovoNordisk on how housing mice near vs below thermoneutrality affects drug-induced weight loss because thermal stress greatly increases energy expenditure. Key to better evaluating data in the quickly growing field of obesity research! www.sciencedirect.com/science/arti...
Reposted by Simon Rössler
Our Synthesis Tag (SynTag) for the synthesis of aggregating peptides and proteins is now published in JACS 🥳 Congratulations to first authors Héloïse & Elyse and everyone else involved ✨✨
pubs.acs.org/doi/10.1021/...
pubs.acs.org/doi/10.1021/...
A Versatile “Synthesis Tag” (SynTag) for the Chemical Synthesis of Aggregating Peptides and Proteins
Solid-phase peptide synthesis (SPPS) and native chemical ligation (NCL) are powerful methods for obtaining peptides and proteins that are otherwise inaccessible. Nonetheless, numerous sequences are di...
pubs.acs.org
December 6, 2024 at 6:39 AM
Our Synthesis Tag (SynTag) for the synthesis of aggregating peptides and proteins is now published in JACS 🥳 Congratulations to first authors Héloïse & Elyse and everyone else involved ✨✨
pubs.acs.org/doi/10.1021/...
pubs.acs.org/doi/10.1021/...
Reposted by Simon Rössler
Are you curious to see what my team and I are up to? Check out our group website here: peptide-discovery.ethz.ch
Homepage
peptide-discovery.ethz.ch
November 21, 2024 at 2:28 PM
Are you curious to see what my team and I are up to? Check out our group website here: peptide-discovery.ethz.ch
Reposted by Simon Rössler
🎨 In case anyone need…
The NIH BioArt Source is an awesome library of *free* professionally drawn illustrations for scientific presentations or figures. Downloadable in HD. Thank you NIH for this invaluable tool 🙏!
Check it out 👇
bioart.niaid.nih.gov
The NIH BioArt Source is an awesome library of *free* professionally drawn illustrations for scientific presentations or figures. Downloadable in HD. Thank you NIH for this invaluable tool 🙏!
Check it out 👇
bioart.niaid.nih.gov
November 23, 2024 at 3:50 PM
🎨 In case anyone need…
The NIH BioArt Source is an awesome library of *free* professionally drawn illustrations for scientific presentations or figures. Downloadable in HD. Thank you NIH for this invaluable tool 🙏!
Check it out 👇
bioart.niaid.nih.gov
The NIH BioArt Source is an awesome library of *free* professionally drawn illustrations for scientific presentations or figures. Downloadable in HD. Thank you NIH for this invaluable tool 🙏!
Check it out 👇
bioart.niaid.nih.gov
MIT researchers in collaboration with Novo Nordisk report in Nature an alternative to injections for the delivery of biologic drugs. This needle-free method leverages an ingestible capsule inspired by squids that releases drugs directly into the digestive tract wall. www.nature.com/articles/s41...
Cephalopod-inspired jetting devices for gastrointestinal drug delivery - Nature
Tethered or ingestible delivery systems that deliver liquid microjets in axial and radial directions can be used to deliver macromolecules to different parts of the gastrointestinal tract with good bi...
www.nature.com
November 25, 2024 at 8:52 AM
MIT researchers in collaboration with Novo Nordisk report in Nature an alternative to injections for the delivery of biologic drugs. This needle-free method leverages an ingestible capsule inspired by squids that releases drugs directly into the digestive tract wall. www.nature.com/articles/s41...
To tackle the challenge of proper glycaemic control for people on insulin therapy, my colleagues at Novo Nordisk have engineered a glucose-responsive insulin, which shows reduced activity at low glucose levels, thereby mitigating the risk of hypoglycemia. www.nature.com/articles/s41...
Glucose-sensitive insulin with attenuation of hypoglycaemia - Nature
NNC2215 is an insulin conjugate that can reversibly adjust its bioactivity in response to a diabetes-relevant glucose range in vivo.
www.nature.com
November 20, 2024 at 8:02 AM
To tackle the challenge of proper glycaemic control for people on insulin therapy, my colleagues at Novo Nordisk have engineered a glucose-responsive insulin, which shows reduced activity at low glucose levels, thereby mitigating the risk of hypoglycemia. www.nature.com/articles/s41...