Shaon Chakrabarti
@shaonchakrabarti.bsky.social
Assistant Professor @NCBS, Bangalore. Combining theory and experiments to understand cancer and circadian clocks from single cell fluctuations.
Pinned
Identifying memory gene expression from single sample scRNA-seq data using power law signatures
Genes with expression levels that fluctuate on time scales longer than cell division times are associated with cancer drug tolerance. However, current methods for identifying such ‘memory’ genes rely ...
tinyurl.com
Inheritable 'memory' genes drive cancer drug tolerance, but their discovery in clinical samples is a major challenge. Our new theory, moving away from Luria-Delbruck, detects them from a *single* scRNA-seq dataset without requiring barcodes! With #ArchishmanRaju and #Suvranil tinyurl.com/4pef8scy
Reposted by Shaon Chakrabarti
#LatestPublication
Dr @shaonchakrabarti.bsky.social & team combine single-cell & population level measurements to show that most of the information of cell fate is already pre-programmed in the cancer cells, well before the addition of the drug.
tinyurl.com/mrydz4rf
🎉Congratulations, team!
Dr @shaonchakrabarti.bsky.social & team combine single-cell & population level measurements to show that most of the information of cell fate is already pre-programmed in the cancer cells, well before the addition of the drug.
tinyurl.com/mrydz4rf
🎉Congratulations, team!
Inheritable cell-states shape drug-persister correlations and population dynamics in cancer cells
Author summary It is now well understood that evasion of drug effects on short time-scales by cancer cells (drug tolerant persisters or DTPs) originates from cell fate outcomes driven by non-genetic h...
tinyurl.com
October 14, 2025 at 12:05 PM
#LatestPublication
Dr @shaonchakrabarti.bsky.social & team combine single-cell & population level measurements to show that most of the information of cell fate is already pre-programmed in the cancer cells, well before the addition of the drug.
tinyurl.com/mrydz4rf
🎉Congratulations, team!
Dr @shaonchakrabarti.bsky.social & team combine single-cell & population level measurements to show that most of the information of cell fate is already pre-programmed in the cancer cells, well before the addition of the drug.
tinyurl.com/mrydz4rf
🎉Congratulations, team!
Reposted by Shaon Chakrabarti
#ResearchExplained!
@shaonchakrabarti.bsky.social's lab at NCBS explored a new strategy to detect the internal clock’s control over the cell cycle, offering valuable insights that could enhance the effectiveness of chronotherapy-based cancer treatments.
Read Here: bit.ly/42X82Ax
✏️ Christeen Paulson
@shaonchakrabarti.bsky.social's lab at NCBS explored a new strategy to detect the internal clock’s control over the cell cycle, offering valuable insights that could enhance the effectiveness of chronotherapy-based cancer treatments.
Read Here: bit.ly/42X82Ax
✏️ Christeen Paulson
May 14, 2025 at 10:09 AM
#ResearchExplained!
@shaonchakrabarti.bsky.social's lab at NCBS explored a new strategy to detect the internal clock’s control over the cell cycle, offering valuable insights that could enhance the effectiveness of chronotherapy-based cancer treatments.
Read Here: bit.ly/42X82Ax
✏️ Christeen Paulson
@shaonchakrabarti.bsky.social's lab at NCBS explored a new strategy to detect the internal clock’s control over the cell cycle, offering valuable insights that could enhance the effectiveness of chronotherapy-based cancer treatments.
Read Here: bit.ly/42X82Ax
✏️ Christeen Paulson
Inheritable 'memory' genes drive cancer drug tolerance, but their discovery in clinical samples is a major challenge. Our new theory, moving away from Luria-Delbruck, detects them from a *single* scRNA-seq dataset without requiring barcodes! With #ArchishmanRaju and #Suvranil tinyurl.com/4pef8scy
Identifying memory gene expression from single sample scRNA-seq data using power law signatures
Genes with expression levels that fluctuate on time scales longer than cell division times are associated with cancer drug tolerance. However, current methods for identifying such ‘memory’ genes rely ...
tinyurl.com
January 20, 2025 at 10:50 AM
Inheritable 'memory' genes drive cancer drug tolerance, but their discovery in clinical samples is a major challenge. Our new theory, moving away from Luria-Delbruck, detects them from a *single* scRNA-seq dataset without requiring barcodes! With #ArchishmanRaju and #Suvranil tinyurl.com/4pef8scy
Reposted by Shaon Chakrabarti
Covering theory and experiments in chronobiology (including hands-on wet lab sessions), ranging from historical perspectives to more modern aspects of high-dimensional data analysis of bio-clocks, the workshop promises to be very exciting. Do apply by 31st December!
December 21, 2024 at 3:44 PM
Covering theory and experiments in chronobiology (including hands-on wet lab sessions), ranging from historical perspectives to more modern aspects of high-dimensional data analysis of bio-clocks, the workshop promises to be very exciting. Do apply by 31st December!
Our article on a cool technique to identify 'Memory Genes' associated with #Cancer #DrugTolerance is now out in
@NatureRevCancer! Also a sneak peek into work about to come out (collab with Archishman Raju) we are really excited about! rdcu.be/d11Jm
@NatureRevCancer! Also a sneak peek into work about to come out (collab with Archishman Raju) we are really excited about! rdcu.be/d11Jm
Identifying memory genes in cancer drug tolerance
Nature Reviews Cancer - In this Journal Club, Chakrabarti discusses a method to dissect the molecular architecture of inheritable gene expression (memory) states that mark cells that transition...
rdcu.be
December 9, 2024 at 2:57 PM
Our article on a cool technique to identify 'Memory Genes' associated with #Cancer #DrugTolerance is now out in
@NatureRevCancer! Also a sneak peek into work about to come out (collab with Archishman Raju) we are really excited about! rdcu.be/d11Jm
@NatureRevCancer! Also a sneak peek into work about to come out (collab with Archishman Raju) we are really excited about! rdcu.be/d11Jm